Indirect fluorometric determination of diclofenac sodium
- Autores
- Castillo, Marcela A.; Bruzzone, Liliana
- Año de publicación
- 2006
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- A simple and easy method of analysis for diclofenac sodium is reported. A spectrofluorometric method for the microdetermination of diclofenac sodium has been developed through its reaction with cerium(IV) in an acidic solution and measurement of the fluorescence of the Ce(III) ions produced. Under the optimum experimental conditions for the oxidation reaction, 1.0 M H 2 SO 4 with 90 min of heating time (100°C), the range of application is 124.3 - 600 ng mL -1 and the limit of detection is 72.7 ng mL -1 . The proposed method was applied to the determination of diclofenac sodium in pharmaceutical tablets. The results of the analysis show a good agreement with those obtained by the official USP 27 HPLC method.
Facultad de Ciencias Exactas - Materia
-
Química
Diclofenaco
Espectrometría de Fluorescencia - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
.jpg)
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/83452
Ver los metadatos del registro completo
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Indirect fluorometric determination of diclofenac sodiumCastillo, Marcela A.Bruzzone, LilianaQuímicaDiclofenacoEspectrometría de FluorescenciaA simple and easy method of analysis for diclofenac sodium is reported. A spectrofluorometric method for the microdetermination of diclofenac sodium has been developed through its reaction with cerium(IV) in an acidic solution and measurement of the fluorescence of the Ce(III) ions produced. Under the optimum experimental conditions for the oxidation reaction, 1.0 M H 2 SO 4 with 90 min of heating time (100°C), the range of application is 124.3 - 600 ng mL -1 and the limit of detection is 72.7 ng mL -1 . The proposed method was applied to the determination of diclofenac sodium in pharmaceutical tablets. The results of the analysis show a good agreement with those obtained by the official USP 27 HPLC method.Facultad de Ciencias Exactas2006-04-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf431-433http://sedici.unlp.edu.ar/handle/10915/83452enginfo:eu-repo/semantics/altIdentifier/issn/0910-6340info:eu-repo/semantics/altIdentifier/doi/10.2116/analsci.22.431info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-10T12:18:27Zoai:sedici.unlp.edu.ar:10915/83452Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-10 12:18:27.861SEDICI (UNLP) - Universidad Nacional de La Platafalse |
| dc.title.none.fl_str_mv |
Indirect fluorometric determination of diclofenac sodium |
| title |
Indirect fluorometric determination of diclofenac sodium |
| spellingShingle |
Indirect fluorometric determination of diclofenac sodium Castillo, Marcela A. Química Diclofenaco Espectrometría de Fluorescencia |
| title_short |
Indirect fluorometric determination of diclofenac sodium |
| title_full |
Indirect fluorometric determination of diclofenac sodium |
| title_fullStr |
Indirect fluorometric determination of diclofenac sodium |
| title_full_unstemmed |
Indirect fluorometric determination of diclofenac sodium |
| title_sort |
Indirect fluorometric determination of diclofenac sodium |
| dc.creator.none.fl_str_mv |
Castillo, Marcela A. Bruzzone, Liliana |
| author |
Castillo, Marcela A. |
| author_facet |
Castillo, Marcela A. Bruzzone, Liliana |
| author_role |
author |
| author2 |
Bruzzone, Liliana |
| author2_role |
author |
| dc.subject.none.fl_str_mv |
Química Diclofenaco Espectrometría de Fluorescencia |
| topic |
Química Diclofenaco Espectrometría de Fluorescencia |
| dc.description.none.fl_txt_mv |
A simple and easy method of analysis for diclofenac sodium is reported. A spectrofluorometric method for the microdetermination of diclofenac sodium has been developed through its reaction with cerium(IV) in an acidic solution and measurement of the fluorescence of the Ce(III) ions produced. Under the optimum experimental conditions for the oxidation reaction, 1.0 M H 2 SO 4 with 90 min of heating time (100°C), the range of application is 124.3 - 600 ng mL -1 and the limit of detection is 72.7 ng mL -1 . The proposed method was applied to the determination of diclofenac sodium in pharmaceutical tablets. The results of the analysis show a good agreement with those obtained by the official USP 27 HPLC method. Facultad de Ciencias Exactas |
| description |
A simple and easy method of analysis for diclofenac sodium is reported. A spectrofluorometric method for the microdetermination of diclofenac sodium has been developed through its reaction with cerium(IV) in an acidic solution and measurement of the fluorescence of the Ce(III) ions produced. Under the optimum experimental conditions for the oxidation reaction, 1.0 M H 2 SO 4 with 90 min of heating time (100°C), the range of application is 124.3 - 600 ng mL -1 and the limit of detection is 72.7 ng mL -1 . The proposed method was applied to the determination of diclofenac sodium in pharmaceutical tablets. The results of the analysis show a good agreement with those obtained by the official USP 27 HPLC method. |
| publishDate |
2006 |
| dc.date.none.fl_str_mv |
2006-04-05 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Articulo http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
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article |
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publishedVersion |
| dc.identifier.none.fl_str_mv |
http://sedici.unlp.edu.ar/handle/10915/83452 |
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eng |
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eng |
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openAccess |
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http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
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