Experimentally designed, validated hplc simultaneous determination of pridinol and diclofenac in their combined pharmaceutical formulations, which allows limiting diclofenac relate...

Autores
Vignaduzzo, Silvana Edit; Castellano, Patricia Margarita; Kaufman, Teodoro Saul
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The development and validation of an HPLC method for the determination of pridinol and diclofenac in their combined formulations and the simultaneous limit testing of diclofenac related compound A is described. The separation was performed on a C18 column. Experimental design and response surface strategies were employed for optimizing detection wavelength (225nm) and mobile phase composition [MeOH:2-propanol:phosphate buffer (50mM, pH 5.5), 48:9:43 (v/v/v), 1mLmin-1], and for validation purposes. The method was successfully applied to the quality control of commercial brands of tablets and capsules. Found impurity levels were below 0.1% (LOQ=0.02%). Stressed samples were also evaluated.
Fil: Vignaduzzo, Silvana Edit. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Castellano, Patricia Margarita. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Kaufman, Teodoro Saul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Materia
DICLOFENAC
DICLOFENAC RELATED COMPOUND A
EXPERIMENTAL DESIGN
HPLC DETERMINATION
PRIDINOL
VALIDATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/133263
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Experimentally designed, validated hplc simultaneous determination of pridinol and diclofenac in their combined pharmaceutical formulations, which allows limiting diclofenac related compound AVignaduzzo, Silvana EditCastellano, Patricia MargaritaKaufman, Teodoro SaulDICLOFENACDICLOFENAC RELATED COMPOUND AEXPERIMENTAL DESIGNHPLC DETERMINATIONPRIDINOLVALIDATIONhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The development and validation of an HPLC method for the determination of pridinol and diclofenac in their combined formulations and the simultaneous limit testing of diclofenac related compound A is described. The separation was performed on a C18 column. Experimental design and response surface strategies were employed for optimizing detection wavelength (225nm) and mobile phase composition [MeOH:2-propanol:phosphate buffer (50mM, pH 5.5), 48:9:43 (v/v/v), 1mLmin-1], and for validation purposes. The method was successfully applied to the quality control of commercial brands of tablets and capsules. Found impurity levels were below 0.1% (LOQ=0.02%). Stressed samples were also evaluated.Fil: Vignaduzzo, Silvana Edit. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Castellano, Patricia Margarita. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Kaufman, Teodoro Saul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaTaylor & Francis2010-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/133263Vignaduzzo, Silvana Edit; Castellano, Patricia Margarita; Kaufman, Teodoro Saul; Experimentally designed, validated hplc simultaneous determination of pridinol and diclofenac in their combined pharmaceutical formulations, which allows limiting diclofenac related compound A; Taylor & Francis; Journal of Liquid Chromatography and Related Technologies; 33; 19; 1-2010; 1720-17321082-6076CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.1080/10826076.2010.519239info:eu-repo/semantics/altIdentifier/doi/10.1080/10826076.2010.519239info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:07:04Zoai:ri.conicet.gov.ar:11336/133263instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:07:05.321CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Experimentally designed, validated hplc simultaneous determination of pridinol and diclofenac in their combined pharmaceutical formulations, which allows limiting diclofenac related compound A
title Experimentally designed, validated hplc simultaneous determination of pridinol and diclofenac in their combined pharmaceutical formulations, which allows limiting diclofenac related compound A
spellingShingle Experimentally designed, validated hplc simultaneous determination of pridinol and diclofenac in their combined pharmaceutical formulations, which allows limiting diclofenac related compound A
Vignaduzzo, Silvana Edit
DICLOFENAC
DICLOFENAC RELATED COMPOUND A
EXPERIMENTAL DESIGN
HPLC DETERMINATION
PRIDINOL
VALIDATION
title_short Experimentally designed, validated hplc simultaneous determination of pridinol and diclofenac in their combined pharmaceutical formulations, which allows limiting diclofenac related compound A
title_full Experimentally designed, validated hplc simultaneous determination of pridinol and diclofenac in their combined pharmaceutical formulations, which allows limiting diclofenac related compound A
title_fullStr Experimentally designed, validated hplc simultaneous determination of pridinol and diclofenac in their combined pharmaceutical formulations, which allows limiting diclofenac related compound A
title_full_unstemmed Experimentally designed, validated hplc simultaneous determination of pridinol and diclofenac in their combined pharmaceutical formulations, which allows limiting diclofenac related compound A
title_sort Experimentally designed, validated hplc simultaneous determination of pridinol and diclofenac in their combined pharmaceutical formulations, which allows limiting diclofenac related compound A
dc.creator.none.fl_str_mv Vignaduzzo, Silvana Edit
Castellano, Patricia Margarita
Kaufman, Teodoro Saul
author Vignaduzzo, Silvana Edit
author_facet Vignaduzzo, Silvana Edit
Castellano, Patricia Margarita
Kaufman, Teodoro Saul
author_role author
author2 Castellano, Patricia Margarita
Kaufman, Teodoro Saul
author2_role author
author
dc.subject.none.fl_str_mv DICLOFENAC
DICLOFENAC RELATED COMPOUND A
EXPERIMENTAL DESIGN
HPLC DETERMINATION
PRIDINOL
VALIDATION
topic DICLOFENAC
DICLOFENAC RELATED COMPOUND A
EXPERIMENTAL DESIGN
HPLC DETERMINATION
PRIDINOL
VALIDATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The development and validation of an HPLC method for the determination of pridinol and diclofenac in their combined formulations and the simultaneous limit testing of diclofenac related compound A is described. The separation was performed on a C18 column. Experimental design and response surface strategies were employed for optimizing detection wavelength (225nm) and mobile phase composition [MeOH:2-propanol:phosphate buffer (50mM, pH 5.5), 48:9:43 (v/v/v), 1mLmin-1], and for validation purposes. The method was successfully applied to the quality control of commercial brands of tablets and capsules. Found impurity levels were below 0.1% (LOQ=0.02%). Stressed samples were also evaluated.
Fil: Vignaduzzo, Silvana Edit. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Castellano, Patricia Margarita. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Kaufman, Teodoro Saul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
description The development and validation of an HPLC method for the determination of pridinol and diclofenac in their combined formulations and the simultaneous limit testing of diclofenac related compound A is described. The separation was performed on a C18 column. Experimental design and response surface strategies were employed for optimizing detection wavelength (225nm) and mobile phase composition [MeOH:2-propanol:phosphate buffer (50mM, pH 5.5), 48:9:43 (v/v/v), 1mLmin-1], and for validation purposes. The method was successfully applied to the quality control of commercial brands of tablets and capsules. Found impurity levels were below 0.1% (LOQ=0.02%). Stressed samples were also evaluated.
publishDate 2010
dc.date.none.fl_str_mv 2010-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/133263
Vignaduzzo, Silvana Edit; Castellano, Patricia Margarita; Kaufman, Teodoro Saul; Experimentally designed, validated hplc simultaneous determination of pridinol and diclofenac in their combined pharmaceutical formulations, which allows limiting diclofenac related compound A; Taylor & Francis; Journal of Liquid Chromatography and Related Technologies; 33; 19; 1-2010; 1720-1732
1082-6076
CONICET Digital
CONICET
url http://hdl.handle.net/11336/133263
identifier_str_mv Vignaduzzo, Silvana Edit; Castellano, Patricia Margarita; Kaufman, Teodoro Saul; Experimentally designed, validated hplc simultaneous determination of pridinol and diclofenac in their combined pharmaceutical formulations, which allows limiting diclofenac related compound A; Taylor & Francis; Journal of Liquid Chromatography and Related Technologies; 33; 19; 1-2010; 1720-1732
1082-6076
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.1080/10826076.2010.519239
info:eu-repo/semantics/altIdentifier/doi/10.1080/10826076.2010.519239
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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