Kinetic-Spectrophotometric Method for Diclofenac Quantification

Autores
Monzón, Celina María; Sarno, María del Carmen Teresa; Delfino, Mario Raul
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This paper introduces a kinetic-spectrophotometric method for diclofenac quantification and its application to pharmaceutical preparations. The redox reaction rate between diclofenac and KMnO4 in a strong acidic environment is determined. Plotting initial slope vs. concentration a good linearity has been found. Linear range of the essay was 5-20 ppm. The effect of temperature on the reaction rate has been studied and Ea was 21.48 kJ/mol. The proposed method was found to be highly precise, having a relative standard deviation, CV% = 1.3% for repeatability (n=10). Recovery of analyte in placebo 98.7 - 108.15%, values that fall within the requirements set by USP and ANMAT (National Drug, Food and Medical Technology Administration of Argentina). This spectrophotometric method was compared with HPLC. Statistical data show no significant difference between them. The proposed method was found to be simple, rapid, specific, allowing the determination without preliminary extraction procedures.
Fil: Monzón, Celina María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Química Básica y Aplicada del Nordeste Argentino. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura. Instituto de Química Básica y Aplicada del Nordeste Argentino; Argentina
Fil: Sarno, María del Carmen Teresa. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas y Naturales y Agrimensura; Argentina
Fil: Delfino, Mario Raul. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas y Naturales y Agrimensura; Argentina
Materia
SPECTROPHOTOMETRY
DICLOFENAC TABLETS
REDOX REACTION
KMnO4
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/78263
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/78263
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Kinetic-Spectrophotometric Method for Diclofenac QuantificationMonzón, Celina MaríaSarno, María del Carmen TeresaDelfino, Mario RaulSPECTROPHOTOMETRYDICLOFENAC TABLETSREDOX REACTIONKMnO4https://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1This paper introduces a kinetic-spectrophotometric method for diclofenac quantification and its application to pharmaceutical preparations. The redox reaction rate between diclofenac and KMnO4 in a strong acidic environment is determined. Plotting initial slope vs. concentration a good linearity has been found. Linear range of the essay was 5-20 ppm. The effect of temperature on the reaction rate has been studied and Ea was 21.48 kJ/mol. The proposed method was found to be highly precise, having a relative standard deviation, CV% = 1.3% for repeatability (n=10). Recovery of analyte in placebo 98.7 - 108.15%, values that fall within the requirements set by USP and ANMAT (National Drug, Food and Medical Technology Administration of Argentina). This spectrophotometric method was compared with HPLC. Statistical data show no significant difference between them. The proposed method was found to be simple, rapid, specific, allowing the determination without preliminary extraction procedures.Fil: Monzón, Celina María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Química Básica y Aplicada del Nordeste Argentino. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura. Instituto de Química Básica y Aplicada del Nordeste Argentino; ArgentinaFil: Sarno, María del Carmen Teresa. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas y Naturales y Agrimensura; ArgentinaFil: Delfino, Mario Raul. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas y Naturales y Agrimensura; ArgentinaIOSR Editorial2012-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/78263Monzón, Celina María; Sarno, María del Carmen Teresa; Delfino, Mario Raul; Kinetic-Spectrophotometric Method for Diclofenac Quantification; IOSR Editorial; IOSR Journal of Pharmacy (IOSRPHR); 2; 5; 1-2012; 13-172250-3013CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.iosrphr.org/papers/v2i5/Part_1/C0251317.pdfinfo:eu-repo/semantics/altIdentifier/doi/10.9790/3013-25101317info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:21:12Zoai:ri.conicet.gov.ar:11336/78263instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:21:12.774CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Kinetic-Spectrophotometric Method for Diclofenac Quantification
title Kinetic-Spectrophotometric Method for Diclofenac Quantification
spellingShingle Kinetic-Spectrophotometric Method for Diclofenac Quantification
Monzón, Celina María
SPECTROPHOTOMETRY
DICLOFENAC TABLETS
REDOX REACTION
KMnO4
title_short Kinetic-Spectrophotometric Method for Diclofenac Quantification
title_full Kinetic-Spectrophotometric Method for Diclofenac Quantification
title_fullStr Kinetic-Spectrophotometric Method for Diclofenac Quantification
title_full_unstemmed Kinetic-Spectrophotometric Method for Diclofenac Quantification
title_sort Kinetic-Spectrophotometric Method for Diclofenac Quantification
dc.creator.none.fl_str_mv Monzón, Celina María
Sarno, María del Carmen Teresa
Delfino, Mario Raul
author Monzón, Celina María
author_facet Monzón, Celina María
Sarno, María del Carmen Teresa
Delfino, Mario Raul
author_role author
author2 Sarno, María del Carmen Teresa
Delfino, Mario Raul
author2_role author
author
dc.subject.none.fl_str_mv SPECTROPHOTOMETRY
DICLOFENAC TABLETS
REDOX REACTION
KMnO4
topic SPECTROPHOTOMETRY
DICLOFENAC TABLETS
REDOX REACTION
KMnO4
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv This paper introduces a kinetic-spectrophotometric method for diclofenac quantification and its application to pharmaceutical preparations. The redox reaction rate between diclofenac and KMnO4 in a strong acidic environment is determined. Plotting initial slope vs. concentration a good linearity has been found. Linear range of the essay was 5-20 ppm. The effect of temperature on the reaction rate has been studied and Ea was 21.48 kJ/mol. The proposed method was found to be highly precise, having a relative standard deviation, CV% = 1.3% for repeatability (n=10). Recovery of analyte in placebo 98.7 - 108.15%, values that fall within the requirements set by USP and ANMAT (National Drug, Food and Medical Technology Administration of Argentina). This spectrophotometric method was compared with HPLC. Statistical data show no significant difference between them. The proposed method was found to be simple, rapid, specific, allowing the determination without preliminary extraction procedures.
Fil: Monzón, Celina María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Química Básica y Aplicada del Nordeste Argentino. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura. Instituto de Química Básica y Aplicada del Nordeste Argentino; Argentina
Fil: Sarno, María del Carmen Teresa. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas y Naturales y Agrimensura; Argentina
Fil: Delfino, Mario Raul. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas y Naturales y Agrimensura; Argentina
description This paper introduces a kinetic-spectrophotometric method for diclofenac quantification and its application to pharmaceutical preparations. The redox reaction rate between diclofenac and KMnO4 in a strong acidic environment is determined. Plotting initial slope vs. concentration a good linearity has been found. Linear range of the essay was 5-20 ppm. The effect of temperature on the reaction rate has been studied and Ea was 21.48 kJ/mol. The proposed method was found to be highly precise, having a relative standard deviation, CV% = 1.3% for repeatability (n=10). Recovery of analyte in placebo 98.7 - 108.15%, values that fall within the requirements set by USP and ANMAT (National Drug, Food and Medical Technology Administration of Argentina). This spectrophotometric method was compared with HPLC. Statistical data show no significant difference between them. The proposed method was found to be simple, rapid, specific, allowing the determination without preliminary extraction procedures.
publishDate 2012
dc.date.none.fl_str_mv 2012-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/78263
Monzón, Celina María; Sarno, María del Carmen Teresa; Delfino, Mario Raul; Kinetic-Spectrophotometric Method for Diclofenac Quantification; IOSR Editorial; IOSR Journal of Pharmacy (IOSRPHR); 2; 5; 1-2012; 13-17
2250-3013
CONICET Digital
CONICET
url http://hdl.handle.net/11336/78263
identifier_str_mv Monzón, Celina María; Sarno, María del Carmen Teresa; Delfino, Mario Raul; Kinetic-Spectrophotometric Method for Diclofenac Quantification; IOSR Editorial; IOSR Journal of Pharmacy (IOSRPHR); 2; 5; 1-2012; 13-17
2250-3013
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.iosrphr.org/papers/v2i5/Part_1/C0251317.pdf
info:eu-repo/semantics/altIdentifier/doi/10.9790/3013-25101317
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv IOSR Editorial
publisher.none.fl_str_mv IOSR Editorial
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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