Diclofenac sodium UV degradation

• Autores: Ruiz, Jimena; Delfino, Mario Raúl; Monzón, Celina María; Jorge, Nelly Lidia; Sarno, María del Carmen Teresa
• Año de publicación: 2015
• Idioma: inglés
• Tipo de recurso: artículo
• Fuente: Asian Journal of Science and Technology, 2015, vol. 6, no. 7, p. 1561-1565.
• Materia: Diclofenac; UV radiation; Photodegradation; Quantum theoretical chemistry
• Institución: Universidad Nacional del Nordeste

Fil: Ruiz, Jimena. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura; Argentina.
Fil: Delfino, Mario Raúl. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas y Naturales y Agrimensura; Argentina.
Fil: Delfino, Mario Raúl. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico; Argentina.
Fil: Monzón, Celina María. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura; Argentina.
Fil: Monzón, Celina María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico; Argentina.
Fil: Jorge, Nelly Lidia. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura; Argentina.
Fil: Sarno, María del Carmen Teresa. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura; Argentina.
Diclofenac sodium (2- [2 - [(2,6-dicloro-fenil) amino] phenyl] sodium acetate) is an nonsteroidal antiinflammatory drug widely used today as an analgesic, anti-arthritic and anti-rheumatic. It is susceptible to stress caused by UV radiation. In this work photodegradation of diclofenac was monitored in batch mode using a photolysis orthogonal chamber. Diclofenac aqueous solutions of pH 9 were subjected to the effect of UV radiation of 254nm from a mercury lamp UVP with wood glass, located at 15 cm from the liquid surface. UV Spectra of solutions exposed for periods of time in the range of 5 minutes to 48 h were scanned. Diclofenac molecule without UV treatment exhibits a maximum at 195 nm and another at 276 nm. At very short treatment times a peak appears around 239 nm, where in the original molecule the absorbance is minimal. Another peak begins to emerge at 289 nm, which becomes more apparent at times of treatment longer than 1 hour. Simultaneously in greater times peaks at 225 and 250 nm appear. The absorptiometric measurements were complemented by the application of quantum theoretical chemistry using the static approximation and density functional theory, B3LYP. The excitations energies B3LYP for diclofenac and for the photolysis products are closed with the experimental measurements. Based on this, a mechanism for the reaction of photolytic degradation of diclofenac in the tested conditions is proposed.