Diclofenac Sodium UV degradation

Autores
Ruiz, Jimena; Delfino, Mario Raul; Monzón, Celina María; Jorge, Nelly Lidia; Sarno, María del Carmen Teresa
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Diclofenac sodium (2- [2 - [(2,6-dicloro-fenil) amino] phenyl] sodium acetate) is an nonsteroidal anti-inflammatory drug widely used today as an analgesic, anti-arthritic and anti-rheumatic. It is susceptible to stress caused by UV radiation. In this work photodegradation of diclofenac was monitored in batch mode using a photolysis orthogonal chamber. Diclofenac aqueous solutions of pH 9 were subjected to the effect of UV radiation of 254nm from a mercury lamp UVP with wood glass, located at 15 cm from the liquid surface. UV Spectra of solutions exposed for periods of time in the range of 5 minutes to 48 h were scanned. Diclofenac molecule without UV treatment exhibits a maximum at 195 nm and another at 276 nm. At very short treatment times a peak appears around 239 nm, where in the original molecule the absorbance is minimal. Another peak begins to emerge at 289 nm, which becomes more apparent at times of treatment longer than 1 hour. Simultaneously in greater times peaks at 225 and 250 nm appear. The absorptiometric measurements were complemented by the application of quantum theoretical chemistry using the static approximation and density functional theory, B3LYP. The excitations energies B3LYP for diclofenac and for the photolysis products are closed with the experimental measurements. Based on this, a mechanism for the reaction of photolytic degradation of diclofenac in the tested conditions is proposed
Fil: Ruiz, Jimena. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura; Argentina
Fil: Delfino, Mario Raul. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Monzón, Celina María. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Química Básica y Aplicada del Nordeste Argentino. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura. Instituto de Química Básica y Aplicada del Nordeste Argentino; Argentina
Fil: Jorge, Nelly Lidia. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura; Argentina
Fil: Sarno, María del Carmen Teresa. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura; Argentina
Materia
Diclofenac
Uv Radiation
Photodegradation
Quantum Theoretical Chemistry
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/44749
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/44749
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Diclofenac Sodium UV degradationRuiz, JimenaDelfino, Mario RaulMonzón, Celina MaríaJorge, Nelly LidiaSarno, María del Carmen TeresaDiclofenacUv RadiationPhotodegradationQuantum Theoretical Chemistryhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Diclofenac sodium (2- [2 - [(2,6-dicloro-fenil) amino] phenyl] sodium acetate) is an nonsteroidal anti-inflammatory drug widely used today as an analgesic, anti-arthritic and anti-rheumatic. It is susceptible to stress caused by UV radiation. In this work photodegradation of diclofenac was monitored in batch mode using a photolysis orthogonal chamber. Diclofenac aqueous solutions of pH 9 were subjected to the effect of UV radiation of 254nm from a mercury lamp UVP with wood glass, located at 15 cm from the liquid surface. UV Spectra of solutions exposed for periods of time in the range of 5 minutes to 48 h were scanned. Diclofenac molecule without UV treatment exhibits a maximum at 195 nm and another at 276 nm. At very short treatment times a peak appears around 239 nm, where in the original molecule the absorbance is minimal. Another peak begins to emerge at 289 nm, which becomes more apparent at times of treatment longer than 1 hour. Simultaneously in greater times peaks at 225 and 250 nm appear. The absorptiometric measurements were complemented by the application of quantum theoretical chemistry using the static approximation and density functional theory, B3LYP. The excitations energies B3LYP for diclofenac and for the photolysis products are closed with the experimental measurements. Based on this, a mechanism for the reaction of photolytic degradation of diclofenac in the tested conditions is proposedFil: Ruiz, Jimena. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura; ArgentinaFil: Delfino, Mario Raul. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Monzón, Celina María. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Química Básica y Aplicada del Nordeste Argentino. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura. Instituto de Química Básica y Aplicada del Nordeste Argentino; ArgentinaFil: Jorge, Nelly Lidia. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura; ArgentinaFil: Sarno, María del Carmen Teresa. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura; ArgentinaAsian Journal of Science and Technology Publishers2015-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/44749Ruiz, Jimena; Delfino, Mario Raul; Monzón, Celina María; Jorge, Nelly Lidia; Sarno, María del Carmen Teresa; Diclofenac Sodium UV degradation; Asian Journal of Science and Technology Publishers; Asian Journal of Science and Technology; 6; 7; 7-2015; 1561-15650976-3376CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.journalajst.com/sites/default/files/2262_0.pdfinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:56:22Zoai:ri.conicet.gov.ar:11336/44749instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:56:22.464CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Diclofenac Sodium UV degradation
title Diclofenac Sodium UV degradation
spellingShingle Diclofenac Sodium UV degradation
Ruiz, Jimena
Diclofenac
Uv Radiation
Photodegradation
Quantum Theoretical Chemistry
title_short Diclofenac Sodium UV degradation
title_full Diclofenac Sodium UV degradation
title_fullStr Diclofenac Sodium UV degradation
title_full_unstemmed Diclofenac Sodium UV degradation
title_sort Diclofenac Sodium UV degradation
dc.creator.none.fl_str_mv Ruiz, Jimena
Delfino, Mario Raul
Monzón, Celina María
Jorge, Nelly Lidia
Sarno, María del Carmen Teresa
author Ruiz, Jimena
author_facet Ruiz, Jimena
Delfino, Mario Raul
Monzón, Celina María
Jorge, Nelly Lidia
Sarno, María del Carmen Teresa
author_role author
author2 Delfino, Mario Raul
Monzón, Celina María
Jorge, Nelly Lidia
Sarno, María del Carmen Teresa
author2_role author
author
author
author
dc.subject.none.fl_str_mv Diclofenac
Uv Radiation
Photodegradation
Quantum Theoretical Chemistry
topic Diclofenac
Uv Radiation
Photodegradation
Quantum Theoretical Chemistry
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Diclofenac sodium (2- [2 - [(2,6-dicloro-fenil) amino] phenyl] sodium acetate) is an nonsteroidal anti-inflammatory drug widely used today as an analgesic, anti-arthritic and anti-rheumatic. It is susceptible to stress caused by UV radiation. In this work photodegradation of diclofenac was monitored in batch mode using a photolysis orthogonal chamber. Diclofenac aqueous solutions of pH 9 were subjected to the effect of UV radiation of 254nm from a mercury lamp UVP with wood glass, located at 15 cm from the liquid surface. UV Spectra of solutions exposed for periods of time in the range of 5 minutes to 48 h were scanned. Diclofenac molecule without UV treatment exhibits a maximum at 195 nm and another at 276 nm. At very short treatment times a peak appears around 239 nm, where in the original molecule the absorbance is minimal. Another peak begins to emerge at 289 nm, which becomes more apparent at times of treatment longer than 1 hour. Simultaneously in greater times peaks at 225 and 250 nm appear. The absorptiometric measurements were complemented by the application of quantum theoretical chemistry using the static approximation and density functional theory, B3LYP. The excitations energies B3LYP for diclofenac and for the photolysis products are closed with the experimental measurements. Based on this, a mechanism for the reaction of photolytic degradation of diclofenac in the tested conditions is proposed
Fil: Ruiz, Jimena. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura; Argentina
Fil: Delfino, Mario Raul. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Monzón, Celina María. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Química Básica y Aplicada del Nordeste Argentino. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura. Instituto de Química Básica y Aplicada del Nordeste Argentino; Argentina
Fil: Jorge, Nelly Lidia. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura; Argentina
Fil: Sarno, María del Carmen Teresa. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura; Argentina
description Diclofenac sodium (2- [2 - [(2,6-dicloro-fenil) amino] phenyl] sodium acetate) is an nonsteroidal anti-inflammatory drug widely used today as an analgesic, anti-arthritic and anti-rheumatic. It is susceptible to stress caused by UV radiation. In this work photodegradation of diclofenac was monitored in batch mode using a photolysis orthogonal chamber. Diclofenac aqueous solutions of pH 9 were subjected to the effect of UV radiation of 254nm from a mercury lamp UVP with wood glass, located at 15 cm from the liquid surface. UV Spectra of solutions exposed for periods of time in the range of 5 minutes to 48 h were scanned. Diclofenac molecule without UV treatment exhibits a maximum at 195 nm and another at 276 nm. At very short treatment times a peak appears around 239 nm, where in the original molecule the absorbance is minimal. Another peak begins to emerge at 289 nm, which becomes more apparent at times of treatment longer than 1 hour. Simultaneously in greater times peaks at 225 and 250 nm appear. The absorptiometric measurements were complemented by the application of quantum theoretical chemistry using the static approximation and density functional theory, B3LYP. The excitations energies B3LYP for diclofenac and for the photolysis products are closed with the experimental measurements. Based on this, a mechanism for the reaction of photolytic degradation of diclofenac in the tested conditions is proposed
publishDate 2015
dc.date.none.fl_str_mv 2015-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/44749
Ruiz, Jimena; Delfino, Mario Raul; Monzón, Celina María; Jorge, Nelly Lidia; Sarno, María del Carmen Teresa; Diclofenac Sodium UV degradation; Asian Journal of Science and Technology Publishers; Asian Journal of Science and Technology; 6; 7; 7-2015; 1561-1565
0976-3376
CONICET Digital
CONICET
url http://hdl.handle.net/11336/44749
identifier_str_mv Ruiz, Jimena; Delfino, Mario Raul; Monzón, Celina María; Jorge, Nelly Lidia; Sarno, María del Carmen Teresa; Diclofenac Sodium UV degradation; Asian Journal of Science and Technology Publishers; Asian Journal of Science and Technology; 6; 7; 7-2015; 1561-1565
0976-3376
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.journalajst.com/sites/default/files/2262_0.pdf
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Asian Journal of Science and Technology Publishers
publisher.none.fl_str_mv Asian Journal of Science and Technology Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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