Fast and Efficient Monitoring of Diclofenac Dissolution Profile by CE

Autores
Monzón, Celina María; Vera Candioti, Luciana; Sarno, María del Carmen Teresa; Delfino, Mario Raul
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Capillary electrophoresis (CE) was used to follow Diclofenac tablet dissolution, in very short times and allowing dissolution testing without volume replacement. By using Student´s t test and F-test, this CE method was compared with HPLC. Statistical data show that there are no significant differences among them. The drug release kinetic of diclofenac tablets was described by various mathematical models and equations. Model-Independent Methods: t50% = 10.34 min; t80% = 20 min; DE% = 79.41% and MDT = 10.85 min, show that diclofenac tablet dissolution rate is very high, having 80% drug dissolution within 20 minutes. Model-Dependent Methods. The kinetics models used were: zero order, first order, Hixson?Crowell cube root law, Higuchi model, and Weibull model. Criteria used to choose the best model was by comparisson of r2 and AIC (Akaike Information Criteria). The model that best adjusts diclofenac tablet dissolution profile was the Hixson-Crowell cube root model.
Fil: Monzón, Celina María. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: Vera Candioti, Luciana. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Química. Cátedra de Química Analítica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: Sarno, María del Carmen Teresa. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura; Argentina
Fil: Delfino, Mario Raul. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Materia
CAPILLARY ELECTROPHORESIS
DICLOFENAC
DISSOLUTION
QUANTIFICATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/31443
Acceder
id CONICETDig_f705c3869d6a08d0776e6c6e1e6d93e2
oai_identifier_str oai:ri.conicet.gov.ar:11336/31443
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Fast and Efficient Monitoring of Diclofenac Dissolution Profile by CEMonzón, Celina MaríaVera Candioti, LucianaSarno, María del Carmen TeresaDelfino, Mario RaulCAPILLARY ELECTROPHORESISDICLOFENACDISSOLUTIONQUANTIFICATIONhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Capillary electrophoresis (CE) was used to follow Diclofenac tablet dissolution, in very short times and allowing dissolution testing without volume replacement. By using Student´s t test and F-test, this CE method was compared with HPLC. Statistical data show that there are no significant differences among them. The drug release kinetic of diclofenac tablets was described by various mathematical models and equations. Model-Independent Methods: t50% = 10.34 min; t80% = 20 min; DE% = 79.41% and MDT = 10.85 min, show that diclofenac tablet dissolution rate is very high, having 80% drug dissolution within 20 minutes. Model-Dependent Methods. The kinetics models used were: zero order, first order, Hixson?Crowell cube root law, Higuchi model, and Weibull model. Criteria used to choose the best model was by comparisson of r2 and AIC (Akaike Information Criteria). The model that best adjusts diclofenac tablet dissolution profile was the Hixson-Crowell cube root model.Fil: Monzón, Celina María. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; ArgentinaFil: Vera Candioti, Luciana. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Química. Cátedra de Química Analítica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; ArgentinaFil: Sarno, María del Carmen Teresa. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura; ArgentinaFil: Delfino, Mario Raul. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; ArgentinaBentham Science Publishers2014-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/31443Delfino, Mario Raul; Sarno, María del Carmen Teresa; Vera Candioti, Luciana; Monzón, Celina María; Fast and Efficient Monitoring of Diclofenac Dissolution Profile by CE; Bentham Science Publishers; Current Pharmaceutical Analysis; 10; 1; 2-2014; 38-431573-4129CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/119349/articleinfo:eu-repo/semantics/altIdentifier/doi/10.2174/157341291001140102110607info:eu-repo/semantics/altIdentifier/url/http://www.ingentaconnect.com/contentone/ben/cpa/2014/00000010/00000001/art00007info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:46:19Zoai:ri.conicet.gov.ar:11336/31443instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:46:19.677CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Fast and Efficient Monitoring of Diclofenac Dissolution Profile by CE
title Fast and Efficient Monitoring of Diclofenac Dissolution Profile by CE
spellingShingle Fast and Efficient Monitoring of Diclofenac Dissolution Profile by CE
Monzón, Celina María
CAPILLARY ELECTROPHORESIS
DICLOFENAC
DISSOLUTION
QUANTIFICATION
title_short Fast and Efficient Monitoring of Diclofenac Dissolution Profile by CE
title_full Fast and Efficient Monitoring of Diclofenac Dissolution Profile by CE
title_fullStr Fast and Efficient Monitoring of Diclofenac Dissolution Profile by CE
title_full_unstemmed Fast and Efficient Monitoring of Diclofenac Dissolution Profile by CE
title_sort Fast and Efficient Monitoring of Diclofenac Dissolution Profile by CE
dc.creator.none.fl_str_mv Monzón, Celina María
Vera Candioti, Luciana
Sarno, María del Carmen Teresa
Delfino, Mario Raul
author Monzón, Celina María
author_facet Monzón, Celina María
Vera Candioti, Luciana
Sarno, María del Carmen Teresa
Delfino, Mario Raul
author_role author
author2 Vera Candioti, Luciana
Sarno, María del Carmen Teresa
Delfino, Mario Raul
author2_role author
author
author
dc.subject.none.fl_str_mv CAPILLARY ELECTROPHORESIS
DICLOFENAC
DISSOLUTION
QUANTIFICATION
topic CAPILLARY ELECTROPHORESIS
DICLOFENAC
DISSOLUTION
QUANTIFICATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Capillary electrophoresis (CE) was used to follow Diclofenac tablet dissolution, in very short times and allowing dissolution testing without volume replacement. By using Student´s t test and F-test, this CE method was compared with HPLC. Statistical data show that there are no significant differences among them. The drug release kinetic of diclofenac tablets was described by various mathematical models and equations. Model-Independent Methods: t50% = 10.34 min; t80% = 20 min; DE% = 79.41% and MDT = 10.85 min, show that diclofenac tablet dissolution rate is very high, having 80% drug dissolution within 20 minutes. Model-Dependent Methods. The kinetics models used were: zero order, first order, Hixson?Crowell cube root law, Higuchi model, and Weibull model. Criteria used to choose the best model was by comparisson of r2 and AIC (Akaike Information Criteria). The model that best adjusts diclofenac tablet dissolution profile was the Hixson-Crowell cube root model.
Fil: Monzón, Celina María. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: Vera Candioti, Luciana. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Química. Cátedra de Química Analítica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: Sarno, María del Carmen Teresa. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura; Argentina
Fil: Delfino, Mario Raul. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
description Capillary electrophoresis (CE) was used to follow Diclofenac tablet dissolution, in very short times and allowing dissolution testing without volume replacement. By using Student´s t test and F-test, this CE method was compared with HPLC. Statistical data show that there are no significant differences among them. The drug release kinetic of diclofenac tablets was described by various mathematical models and equations. Model-Independent Methods: t50% = 10.34 min; t80% = 20 min; DE% = 79.41% and MDT = 10.85 min, show that diclofenac tablet dissolution rate is very high, having 80% drug dissolution within 20 minutes. Model-Dependent Methods. The kinetics models used were: zero order, first order, Hixson?Crowell cube root law, Higuchi model, and Weibull model. Criteria used to choose the best model was by comparisson of r2 and AIC (Akaike Information Criteria). The model that best adjusts diclofenac tablet dissolution profile was the Hixson-Crowell cube root model.
publishDate 2014
dc.date.none.fl_str_mv 2014-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/31443
Delfino, Mario Raul; Sarno, María del Carmen Teresa; Vera Candioti, Luciana; Monzón, Celina María; Fast and Efficient Monitoring of Diclofenac Dissolution Profile by CE; Bentham Science Publishers; Current Pharmaceutical Analysis; 10; 1; 2-2014; 38-43
1573-4129
CONICET Digital
CONICET
url http://hdl.handle.net/11336/31443
identifier_str_mv Delfino, Mario Raul; Sarno, María del Carmen Teresa; Vera Candioti, Luciana; Monzón, Celina María; Fast and Efficient Monitoring of Diclofenac Dissolution Profile by CE; Bentham Science Publishers; Current Pharmaceutical Analysis; 10; 1; 2-2014; 38-43
1573-4129
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/119349/article
info:eu-repo/semantics/altIdentifier/doi/10.2174/157341291001140102110607
info:eu-repo/semantics/altIdentifier/url/http://www.ingentaconnect.com/contentone/ben/cpa/2014/00000010/00000001/art00007
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613446711115776
score 13.070432

Publicaciones similares