Effect of epinephrine on the oxidative desaturation of fatty acids in the rat

Autores
Tacconi de Gómez Dumm, Irma Nelva; Tacconi de Alaniz, María Josefa; Brenner, Rodolfo Roberto
Año de publicación
1976
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The effect of epinephrine on the oxidative desaturation of fatty acids by liver microsomal prepara- tions of rats has been studied. Administration of epi- nephrine (1 mg/kg body weight) produced a significant decrease in desaturation of ( 1-14C)linoleic acid to y- linolenic acid and of ( 1 -14C)cr-linolenic acid to octadeca- 6,9,12,15-tetraenoic acid 12 hr after the injection. Lower doses produced a lesser effect on the A6-desaturation activity. Epinephrine administration modified the V,,, of linoleic acid desaturation but not the K,. There was also a slight increase in palmityl desaturation activity. The ef- fect of epinephrine on A6-desaturation activity was postulated to be mediated through an enhancement of the intracellular cyclic AMP levels that lead to an increase of a glucose metabolite. This metabolite would inhibit A6-desaturation activity.
Facultad de Ciencias Médicas
Materia
Ciencias Médicas
Palmitic acid
Linoleic acid
alpha-linolenic acid
Glucose metabolism
Liver microsomes
Cyclic AMP
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/123448
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/123448
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Effect of epinephrine on the oxidative desaturation of fatty acids in the ratTacconi de Gómez Dumm, Irma NelvaTacconi de Alaniz, María JosefaBrenner, Rodolfo RobertoCiencias MédicasPalmitic acidLinoleic acidalpha-linolenic acidGlucose metabolismLiver microsomesCyclic AMPThe effect of epinephrine on the oxidative desaturation of fatty acids by liver microsomal prepara- tions of rats has been studied. Administration of epi- nephrine (1 mg/kg body weight) produced a significant decrease in desaturation of ( 1-14C)linoleic acid to y- linolenic acid and of ( 1 -14C)cr-linolenic acid to octadeca- 6,9,12,15-tetraenoic acid 12 hr after the injection. Lower doses produced a lesser effect on the A6-desaturation activity. Epinephrine administration modified the V,,, of linoleic acid desaturation but not the K,. There was also a slight increase in palmityl desaturation activity. The ef- fect of epinephrine on A6-desaturation activity was postulated to be mediated through an enhancement of the intracellular cyclic AMP levels that lead to an increase of a glucose metabolite. This metabolite would inhibit A6-desaturation activity.Facultad de Ciencias Médicas1976info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf616-621http://sedici.unlp.edu.ar/handle/10915/123448enginfo:eu-repo/semantics/altIdentifier/issn/0022-2275info:eu-repo/semantics/altIdentifier/pmid/186549info:eu-repo/semantics/altIdentifier/doi/10.1016/s0022-2275(20)41733-xinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:29:14Zoai:sedici.unlp.edu.ar:10915/123448Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:29:15.218SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Effect of epinephrine on the oxidative desaturation of fatty acids in the rat
title Effect of epinephrine on the oxidative desaturation of fatty acids in the rat
spellingShingle Effect of epinephrine on the oxidative desaturation of fatty acids in the rat
Tacconi de Gómez Dumm, Irma Nelva
Ciencias Médicas
Palmitic acid
Linoleic acid
alpha-linolenic acid
Glucose metabolism
Liver microsomes
Cyclic AMP
title_short Effect of epinephrine on the oxidative desaturation of fatty acids in the rat
title_full Effect of epinephrine on the oxidative desaturation of fatty acids in the rat
title_fullStr Effect of epinephrine on the oxidative desaturation of fatty acids in the rat
title_full_unstemmed Effect of epinephrine on the oxidative desaturation of fatty acids in the rat
title_sort Effect of epinephrine on the oxidative desaturation of fatty acids in the rat
dc.creator.none.fl_str_mv Tacconi de Gómez Dumm, Irma Nelva
Tacconi de Alaniz, María Josefa
Brenner, Rodolfo Roberto
author Tacconi de Gómez Dumm, Irma Nelva
author_facet Tacconi de Gómez Dumm, Irma Nelva
Tacconi de Alaniz, María Josefa
Brenner, Rodolfo Roberto
author_role author
author2 Tacconi de Alaniz, María Josefa
Brenner, Rodolfo Roberto
author2_role author
author
dc.subject.none.fl_str_mv Ciencias Médicas
Palmitic acid
Linoleic acid
alpha-linolenic acid
Glucose metabolism
Liver microsomes
Cyclic AMP
topic Ciencias Médicas
Palmitic acid
Linoleic acid
alpha-linolenic acid
Glucose metabolism
Liver microsomes
Cyclic AMP
dc.description.none.fl_txt_mv The effect of epinephrine on the oxidative desaturation of fatty acids by liver microsomal prepara- tions of rats has been studied. Administration of epi- nephrine (1 mg/kg body weight) produced a significant decrease in desaturation of ( 1-14C)linoleic acid to y- linolenic acid and of ( 1 -14C)cr-linolenic acid to octadeca- 6,9,12,15-tetraenoic acid 12 hr after the injection. Lower doses produced a lesser effect on the A6-desaturation activity. Epinephrine administration modified the V,,, of linoleic acid desaturation but not the K,. There was also a slight increase in palmityl desaturation activity. The ef- fect of epinephrine on A6-desaturation activity was postulated to be mediated through an enhancement of the intracellular cyclic AMP levels that lead to an increase of a glucose metabolite. This metabolite would inhibit A6-desaturation activity.
Facultad de Ciencias Médicas
description The effect of epinephrine on the oxidative desaturation of fatty acids by liver microsomal prepara- tions of rats has been studied. Administration of epi- nephrine (1 mg/kg body weight) produced a significant decrease in desaturation of ( 1-14C)linoleic acid to y- linolenic acid and of ( 1 -14C)cr-linolenic acid to octadeca- 6,9,12,15-tetraenoic acid 12 hr after the injection. Lower doses produced a lesser effect on the A6-desaturation activity. Epinephrine administration modified the V,,, of linoleic acid desaturation but not the K,. There was also a slight increase in palmityl desaturation activity. The ef- fect of epinephrine on A6-desaturation activity was postulated to be mediated through an enhancement of the intracellular cyclic AMP levels that lead to an increase of a glucose metabolite. This metabolite would inhibit A6-desaturation activity.
publishDate 1976
dc.date.none.fl_str_mv 1976
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/123448
url http://sedici.unlp.edu.ar/handle/10915/123448
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/0022-2275
info:eu-repo/semantics/altIdentifier/pmid/186549
info:eu-repo/semantics/altIdentifier/doi/10.1016/s0022-2275(20)41733-x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
616-621
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.070432

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