Effect of catecholamines and β-blockers on linoleic acid desaturation activity

Autores
Tacconi de Gómez Dumm, Irma Nelva; Tacconi de Alaniz, María Josefa; Brenner, Rodolfo Roberto
Año de publicación
1978
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The effect of catecholamines and adrenergic blocking agents on the oxidative desaturation of linoleic acid in rat liver microsomes was studied. Epinephrine (1 mg/kg/body weight) produced a significant decrease on the conversion of [1-14C]linoleic acid to gamma-linolenic acid. The effect of epinephrine was blocked by single injections of the beta blockers propranolol (10 mg/kg body weight) or dichloroisoproterenol 30 min before the hormone treatment. Isoproterenol (100 microgram/kg body weight) produced a significant decrease on the activity of the linoleyl-CoA desaturase. The effect of the catecholamines was postulated to be mediated through beta receptors by an enhancement of the intracellular levels of cyclic AMP.
Facultad de Ciencias Médicas
Materia
Medicina
Bioquímica
blocking agent
linoleic acid
rat liver
hormone treatment
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/139001
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/139001
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Effect of catecholamines and β-blockers on linoleic acid desaturation activityTacconi de Gómez Dumm, Irma NelvaTacconi de Alaniz, María JosefaBrenner, Rodolfo RobertoMedicinaBioquímicablocking agentlinoleic acidrat liverhormone treatmentThe effect of catecholamines and adrenergic blocking agents on the oxidative desaturation of linoleic acid in rat liver microsomes was studied. Epinephrine (1 mg/kg/body weight) produced a significant decrease on the conversion of [1-14C]linoleic acid to gamma-linolenic acid. The effect of epinephrine was blocked by single injections of the beta blockers propranolol (10 mg/kg body weight) or dichloroisoproterenol 30 min before the hormone treatment. Isoproterenol (100 microgram/kg body weight) produced a significant decrease on the activity of the linoleyl-CoA desaturase. The effect of the catecholamines was postulated to be mediated through beta receptors by an enhancement of the intracellular levels of cyclic AMP.Facultad de Ciencias Médicas1978info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf649-652http://sedici.unlp.edu.ar/handle/10915/139001enginfo:eu-repo/semantics/altIdentifier/issn/0024-4201info:eu-repo/semantics/altIdentifier/issn/1558-9307info:eu-repo/semantics/altIdentifier/doi/10.1007/bf02533740info:eu-repo/semantics/altIdentifier/pmid/27520107; 31543info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:31:52Zoai:sedici.unlp.edu.ar:10915/139001Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:31:53.244SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Effect of catecholamines and β-blockers on linoleic acid desaturation activity
title Effect of catecholamines and β-blockers on linoleic acid desaturation activity
spellingShingle Effect of catecholamines and β-blockers on linoleic acid desaturation activity
Tacconi de Gómez Dumm, Irma Nelva
Medicina
Bioquímica
blocking agent
linoleic acid
rat liver
hormone treatment
title_short Effect of catecholamines and β-blockers on linoleic acid desaturation activity
title_full Effect of catecholamines and β-blockers on linoleic acid desaturation activity
title_fullStr Effect of catecholamines and β-blockers on linoleic acid desaturation activity
title_full_unstemmed Effect of catecholamines and β-blockers on linoleic acid desaturation activity
title_sort Effect of catecholamines and β-blockers on linoleic acid desaturation activity
dc.creator.none.fl_str_mv Tacconi de Gómez Dumm, Irma Nelva
Tacconi de Alaniz, María Josefa
Brenner, Rodolfo Roberto
author Tacconi de Gómez Dumm, Irma Nelva
author_facet Tacconi de Gómez Dumm, Irma Nelva
Tacconi de Alaniz, María Josefa
Brenner, Rodolfo Roberto
author_role author
author2 Tacconi de Alaniz, María Josefa
Brenner, Rodolfo Roberto
author2_role author
author
dc.subject.none.fl_str_mv Medicina
Bioquímica
blocking agent
linoleic acid
rat liver
hormone treatment
topic Medicina
Bioquímica
blocking agent
linoleic acid
rat liver
hormone treatment
dc.description.none.fl_txt_mv The effect of catecholamines and adrenergic blocking agents on the oxidative desaturation of linoleic acid in rat liver microsomes was studied. Epinephrine (1 mg/kg/body weight) produced a significant decrease on the conversion of [1-14C]linoleic acid to gamma-linolenic acid. The effect of epinephrine was blocked by single injections of the beta blockers propranolol (10 mg/kg body weight) or dichloroisoproterenol 30 min before the hormone treatment. Isoproterenol (100 microgram/kg body weight) produced a significant decrease on the activity of the linoleyl-CoA desaturase. The effect of the catecholamines was postulated to be mediated through beta receptors by an enhancement of the intracellular levels of cyclic AMP.
Facultad de Ciencias Médicas
description The effect of catecholamines and adrenergic blocking agents on the oxidative desaturation of linoleic acid in rat liver microsomes was studied. Epinephrine (1 mg/kg/body weight) produced a significant decrease on the conversion of [1-14C]linoleic acid to gamma-linolenic acid. The effect of epinephrine was blocked by single injections of the beta blockers propranolol (10 mg/kg body weight) or dichloroisoproterenol 30 min before the hormone treatment. Isoproterenol (100 microgram/kg body weight) produced a significant decrease on the activity of the linoleyl-CoA desaturase. The effect of the catecholamines was postulated to be mediated through beta receptors by an enhancement of the intracellular levels of cyclic AMP.
publishDate 1978
dc.date.none.fl_str_mv 1978
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/139001
url http://sedici.unlp.edu.ar/handle/10915/139001
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/0024-4201
info:eu-repo/semantics/altIdentifier/issn/1558-9307
info:eu-repo/semantics/altIdentifier/doi/10.1007/bf02533740
info:eu-repo/semantics/altIdentifier/pmid/27520107; 31543
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
649-652
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.070432

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