Oxidative desaturation of α-linolenic, linoleic, and stearic acids by human liver microsomes

Autores
Tacconi de Gómez Dumm, Irma Nelva; Brenner, Rodolfo Roberto
Año de publicación
1975
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The desaturation of stearic, linoleic, and α-linolenic acids by human liver microsomes were studied. The microsomes were isolated from liver biopsies obtained during operations. It was shown that human liver microsomes are able to desaturate 1-¹⁴C-α-linolenic acid to octadeca-6,9,12,15-tetraenoic acid; 1-¹⁴C-linoleic acid to γ-linolenic acid; and 1-¹⁴C-stearic acid to oleic acid in the same system described in the rat. However, the desaturation activity obtained was low compared to other mammals. This effect was attributed to fasting, premedication, or the anaesthesia.
Facultad de Ciencias Exactas
Materia
Bioquímica
Desaturation of acids
Human liver microsomes
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/146061
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/146061
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Oxidative desaturation of α-linolenic, linoleic, and stearic acids by human liver microsomesTacconi de Gómez Dumm, Irma NelvaBrenner, Rodolfo RobertoBioquímicaDesaturation of acidsHuman liver microsomesThe desaturation of stearic, linoleic, and α-linolenic acids by human liver microsomes were studied. The microsomes were isolated from liver biopsies obtained during operations. It was shown that human liver microsomes are able to desaturate 1-¹⁴C-α-linolenic acid to octadeca-6,9,12,15-tetraenoic acid; 1-¹⁴C-linoleic acid to γ-linolenic acid; and 1-¹⁴C-stearic acid to oleic acid in the same system described in the rat. However, the desaturation activity obtained was low compared to other mammals. This effect was attributed to fasting, premedication, or the anaesthesia.Facultad de Ciencias Exactas1975info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf315-317http://sedici.unlp.edu.ar/handle/10915/146061enginfo:eu-repo/semantics/altIdentifier/issn/0024-4201info:eu-repo/semantics/altIdentifier/issn/1558-9307info:eu-repo/semantics/altIdentifier/doi/10.1007/bf02532451info:eu-repo/semantics/altIdentifier/pmid/1134219info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-10-15T11:24:14Zoai:sedici.unlp.edu.ar:10915/146061Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-10-15 11:24:14.908SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Oxidative desaturation of α-linolenic, linoleic, and stearic acids by human liver microsomes
title Oxidative desaturation of α-linolenic, linoleic, and stearic acids by human liver microsomes
spellingShingle Oxidative desaturation of α-linolenic, linoleic, and stearic acids by human liver microsomes
Tacconi de Gómez Dumm, Irma Nelva
Bioquímica
Desaturation of acids
Human liver microsomes
title_short Oxidative desaturation of α-linolenic, linoleic, and stearic acids by human liver microsomes
title_full Oxidative desaturation of α-linolenic, linoleic, and stearic acids by human liver microsomes
title_fullStr Oxidative desaturation of α-linolenic, linoleic, and stearic acids by human liver microsomes
title_full_unstemmed Oxidative desaturation of α-linolenic, linoleic, and stearic acids by human liver microsomes
title_sort Oxidative desaturation of α-linolenic, linoleic, and stearic acids by human liver microsomes
dc.creator.none.fl_str_mv Tacconi de Gómez Dumm, Irma Nelva
Brenner, Rodolfo Roberto
author Tacconi de Gómez Dumm, Irma Nelva
author_facet Tacconi de Gómez Dumm, Irma Nelva
Brenner, Rodolfo Roberto
author_role author
author2 Brenner, Rodolfo Roberto
author2_role author
dc.subject.none.fl_str_mv Bioquímica
Desaturation of acids
Human liver microsomes
topic Bioquímica
Desaturation of acids
Human liver microsomes
dc.description.none.fl_txt_mv The desaturation of stearic, linoleic, and α-linolenic acids by human liver microsomes were studied. The microsomes were isolated from liver biopsies obtained during operations. It was shown that human liver microsomes are able to desaturate 1-¹⁴C-α-linolenic acid to octadeca-6,9,12,15-tetraenoic acid; 1-¹⁴C-linoleic acid to γ-linolenic acid; and 1-¹⁴C-stearic acid to oleic acid in the same system described in the rat. However, the desaturation activity obtained was low compared to other mammals. This effect was attributed to fasting, premedication, or the anaesthesia.
Facultad de Ciencias Exactas
description The desaturation of stearic, linoleic, and α-linolenic acids by human liver microsomes were studied. The microsomes were isolated from liver biopsies obtained during operations. It was shown that human liver microsomes are able to desaturate 1-¹⁴C-α-linolenic acid to octadeca-6,9,12,15-tetraenoic acid; 1-¹⁴C-linoleic acid to γ-linolenic acid; and 1-¹⁴C-stearic acid to oleic acid in the same system described in the rat. However, the desaturation activity obtained was low compared to other mammals. This effect was attributed to fasting, premedication, or the anaesthesia.
publishDate 1975
dc.date.none.fl_str_mv 1975
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/146061
url http://sedici.unlp.edu.ar/handle/10915/146061
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/0024-4201
info:eu-repo/semantics/altIdentifier/issn/1558-9307
info:eu-repo/semantics/altIdentifier/doi/10.1007/bf02532451
info:eu-repo/semantics/altIdentifier/pmid/1134219
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
315-317
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.22299

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