Effect of epinephrine and dibutyryl cyclic AMP on Δ5-desaturation activity of rat liver microsomes
- Autores
- Tacconi de Gómez Dumm, Irma Nelva; Tacconi de Alaniz, María Josefa; Brenner, Rodolfo Roberto
- Año de publicación
- 1980
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The effect of epinephrine and dibutyryl cyclic AMP on the oxidative desaturation of [1-14C]-eicosatrienoic acid to arachidonic acid of rat liver microsomes has been studied. Epinephrine, at a dose of 1 mg/kg/body weight, produced a significant decrease on Δ5-desaturation activity 3 hr after the injection. This effect was maintained up to 12 hr and reached the control values 48 hr after the hormone administration. Dibutyryl cyclic AMP treatment for 24 hr (5 mg/8 hr/100 g body weight) also produced a significant decrease of the conversion of eicosatrienoic acid to arachidonic acid in rat liver microsomes. The effect of epinephrine on Δ5-desaturation activity was postulated to be evoked through an increase of the intracellular concentration of cyclic AMP.
Facultad de Ciencias Médicas - Materia
-
Bioquímica
Epinephrine
Dibutyryl cyclic AMP
Δ5-desaturation - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/144599
Ver los metadatos del registro completo
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Effect of epinephrine and dibutyryl cyclic AMP on Δ5-desaturation activity of rat liver microsomesTacconi de Gómez Dumm, Irma NelvaTacconi de Alaniz, María JosefaBrenner, Rodolfo RobertoBioquímicaEpinephrineDibutyryl cyclic AMPΔ5-desaturationThe effect of epinephrine and dibutyryl cyclic AMP on the oxidative desaturation of [1-14C]-eicosatrienoic acid to arachidonic acid of rat liver microsomes has been studied. Epinephrine, at a dose of 1 mg/kg/body weight, produced a significant decrease on Δ5-desaturation activity 3 hr after the injection. This effect was maintained up to 12 hr and reached the control values 48 hr after the hormone administration. Dibutyryl cyclic AMP treatment for 24 hr (5 mg/8 hr/100 g body weight) also produced a significant decrease of the conversion of eicosatrienoic acid to arachidonic acid in rat liver microsomes. The effect of epinephrine on Δ5-desaturation activity was postulated to be evoked through an increase of the intracellular concentration of cyclic AMP.Facultad de Ciencias Médicas1980info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf1064-1066http://sedici.unlp.edu.ar/handle/10915/144599enginfo:eu-repo/semantics/altIdentifier/issn/0024-4201info:eu-repo/semantics/altIdentifier/issn/1558-9307info:eu-repo/semantics/altIdentifier/doi/10.1007/bf02534325info:eu-repo/semantics/altIdentifier/pmid/6261074info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-10-15T11:24:20Zoai:sedici.unlp.edu.ar:10915/144599Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-10-15 11:24:20.982SEDICI (UNLP) - Universidad Nacional de La Platafalse |
dc.title.none.fl_str_mv |
Effect of epinephrine and dibutyryl cyclic AMP on Δ5-desaturation activity of rat liver microsomes |
title |
Effect of epinephrine and dibutyryl cyclic AMP on Δ5-desaturation activity of rat liver microsomes |
spellingShingle |
Effect of epinephrine and dibutyryl cyclic AMP on Δ5-desaturation activity of rat liver microsomes Tacconi de Gómez Dumm, Irma Nelva Bioquímica Epinephrine Dibutyryl cyclic AMP Δ5-desaturation |
title_short |
Effect of epinephrine and dibutyryl cyclic AMP on Δ5-desaturation activity of rat liver microsomes |
title_full |
Effect of epinephrine and dibutyryl cyclic AMP on Δ5-desaturation activity of rat liver microsomes |
title_fullStr |
Effect of epinephrine and dibutyryl cyclic AMP on Δ5-desaturation activity of rat liver microsomes |
title_full_unstemmed |
Effect of epinephrine and dibutyryl cyclic AMP on Δ5-desaturation activity of rat liver microsomes |
title_sort |
Effect of epinephrine and dibutyryl cyclic AMP on Δ5-desaturation activity of rat liver microsomes |
dc.creator.none.fl_str_mv |
Tacconi de Gómez Dumm, Irma Nelva Tacconi de Alaniz, María Josefa Brenner, Rodolfo Roberto |
author |
Tacconi de Gómez Dumm, Irma Nelva |
author_facet |
Tacconi de Gómez Dumm, Irma Nelva Tacconi de Alaniz, María Josefa Brenner, Rodolfo Roberto |
author_role |
author |
author2 |
Tacconi de Alaniz, María Josefa Brenner, Rodolfo Roberto |
author2_role |
author author |
dc.subject.none.fl_str_mv |
Bioquímica Epinephrine Dibutyryl cyclic AMP Δ5-desaturation |
topic |
Bioquímica Epinephrine Dibutyryl cyclic AMP Δ5-desaturation |
dc.description.none.fl_txt_mv |
The effect of epinephrine and dibutyryl cyclic AMP on the oxidative desaturation of [1-14C]-eicosatrienoic acid to arachidonic acid of rat liver microsomes has been studied. Epinephrine, at a dose of 1 mg/kg/body weight, produced a significant decrease on Δ5-desaturation activity 3 hr after the injection. This effect was maintained up to 12 hr and reached the control values 48 hr after the hormone administration. Dibutyryl cyclic AMP treatment for 24 hr (5 mg/8 hr/100 g body weight) also produced a significant decrease of the conversion of eicosatrienoic acid to arachidonic acid in rat liver microsomes. The effect of epinephrine on Δ5-desaturation activity was postulated to be evoked through an increase of the intracellular concentration of cyclic AMP. Facultad de Ciencias Médicas |
description |
The effect of epinephrine and dibutyryl cyclic AMP on the oxidative desaturation of [1-14C]-eicosatrienoic acid to arachidonic acid of rat liver microsomes has been studied. Epinephrine, at a dose of 1 mg/kg/body weight, produced a significant decrease on Δ5-desaturation activity 3 hr after the injection. This effect was maintained up to 12 hr and reached the control values 48 hr after the hormone administration. Dibutyryl cyclic AMP treatment for 24 hr (5 mg/8 hr/100 g body weight) also produced a significant decrease of the conversion of eicosatrienoic acid to arachidonic acid in rat liver microsomes. The effect of epinephrine on Δ5-desaturation activity was postulated to be evoked through an increase of the intracellular concentration of cyclic AMP. |
publishDate |
1980 |
dc.date.none.fl_str_mv |
1980 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Articulo http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://sedici.unlp.edu.ar/handle/10915/144599 |
url |
http://sedici.unlp.edu.ar/handle/10915/144599 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/issn/0024-4201 info:eu-repo/semantics/altIdentifier/issn/1558-9307 info:eu-repo/semantics/altIdentifier/doi/10.1007/bf02534325 info:eu-repo/semantics/altIdentifier/pmid/6261074 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
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openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
dc.format.none.fl_str_mv |
application/pdf 1064-1066 |
dc.source.none.fl_str_mv |
reponame:SEDICI (UNLP) instname:Universidad Nacional de La Plata instacron:UNLP |
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SEDICI (UNLP) - Universidad Nacional de La Plata |
repository.mail.fl_str_mv |
alira@sedici.unlp.edu.ar |
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