Effect of epinephrine and dibutyryl cyclic AMP on Δ5-desaturation activity of rat liver microsomes

Autores
Tacconi de Gómez Dumm, Irma Nelva; Tacconi de Alaniz, María Josefa; Brenner, Rodolfo Roberto
Año de publicación
1980
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The effect of epinephrine and dibutyryl cyclic AMP on the oxidative desaturation of [1-14C]-eicosatrienoic acid to arachidonic acid of rat liver microsomes has been studied. Epinephrine, at a dose of 1 mg/kg/body weight, produced a significant decrease on Δ5-desaturation activity 3 hr after the injection. This effect was maintained up to 12 hr and reached the control values 48 hr after the hormone administration. Dibutyryl cyclic AMP treatment for 24 hr (5 mg/8 hr/100 g body weight) also produced a significant decrease of the conversion of eicosatrienoic acid to arachidonic acid in rat liver microsomes. The effect of epinephrine on Δ5-desaturation activity was postulated to be evoked through an increase of the intracellular concentration of cyclic AMP.
Facultad de Ciencias Médicas
Materia
Bioquímica
Epinephrine
Dibutyryl cyclic AMP
Δ5-desaturation
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/144599

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network_name_str SEDICI (UNLP)
spelling Effect of epinephrine and dibutyryl cyclic AMP on Δ5-desaturation activity of rat liver microsomesTacconi de Gómez Dumm, Irma NelvaTacconi de Alaniz, María JosefaBrenner, Rodolfo RobertoBioquímicaEpinephrineDibutyryl cyclic AMPΔ5-desaturationThe effect of epinephrine and dibutyryl cyclic AMP on the oxidative desaturation of [1-14C]-eicosatrienoic acid to arachidonic acid of rat liver microsomes has been studied. Epinephrine, at a dose of 1 mg/kg/body weight, produced a significant decrease on Δ5-desaturation activity 3 hr after the injection. This effect was maintained up to 12 hr and reached the control values 48 hr after the hormone administration. Dibutyryl cyclic AMP treatment for 24 hr (5 mg/8 hr/100 g body weight) also produced a significant decrease of the conversion of eicosatrienoic acid to arachidonic acid in rat liver microsomes. The effect of epinephrine on Δ5-desaturation activity was postulated to be evoked through an increase of the intracellular concentration of cyclic AMP.Facultad de Ciencias Médicas1980info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf1064-1066http://sedici.unlp.edu.ar/handle/10915/144599enginfo:eu-repo/semantics/altIdentifier/issn/0024-4201info:eu-repo/semantics/altIdentifier/issn/1558-9307info:eu-repo/semantics/altIdentifier/doi/10.1007/bf02534325info:eu-repo/semantics/altIdentifier/pmid/6261074info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-10-15T11:24:20Zoai:sedici.unlp.edu.ar:10915/144599Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-10-15 11:24:20.982SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Effect of epinephrine and dibutyryl cyclic AMP on Δ5-desaturation activity of rat liver microsomes
title Effect of epinephrine and dibutyryl cyclic AMP on Δ5-desaturation activity of rat liver microsomes
spellingShingle Effect of epinephrine and dibutyryl cyclic AMP on Δ5-desaturation activity of rat liver microsomes
Tacconi de Gómez Dumm, Irma Nelva
Bioquímica
Epinephrine
Dibutyryl cyclic AMP
Δ5-desaturation
title_short Effect of epinephrine and dibutyryl cyclic AMP on Δ5-desaturation activity of rat liver microsomes
title_full Effect of epinephrine and dibutyryl cyclic AMP on Δ5-desaturation activity of rat liver microsomes
title_fullStr Effect of epinephrine and dibutyryl cyclic AMP on Δ5-desaturation activity of rat liver microsomes
title_full_unstemmed Effect of epinephrine and dibutyryl cyclic AMP on Δ5-desaturation activity of rat liver microsomes
title_sort Effect of epinephrine and dibutyryl cyclic AMP on Δ5-desaturation activity of rat liver microsomes
dc.creator.none.fl_str_mv Tacconi de Gómez Dumm, Irma Nelva
Tacconi de Alaniz, María Josefa
Brenner, Rodolfo Roberto
author Tacconi de Gómez Dumm, Irma Nelva
author_facet Tacconi de Gómez Dumm, Irma Nelva
Tacconi de Alaniz, María Josefa
Brenner, Rodolfo Roberto
author_role author
author2 Tacconi de Alaniz, María Josefa
Brenner, Rodolfo Roberto
author2_role author
author
dc.subject.none.fl_str_mv Bioquímica
Epinephrine
Dibutyryl cyclic AMP
Δ5-desaturation
topic Bioquímica
Epinephrine
Dibutyryl cyclic AMP
Δ5-desaturation
dc.description.none.fl_txt_mv The effect of epinephrine and dibutyryl cyclic AMP on the oxidative desaturation of [1-14C]-eicosatrienoic acid to arachidonic acid of rat liver microsomes has been studied. Epinephrine, at a dose of 1 mg/kg/body weight, produced a significant decrease on Δ5-desaturation activity 3 hr after the injection. This effect was maintained up to 12 hr and reached the control values 48 hr after the hormone administration. Dibutyryl cyclic AMP treatment for 24 hr (5 mg/8 hr/100 g body weight) also produced a significant decrease of the conversion of eicosatrienoic acid to arachidonic acid in rat liver microsomes. The effect of epinephrine on Δ5-desaturation activity was postulated to be evoked through an increase of the intracellular concentration of cyclic AMP.
Facultad de Ciencias Médicas
description The effect of epinephrine and dibutyryl cyclic AMP on the oxidative desaturation of [1-14C]-eicosatrienoic acid to arachidonic acid of rat liver microsomes has been studied. Epinephrine, at a dose of 1 mg/kg/body weight, produced a significant decrease on Δ5-desaturation activity 3 hr after the injection. This effect was maintained up to 12 hr and reached the control values 48 hr after the hormone administration. Dibutyryl cyclic AMP treatment for 24 hr (5 mg/8 hr/100 g body weight) also produced a significant decrease of the conversion of eicosatrienoic acid to arachidonic acid in rat liver microsomes. The effect of epinephrine on Δ5-desaturation activity was postulated to be evoked through an increase of the intracellular concentration of cyclic AMP.
publishDate 1980
dc.date.none.fl_str_mv 1980
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/144599
url http://sedici.unlp.edu.ar/handle/10915/144599
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/0024-4201
info:eu-repo/semantics/altIdentifier/issn/1558-9307
info:eu-repo/semantics/altIdentifier/doi/10.1007/bf02534325
info:eu-repo/semantics/altIdentifier/pmid/6261074
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
1064-1066
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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