Novel Chitosan Coated Magnetic Nanocarriers for the Targeted Diclofenac Delivery

Autores
Agotegaray, Mariela Alejandra; Palma, Santiago Daniel; Lassalle, Verónica Leticia
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
New magnetic devices consisting of magnetite functionalized with oleic acid and Chitosan have been synthesized and employed to the loading of Diclofenac as potential tool for treatment of targeted inflammatory diseases. Magnetic loaded and un-loaded nanoparticles have been thoroughly characterized by infrared spectroscopy, ransmission electron microscopy, determination of hydrodynamic diameter by Dynamic light scattering and zeta potential measurements at different pH conditions. A study of the release of Diclofenac has been performed in vitro and available mathematical models have been used to determine the release kinetic. Both properties and release data reveal that this nanomagnetic platform would be suitable for in vivo assays.
Fil: Agotegaray, Mariela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Palma, Santiago Daniel. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Lassalle, Verónica Leticia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Materia
Magnetite
Nanocarrier
Release Kinetic
Diclofenac
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/40390
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Novel Chitosan Coated Magnetic Nanocarriers for the Targeted Diclofenac DeliveryAgotegaray, Mariela AlejandraPalma, Santiago DanielLassalle, Verónica LeticiaMagnetiteNanocarrierRelease KineticDiclofenachttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2New magnetic devices consisting of magnetite functionalized with oleic acid and Chitosan have been synthesized and employed to the loading of Diclofenac as potential tool for treatment of targeted inflammatory diseases. Magnetic loaded and un-loaded nanoparticles have been thoroughly characterized by infrared spectroscopy, ransmission electron microscopy, determination of hydrodynamic diameter by Dynamic light scattering and zeta potential measurements at different pH conditions. A study of the release of Diclofenac has been performed in vitro and available mathematical models have been used to determine the release kinetic. Both properties and release data reveal that this nanomagnetic platform would be suitable for in vivo assays.Fil: Agotegaray, Mariela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; ArgentinaFil: Palma, Santiago Daniel. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Lassalle, Verónica Leticia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; ArgentinaAmerican Scientific Publishers2014-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/40390Agotegaray, Mariela Alejandra; Palma, Santiago Daniel; Lassalle, Verónica Leticia; Novel Chitosan Coated Magnetic Nanocarriers for the Targeted Diclofenac Delivery; American Scientific Publishers; Journal of Nanoscience and Nanotechnology; 14; 5-2014; 3343-33471533-4880CONICET DigitalCONICETenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:13:04Zoai:ri.conicet.gov.ar:11336/40390instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:13:05.302CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Novel Chitosan Coated Magnetic Nanocarriers for the Targeted Diclofenac Delivery
title Novel Chitosan Coated Magnetic Nanocarriers for the Targeted Diclofenac Delivery
spellingShingle Novel Chitosan Coated Magnetic Nanocarriers for the Targeted Diclofenac Delivery
Agotegaray, Mariela Alejandra
Magnetite
Nanocarrier
Release Kinetic
Diclofenac
title_short Novel Chitosan Coated Magnetic Nanocarriers for the Targeted Diclofenac Delivery
title_full Novel Chitosan Coated Magnetic Nanocarriers for the Targeted Diclofenac Delivery
title_fullStr Novel Chitosan Coated Magnetic Nanocarriers for the Targeted Diclofenac Delivery
title_full_unstemmed Novel Chitosan Coated Magnetic Nanocarriers for the Targeted Diclofenac Delivery
title_sort Novel Chitosan Coated Magnetic Nanocarriers for the Targeted Diclofenac Delivery
dc.creator.none.fl_str_mv Agotegaray, Mariela Alejandra
Palma, Santiago Daniel
Lassalle, Verónica Leticia
author Agotegaray, Mariela Alejandra
author_facet Agotegaray, Mariela Alejandra
Palma, Santiago Daniel
Lassalle, Verónica Leticia
author_role author
author2 Palma, Santiago Daniel
Lassalle, Verónica Leticia
author2_role author
author
dc.subject.none.fl_str_mv Magnetite
Nanocarrier
Release Kinetic
Diclofenac
topic Magnetite
Nanocarrier
Release Kinetic
Diclofenac
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv New magnetic devices consisting of magnetite functionalized with oleic acid and Chitosan have been synthesized and employed to the loading of Diclofenac as potential tool for treatment of targeted inflammatory diseases. Magnetic loaded and un-loaded nanoparticles have been thoroughly characterized by infrared spectroscopy, ransmission electron microscopy, determination of hydrodynamic diameter by Dynamic light scattering and zeta potential measurements at different pH conditions. A study of the release of Diclofenac has been performed in vitro and available mathematical models have been used to determine the release kinetic. Both properties and release data reveal that this nanomagnetic platform would be suitable for in vivo assays.
Fil: Agotegaray, Mariela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Palma, Santiago Daniel. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Lassalle, Verónica Leticia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
description New magnetic devices consisting of magnetite functionalized with oleic acid and Chitosan have been synthesized and employed to the loading of Diclofenac as potential tool for treatment of targeted inflammatory diseases. Magnetic loaded and un-loaded nanoparticles have been thoroughly characterized by infrared spectroscopy, ransmission electron microscopy, determination of hydrodynamic diameter by Dynamic light scattering and zeta potential measurements at different pH conditions. A study of the release of Diclofenac has been performed in vitro and available mathematical models have been used to determine the release kinetic. Both properties and release data reveal that this nanomagnetic platform would be suitable for in vivo assays.
publishDate 2014
dc.date.none.fl_str_mv 2014-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/40390
Agotegaray, Mariela Alejandra; Palma, Santiago Daniel; Lassalle, Verónica Leticia; Novel Chitosan Coated Magnetic Nanocarriers for the Targeted Diclofenac Delivery; American Scientific Publishers; Journal of Nanoscience and Nanotechnology; 14; 5-2014; 3343-3347
1533-4880
CONICET Digital
CONICET
url http://hdl.handle.net/11336/40390
identifier_str_mv Agotegaray, Mariela Alejandra; Palma, Santiago Daniel; Lassalle, Verónica Leticia; Novel Chitosan Coated Magnetic Nanocarriers for the Targeted Diclofenac Delivery; American Scientific Publishers; Journal of Nanoscience and Nanotechnology; 14; 5-2014; 3343-3347
1533-4880
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Scientific Publishers
publisher.none.fl_str_mv American Scientific Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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