Stage dependent susceptibility to Copper in Rhinella arenarum embryos and larvae

Autores
Aronzon, Carolina Mariel; Sandoval, María Teresa; Herkovits, Jorge; Perez Coll, Cristina Silvia
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Copper toxicity in different embryonic and larval stages of the common South American toad Rhinella arenarum was evaluated by means of continuous and 24-h pulse treatments in 12 different developmental stages. Lethal concentrations (LC) of 10, 50, and 90% of continuous treatment with Cu from early blastula (S.4), complete operculum (S.25), and hind limb bud (S.28) stages were plotted from 24 to 168 h, resulting from S.4 in a 24-h LC50 of 137 mg Cu2þ/L and a 168-h LC50 of 19.5mg Cu2þ/L. This result was in agreement with pulse treatments that showed a high resistance to Cu at blastula and gastrula stages, whereas the organogenic period, between muscular response (S.18) and open mouth (S.21), was very susceptible to this metal. Continuous treatments from S.25 showed no significant differences along exposure time (168-h LC50¼51mg Cu2þ/L), but in the case of S.28 toxicity increased slightly from a 24-h LC50 of 138.6 mg Cu2þ/L to a 168-h LC50 of 104 mg Cu2þ/L, pointing out that, although the larval period was significantly more resistant to Cu, there was also a remarkable stage-dependent susceptibility to this metal. Copper teratogenic potential was approximately two, and main adverse effects were reduced body size, axial flexure, microcephaly, acephaly, mouth malformations, agenesis of or underdeveloped gills, agenesis of or underdeveloped tail, and hydropsy. The results are discussed considering Cu toxicity mechanisms, an evolutionary perspective, and environmental protection.
Fil: Aronzon, Carolina Mariel. Universidad Nacional de San Martín. Instituto de Investigación en Ingeniería Ambiental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sandoval, María Teresa. Universidad Nacional del Nordeste; Argentina
Fil: Herkovits, Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Perez Coll, Cristina Silvia. Universidad Nacional de San Martín. Instituto de Investigación en Ingeniería Ambiental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
COPPER
AMPHIBIAN DEVELOPMENT
STAGE DEPENDENT SUSCEPTIBILITY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/194189
Acceder
id CONICETDig_d26ef60c605d0823c755994e5e37768d
oai_identifier_str oai:ri.conicet.gov.ar:11336/194189
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Stage dependent susceptibility to Copper in Rhinella arenarum embryos and larvaeAronzon, Carolina MarielSandoval, María TeresaHerkovits, JorgePerez Coll, Cristina SilviaCOPPERAMPHIBIAN DEVELOPMENTSTAGE DEPENDENT SUSCEPTIBILITYhttps://purl.org/becyt/ford/1.5https://purl.org/becyt/ford/1Copper toxicity in different embryonic and larval stages of the common South American toad Rhinella arenarum was evaluated by means of continuous and 24-h pulse treatments in 12 different developmental stages. Lethal concentrations (LC) of 10, 50, and 90% of continuous treatment with Cu from early blastula (S.4), complete operculum (S.25), and hind limb bud (S.28) stages were plotted from 24 to 168 h, resulting from S.4 in a 24-h LC50 of 137 mg Cu2þ/L and a 168-h LC50 of 19.5mg Cu2þ/L. This result was in agreement with pulse treatments that showed a high resistance to Cu at blastula and gastrula stages, whereas the organogenic period, between muscular response (S.18) and open mouth (S.21), was very susceptible to this metal. Continuous treatments from S.25 showed no significant differences along exposure time (168-h LC50¼51mg Cu2þ/L), but in the case of S.28 toxicity increased slightly from a 24-h LC50 of 138.6 mg Cu2þ/L to a 168-h LC50 of 104 mg Cu2þ/L, pointing out that, although the larval period was significantly more resistant to Cu, there was also a remarkable stage-dependent susceptibility to this metal. Copper teratogenic potential was approximately two, and main adverse effects were reduced body size, axial flexure, microcephaly, acephaly, mouth malformations, agenesis of or underdeveloped gills, agenesis of or underdeveloped tail, and hydropsy. The results are discussed considering Cu toxicity mechanisms, an evolutionary perspective, and environmental protection.Fil: Aronzon, Carolina Mariel. Universidad Nacional de San Martín. Instituto de Investigación en Ingeniería Ambiental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Sandoval, María Teresa. Universidad Nacional del Nordeste; ArgentinaFil: Herkovits, Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Perez Coll, Cristina Silvia. Universidad Nacional de San Martín. Instituto de Investigación en Ingeniería Ambiental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaSociety of Environmental Toxicology and Chemistry2011-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/194189Aronzon, Carolina Mariel; Sandoval, María Teresa; Herkovits, Jorge; Perez Coll, Cristina Silvia; Stage dependent susceptibility to Copper in Rhinella arenarum embryos and larvae; Society of Environmental Toxicology and Chemistry; Environmental Toxicology and Chemistry; 30; 12-2011; 2771-27770730-7268CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://setac.onlinelibrary.wiley.com/doi/full/10.1002/etc.674info:eu-repo/semantics/altIdentifier/doi/10.1002/etc.674info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:42:33Zoai:ri.conicet.gov.ar:11336/194189instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:42:33.953CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Stage dependent susceptibility to Copper in Rhinella arenarum embryos and larvae
title Stage dependent susceptibility to Copper in Rhinella arenarum embryos and larvae
spellingShingle Stage dependent susceptibility to Copper in Rhinella arenarum embryos and larvae
Aronzon, Carolina Mariel
COPPER
AMPHIBIAN DEVELOPMENT
STAGE DEPENDENT SUSCEPTIBILITY
title_short Stage dependent susceptibility to Copper in Rhinella arenarum embryos and larvae
title_full Stage dependent susceptibility to Copper in Rhinella arenarum embryos and larvae
title_fullStr Stage dependent susceptibility to Copper in Rhinella arenarum embryos and larvae
title_full_unstemmed Stage dependent susceptibility to Copper in Rhinella arenarum embryos and larvae
title_sort Stage dependent susceptibility to Copper in Rhinella arenarum embryos and larvae
dc.creator.none.fl_str_mv Aronzon, Carolina Mariel
Sandoval, María Teresa
Herkovits, Jorge
Perez Coll, Cristina Silvia
author Aronzon, Carolina Mariel
author_facet Aronzon, Carolina Mariel
Sandoval, María Teresa
Herkovits, Jorge
Perez Coll, Cristina Silvia
author_role author
author2 Sandoval, María Teresa
Herkovits, Jorge
Perez Coll, Cristina Silvia
author2_role author
author
author
dc.subject.none.fl_str_mv COPPER
AMPHIBIAN DEVELOPMENT
STAGE DEPENDENT SUSCEPTIBILITY
topic COPPER
AMPHIBIAN DEVELOPMENT
STAGE DEPENDENT SUSCEPTIBILITY
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.5
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Copper toxicity in different embryonic and larval stages of the common South American toad Rhinella arenarum was evaluated by means of continuous and 24-h pulse treatments in 12 different developmental stages. Lethal concentrations (LC) of 10, 50, and 90% of continuous treatment with Cu from early blastula (S.4), complete operculum (S.25), and hind limb bud (S.28) stages were plotted from 24 to 168 h, resulting from S.4 in a 24-h LC50 of 137 mg Cu2þ/L and a 168-h LC50 of 19.5mg Cu2þ/L. This result was in agreement with pulse treatments that showed a high resistance to Cu at blastula and gastrula stages, whereas the organogenic period, between muscular response (S.18) and open mouth (S.21), was very susceptible to this metal. Continuous treatments from S.25 showed no significant differences along exposure time (168-h LC50¼51mg Cu2þ/L), but in the case of S.28 toxicity increased slightly from a 24-h LC50 of 138.6 mg Cu2þ/L to a 168-h LC50 of 104 mg Cu2þ/L, pointing out that, although the larval period was significantly more resistant to Cu, there was also a remarkable stage-dependent susceptibility to this metal. Copper teratogenic potential was approximately two, and main adverse effects were reduced body size, axial flexure, microcephaly, acephaly, mouth malformations, agenesis of or underdeveloped gills, agenesis of or underdeveloped tail, and hydropsy. The results are discussed considering Cu toxicity mechanisms, an evolutionary perspective, and environmental protection.
Fil: Aronzon, Carolina Mariel. Universidad Nacional de San Martín. Instituto de Investigación en Ingeniería Ambiental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sandoval, María Teresa. Universidad Nacional del Nordeste; Argentina
Fil: Herkovits, Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Perez Coll, Cristina Silvia. Universidad Nacional de San Martín. Instituto de Investigación en Ingeniería Ambiental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Copper toxicity in different embryonic and larval stages of the common South American toad Rhinella arenarum was evaluated by means of continuous and 24-h pulse treatments in 12 different developmental stages. Lethal concentrations (LC) of 10, 50, and 90% of continuous treatment with Cu from early blastula (S.4), complete operculum (S.25), and hind limb bud (S.28) stages were plotted from 24 to 168 h, resulting from S.4 in a 24-h LC50 of 137 mg Cu2þ/L and a 168-h LC50 of 19.5mg Cu2þ/L. This result was in agreement with pulse treatments that showed a high resistance to Cu at blastula and gastrula stages, whereas the organogenic period, between muscular response (S.18) and open mouth (S.21), was very susceptible to this metal. Continuous treatments from S.25 showed no significant differences along exposure time (168-h LC50¼51mg Cu2þ/L), but in the case of S.28 toxicity increased slightly from a 24-h LC50 of 138.6 mg Cu2þ/L to a 168-h LC50 of 104 mg Cu2þ/L, pointing out that, although the larval period was significantly more resistant to Cu, there was also a remarkable stage-dependent susceptibility to this metal. Copper teratogenic potential was approximately two, and main adverse effects were reduced body size, axial flexure, microcephaly, acephaly, mouth malformations, agenesis of or underdeveloped gills, agenesis of or underdeveloped tail, and hydropsy. The results are discussed considering Cu toxicity mechanisms, an evolutionary perspective, and environmental protection.
publishDate 2011
dc.date.none.fl_str_mv 2011-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/194189
Aronzon, Carolina Mariel; Sandoval, María Teresa; Herkovits, Jorge; Perez Coll, Cristina Silvia; Stage dependent susceptibility to Copper in Rhinella arenarum embryos and larvae; Society of Environmental Toxicology and Chemistry; Environmental Toxicology and Chemistry; 30; 12-2011; 2771-2777
0730-7268
CONICET Digital
CONICET
url http://hdl.handle.net/11336/194189
identifier_str_mv Aronzon, Carolina Mariel; Sandoval, María Teresa; Herkovits, Jorge; Perez Coll, Cristina Silvia; Stage dependent susceptibility to Copper in Rhinella arenarum embryos and larvae; Society of Environmental Toxicology and Chemistry; Environmental Toxicology and Chemistry; 30; 12-2011; 2771-2777
0730-7268
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://setac.onlinelibrary.wiley.com/doi/full/10.1002/etc.674
info:eu-repo/semantics/altIdentifier/doi/10.1002/etc.674
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Society of Environmental Toxicology and Chemistry
publisher.none.fl_str_mv Society of Environmental Toxicology and Chemistry
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.238319

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