Developmental toxicity and risk assessment of nonylphenol to the South American toad, Rhinella arenarum

Autores
Aronzon, Carolina Mariel; Babay, Paola Alejandra; Perez Coll, Cristina Silvia
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The toxicity of Nonylphenol, an emerging pollutant, on the common South American toad Rhinella arenarum was stage and time dependent, thus Median Lethal Concentrations (LC50) for acute (96 h), short-term chronic (168 h) and chronic exposure (336 h) were 1.06; 0.96 and 0.17 mgNP/L from embryonic period (S.4), whereas for exposure from larvae (S.25), LC50 remained constant at 0.37 mgNP/L from 96 h to 168 h, decreasing to 0.11 mgNP/L at 336 h. NOEC-168 h for exposure from embryos was 0.025 mgNP/L. The Teratogenic Potential (NOEC-lethality/NOEC-sublethal effects) was 23 times higher than the threshold value, indicating a high risk for embryos to be malformed in absence of significant lethality and representing a threat for the species conservation. By comparing with other amphibians, the early development of R. arenarum was very sensitive to NP. The results highlight the relevance of extending the exposure time and look for the most sensitive stage in order to perform the bioassays for conservation purposes.
Fil: Aronzon, Carolina Mariel. Universidad Nacional de San Martín. Instituto de Investigación e Ingeniería Ambiental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Babay, Paola Alejandra. Comisión Nacional de Energía Atómica; Argentina
Fil: Perez Coll, Cristina Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Martín. Instituto de Investigación e Ingeniería Ambiental; Argentina
Materia
Amphibians
Embryo-larval development
Stage-dependent susceptibility
Teratogenesis
Nonylphenol
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/32755
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Developmental toxicity and risk assessment of nonylphenol to the South American toad, Rhinella arenarumAronzon, Carolina MarielBabay, Paola AlejandraPerez Coll, Cristina SilviaAmphibiansEmbryo-larval developmentStage-dependent susceptibilityTeratogenesisNonylphenolhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The toxicity of Nonylphenol, an emerging pollutant, on the common South American toad Rhinella arenarum was stage and time dependent, thus Median Lethal Concentrations (LC50) for acute (96 h), short-term chronic (168 h) and chronic exposure (336 h) were 1.06; 0.96 and 0.17 mgNP/L from embryonic period (S.4), whereas for exposure from larvae (S.25), LC50 remained constant at 0.37 mgNP/L from 96 h to 168 h, decreasing to 0.11 mgNP/L at 336 h. NOEC-168 h for exposure from embryos was 0.025 mgNP/L. The Teratogenic Potential (NOEC-lethality/NOEC-sublethal effects) was 23 times higher than the threshold value, indicating a high risk for embryos to be malformed in absence of significant lethality and representing a threat for the species conservation. By comparing with other amphibians, the early development of R. arenarum was very sensitive to NP. The results highlight the relevance of extending the exposure time and look for the most sensitive stage in order to perform the bioassays for conservation purposes.Fil: Aronzon, Carolina Mariel. Universidad Nacional de San Martín. Instituto de Investigación e Ingeniería Ambiental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Babay, Paola Alejandra. Comisión Nacional de Energía Atómica; ArgentinaFil: Perez Coll, Cristina Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Martín. Instituto de Investigación e Ingeniería Ambiental; ArgentinaElsevier2014-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/32755Perez Coll, Cristina Silvia; Aronzon, Carolina Mariel; Babay, Paola Alejandra; Developmental toxicity and risk assessment of nonylphenol to the South American toad, Rhinella arenarum; Elsevier; Environmental Toxicology and Pharmacology; 38; 2; 8-2014; 634-6421382-6689CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.etap.2014.08.014info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1382668914002002info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:59:32Zoai:ri.conicet.gov.ar:11336/32755instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:59:33.185CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Developmental toxicity and risk assessment of nonylphenol to the South American toad, Rhinella arenarum
title Developmental toxicity and risk assessment of nonylphenol to the South American toad, Rhinella arenarum
spellingShingle Developmental toxicity and risk assessment of nonylphenol to the South American toad, Rhinella arenarum
Aronzon, Carolina Mariel
Amphibians
Embryo-larval development
Stage-dependent susceptibility
Teratogenesis
Nonylphenol
title_short Developmental toxicity and risk assessment of nonylphenol to the South American toad, Rhinella arenarum
title_full Developmental toxicity and risk assessment of nonylphenol to the South American toad, Rhinella arenarum
title_fullStr Developmental toxicity and risk assessment of nonylphenol to the South American toad, Rhinella arenarum
title_full_unstemmed Developmental toxicity and risk assessment of nonylphenol to the South American toad, Rhinella arenarum
title_sort Developmental toxicity and risk assessment of nonylphenol to the South American toad, Rhinella arenarum
dc.creator.none.fl_str_mv Aronzon, Carolina Mariel
Babay, Paola Alejandra
Perez Coll, Cristina Silvia
author Aronzon, Carolina Mariel
author_facet Aronzon, Carolina Mariel
Babay, Paola Alejandra
Perez Coll, Cristina Silvia
author_role author
author2 Babay, Paola Alejandra
Perez Coll, Cristina Silvia
author2_role author
author
dc.subject.none.fl_str_mv Amphibians
Embryo-larval development
Stage-dependent susceptibility
Teratogenesis
Nonylphenol
topic Amphibians
Embryo-larval development
Stage-dependent susceptibility
Teratogenesis
Nonylphenol
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The toxicity of Nonylphenol, an emerging pollutant, on the common South American toad Rhinella arenarum was stage and time dependent, thus Median Lethal Concentrations (LC50) for acute (96 h), short-term chronic (168 h) and chronic exposure (336 h) were 1.06; 0.96 and 0.17 mgNP/L from embryonic period (S.4), whereas for exposure from larvae (S.25), LC50 remained constant at 0.37 mgNP/L from 96 h to 168 h, decreasing to 0.11 mgNP/L at 336 h. NOEC-168 h for exposure from embryos was 0.025 mgNP/L. The Teratogenic Potential (NOEC-lethality/NOEC-sublethal effects) was 23 times higher than the threshold value, indicating a high risk for embryos to be malformed in absence of significant lethality and representing a threat for the species conservation. By comparing with other amphibians, the early development of R. arenarum was very sensitive to NP. The results highlight the relevance of extending the exposure time and look for the most sensitive stage in order to perform the bioassays for conservation purposes.
Fil: Aronzon, Carolina Mariel. Universidad Nacional de San Martín. Instituto de Investigación e Ingeniería Ambiental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Babay, Paola Alejandra. Comisión Nacional de Energía Atómica; Argentina
Fil: Perez Coll, Cristina Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Martín. Instituto de Investigación e Ingeniería Ambiental; Argentina
description The toxicity of Nonylphenol, an emerging pollutant, on the common South American toad Rhinella arenarum was stage and time dependent, thus Median Lethal Concentrations (LC50) for acute (96 h), short-term chronic (168 h) and chronic exposure (336 h) were 1.06; 0.96 and 0.17 mgNP/L from embryonic period (S.4), whereas for exposure from larvae (S.25), LC50 remained constant at 0.37 mgNP/L from 96 h to 168 h, decreasing to 0.11 mgNP/L at 336 h. NOEC-168 h for exposure from embryos was 0.025 mgNP/L. The Teratogenic Potential (NOEC-lethality/NOEC-sublethal effects) was 23 times higher than the threshold value, indicating a high risk for embryos to be malformed in absence of significant lethality and representing a threat for the species conservation. By comparing with other amphibians, the early development of R. arenarum was very sensitive to NP. The results highlight the relevance of extending the exposure time and look for the most sensitive stage in order to perform the bioassays for conservation purposes.
publishDate 2014
dc.date.none.fl_str_mv 2014-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/32755
Perez Coll, Cristina Silvia; Aronzon, Carolina Mariel; Babay, Paola Alejandra; Developmental toxicity and risk assessment of nonylphenol to the South American toad, Rhinella arenarum; Elsevier; Environmental Toxicology and Pharmacology; 38; 2; 8-2014; 634-642
1382-6689
CONICET Digital
CONICET
url http://hdl.handle.net/11336/32755
identifier_str_mv Perez Coll, Cristina Silvia; Aronzon, Carolina Mariel; Babay, Paola Alejandra; Developmental toxicity and risk assessment of nonylphenol to the South American toad, Rhinella arenarum; Elsevier; Environmental Toxicology and Pharmacology; 38; 2; 8-2014; 634-642
1382-6689
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.etap.2014.08.014
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1382668914002002
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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