Developmental toxicity and risk assessment of nonylphenol to the South American toad, Rhinella arenarum.

Autores
Aronzon, Carolina Mariel; Babay, Paola Alejandra; Perez Coll, Cristina Silvia
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The toxicity of Nonylphenol, an emerging pollutant, on the common South American toad Rhinella arenarum was stage and time dependent, thus Median Lethal Concentrations (LC50) for acute (96 h), short-term chronic (168 h) and chronic exposure (336 h) were 1.06; 0.96 and 0.17 mgNP/L from embryonic period (S.4), whereas for exposure from larvae (S.25), LC50 remained constant at 0.37 mgNP/L from 96 h to 168 h, decreasing to 0.11 mgNP/L at 336 h. NOEC-168 h for exposure from embryos was 0.025 mgNP/L. The Teratogenic Potential (NOEC-lethality/NOEC-sublethal effects) was 23 times higher than the threshold value, indicating a high risk for embryos to be malformed in absence of significant lethality and representing a threat for the species conservation. By comparing with other amphibians, the early development of R. arenarum was very sensitive to NP. The results highlight the relevance of extending the exposure time and look for the most sensitive stage in order to perform the bioassays for conservation purposes.
Fil: Aronzon, Carolina Mariel. Universidad Nacional de San Martín. Instituto de Investigación e Ingeniería Ambiental; Argentina.
Fil: Babay, Paola Alejandra. Comisión Nacional de Energía Atómica; Argentina
Fil: Perez Coll, Cristina Silvia. Universidad Nacional de San Martín. Instituto de Investigación e Ingeniería Ambiental; Argentina
Fuente
Environmental Toxicology and Pharmacology, 2014 38(2): 634-642 Elsevier Science Bv
http://dx.doi.org/10.1016/j.etap.2014.08.014
Materia
AMPHIBIANS
EMBRYO-LARVAL DEVELOPMENT
STAGE-DEPENDENT SUSCEPTIBILITY
TERATOGENESIS
NONYLPHENOL
CIENCIAS BIOLÓGICAS
CIENCIAS NATURALES Y EXACTAS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
Repositorio Institucional (UNSAM)
Institución
Universidad Nacional de General San Martín
OAI Identificador
oai:ri.unsam.edu.ar:123456789/1004
Acceder
id RIUNSAM_300fa0d52b8f75c9ce570bc459cb1387
oai_identifier_str oai:ri.unsam.edu.ar:123456789/1004
network_acronym_str RIUNSAM
repository_id_str s
network_name_str Repositorio Institucional (UNSAM)
spelling Developmental toxicity and risk assessment of nonylphenol to the South American toad, Rhinella arenarum.Aronzon, Carolina MarielBabay, Paola AlejandraPerez Coll, Cristina SilviaAMPHIBIANSEMBRYO-LARVAL DEVELOPMENTSTAGE-DEPENDENT SUSCEPTIBILITYTERATOGENESISNONYLPHENOLCIENCIAS BIOLÓGICASCIENCIAS NATURALES Y EXACTASThe toxicity of Nonylphenol, an emerging pollutant, on the common South American toad Rhinella arenarum was stage and time dependent, thus Median Lethal Concentrations (LC50) for acute (96 h), short-term chronic (168 h) and chronic exposure (336 h) were 1.06; 0.96 and 0.17 mgNP/L from embryonic period (S.4), whereas for exposure from larvae (S.25), LC50 remained constant at 0.37 mgNP/L from 96 h to 168 h, decreasing to 0.11 mgNP/L at 336 h. NOEC-168 h for exposure from embryos was 0.025 mgNP/L. The Teratogenic Potential (NOEC-lethality/NOEC-sublethal effects) was 23 times higher than the threshold value, indicating a high risk for embryos to be malformed in absence of significant lethality and representing a threat for the species conservation. By comparing with other amphibians, the early development of R. arenarum was very sensitive to NP. The results highlight the relevance of extending the exposure time and look for the most sensitive stage in order to perform the bioassays for conservation purposes.Fil: Aronzon, Carolina Mariel. Universidad Nacional de San Martín. Instituto de Investigación e Ingeniería Ambiental; Argentina.Fil: Babay, Paola Alejandra. Comisión Nacional de Energía Atómica; ArgentinaFil: Perez Coll, Cristina Silvia. Universidad Nacional de San Martín. Instituto de Investigación e Ingeniería Ambiental; ArgentinaElsevier Science Bv2014-08info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfpp. 634-642application/pdfAronzon, C. M. ; Babay, P. A. y Perez Coll, C. S. (aug 2014) Developmental toxicity and risk assessment of nonylphenol to the South American toad, Rhinella arenarum; En: Environmental Toxicology and Pharmacology. Elsevier, 38 (2) 634-6421382-6689ETP-AM 2014 3iA A-B-PChttps://ri.unsam.edu.ar/handle/123456789/1004Environmental Toxicology and Pharmacology, 2014 38(2): 634-642 Elsevier Science Bvhttp://dx.doi.org/10.1016/j.etap.2014.08.014reponame:Repositorio Institucional (UNSAM)instname:Universidad Nacional de General San Martínenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/Creative Commons Atribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5)2025-09-04T11:15:44Zoai:ri.unsam.edu.ar:123456789/1004instacron:UNSAMInstitucionalhttp://ri.unsam.edu.arUniversidad públicaNo correspondehttp://ri.unsam.edu.ar/oai/lpastran@unsam.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:s2025-09-04 11:16:39.568Repositorio Institucional (UNSAM) - Universidad Nacional de General San Martínfalse
dc.title.none.fl_str_mv Developmental toxicity and risk assessment of nonylphenol to the South American toad, Rhinella arenarum.
title Developmental toxicity and risk assessment of nonylphenol to the South American toad, Rhinella arenarum.
spellingShingle Developmental toxicity and risk assessment of nonylphenol to the South American toad, Rhinella arenarum.
Aronzon, Carolina Mariel
AMPHIBIANS
EMBRYO-LARVAL DEVELOPMENT
STAGE-DEPENDENT SUSCEPTIBILITY
TERATOGENESIS
NONYLPHENOL
CIENCIAS BIOLÓGICAS
CIENCIAS NATURALES Y EXACTAS
title_short Developmental toxicity and risk assessment of nonylphenol to the South American toad, Rhinella arenarum.
title_full Developmental toxicity and risk assessment of nonylphenol to the South American toad, Rhinella arenarum.
title_fullStr Developmental toxicity and risk assessment of nonylphenol to the South American toad, Rhinella arenarum.
title_full_unstemmed Developmental toxicity and risk assessment of nonylphenol to the South American toad, Rhinella arenarum.
title_sort Developmental toxicity and risk assessment of nonylphenol to the South American toad, Rhinella arenarum.
dc.creator.none.fl_str_mv Aronzon, Carolina Mariel
Babay, Paola Alejandra
Perez Coll, Cristina Silvia
author Aronzon, Carolina Mariel
author_facet Aronzon, Carolina Mariel
Babay, Paola Alejandra
Perez Coll, Cristina Silvia
author_role author
author2 Babay, Paola Alejandra
Perez Coll, Cristina Silvia
author2_role author
author
dc.subject.none.fl_str_mv AMPHIBIANS
EMBRYO-LARVAL DEVELOPMENT
STAGE-DEPENDENT SUSCEPTIBILITY
TERATOGENESIS
NONYLPHENOL
CIENCIAS BIOLÓGICAS
CIENCIAS NATURALES Y EXACTAS
topic AMPHIBIANS
EMBRYO-LARVAL DEVELOPMENT
STAGE-DEPENDENT SUSCEPTIBILITY
TERATOGENESIS
NONYLPHENOL
CIENCIAS BIOLÓGICAS
CIENCIAS NATURALES Y EXACTAS
dc.description.none.fl_txt_mv The toxicity of Nonylphenol, an emerging pollutant, on the common South American toad Rhinella arenarum was stage and time dependent, thus Median Lethal Concentrations (LC50) for acute (96 h), short-term chronic (168 h) and chronic exposure (336 h) were 1.06; 0.96 and 0.17 mgNP/L from embryonic period (S.4), whereas for exposure from larvae (S.25), LC50 remained constant at 0.37 mgNP/L from 96 h to 168 h, decreasing to 0.11 mgNP/L at 336 h. NOEC-168 h for exposure from embryos was 0.025 mgNP/L. The Teratogenic Potential (NOEC-lethality/NOEC-sublethal effects) was 23 times higher than the threshold value, indicating a high risk for embryos to be malformed in absence of significant lethality and representing a threat for the species conservation. By comparing with other amphibians, the early development of R. arenarum was very sensitive to NP. The results highlight the relevance of extending the exposure time and look for the most sensitive stage in order to perform the bioassays for conservation purposes.
Fil: Aronzon, Carolina Mariel. Universidad Nacional de San Martín. Instituto de Investigación e Ingeniería Ambiental; Argentina.
Fil: Babay, Paola Alejandra. Comisión Nacional de Energía Atómica; Argentina
Fil: Perez Coll, Cristina Silvia. Universidad Nacional de San Martín. Instituto de Investigación e Ingeniería Ambiental; Argentina
description The toxicity of Nonylphenol, an emerging pollutant, on the common South American toad Rhinella arenarum was stage and time dependent, thus Median Lethal Concentrations (LC50) for acute (96 h), short-term chronic (168 h) and chronic exposure (336 h) were 1.06; 0.96 and 0.17 mgNP/L from embryonic period (S.4), whereas for exposure from larvae (S.25), LC50 remained constant at 0.37 mgNP/L from 96 h to 168 h, decreasing to 0.11 mgNP/L at 336 h. NOEC-168 h for exposure from embryos was 0.025 mgNP/L. The Teratogenic Potential (NOEC-lethality/NOEC-sublethal effects) was 23 times higher than the threshold value, indicating a high risk for embryos to be malformed in absence of significant lethality and representing a threat for the species conservation. By comparing with other amphibians, the early development of R. arenarum was very sensitive to NP. The results highlight the relevance of extending the exposure time and look for the most sensitive stage in order to perform the bioassays for conservation purposes.
publishDate 2014
dc.date.none.fl_str_mv 2014-08
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
status_str publishedVersion
format article
dc.identifier.none.fl_str_mv Aronzon, C. M. ; Babay, P. A. y Perez Coll, C. S. (aug 2014) Developmental toxicity and risk assessment of nonylphenol to the South American toad, Rhinella arenarum; En: Environmental Toxicology and Pharmacology. Elsevier, 38 (2) 634-642
1382-6689
ETP-AM 2014 3iA A-B-PC
https://ri.unsam.edu.ar/handle/123456789/1004
identifier_str_mv Aronzon, C. M. ; Babay, P. A. y Perez Coll, C. S. (aug 2014) Developmental toxicity and risk assessment of nonylphenol to the South American toad, Rhinella arenarum; En: Environmental Toxicology and Pharmacology. Elsevier, 38 (2) 634-642
1382-6689
ETP-AM 2014 3iA A-B-PC
url https://ri.unsam.edu.ar/handle/123456789/1004
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Creative Commons Atribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5)
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Creative Commons Atribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5)
dc.format.none.fl_str_mv application/pdf
pp. 634-642
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Bv
publisher.none.fl_str_mv Elsevier Science Bv
dc.source.none.fl_str_mv Environmental Toxicology and Pharmacology, 2014 38(2): 634-642 Elsevier Science Bv
http://dx.doi.org/10.1016/j.etap.2014.08.014
reponame:Repositorio Institucional (UNSAM)
instname:Universidad Nacional de General San Martín
reponame_str Repositorio Institucional (UNSAM)
collection Repositorio Institucional (UNSAM)
instname_str Universidad Nacional de General San Martín
repository.name.fl_str_mv Repositorio Institucional (UNSAM) - Universidad Nacional de General San Martín
repository.mail.fl_str_mv lpastran@unsam.edu.ar
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score 12.623145

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