Salvia hispanica L. (chia) seed improves skeletal muscle lipotoxicity and insulin sensitivity in rats fed a sucrose-rich diet by modulating intramuscular lipid metabolism

Autores
Ferreira Cordoneda, Maria del Rosario; Oliva, Maria Eugenia; Aiassa, Victoria; D'alessandro, Maria Eugenia Guadalupe
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This study investigates the possible mechanisms involved in the beneficial effect of chia seed on skeletal muscle lipotoxicity and insulin resistance in rats fed a sucrose-rich diet (SRD). Results showed that chia seed reduced the increased lipid content in the skeletal muscle of SRD-fed rats. This was accompanied by an increase of muscle-type carnitine palmitoyltransferase 1 enzyme activity, peroxisome proliferator-activated receptors (PPARα, PPARγ) and phosphorylated AMP activated protein kinase protein levels. Moreover, the precursor and mature forms of sterol regulatory element-binding protein-1 and lipogenic enzyme activities were decreased. Fatty acid translocase FAT/CD 36 and n-3/n-6 fatty acids ratio of membrane phospholipids were increased. This work shows that an increase in the key factors levels associated with muscle oxidative capacity and a reduction in the lipogenic pathway would be some mechanisms involved in the beneficial effects of chia seed on skeletal muscle lipotoxicity in insulin resistant SRD-fed rats.
Fil: Ferreira Cordoneda, Maria del Rosario. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: Oliva, Maria Eugenia. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: Aiassa, Victoria. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentina
Fil: D'alessandro, Maria Eugenia Guadalupe. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Materia
INSULIN RESISTANCE
LIPOTOXICITY
SALVIA HISPANICA L.
SKELETAL MUSCLE
SUCROSE-RICH DIET
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/170140

id CONICETDig_c0a53888e26aab5a7c3d5bb98085e939
oai_identifier_str oai:ri.conicet.gov.ar:11336/170140
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Salvia hispanica L. (chia) seed improves skeletal muscle lipotoxicity and insulin sensitivity in rats fed a sucrose-rich diet by modulating intramuscular lipid metabolismFerreira Cordoneda, Maria del RosarioOliva, Maria EugeniaAiassa, VictoriaD'alessandro, Maria Eugenia GuadalupeINSULIN RESISTANCELIPOTOXICITYSALVIA HISPANICA L.SKELETAL MUSCLESUCROSE-RICH DIEThttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3This study investigates the possible mechanisms involved in the beneficial effect of chia seed on skeletal muscle lipotoxicity and insulin resistance in rats fed a sucrose-rich diet (SRD). Results showed that chia seed reduced the increased lipid content in the skeletal muscle of SRD-fed rats. This was accompanied by an increase of muscle-type carnitine palmitoyltransferase 1 enzyme activity, peroxisome proliferator-activated receptors (PPARα, PPARγ) and phosphorylated AMP activated protein kinase protein levels. Moreover, the precursor and mature forms of sterol regulatory element-binding protein-1 and lipogenic enzyme activities were decreased. Fatty acid translocase FAT/CD 36 and n-3/n-6 fatty acids ratio of membrane phospholipids were increased. This work shows that an increase in the key factors levels associated with muscle oxidative capacity and a reduction in the lipogenic pathway would be some mechanisms involved in the beneficial effects of chia seed on skeletal muscle lipotoxicity in insulin resistant SRD-fed rats.Fil: Ferreira Cordoneda, Maria del Rosario. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; ArgentinaFil: Oliva, Maria Eugenia. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; ArgentinaFil: Aiassa, Victoria. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; ArgentinaFil: D'alessandro, Maria Eugenia Guadalupe. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; ArgentinaElsevier2020-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/170140Ferreira Cordoneda, Maria del Rosario; Oliva, Maria Eugenia; Aiassa, Victoria; D'alessandro, Maria Eugenia Guadalupe; Salvia hispanica L. (chia) seed improves skeletal muscle lipotoxicity and insulin sensitivity in rats fed a sucrose-rich diet by modulating intramuscular lipid metabolism; Elsevier; Journal of Functional Foods; 66; 3-2020; 1-91756-4646CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://authors.elsevier.com/sd/article/S1756464619306991info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jff.2019.103775info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:49:34Zoai:ri.conicet.gov.ar:11336/170140instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:49:34.865CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Salvia hispanica L. (chia) seed improves skeletal muscle lipotoxicity and insulin sensitivity in rats fed a sucrose-rich diet by modulating intramuscular lipid metabolism
title Salvia hispanica L. (chia) seed improves skeletal muscle lipotoxicity and insulin sensitivity in rats fed a sucrose-rich diet by modulating intramuscular lipid metabolism
spellingShingle Salvia hispanica L. (chia) seed improves skeletal muscle lipotoxicity and insulin sensitivity in rats fed a sucrose-rich diet by modulating intramuscular lipid metabolism
Ferreira Cordoneda, Maria del Rosario
INSULIN RESISTANCE
LIPOTOXICITY
SALVIA HISPANICA L.
SKELETAL MUSCLE
SUCROSE-RICH DIET
title_short Salvia hispanica L. (chia) seed improves skeletal muscle lipotoxicity and insulin sensitivity in rats fed a sucrose-rich diet by modulating intramuscular lipid metabolism
title_full Salvia hispanica L. (chia) seed improves skeletal muscle lipotoxicity and insulin sensitivity in rats fed a sucrose-rich diet by modulating intramuscular lipid metabolism
title_fullStr Salvia hispanica L. (chia) seed improves skeletal muscle lipotoxicity and insulin sensitivity in rats fed a sucrose-rich diet by modulating intramuscular lipid metabolism
title_full_unstemmed Salvia hispanica L. (chia) seed improves skeletal muscle lipotoxicity and insulin sensitivity in rats fed a sucrose-rich diet by modulating intramuscular lipid metabolism
title_sort Salvia hispanica L. (chia) seed improves skeletal muscle lipotoxicity and insulin sensitivity in rats fed a sucrose-rich diet by modulating intramuscular lipid metabolism
dc.creator.none.fl_str_mv Ferreira Cordoneda, Maria del Rosario
Oliva, Maria Eugenia
Aiassa, Victoria
D'alessandro, Maria Eugenia Guadalupe
author Ferreira Cordoneda, Maria del Rosario
author_facet Ferreira Cordoneda, Maria del Rosario
Oliva, Maria Eugenia
Aiassa, Victoria
D'alessandro, Maria Eugenia Guadalupe
author_role author
author2 Oliva, Maria Eugenia
Aiassa, Victoria
D'alessandro, Maria Eugenia Guadalupe
author2_role author
author
author
dc.subject.none.fl_str_mv INSULIN RESISTANCE
LIPOTOXICITY
SALVIA HISPANICA L.
SKELETAL MUSCLE
SUCROSE-RICH DIET
topic INSULIN RESISTANCE
LIPOTOXICITY
SALVIA HISPANICA L.
SKELETAL MUSCLE
SUCROSE-RICH DIET
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv This study investigates the possible mechanisms involved in the beneficial effect of chia seed on skeletal muscle lipotoxicity and insulin resistance in rats fed a sucrose-rich diet (SRD). Results showed that chia seed reduced the increased lipid content in the skeletal muscle of SRD-fed rats. This was accompanied by an increase of muscle-type carnitine palmitoyltransferase 1 enzyme activity, peroxisome proliferator-activated receptors (PPARα, PPARγ) and phosphorylated AMP activated protein kinase protein levels. Moreover, the precursor and mature forms of sterol regulatory element-binding protein-1 and lipogenic enzyme activities were decreased. Fatty acid translocase FAT/CD 36 and n-3/n-6 fatty acids ratio of membrane phospholipids were increased. This work shows that an increase in the key factors levels associated with muscle oxidative capacity and a reduction in the lipogenic pathway would be some mechanisms involved in the beneficial effects of chia seed on skeletal muscle lipotoxicity in insulin resistant SRD-fed rats.
Fil: Ferreira Cordoneda, Maria del Rosario. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: Oliva, Maria Eugenia. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: Aiassa, Victoria. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentina
Fil: D'alessandro, Maria Eugenia Guadalupe. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
description This study investigates the possible mechanisms involved in the beneficial effect of chia seed on skeletal muscle lipotoxicity and insulin resistance in rats fed a sucrose-rich diet (SRD). Results showed that chia seed reduced the increased lipid content in the skeletal muscle of SRD-fed rats. This was accompanied by an increase of muscle-type carnitine palmitoyltransferase 1 enzyme activity, peroxisome proliferator-activated receptors (PPARα, PPARγ) and phosphorylated AMP activated protein kinase protein levels. Moreover, the precursor and mature forms of sterol regulatory element-binding protein-1 and lipogenic enzyme activities were decreased. Fatty acid translocase FAT/CD 36 and n-3/n-6 fatty acids ratio of membrane phospholipids were increased. This work shows that an increase in the key factors levels associated with muscle oxidative capacity and a reduction in the lipogenic pathway would be some mechanisms involved in the beneficial effects of chia seed on skeletal muscle lipotoxicity in insulin resistant SRD-fed rats.
publishDate 2020
dc.date.none.fl_str_mv 2020-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/170140
Ferreira Cordoneda, Maria del Rosario; Oliva, Maria Eugenia; Aiassa, Victoria; D'alessandro, Maria Eugenia Guadalupe; Salvia hispanica L. (chia) seed improves skeletal muscle lipotoxicity and insulin sensitivity in rats fed a sucrose-rich diet by modulating intramuscular lipid metabolism; Elsevier; Journal of Functional Foods; 66; 3-2020; 1-9
1756-4646
CONICET Digital
CONICET
url http://hdl.handle.net/11336/170140
identifier_str_mv Ferreira Cordoneda, Maria del Rosario; Oliva, Maria Eugenia; Aiassa, Victoria; D'alessandro, Maria Eugenia Guadalupe; Salvia hispanica L. (chia) seed improves skeletal muscle lipotoxicity and insulin sensitivity in rats fed a sucrose-rich diet by modulating intramuscular lipid metabolism; Elsevier; Journal of Functional Foods; 66; 3-2020; 1-9
1756-4646
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://authors.elsevier.com/sd/article/S1756464619306991
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jff.2019.103775
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268981173420032
score 13.13397