Salvia hispanica L. (chia) seed improves skeletal muscle lipotoxicity and insulin sensitivity in rats fed a sucrose-rich diet by modulating intramuscular lipid metabolism
- Autores
- Ferreira Cordoneda, Maria del Rosario; Oliva, Maria Eugenia; Aiassa, Victoria; D'alessandro, Maria Eugenia Guadalupe
- Año de publicación
- 2020
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- This study investigates the possible mechanisms involved in the beneficial effect of chia seed on skeletal muscle lipotoxicity and insulin resistance in rats fed a sucrose-rich diet (SRD). Results showed that chia seed reduced the increased lipid content in the skeletal muscle of SRD-fed rats. This was accompanied by an increase of muscle-type carnitine palmitoyltransferase 1 enzyme activity, peroxisome proliferator-activated receptors (PPARα, PPARγ) and phosphorylated AMP activated protein kinase protein levels. Moreover, the precursor and mature forms of sterol regulatory element-binding protein-1 and lipogenic enzyme activities were decreased. Fatty acid translocase FAT/CD 36 and n-3/n-6 fatty acids ratio of membrane phospholipids were increased. This work shows that an increase in the key factors levels associated with muscle oxidative capacity and a reduction in the lipogenic pathway would be some mechanisms involved in the beneficial effects of chia seed on skeletal muscle lipotoxicity in insulin resistant SRD-fed rats.
Fil: Ferreira Cordoneda, Maria del Rosario. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: Oliva, Maria Eugenia. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: Aiassa, Victoria. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentina
Fil: D'alessandro, Maria Eugenia Guadalupe. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina - Materia
-
INSULIN RESISTANCE
LIPOTOXICITY
SALVIA HISPANICA L.
SKELETAL MUSCLE
SUCROSE-RICH DIET - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/170140
Ver los metadatos del registro completo
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CONICET Digital (CONICET) |
spelling |
Salvia hispanica L. (chia) seed improves skeletal muscle lipotoxicity and insulin sensitivity in rats fed a sucrose-rich diet by modulating intramuscular lipid metabolismFerreira Cordoneda, Maria del RosarioOliva, Maria EugeniaAiassa, VictoriaD'alessandro, Maria Eugenia GuadalupeINSULIN RESISTANCELIPOTOXICITYSALVIA HISPANICA L.SKELETAL MUSCLESUCROSE-RICH DIEThttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3This study investigates the possible mechanisms involved in the beneficial effect of chia seed on skeletal muscle lipotoxicity and insulin resistance in rats fed a sucrose-rich diet (SRD). Results showed that chia seed reduced the increased lipid content in the skeletal muscle of SRD-fed rats. This was accompanied by an increase of muscle-type carnitine palmitoyltransferase 1 enzyme activity, peroxisome proliferator-activated receptors (PPARα, PPARγ) and phosphorylated AMP activated protein kinase protein levels. Moreover, the precursor and mature forms of sterol regulatory element-binding protein-1 and lipogenic enzyme activities were decreased. Fatty acid translocase FAT/CD 36 and n-3/n-6 fatty acids ratio of membrane phospholipids were increased. This work shows that an increase in the key factors levels associated with muscle oxidative capacity and a reduction in the lipogenic pathway would be some mechanisms involved in the beneficial effects of chia seed on skeletal muscle lipotoxicity in insulin resistant SRD-fed rats.Fil: Ferreira Cordoneda, Maria del Rosario. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; ArgentinaFil: Oliva, Maria Eugenia. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; ArgentinaFil: Aiassa, Victoria. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; ArgentinaFil: D'alessandro, Maria Eugenia Guadalupe. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; ArgentinaElsevier2020-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/170140Ferreira Cordoneda, Maria del Rosario; Oliva, Maria Eugenia; Aiassa, Victoria; D'alessandro, Maria Eugenia Guadalupe; Salvia hispanica L. (chia) seed improves skeletal muscle lipotoxicity and insulin sensitivity in rats fed a sucrose-rich diet by modulating intramuscular lipid metabolism; Elsevier; Journal of Functional Foods; 66; 3-2020; 1-91756-4646CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://authors.elsevier.com/sd/article/S1756464619306991info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jff.2019.103775info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:49:34Zoai:ri.conicet.gov.ar:11336/170140instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:49:34.865CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Salvia hispanica L. (chia) seed improves skeletal muscle lipotoxicity and insulin sensitivity in rats fed a sucrose-rich diet by modulating intramuscular lipid metabolism |
title |
Salvia hispanica L. (chia) seed improves skeletal muscle lipotoxicity and insulin sensitivity in rats fed a sucrose-rich diet by modulating intramuscular lipid metabolism |
spellingShingle |
Salvia hispanica L. (chia) seed improves skeletal muscle lipotoxicity and insulin sensitivity in rats fed a sucrose-rich diet by modulating intramuscular lipid metabolism Ferreira Cordoneda, Maria del Rosario INSULIN RESISTANCE LIPOTOXICITY SALVIA HISPANICA L. SKELETAL MUSCLE SUCROSE-RICH DIET |
title_short |
Salvia hispanica L. (chia) seed improves skeletal muscle lipotoxicity and insulin sensitivity in rats fed a sucrose-rich diet by modulating intramuscular lipid metabolism |
title_full |
Salvia hispanica L. (chia) seed improves skeletal muscle lipotoxicity and insulin sensitivity in rats fed a sucrose-rich diet by modulating intramuscular lipid metabolism |
title_fullStr |
Salvia hispanica L. (chia) seed improves skeletal muscle lipotoxicity and insulin sensitivity in rats fed a sucrose-rich diet by modulating intramuscular lipid metabolism |
title_full_unstemmed |
Salvia hispanica L. (chia) seed improves skeletal muscle lipotoxicity and insulin sensitivity in rats fed a sucrose-rich diet by modulating intramuscular lipid metabolism |
title_sort |
Salvia hispanica L. (chia) seed improves skeletal muscle lipotoxicity and insulin sensitivity in rats fed a sucrose-rich diet by modulating intramuscular lipid metabolism |
dc.creator.none.fl_str_mv |
Ferreira Cordoneda, Maria del Rosario Oliva, Maria Eugenia Aiassa, Victoria D'alessandro, Maria Eugenia Guadalupe |
author |
Ferreira Cordoneda, Maria del Rosario |
author_facet |
Ferreira Cordoneda, Maria del Rosario Oliva, Maria Eugenia Aiassa, Victoria D'alessandro, Maria Eugenia Guadalupe |
author_role |
author |
author2 |
Oliva, Maria Eugenia Aiassa, Victoria D'alessandro, Maria Eugenia Guadalupe |
author2_role |
author author author |
dc.subject.none.fl_str_mv |
INSULIN RESISTANCE LIPOTOXICITY SALVIA HISPANICA L. SKELETAL MUSCLE SUCROSE-RICH DIET |
topic |
INSULIN RESISTANCE LIPOTOXICITY SALVIA HISPANICA L. SKELETAL MUSCLE SUCROSE-RICH DIET |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
This study investigates the possible mechanisms involved in the beneficial effect of chia seed on skeletal muscle lipotoxicity and insulin resistance in rats fed a sucrose-rich diet (SRD). Results showed that chia seed reduced the increased lipid content in the skeletal muscle of SRD-fed rats. This was accompanied by an increase of muscle-type carnitine palmitoyltransferase 1 enzyme activity, peroxisome proliferator-activated receptors (PPARα, PPARγ) and phosphorylated AMP activated protein kinase protein levels. Moreover, the precursor and mature forms of sterol regulatory element-binding protein-1 and lipogenic enzyme activities were decreased. Fatty acid translocase FAT/CD 36 and n-3/n-6 fatty acids ratio of membrane phospholipids were increased. This work shows that an increase in the key factors levels associated with muscle oxidative capacity and a reduction in the lipogenic pathway would be some mechanisms involved in the beneficial effects of chia seed on skeletal muscle lipotoxicity in insulin resistant SRD-fed rats. Fil: Ferreira Cordoneda, Maria del Rosario. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina Fil: Oliva, Maria Eugenia. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina Fil: Aiassa, Victoria. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentina Fil: D'alessandro, Maria Eugenia Guadalupe. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina |
description |
This study investigates the possible mechanisms involved in the beneficial effect of chia seed on skeletal muscle lipotoxicity and insulin resistance in rats fed a sucrose-rich diet (SRD). Results showed that chia seed reduced the increased lipid content in the skeletal muscle of SRD-fed rats. This was accompanied by an increase of muscle-type carnitine palmitoyltransferase 1 enzyme activity, peroxisome proliferator-activated receptors (PPARα, PPARγ) and phosphorylated AMP activated protein kinase protein levels. Moreover, the precursor and mature forms of sterol regulatory element-binding protein-1 and lipogenic enzyme activities were decreased. Fatty acid translocase FAT/CD 36 and n-3/n-6 fatty acids ratio of membrane phospholipids were increased. This work shows that an increase in the key factors levels associated with muscle oxidative capacity and a reduction in the lipogenic pathway would be some mechanisms involved in the beneficial effects of chia seed on skeletal muscle lipotoxicity in insulin resistant SRD-fed rats. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-03 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/170140 Ferreira Cordoneda, Maria del Rosario; Oliva, Maria Eugenia; Aiassa, Victoria; D'alessandro, Maria Eugenia Guadalupe; Salvia hispanica L. (chia) seed improves skeletal muscle lipotoxicity and insulin sensitivity in rats fed a sucrose-rich diet by modulating intramuscular lipid metabolism; Elsevier; Journal of Functional Foods; 66; 3-2020; 1-9 1756-4646 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/170140 |
identifier_str_mv |
Ferreira Cordoneda, Maria del Rosario; Oliva, Maria Eugenia; Aiassa, Victoria; D'alessandro, Maria Eugenia Guadalupe; Salvia hispanica L. (chia) seed improves skeletal muscle lipotoxicity and insulin sensitivity in rats fed a sucrose-rich diet by modulating intramuscular lipid metabolism; Elsevier; Journal of Functional Foods; 66; 3-2020; 1-9 1756-4646 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://authors.elsevier.com/sd/article/S1756464619306991 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jff.2019.103775 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1842268981173420032 |
score |
13.13397 |