The reduction of dietary sucrose improves dyslipidemia, adiposity, and insulin secretion in an insulin-resistant rat model

Autores
Fortino, María Alejandra; Lombardo, Yolanda; Chicco, Adriana Graciela
Año de publicación
2007
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The purpose of the present work was to investigate whether changes in the type of carbohydrate in the diet are able to improve and/or reverse hyperlipemia, impaired glucose homeostasis, and insulin secretion from beta cells induced in rats by chronically feeding a high sucrose intake.Methods For 30 wk male Wistar rats received a sucrose-rich diet (63% w/w) or a control diet in which sucrose was replaced by starch. After this period, the sucrose-fed animals were randomly divided into two groups: the first group continued with this diet up to 42 wk and the other received the same diet but with a 20% reduction in the amount of sucrose and the rest of the carbohydrate being replaced by starch. Rats were fed with this diet for the next 12 wk.The reduction of the amount of sucrose in the diet showed a substantial improvement of dyslipidemia associated with an amelioration of ?in vivo? very low-density lipoprotein-triacylglycerol secretion and triacylglycerol removal rate from the circulation. Glucose homeostasis and glucose-induced insulin release from beta cells were improved although these values did not reach those observed in rats fed a control diet. Visceral adiposity was also significantly reduced. Conclusion: These data are consistent with the suggestion that the composition of the diet could contribute to improvements in dyslipidemia, insulin resistance, and adiposity by direct effects on the lipid metabolism and insulin action and indirectly through the reduction of visceral fat mass and distribution.
Fil: Fortino, María Alejandra. Universidad Nacional del Litoral; Argentina
Fil: Lombardo, Yolanda. Universidad Nacional del Litoral; Argentina
Fil: Chicco, Adriana Graciela. Universidad Nacional del Litoral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
DYSLIPIDEMIA
ISNULIN RESISTANCE
SUCROSE RICH DIET
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/114386
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/114386
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The reduction of dietary sucrose improves dyslipidemia, adiposity, and insulin secretion in an insulin-resistant rat modelFortino, María AlejandraLombardo, YolandaChicco, Adriana GracielaDYSLIPIDEMIAISNULIN RESISTANCESUCROSE RICH DIEThttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3The purpose of the present work was to investigate whether changes in the type of carbohydrate in the diet are able to improve and/or reverse hyperlipemia, impaired glucose homeostasis, and insulin secretion from beta cells induced in rats by chronically feeding a high sucrose intake.Methods For 30 wk male Wistar rats received a sucrose-rich diet (63% w/w) or a control diet in which sucrose was replaced by starch. After this period, the sucrose-fed animals were randomly divided into two groups: the first group continued with this diet up to 42 wk and the other received the same diet but with a 20% reduction in the amount of sucrose and the rest of the carbohydrate being replaced by starch. Rats were fed with this diet for the next 12 wk.The reduction of the amount of sucrose in the diet showed a substantial improvement of dyslipidemia associated with an amelioration of ?in vivo? very low-density lipoprotein-triacylglycerol secretion and triacylglycerol removal rate from the circulation. Glucose homeostasis and glucose-induced insulin release from beta cells were improved although these values did not reach those observed in rats fed a control diet. Visceral adiposity was also significantly reduced. Conclusion: These data are consistent with the suggestion that the composition of the diet could contribute to improvements in dyslipidemia, insulin resistance, and adiposity by direct effects on the lipid metabolism and insulin action and indirectly through the reduction of visceral fat mass and distribution.Fil: Fortino, María Alejandra. Universidad Nacional del Litoral; ArgentinaFil: Lombardo, Yolanda. Universidad Nacional del Litoral; ArgentinaFil: Chicco, Adriana Graciela. Universidad Nacional del Litoral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier Science Inc2007-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/114386Fortino, María Alejandra; Lombardo, Yolanda; Chicco, Adriana Graciela; The reduction of dietary sucrose improves dyslipidemia, adiposity, and insulin secretion in an insulin-resistant rat model; Elsevier Science Inc; Nutrition; 23; 6; 12-2007; 489-4970899-9007CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.nut.2007.04.007info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:03:25Zoai:ri.conicet.gov.ar:11336/114386instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:03:26.526CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The reduction of dietary sucrose improves dyslipidemia, adiposity, and insulin secretion in an insulin-resistant rat model
title The reduction of dietary sucrose improves dyslipidemia, adiposity, and insulin secretion in an insulin-resistant rat model
spellingShingle The reduction of dietary sucrose improves dyslipidemia, adiposity, and insulin secretion in an insulin-resistant rat model
Fortino, María Alejandra
DYSLIPIDEMIA
ISNULIN RESISTANCE
SUCROSE RICH DIET
title_short The reduction of dietary sucrose improves dyslipidemia, adiposity, and insulin secretion in an insulin-resistant rat model
title_full The reduction of dietary sucrose improves dyslipidemia, adiposity, and insulin secretion in an insulin-resistant rat model
title_fullStr The reduction of dietary sucrose improves dyslipidemia, adiposity, and insulin secretion in an insulin-resistant rat model
title_full_unstemmed The reduction of dietary sucrose improves dyslipidemia, adiposity, and insulin secretion in an insulin-resistant rat model
title_sort The reduction of dietary sucrose improves dyslipidemia, adiposity, and insulin secretion in an insulin-resistant rat model
dc.creator.none.fl_str_mv Fortino, María Alejandra
Lombardo, Yolanda
Chicco, Adriana Graciela
author Fortino, María Alejandra
author_facet Fortino, María Alejandra
Lombardo, Yolanda
Chicco, Adriana Graciela
author_role author
author2 Lombardo, Yolanda
Chicco, Adriana Graciela
author2_role author
author
dc.subject.none.fl_str_mv DYSLIPIDEMIA
ISNULIN RESISTANCE
SUCROSE RICH DIET
topic DYSLIPIDEMIA
ISNULIN RESISTANCE
SUCROSE RICH DIET
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The purpose of the present work was to investigate whether changes in the type of carbohydrate in the diet are able to improve and/or reverse hyperlipemia, impaired glucose homeostasis, and insulin secretion from beta cells induced in rats by chronically feeding a high sucrose intake.Methods For 30 wk male Wistar rats received a sucrose-rich diet (63% w/w) or a control diet in which sucrose was replaced by starch. After this period, the sucrose-fed animals were randomly divided into two groups: the first group continued with this diet up to 42 wk and the other received the same diet but with a 20% reduction in the amount of sucrose and the rest of the carbohydrate being replaced by starch. Rats were fed with this diet for the next 12 wk.The reduction of the amount of sucrose in the diet showed a substantial improvement of dyslipidemia associated with an amelioration of ?in vivo? very low-density lipoprotein-triacylglycerol secretion and triacylglycerol removal rate from the circulation. Glucose homeostasis and glucose-induced insulin release from beta cells were improved although these values did not reach those observed in rats fed a control diet. Visceral adiposity was also significantly reduced. Conclusion: These data are consistent with the suggestion that the composition of the diet could contribute to improvements in dyslipidemia, insulin resistance, and adiposity by direct effects on the lipid metabolism and insulin action and indirectly through the reduction of visceral fat mass and distribution.
Fil: Fortino, María Alejandra. Universidad Nacional del Litoral; Argentina
Fil: Lombardo, Yolanda. Universidad Nacional del Litoral; Argentina
Fil: Chicco, Adriana Graciela. Universidad Nacional del Litoral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description The purpose of the present work was to investigate whether changes in the type of carbohydrate in the diet are able to improve and/or reverse hyperlipemia, impaired glucose homeostasis, and insulin secretion from beta cells induced in rats by chronically feeding a high sucrose intake.Methods For 30 wk male Wistar rats received a sucrose-rich diet (63% w/w) or a control diet in which sucrose was replaced by starch. After this period, the sucrose-fed animals were randomly divided into two groups: the first group continued with this diet up to 42 wk and the other received the same diet but with a 20% reduction in the amount of sucrose and the rest of the carbohydrate being replaced by starch. Rats were fed with this diet for the next 12 wk.The reduction of the amount of sucrose in the diet showed a substantial improvement of dyslipidemia associated with an amelioration of ?in vivo? very low-density lipoprotein-triacylglycerol secretion and triacylglycerol removal rate from the circulation. Glucose homeostasis and glucose-induced insulin release from beta cells were improved although these values did not reach those observed in rats fed a control diet. Visceral adiposity was also significantly reduced. Conclusion: These data are consistent with the suggestion that the composition of the diet could contribute to improvements in dyslipidemia, insulin resistance, and adiposity by direct effects on the lipid metabolism and insulin action and indirectly through the reduction of visceral fat mass and distribution.
publishDate 2007
dc.date.none.fl_str_mv 2007-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/114386
Fortino, María Alejandra; Lombardo, Yolanda; Chicco, Adriana Graciela; The reduction of dietary sucrose improves dyslipidemia, adiposity, and insulin secretion in an insulin-resistant rat model; Elsevier Science Inc; Nutrition; 23; 6; 12-2007; 489-497
0899-9007
CONICET Digital
CONICET
url http://hdl.handle.net/11336/114386
identifier_str_mv Fortino, María Alejandra; Lombardo, Yolanda; Chicco, Adriana Graciela; The reduction of dietary sucrose improves dyslipidemia, adiposity, and insulin secretion in an insulin-resistant rat model; Elsevier Science Inc; Nutrition; 23; 6; 12-2007; 489-497
0899-9007
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.nut.2007.04.007
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Inc
publisher.none.fl_str_mv Elsevier Science Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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