Dietary Salvia hispanica L. Seed Counteracted Kidney Failure in Experimental Metabolic Syndrome

Autores
Creus, Agustina; Ingaramo, Paola Inés; Oliva, Maria Eugenia; D'alessandro, Maria Eugenia Guadalupe
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Metabolic Syndrome (MS) has become a major health hazard in the current world by triggering cardiovascular and renal pathologies. Chia seed is a rich source of bioactive food components (n-3 fatty acids, antioxidants, fiber, among others) with several benefits on cardiovascular health. Therefore, we hypothesized that the intake of chia seed could counteracts kidney failure of MS by protecting against lipid accretion, oxidative stress and fibrosis in this tissue. An experimental model of MS was induced by feeding male Wistar rats for 3 months with a sucrose-rich diet (SRD) containing corn oil as source of fat. During the next 3 months, half the animals continued with SRD. The other half received the SRD in which corn oil was replaced by Salvia hispanica L. seeds (chia) (SRD+C). The control group received a reference diet (RD). In experimental MS dietary administration of chia seed significantly decreased albumin and glucose urine levels (p<0.05). Chia reverted fibrosis (SiriusRed-collagen staining), morphological anomalies and the altered markers (PEPCK and FBPase) of renal glucose metabolism (p<0.05). These effects were accompanied by a decrease of the accumulation of triglycerides and oxidative stress biomarkers (ROS and lipid peroxides) in kidney (p<0.05). The mechanisms included down-regulation of key enzymes of fatty acid biosynthesis (ACC, FAS and G6PDH) and up-regulation of antioxidant defenses (GSH, GR and GPx activities). Dietary chia seed counteracted the renal failure in an experimental model of MS, indicating that could be an exceptional food for the clinical management of this disorder.
Fil: Creus, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentina
Fil: Ingaramo, Paola Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; Argentina
Fil: Oliva, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentina
Fil: D'alessandro, Maria Eugenia Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentina
Materia
METABOLIC SYNDROME
KIDNEY FAILURE
SALVIA HISPANICA L.
ALPHA-LINOLENIC ACID
HYPERTENSION
LIPOTOXICITY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/215042
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/215042
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Dietary Salvia hispanica L. Seed Counteracted Kidney Failure in Experimental Metabolic SyndromeCreus, AgustinaIngaramo, Paola InésOliva, Maria EugeniaD'alessandro, Maria Eugenia GuadalupeMETABOLIC SYNDROMEKIDNEY FAILURESALVIA HISPANICA L.ALPHA-LINOLENIC ACIDHYPERTENSIONLIPOTOXICITYhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Metabolic Syndrome (MS) has become a major health hazard in the current world by triggering cardiovascular and renal pathologies. Chia seed is a rich source of bioactive food components (n-3 fatty acids, antioxidants, fiber, among others) with several benefits on cardiovascular health. Therefore, we hypothesized that the intake of chia seed could counteracts kidney failure of MS by protecting against lipid accretion, oxidative stress and fibrosis in this tissue. An experimental model of MS was induced by feeding male Wistar rats for 3 months with a sucrose-rich diet (SRD) containing corn oil as source of fat. During the next 3 months, half the animals continued with SRD. The other half received the SRD in which corn oil was replaced by Salvia hispanica L. seeds (chia) (SRD+C). The control group received a reference diet (RD). In experimental MS dietary administration of chia seed significantly decreased albumin and glucose urine levels (p<0.05). Chia reverted fibrosis (SiriusRed-collagen staining), morphological anomalies and the altered markers (PEPCK and FBPase) of renal glucose metabolism (p<0.05). These effects were accompanied by a decrease of the accumulation of triglycerides and oxidative stress biomarkers (ROS and lipid peroxides) in kidney (p<0.05). The mechanisms included down-regulation of key enzymes of fatty acid biosynthesis (ACC, FAS and G6PDH) and up-regulation of antioxidant defenses (GSH, GR and GPx activities). Dietary chia seed counteracted the renal failure in an experimental model of MS, indicating that could be an exceptional food for the clinical management of this disorder.Fil: Creus, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; ArgentinaFil: Ingaramo, Paola Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; ArgentinaFil: Oliva, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; ArgentinaFil: D'alessandro, Maria Eugenia Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; ArgentinaScience Repository2022-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/215042Creus, Agustina; Ingaramo, Paola Inés; Oliva, Maria Eugenia; D'alessandro, Maria Eugenia Guadalupe; Dietary Salvia hispanica L. Seed Counteracted Kidney Failure in Experimental Metabolic Syndrome; Science Repository; Journal of Food Nutrition and Metabolism; 2022; 10-2022; 1-112674-2411CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencerepository.org/dietary-salvia-hispanica-l-seed_JFNM-2022-1-103info:eu-repo/semantics/altIdentifier/doi/10.31487/j.JFNM.2022.01.03info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:19:38Zoai:ri.conicet.gov.ar:11336/215042instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:19:38.426CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Dietary Salvia hispanica L. Seed Counteracted Kidney Failure in Experimental Metabolic Syndrome
title Dietary Salvia hispanica L. Seed Counteracted Kidney Failure in Experimental Metabolic Syndrome
spellingShingle Dietary Salvia hispanica L. Seed Counteracted Kidney Failure in Experimental Metabolic Syndrome
Creus, Agustina
METABOLIC SYNDROME
KIDNEY FAILURE
SALVIA HISPANICA L.
ALPHA-LINOLENIC ACID
HYPERTENSION
LIPOTOXICITY
title_short Dietary Salvia hispanica L. Seed Counteracted Kidney Failure in Experimental Metabolic Syndrome
title_full Dietary Salvia hispanica L. Seed Counteracted Kidney Failure in Experimental Metabolic Syndrome
title_fullStr Dietary Salvia hispanica L. Seed Counteracted Kidney Failure in Experimental Metabolic Syndrome
title_full_unstemmed Dietary Salvia hispanica L. Seed Counteracted Kidney Failure in Experimental Metabolic Syndrome
title_sort Dietary Salvia hispanica L. Seed Counteracted Kidney Failure in Experimental Metabolic Syndrome
dc.creator.none.fl_str_mv Creus, Agustina
Ingaramo, Paola Inés
Oliva, Maria Eugenia
D'alessandro, Maria Eugenia Guadalupe
author Creus, Agustina
author_facet Creus, Agustina
Ingaramo, Paola Inés
Oliva, Maria Eugenia
D'alessandro, Maria Eugenia Guadalupe
author_role author
author2 Ingaramo, Paola Inés
Oliva, Maria Eugenia
D'alessandro, Maria Eugenia Guadalupe
author2_role author
author
author
dc.subject.none.fl_str_mv METABOLIC SYNDROME
KIDNEY FAILURE
SALVIA HISPANICA L.
ALPHA-LINOLENIC ACID
HYPERTENSION
LIPOTOXICITY
topic METABOLIC SYNDROME
KIDNEY FAILURE
SALVIA HISPANICA L.
ALPHA-LINOLENIC ACID
HYPERTENSION
LIPOTOXICITY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Metabolic Syndrome (MS) has become a major health hazard in the current world by triggering cardiovascular and renal pathologies. Chia seed is a rich source of bioactive food components (n-3 fatty acids, antioxidants, fiber, among others) with several benefits on cardiovascular health. Therefore, we hypothesized that the intake of chia seed could counteracts kidney failure of MS by protecting against lipid accretion, oxidative stress and fibrosis in this tissue. An experimental model of MS was induced by feeding male Wistar rats for 3 months with a sucrose-rich diet (SRD) containing corn oil as source of fat. During the next 3 months, half the animals continued with SRD. The other half received the SRD in which corn oil was replaced by Salvia hispanica L. seeds (chia) (SRD+C). The control group received a reference diet (RD). In experimental MS dietary administration of chia seed significantly decreased albumin and glucose urine levels (p<0.05). Chia reverted fibrosis (SiriusRed-collagen staining), morphological anomalies and the altered markers (PEPCK and FBPase) of renal glucose metabolism (p<0.05). These effects were accompanied by a decrease of the accumulation of triglycerides and oxidative stress biomarkers (ROS and lipid peroxides) in kidney (p<0.05). The mechanisms included down-regulation of key enzymes of fatty acid biosynthesis (ACC, FAS and G6PDH) and up-regulation of antioxidant defenses (GSH, GR and GPx activities). Dietary chia seed counteracted the renal failure in an experimental model of MS, indicating that could be an exceptional food for the clinical management of this disorder.
Fil: Creus, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentina
Fil: Ingaramo, Paola Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; Argentina
Fil: Oliva, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentina
Fil: D'alessandro, Maria Eugenia Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentina
description Metabolic Syndrome (MS) has become a major health hazard in the current world by triggering cardiovascular and renal pathologies. Chia seed is a rich source of bioactive food components (n-3 fatty acids, antioxidants, fiber, among others) with several benefits on cardiovascular health. Therefore, we hypothesized that the intake of chia seed could counteracts kidney failure of MS by protecting against lipid accretion, oxidative stress and fibrosis in this tissue. An experimental model of MS was induced by feeding male Wistar rats for 3 months with a sucrose-rich diet (SRD) containing corn oil as source of fat. During the next 3 months, half the animals continued with SRD. The other half received the SRD in which corn oil was replaced by Salvia hispanica L. seeds (chia) (SRD+C). The control group received a reference diet (RD). In experimental MS dietary administration of chia seed significantly decreased albumin and glucose urine levels (p<0.05). Chia reverted fibrosis (SiriusRed-collagen staining), morphological anomalies and the altered markers (PEPCK and FBPase) of renal glucose metabolism (p<0.05). These effects were accompanied by a decrease of the accumulation of triglycerides and oxidative stress biomarkers (ROS and lipid peroxides) in kidney (p<0.05). The mechanisms included down-regulation of key enzymes of fatty acid biosynthesis (ACC, FAS and G6PDH) and up-regulation of antioxidant defenses (GSH, GR and GPx activities). Dietary chia seed counteracted the renal failure in an experimental model of MS, indicating that could be an exceptional food for the clinical management of this disorder.
publishDate 2022
dc.date.none.fl_str_mv 2022-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/215042
Creus, Agustina; Ingaramo, Paola Inés; Oliva, Maria Eugenia; D'alessandro, Maria Eugenia Guadalupe; Dietary Salvia hispanica L. Seed Counteracted Kidney Failure in Experimental Metabolic Syndrome; Science Repository; Journal of Food Nutrition and Metabolism; 2022; 10-2022; 1-11
2674-2411
CONICET Digital
CONICET
url http://hdl.handle.net/11336/215042
identifier_str_mv Creus, Agustina; Ingaramo, Paola Inés; Oliva, Maria Eugenia; D'alessandro, Maria Eugenia Guadalupe; Dietary Salvia hispanica L. Seed Counteracted Kidney Failure in Experimental Metabolic Syndrome; Science Repository; Journal of Food Nutrition and Metabolism; 2022; 10-2022; 1-11
2674-2411
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencerepository.org/dietary-salvia-hispanica-l-seed_JFNM-2022-1-103
info:eu-repo/semantics/altIdentifier/doi/10.31487/j.JFNM.2022.01.03
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Science Repository
publisher.none.fl_str_mv Science Repository
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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