Neuronal Regulation of State- Dependent Foraging in Caenorhabditis elegans

Autores
Rayes, Diego Hernán
Año de publicación
2024
Idioma
español castellano
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Organisms exhibit flexible behaviors in response to the same stimulus, depending on their internal physiological states. For example, when animals are satiated and encounter non- preferred food sources, they typically exhibit reduced engagement, often redirecting their search toward more desirable options. However, after prolonged fasting, even less preferred food becomes valuable. Despite decades of research on feeding behaviors, the neural mechanisms that allow animals to adapt their responses based on their nutritional status remain elusive. Serotonin (5-HT), commonly referred to as the "happiness hormone," increases in response to food stimuli and modulates feeding behavior across species, suggesting a conserved role. In contrast, catecholamines, which are central to the stress response, regulate appetite by suppressing food intake in many animals. Using the nematode Caenorhabditis elegans—an organism with a simple, well-characterized nervous system—we investigate how the serotonergic and catecholaminergic systems interact to modulate food- related behaviors. Our findings provide key insights into how C. elegans integrates internal states to adjust its foraging strategies. Given the conservation of neuronal components across species, our results could offer a valuable framework for understanding the molecular mechanisms underlying state-dependent feeding behaviors in other organisms
Fil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Taller Biologia celular y Del Desarrollo
Chascomus
Argentina
Taller de Biología Celular y del Desarrollo
Materia
elegans
food
starvation
neural circuits
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/273724
Acceder
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spelling Neuronal Regulation of State- Dependent Foraging in Caenorhabditis elegansRayes, Diego Hernánelegansfoodstarvationneural circuitshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Organisms exhibit flexible behaviors in response to the same stimulus, depending on their internal physiological states. For example, when animals are satiated and encounter non- preferred food sources, they typically exhibit reduced engagement, often redirecting their search toward more desirable options. However, after prolonged fasting, even less preferred food becomes valuable. Despite decades of research on feeding behaviors, the neural mechanisms that allow animals to adapt their responses based on their nutritional status remain elusive. Serotonin (5-HT), commonly referred to as the "happiness hormone," increases in response to food stimuli and modulates feeding behavior across species, suggesting a conserved role. In contrast, catecholamines, which are central to the stress response, regulate appetite by suppressing food intake in many animals. Using the nematode Caenorhabditis elegans—an organism with a simple, well-characterized nervous system—we investigate how the serotonergic and catecholaminergic systems interact to modulate food- related behaviors. Our findings provide key insights into how C. elegans integrates internal states to adjust its foraging strategies. Given the conservation of neuronal components across species, our results could offer a valuable framework for understanding the molecular mechanisms underlying state-dependent feeding behaviors in other organismsFil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaTaller Biologia celular y Del DesarrolloChascomusArgentinaTaller de Biología Celular y del DesarrolloTaller Biologia celular y del desarrollo2024info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectTallerBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/273724Neuronal Regulation of State- Dependent Foraging in Caenorhabditis elegans; Taller Biologia celular y Del Desarrollo; Chascomus; Argentina; 2024; 11-11CONICET DigitalCONICETspainfo:eu-repo/semantics/altIdentifier/url/https://tallerbcd.wixsite.com/tallerbcdNacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:15:51Zoai:ri.conicet.gov.ar:11336/273724instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:15:51.31CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Neuronal Regulation of State- Dependent Foraging in Caenorhabditis elegans
title Neuronal Regulation of State- Dependent Foraging in Caenorhabditis elegans
spellingShingle Neuronal Regulation of State- Dependent Foraging in Caenorhabditis elegans
Rayes, Diego Hernán
elegans
food
starvation
neural circuits
title_short Neuronal Regulation of State- Dependent Foraging in Caenorhabditis elegans
title_full Neuronal Regulation of State- Dependent Foraging in Caenorhabditis elegans
title_fullStr Neuronal Regulation of State- Dependent Foraging in Caenorhabditis elegans
title_full_unstemmed Neuronal Regulation of State- Dependent Foraging in Caenorhabditis elegans
title_sort Neuronal Regulation of State- Dependent Foraging in Caenorhabditis elegans
dc.creator.none.fl_str_mv Rayes, Diego Hernán
author Rayes, Diego Hernán
author_facet Rayes, Diego Hernán
author_role author
dc.subject.none.fl_str_mv elegans
food
starvation
neural circuits
topic elegans
food
starvation
neural circuits
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Organisms exhibit flexible behaviors in response to the same stimulus, depending on their internal physiological states. For example, when animals are satiated and encounter non- preferred food sources, they typically exhibit reduced engagement, often redirecting their search toward more desirable options. However, after prolonged fasting, even less preferred food becomes valuable. Despite decades of research on feeding behaviors, the neural mechanisms that allow animals to adapt their responses based on their nutritional status remain elusive. Serotonin (5-HT), commonly referred to as the "happiness hormone," increases in response to food stimuli and modulates feeding behavior across species, suggesting a conserved role. In contrast, catecholamines, which are central to the stress response, regulate appetite by suppressing food intake in many animals. Using the nematode Caenorhabditis elegans—an organism with a simple, well-characterized nervous system—we investigate how the serotonergic and catecholaminergic systems interact to modulate food- related behaviors. Our findings provide key insights into how C. elegans integrates internal states to adjust its foraging strategies. Given the conservation of neuronal components across species, our results could offer a valuable framework for understanding the molecular mechanisms underlying state-dependent feeding behaviors in other organisms
Fil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Taller Biologia celular y Del Desarrollo
Chascomus
Argentina
Taller de Biología Celular y del Desarrollo
description Organisms exhibit flexible behaviors in response to the same stimulus, depending on their internal physiological states. For example, when animals are satiated and encounter non- preferred food sources, they typically exhibit reduced engagement, often redirecting their search toward more desirable options. However, after prolonged fasting, even less preferred food becomes valuable. Despite decades of research on feeding behaviors, the neural mechanisms that allow animals to adapt their responses based on their nutritional status remain elusive. Serotonin (5-HT), commonly referred to as the "happiness hormone," increases in response to food stimuli and modulates feeding behavior across species, suggesting a conserved role. In contrast, catecholamines, which are central to the stress response, regulate appetite by suppressing food intake in many animals. Using the nematode Caenorhabditis elegans—an organism with a simple, well-characterized nervous system—we investigate how the serotonergic and catecholaminergic systems interact to modulate food- related behaviors. Our findings provide key insights into how C. elegans integrates internal states to adjust its foraging strategies. Given the conservation of neuronal components across species, our results could offer a valuable framework for understanding the molecular mechanisms underlying state-dependent feeding behaviors in other organisms
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
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Book
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/273724
Neuronal Regulation of State- Dependent Foraging in Caenorhabditis elegans; Taller Biologia celular y Del Desarrollo; Chascomus; Argentina; 2024; 11-11
CONICET Digital
CONICET
url http://hdl.handle.net/11336/273724
identifier_str_mv Neuronal Regulation of State- Dependent Foraging in Caenorhabditis elegans; Taller Biologia celular y Del Desarrollo; Chascomus; Argentina; 2024; 11-11
CONICET Digital
CONICET
dc.language.none.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://tallerbcd.wixsite.com/tallerbcd
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.coverage.none.fl_str_mv Nacional
dc.publisher.none.fl_str_mv Taller Biologia celular y del desarrollo
publisher.none.fl_str_mv Taller Biologia celular y del desarrollo
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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