Neural modulation of behavioral state transitions in foraging strategies in C. elegans

Autores
Blanco, Maria Gabriela; Florman, Jeremy; Alkema, Mark; de Rosa, Maria Jose; Rayes, Diego Hernán
Año de publicación
2023
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Adequate feeding behavior is essential for animal survival and it is regulated not only by the digestive system but also by the nervous system (NS). The NS allows the animal to respond flexibly to changes in the environment depending on the availability of food and the nutritional internal state. Despite feeding behaviors have been studied for decades, understanding the mechanisms involved in different animals´ responses to food depending on its internal state (satiated or fasted/stressed) is still a major challenge. Referred to as the “happiness hormone”, serotonin (5-HT) has been shown to increase with food stimulus and modulate feeding in different animals, suggesting that the role of 5-HT is conserved in nature. On the other hand, noradrenaline (NA), implicated in triggering a stress response, is involved in appetite control by reducing food ingestion. Interestingly, there are reports showing that a lesion of the serotonergic system enhances the effect of noradrenergic drugs. These findings indicate an interaction between serotonergic and noradrenergic signaling. However, the mechanism and relevance of this interplay are not entirely clear. Therefore, our goal is to investigate the molecular processes underlying this interaction. The complexity of the mammalian brain complicates the study of neuronal processes. The nematode Caenorhabditis elegans is suitable for understanding neuronal signaling because of its simple and well-described nervous system. We found that during prolonged fasting, animals decrease their locomotion, which can be resumed by adding tyramine (TA), the analog of NA in invertebrates. 5-HT produces the opposite effect by reducing locomotion, suggesting that 5-HT acts antagonistically to TA. Moreover, it has been shown that when the environment improves and fasted animals encounter food, they release 5-HT to slow their locomotion and promote feeding. Interestingly, we found that this slowing response and the activity of the serotonergic neurons upon food encounter are enhanced in TA-deficient mutants compared to wild-type animals. Given that we also show that TA levels decrease during fasting, we hypothesize that this disinhibits the serotonergic neurons and favors their activity upon refeeding, allowing the animal to exploit the new source of food. Considering the conservation of neuronal components, we believe that our results may contribute to the understanding of the nervous control of state dependent foraging strategies
Fil: Blanco, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Florman, Jeremy. University of Massachusetts; Estados Unidos
Fil: Alkema, Mark. University of Massachusetts; Estados Unidos
Fil: de Rosa, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
24th International C. elegans Conference
Glasgow
Reino Unido
Genetics Society of America
Materia
C. ELEGANS
BIOAMINES
NEURONAL CIRCUITS
FEEDING BEHAVIOR
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/241421
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/241421
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Neural modulation of behavioral state transitions in foraging strategies in C. elegansBlanco, Maria GabrielaFlorman, JeremyAlkema, Markde Rosa, Maria JoseRayes, Diego HernánC. ELEGANSBIOAMINESNEURONAL CIRCUITSFEEDING BEHAVIORhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Adequate feeding behavior is essential for animal survival and it is regulated not only by the digestive system but also by the nervous system (NS). The NS allows the animal to respond flexibly to changes in the environment depending on the availability of food and the nutritional internal state. Despite feeding behaviors have been studied for decades, understanding the mechanisms involved in different animals´ responses to food depending on its internal state (satiated or fasted/stressed) is still a major challenge. Referred to as the “happiness hormone”, serotonin (5-HT) has been shown to increase with food stimulus and modulate feeding in different animals, suggesting that the role of 5-HT is conserved in nature. On the other hand, noradrenaline (NA), implicated in triggering a stress response, is involved in appetite control by reducing food ingestion. Interestingly, there are reports showing that a lesion of the serotonergic system enhances the effect of noradrenergic drugs. These findings indicate an interaction between serotonergic and noradrenergic signaling. However, the mechanism and relevance of this interplay are not entirely clear. Therefore, our goal is to investigate the molecular processes underlying this interaction. The complexity of the mammalian brain complicates the study of neuronal processes. The nematode Caenorhabditis elegans is suitable for understanding neuronal signaling because of its simple and well-described nervous system. We found that during prolonged fasting, animals decrease their locomotion, which can be resumed by adding tyramine (TA), the analog of NA in invertebrates. 5-HT produces the opposite effect by reducing locomotion, suggesting that 5-HT acts antagonistically to TA. Moreover, it has been shown that when the environment improves and fasted animals encounter food, they release 5-HT to slow their locomotion and promote feeding. Interestingly, we found that this slowing response and the activity of the serotonergic neurons upon food encounter are enhanced in TA-deficient mutants compared to wild-type animals. Given that we also show that TA levels decrease during fasting, we hypothesize that this disinhibits the serotonergic neurons and favors their activity upon refeeding, allowing the animal to exploit the new source of food. Considering the conservation of neuronal components, we believe that our results may contribute to the understanding of the nervous control of state dependent foraging strategiesFil: Blanco, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Florman, Jeremy. University of Massachusetts; Estados UnidosFil: Alkema, Mark. University of Massachusetts; Estados UnidosFil: de Rosa, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina24th International C. elegans ConferenceGlasgowReino UnidoGenetics Society of AmericaGenetics Society of America2023info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectConferenciaJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/241421Neural modulation of behavioral state transitions in foraging strategies in C. elegans; 24th International C. elegans Conference; Glasgow; Reino Unido; 2023; 380-380CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://genetics-gsa.org/celegans2023/Internacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:45:53Zoai:ri.conicet.gov.ar:11336/241421instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:45:53.655CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Neural modulation of behavioral state transitions in foraging strategies in C. elegans
title Neural modulation of behavioral state transitions in foraging strategies in C. elegans
spellingShingle Neural modulation of behavioral state transitions in foraging strategies in C. elegans
Blanco, Maria Gabriela
C. ELEGANS
BIOAMINES
NEURONAL CIRCUITS
FEEDING BEHAVIOR
title_short Neural modulation of behavioral state transitions in foraging strategies in C. elegans
title_full Neural modulation of behavioral state transitions in foraging strategies in C. elegans
title_fullStr Neural modulation of behavioral state transitions in foraging strategies in C. elegans
title_full_unstemmed Neural modulation of behavioral state transitions in foraging strategies in C. elegans
title_sort Neural modulation of behavioral state transitions in foraging strategies in C. elegans
dc.creator.none.fl_str_mv Blanco, Maria Gabriela
Florman, Jeremy
Alkema, Mark
de Rosa, Maria Jose
Rayes, Diego Hernán
author Blanco, Maria Gabriela
author_facet Blanco, Maria Gabriela
Florman, Jeremy
Alkema, Mark
de Rosa, Maria Jose
Rayes, Diego Hernán
author_role author
author2 Florman, Jeremy
Alkema, Mark
de Rosa, Maria Jose
Rayes, Diego Hernán
author2_role author
author
author
author
dc.subject.none.fl_str_mv C. ELEGANS
BIOAMINES
NEURONAL CIRCUITS
FEEDING BEHAVIOR
topic C. ELEGANS
BIOAMINES
NEURONAL CIRCUITS
FEEDING BEHAVIOR
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Adequate feeding behavior is essential for animal survival and it is regulated not only by the digestive system but also by the nervous system (NS). The NS allows the animal to respond flexibly to changes in the environment depending on the availability of food and the nutritional internal state. Despite feeding behaviors have been studied for decades, understanding the mechanisms involved in different animals´ responses to food depending on its internal state (satiated or fasted/stressed) is still a major challenge. Referred to as the “happiness hormone”, serotonin (5-HT) has been shown to increase with food stimulus and modulate feeding in different animals, suggesting that the role of 5-HT is conserved in nature. On the other hand, noradrenaline (NA), implicated in triggering a stress response, is involved in appetite control by reducing food ingestion. Interestingly, there are reports showing that a lesion of the serotonergic system enhances the effect of noradrenergic drugs. These findings indicate an interaction between serotonergic and noradrenergic signaling. However, the mechanism and relevance of this interplay are not entirely clear. Therefore, our goal is to investigate the molecular processes underlying this interaction. The complexity of the mammalian brain complicates the study of neuronal processes. The nematode Caenorhabditis elegans is suitable for understanding neuronal signaling because of its simple and well-described nervous system. We found that during prolonged fasting, animals decrease their locomotion, which can be resumed by adding tyramine (TA), the analog of NA in invertebrates. 5-HT produces the opposite effect by reducing locomotion, suggesting that 5-HT acts antagonistically to TA. Moreover, it has been shown that when the environment improves and fasted animals encounter food, they release 5-HT to slow their locomotion and promote feeding. Interestingly, we found that this slowing response and the activity of the serotonergic neurons upon food encounter are enhanced in TA-deficient mutants compared to wild-type animals. Given that we also show that TA levels decrease during fasting, we hypothesize that this disinhibits the serotonergic neurons and favors their activity upon refeeding, allowing the animal to exploit the new source of food. Considering the conservation of neuronal components, we believe that our results may contribute to the understanding of the nervous control of state dependent foraging strategies
Fil: Blanco, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Florman, Jeremy. University of Massachusetts; Estados Unidos
Fil: Alkema, Mark. University of Massachusetts; Estados Unidos
Fil: de Rosa, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
24th International C. elegans Conference
Glasgow
Reino Unido
Genetics Society of America
description Adequate feeding behavior is essential for animal survival and it is regulated not only by the digestive system but also by the nervous system (NS). The NS allows the animal to respond flexibly to changes in the environment depending on the availability of food and the nutritional internal state. Despite feeding behaviors have been studied for decades, understanding the mechanisms involved in different animals´ responses to food depending on its internal state (satiated or fasted/stressed) is still a major challenge. Referred to as the “happiness hormone”, serotonin (5-HT) has been shown to increase with food stimulus and modulate feeding in different animals, suggesting that the role of 5-HT is conserved in nature. On the other hand, noradrenaline (NA), implicated in triggering a stress response, is involved in appetite control by reducing food ingestion. Interestingly, there are reports showing that a lesion of the serotonergic system enhances the effect of noradrenergic drugs. These findings indicate an interaction between serotonergic and noradrenergic signaling. However, the mechanism and relevance of this interplay are not entirely clear. Therefore, our goal is to investigate the molecular processes underlying this interaction. The complexity of the mammalian brain complicates the study of neuronal processes. The nematode Caenorhabditis elegans is suitable for understanding neuronal signaling because of its simple and well-described nervous system. We found that during prolonged fasting, animals decrease their locomotion, which can be resumed by adding tyramine (TA), the analog of NA in invertebrates. 5-HT produces the opposite effect by reducing locomotion, suggesting that 5-HT acts antagonistically to TA. Moreover, it has been shown that when the environment improves and fasted animals encounter food, they release 5-HT to slow their locomotion and promote feeding. Interestingly, we found that this slowing response and the activity of the serotonergic neurons upon food encounter are enhanced in TA-deficient mutants compared to wild-type animals. Given that we also show that TA levels decrease during fasting, we hypothesize that this disinhibits the serotonergic neurons and favors their activity upon refeeding, allowing the animal to exploit the new source of food. Considering the conservation of neuronal components, we believe that our results may contribute to the understanding of the nervous control of state dependent foraging strategies
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Conferencia
Journal
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/241421
Neural modulation of behavioral state transitions in foraging strategies in C. elegans; 24th International C. elegans Conference; Glasgow; Reino Unido; 2023; 380-380
CONICET Digital
CONICET
url http://hdl.handle.net/11336/241421
identifier_str_mv Neural modulation of behavioral state transitions in foraging strategies in C. elegans; 24th International C. elegans Conference; Glasgow; Reino Unido; 2023; 380-380
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://genetics-gsa.org/celegans2023/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.coverage.none.fl_str_mv Internacional
dc.publisher.none.fl_str_mv Genetics Society of America
publisher.none.fl_str_mv Genetics Society of America
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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