Neural modulation of Stress Response in C.elegans

Autores
de Rosa, Maria Jose; Veuthey, Tania Vanesa; Blanco, Maria Gabriela; Alkema, Mark J.; Rayes, Diego Hernán
Año de publicación
2017
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
In response to environmental challenges, such as high temperature, starvation, oxidative stress or pathogenic infection, unicellular organisms and isolated cells in *culture have the intrinsic capacity to cell autonomously trigger widely conserved mechanisms with the aim of maintaining the protein homeostasis and minimize intracellular protein aggregation. These mechanisms of stress response include the induction of heat-shock proteins (HSPs), molecular chaperons that prevent protein misfolding, and the up-regulation of superoxide dismutase (SOD) and catalase, enzymes that protect the cells against reactive oxygen species protein damage. Another process that is triggered in cells exposed to stress is the autophagy, which permits the degradation of different biomolecules with the aim of both, satisfying cell energy demands and maintaining the proteostasis under these unfavorable conditions. Activation of these mechanisms in a purely autonomously way could have serious deleterious effects in the context of a multicellular organism. Nevertheless, the mechanisms that allow the metazoos to integrate and coordinate the cellular response to stress is poorly understood. Studies in C.e/egans have shown that sensory neurons play a key role in the coordination of this intrinsic capacity of cells. However, the signals and molecular mechanisms that integrate stress perception with the up-regulation of HSPs, SODs and/or autophagy in non-neuronal cells are completely unknown. Our analysis of the C.elegans wiring map reveals that the circuits activated upon stress converge in RIM, an interneuron located in the worm nerve ring, leading to the intriguing hypothesis that this neuron integrates the sensory information and coordinates the stress response through neuroendocrine signals. In this talk, we will describe molecular and cellular pathways underlaying the central coordination of the stress response in worms. Our final aim is to completely understand how the nervous system controls the stress response against life threatening environmental conditions in a complete organism as C.elegans
Fil: de Rosa, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Veuthey, Tania Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Blanco, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Alkema, Mark J.. University Of Massachussets. Medical School. Department Of Neurobiology; Estados Unidos
Fil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
First Latin American Worm Meeting
Montevideo
Uruguay
Instituto Pasteur Montevideo
Latin American Worm Meeting
Materia
c.elegans
neural circuits
stress
biogenic amines
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/241511
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Neural modulation of Stress Response in C.elegansde Rosa, Maria JoseVeuthey, Tania VanesaBlanco, Maria GabrielaAlkema, Mark J.Rayes, Diego Hernánc.elegansneural circuitsstressbiogenic amineshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1In response to environmental challenges, such as high temperature, starvation, oxidative stress or pathogenic infection, unicellular organisms and isolated cells in *culture have the intrinsic capacity to cell autonomously trigger widely conserved mechanisms with the aim of maintaining the protein homeostasis and minimize intracellular protein aggregation. These mechanisms of stress response include the induction of heat-shock proteins (HSPs), molecular chaperons that prevent protein misfolding, and the up-regulation of superoxide dismutase (SOD) and catalase, enzymes that protect the cells against reactive oxygen species protein damage. Another process that is triggered in cells exposed to stress is the autophagy, which permits the degradation of different biomolecules with the aim of both, satisfying cell energy demands and maintaining the proteostasis under these unfavorable conditions. Activation of these mechanisms in a purely autonomously way could have serious deleterious effects in the context of a multicellular organism. Nevertheless, the mechanisms that allow the metazoos to integrate and coordinate the cellular response to stress is poorly understood. Studies in C.e/egans have shown that sensory neurons play a key role in the coordination of this intrinsic capacity of cells. However, the signals and molecular mechanisms that integrate stress perception with the up-regulation of HSPs, SODs and/or autophagy in non-neuronal cells are completely unknown. Our analysis of the C.elegans wiring map reveals that the circuits activated upon stress converge in RIM, an interneuron located in the worm nerve ring, leading to the intriguing hypothesis that this neuron integrates the sensory information and coordinates the stress response through neuroendocrine signals. In this talk, we will describe molecular and cellular pathways underlaying the central coordination of the stress response in worms. Our final aim is to completely understand how the nervous system controls the stress response against life threatening environmental conditions in a complete organism as C.elegansFil: de Rosa, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Veuthey, Tania Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Blanco, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Alkema, Mark J.. University Of Massachussets. Medical School. Department Of Neurobiology; Estados UnidosFil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFirst Latin American Worm MeetingMontevideoUruguayInstituto Pasteur MontevideoLatin American Worm MeetingInstituto Pasteur2017info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectConferenciaBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/241511Neural modulation of Stress Response in C.elegans; First Latin American Worm Meeting; Montevideo; Uruguay; 2017; 1-1CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://gusaneros.com/swms/Internacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:40:57Zoai:ri.conicet.gov.ar:11336/241511instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:40:57.909CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Neural modulation of Stress Response in C.elegans
title Neural modulation of Stress Response in C.elegans
spellingShingle Neural modulation of Stress Response in C.elegans
de Rosa, Maria Jose
c.elegans
neural circuits
stress
biogenic amines
title_short Neural modulation of Stress Response in C.elegans
title_full Neural modulation of Stress Response in C.elegans
title_fullStr Neural modulation of Stress Response in C.elegans
title_full_unstemmed Neural modulation of Stress Response in C.elegans
title_sort Neural modulation of Stress Response in C.elegans
dc.creator.none.fl_str_mv de Rosa, Maria Jose
Veuthey, Tania Vanesa
Blanco, Maria Gabriela
Alkema, Mark J.
Rayes, Diego Hernán
author de Rosa, Maria Jose
author_facet de Rosa, Maria Jose
Veuthey, Tania Vanesa
Blanco, Maria Gabriela
Alkema, Mark J.
Rayes, Diego Hernán
author_role author
author2 Veuthey, Tania Vanesa
Blanco, Maria Gabriela
Alkema, Mark J.
Rayes, Diego Hernán
author2_role author
author
author
author
dc.subject.none.fl_str_mv c.elegans
neural circuits
stress
biogenic amines
topic c.elegans
neural circuits
stress
biogenic amines
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv In response to environmental challenges, such as high temperature, starvation, oxidative stress or pathogenic infection, unicellular organisms and isolated cells in *culture have the intrinsic capacity to cell autonomously trigger widely conserved mechanisms with the aim of maintaining the protein homeostasis and minimize intracellular protein aggregation. These mechanisms of stress response include the induction of heat-shock proteins (HSPs), molecular chaperons that prevent protein misfolding, and the up-regulation of superoxide dismutase (SOD) and catalase, enzymes that protect the cells against reactive oxygen species protein damage. Another process that is triggered in cells exposed to stress is the autophagy, which permits the degradation of different biomolecules with the aim of both, satisfying cell energy demands and maintaining the proteostasis under these unfavorable conditions. Activation of these mechanisms in a purely autonomously way could have serious deleterious effects in the context of a multicellular organism. Nevertheless, the mechanisms that allow the metazoos to integrate and coordinate the cellular response to stress is poorly understood. Studies in C.e/egans have shown that sensory neurons play a key role in the coordination of this intrinsic capacity of cells. However, the signals and molecular mechanisms that integrate stress perception with the up-regulation of HSPs, SODs and/or autophagy in non-neuronal cells are completely unknown. Our analysis of the C.elegans wiring map reveals that the circuits activated upon stress converge in RIM, an interneuron located in the worm nerve ring, leading to the intriguing hypothesis that this neuron integrates the sensory information and coordinates the stress response through neuroendocrine signals. In this talk, we will describe molecular and cellular pathways underlaying the central coordination of the stress response in worms. Our final aim is to completely understand how the nervous system controls the stress response against life threatening environmental conditions in a complete organism as C.elegans
Fil: de Rosa, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Veuthey, Tania Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Blanco, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Alkema, Mark J.. University Of Massachussets. Medical School. Department Of Neurobiology; Estados Unidos
Fil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
First Latin American Worm Meeting
Montevideo
Uruguay
Instituto Pasteur Montevideo
Latin American Worm Meeting
description In response to environmental challenges, such as high temperature, starvation, oxidative stress or pathogenic infection, unicellular organisms and isolated cells in *culture have the intrinsic capacity to cell autonomously trigger widely conserved mechanisms with the aim of maintaining the protein homeostasis and minimize intracellular protein aggregation. These mechanisms of stress response include the induction of heat-shock proteins (HSPs), molecular chaperons that prevent protein misfolding, and the up-regulation of superoxide dismutase (SOD) and catalase, enzymes that protect the cells against reactive oxygen species protein damage. Another process that is triggered in cells exposed to stress is the autophagy, which permits the degradation of different biomolecules with the aim of both, satisfying cell energy demands and maintaining the proteostasis under these unfavorable conditions. Activation of these mechanisms in a purely autonomously way could have serious deleterious effects in the context of a multicellular organism. Nevertheless, the mechanisms that allow the metazoos to integrate and coordinate the cellular response to stress is poorly understood. Studies in C.e/egans have shown that sensory neurons play a key role in the coordination of this intrinsic capacity of cells. However, the signals and molecular mechanisms that integrate stress perception with the up-regulation of HSPs, SODs and/or autophagy in non-neuronal cells are completely unknown. Our analysis of the C.elegans wiring map reveals that the circuits activated upon stress converge in RIM, an interneuron located in the worm nerve ring, leading to the intriguing hypothesis that this neuron integrates the sensory information and coordinates the stress response through neuroendocrine signals. In this talk, we will describe molecular and cellular pathways underlaying the central coordination of the stress response in worms. Our final aim is to completely understand how the nervous system controls the stress response against life threatening environmental conditions in a complete organism as C.elegans
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Conferencia
Book
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/241511
Neural modulation of Stress Response in C.elegans; First Latin American Worm Meeting; Montevideo; Uruguay; 2017; 1-1
CONICET Digital
CONICET
url http://hdl.handle.net/11336/241511
identifier_str_mv Neural modulation of Stress Response in C.elegans; First Latin American Worm Meeting; Montevideo; Uruguay; 2017; 1-1
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://gusaneros.com/swms/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.coverage.none.fl_str_mv Internacional
dc.publisher.none.fl_str_mv Instituto Pasteur
publisher.none.fl_str_mv Instituto Pasteur
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
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repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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