Autonomic nervous system activation during social cognition tasks in patients with schizophrenia and their unaffected relatives

Autores
Jáuregui, Ignacio Oscar; Costanzo, Elsa Y.; de Achaval, Delfina; Villarreal, Mirta Fabiana; Chu, Elvina; Mora, Martina C.; Vigo, Daniel Eduardo; Castro, Mariana Nair; Leiguarda, Ramón C.; Bär, Karl-Jürgen; Guinjoan, Salvador Martín
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objective: To determine if patients with schizophrenia and their unaffected first degree relatives have abnormal autonomic nervous system (ANS) responses to social cognition tasks. Background: Social cognition impairments are significant in schizophrenia. ANS activity has been shown to be abnormal in schizophrenia patients, and some of these abnormalities seem to be shared by unaffected relatives of afflicted persons. Method: Heart rate variability (HRV) was measured at rest, and while performing social cognition tasks in patients with schizophrenia, their nonpsychotic firstdegree relatives, and matched healthy persons (n=19 in each group). Results: Social cognition tasks induced a shortening of the RR interval in unaffected relatives, but not in patients. Social cognition tasks generated decreases in high-frequency (HF, indicative of cardiac vagal activity) and in low frequency (LF, reflecting predominantly sympathetic activity) HRV in patients, while in relatives the decrease occurred in The HF component only. LF-HRV was higher in patients during a theory of mind task compared with a control task. These changes were not observed in healthy persons. Conclusions: Social cognitive tasks induce a pattern of peripheral autonomic activity different from that seen in generic arousal responses, and such pattern is abnormal in schizophrenia patients. Autonomic abnormalities in unaffected first degree relatives seem restricted to the parasympathetic division of the ANS.
Fil: Jáuregui, Ignacio Oscar. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Costanzo, Elsa Y.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: de Achaval, Delfina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Villarreal, Mirta Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Chu, Elvina. University College London; Estados Unidos
Fil: Mora, Martina C.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Vigo, Daniel Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Pontificia Universidad Católica Argentina "Santa María de Los Buenos Aires"; Argentina
Fil: Castro, Mariana Nair. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Leiguarda, Ramón C.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Bär, Karl-Jürgen. Universitat Jena; Alemania
Fil: Guinjoan, Salvador Martín. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Psicología; Argentina
Materia
Schizophrenia
Social Cognition
Autonomic Nervous System
Endophenotype
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/16382
Acceder
id CONICETDig_a4e260a31484bb968eda33bc86293374
oai_identifier_str oai:ri.conicet.gov.ar:11336/16382
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Autonomic nervous system activation during social cognition tasks in patients with schizophrenia and their unaffected relativesJáuregui, Ignacio OscarCostanzo, Elsa Y.de Achaval, DelfinaVillarreal, Mirta FabianaChu, ElvinaMora, Martina C.Vigo, Daniel EduardoCastro, Mariana NairLeiguarda, Ramón C.Bär, Karl-JürgenGuinjoan, Salvador MartínSchizophreniaSocial CognitionAutonomic Nervous SystemEndophenotypehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Objective: To determine if patients with schizophrenia and their unaffected first degree relatives have abnormal autonomic nervous system (ANS) responses to social cognition tasks. Background: Social cognition impairments are significant in schizophrenia. ANS activity has been shown to be abnormal in schizophrenia patients, and some of these abnormalities seem to be shared by unaffected relatives of afflicted persons. Method: Heart rate variability (HRV) was measured at rest, and while performing social cognition tasks in patients with schizophrenia, their nonpsychotic firstdegree relatives, and matched healthy persons (n=19 in each group). Results: Social cognition tasks induced a shortening of the RR interval in unaffected relatives, but not in patients. Social cognition tasks generated decreases in high-frequency (HF, indicative of cardiac vagal activity) and in low frequency (LF, reflecting predominantly sympathetic activity) HRV in patients, while in relatives the decrease occurred in The HF component only. LF-HRV was higher in patients during a theory of mind task compared with a control task. These changes were not observed in healthy persons. Conclusions: Social cognitive tasks induce a pattern of peripheral autonomic activity different from that seen in generic arousal responses, and such pattern is abnormal in schizophrenia patients. Autonomic abnormalities in unaffected first degree relatives seem restricted to the parasympathetic division of the ANS.Fil: Jáuregui, Ignacio Oscar. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Costanzo, Elsa Y.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: de Achaval, Delfina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Villarreal, Mirta Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Chu, Elvina. University College London; Estados UnidosFil: Mora, Martina C.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Vigo, Daniel Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Pontificia Universidad Católica Argentina "Santa María de Los Buenos Aires"; ArgentinaFil: Castro, Mariana Nair. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Leiguarda, Ramón C.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Bär, Karl-Jürgen. Universitat Jena; AlemaniaFil: Guinjoan, Salvador Martín. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Psicología; ArgentinaLippincott Williams2011-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/16382Jáuregui, Ignacio Oscar; Costanzo, Elsa Y.; de Achaval, Delfina; Villarreal, Mirta Fabiana; Chu, Elvina; et al.; Autonomic nervous system activation during social cognition tasks in patients with schizophrenia and their unaffected relatives; Lippincott Williams ; Cognitive And Behavioral Neurology; 24; 4; 12-2011; 194-2031543-3633enginfo:eu-repo/semantics/altIdentifier/url/http://journals.lww.com/cogbehavneurol/pages/articleviewer.aspx?year=2011&issue=12000&article=00004&type=abstractinfo:eu-repo/semantics/altIdentifier/doi/10.1097/WNN.0b013e31824007e9info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-29T12:31:58Zoai:ri.conicet.gov.ar:11336/16382instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-29 12:31:58.398CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Autonomic nervous system activation during social cognition tasks in patients with schizophrenia and their unaffected relatives
title Autonomic nervous system activation during social cognition tasks in patients with schizophrenia and their unaffected relatives
spellingShingle Autonomic nervous system activation during social cognition tasks in patients with schizophrenia and their unaffected relatives
Jáuregui, Ignacio Oscar
Schizophrenia
Social Cognition
Autonomic Nervous System
Endophenotype
title_short Autonomic nervous system activation during social cognition tasks in patients with schizophrenia and their unaffected relatives
title_full Autonomic nervous system activation during social cognition tasks in patients with schizophrenia and their unaffected relatives
title_fullStr Autonomic nervous system activation during social cognition tasks in patients with schizophrenia and their unaffected relatives
title_full_unstemmed Autonomic nervous system activation during social cognition tasks in patients with schizophrenia and their unaffected relatives
title_sort Autonomic nervous system activation during social cognition tasks in patients with schizophrenia and their unaffected relatives
dc.creator.none.fl_str_mv Jáuregui, Ignacio Oscar
Costanzo, Elsa Y.
de Achaval, Delfina
Villarreal, Mirta Fabiana
Chu, Elvina
Mora, Martina C.
Vigo, Daniel Eduardo
Castro, Mariana Nair
Leiguarda, Ramón C.
Bär, Karl-Jürgen
Guinjoan, Salvador Martín
author Jáuregui, Ignacio Oscar
author_facet Jáuregui, Ignacio Oscar
Costanzo, Elsa Y.
de Achaval, Delfina
Villarreal, Mirta Fabiana
Chu, Elvina
Mora, Martina C.
Vigo, Daniel Eduardo
Castro, Mariana Nair
Leiguarda, Ramón C.
Bär, Karl-Jürgen
Guinjoan, Salvador Martín
author_role author
author2 Costanzo, Elsa Y.
de Achaval, Delfina
Villarreal, Mirta Fabiana
Chu, Elvina
Mora, Martina C.
Vigo, Daniel Eduardo
Castro, Mariana Nair
Leiguarda, Ramón C.
Bär, Karl-Jürgen
Guinjoan, Salvador Martín
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Schizophrenia
Social Cognition
Autonomic Nervous System
Endophenotype
topic Schizophrenia
Social Cognition
Autonomic Nervous System
Endophenotype
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Objective: To determine if patients with schizophrenia and their unaffected first degree relatives have abnormal autonomic nervous system (ANS) responses to social cognition tasks. Background: Social cognition impairments are significant in schizophrenia. ANS activity has been shown to be abnormal in schizophrenia patients, and some of these abnormalities seem to be shared by unaffected relatives of afflicted persons. Method: Heart rate variability (HRV) was measured at rest, and while performing social cognition tasks in patients with schizophrenia, their nonpsychotic firstdegree relatives, and matched healthy persons (n=19 in each group). Results: Social cognition tasks induced a shortening of the RR interval in unaffected relatives, but not in patients. Social cognition tasks generated decreases in high-frequency (HF, indicative of cardiac vagal activity) and in low frequency (LF, reflecting predominantly sympathetic activity) HRV in patients, while in relatives the decrease occurred in The HF component only. LF-HRV was higher in patients during a theory of mind task compared with a control task. These changes were not observed in healthy persons. Conclusions: Social cognitive tasks induce a pattern of peripheral autonomic activity different from that seen in generic arousal responses, and such pattern is abnormal in schizophrenia patients. Autonomic abnormalities in unaffected first degree relatives seem restricted to the parasympathetic division of the ANS.
Fil: Jáuregui, Ignacio Oscar. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Costanzo, Elsa Y.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: de Achaval, Delfina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Villarreal, Mirta Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Chu, Elvina. University College London; Estados Unidos
Fil: Mora, Martina C.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Vigo, Daniel Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Pontificia Universidad Católica Argentina "Santa María de Los Buenos Aires"; Argentina
Fil: Castro, Mariana Nair. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Leiguarda, Ramón C.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Bär, Karl-Jürgen. Universitat Jena; Alemania
Fil: Guinjoan, Salvador Martín. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Psicología; Argentina
description Objective: To determine if patients with schizophrenia and their unaffected first degree relatives have abnormal autonomic nervous system (ANS) responses to social cognition tasks. Background: Social cognition impairments are significant in schizophrenia. ANS activity has been shown to be abnormal in schizophrenia patients, and some of these abnormalities seem to be shared by unaffected relatives of afflicted persons. Method: Heart rate variability (HRV) was measured at rest, and while performing social cognition tasks in patients with schizophrenia, their nonpsychotic firstdegree relatives, and matched healthy persons (n=19 in each group). Results: Social cognition tasks induced a shortening of the RR interval in unaffected relatives, but not in patients. Social cognition tasks generated decreases in high-frequency (HF, indicative of cardiac vagal activity) and in low frequency (LF, reflecting predominantly sympathetic activity) HRV in patients, while in relatives the decrease occurred in The HF component only. LF-HRV was higher in patients during a theory of mind task compared with a control task. These changes were not observed in healthy persons. Conclusions: Social cognitive tasks induce a pattern of peripheral autonomic activity different from that seen in generic arousal responses, and such pattern is abnormal in schizophrenia patients. Autonomic abnormalities in unaffected first degree relatives seem restricted to the parasympathetic division of the ANS.
publishDate 2011
dc.date.none.fl_str_mv 2011-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/16382
Jáuregui, Ignacio Oscar; Costanzo, Elsa Y.; de Achaval, Delfina; Villarreal, Mirta Fabiana; Chu, Elvina; et al.; Autonomic nervous system activation during social cognition tasks in patients with schizophrenia and their unaffected relatives; Lippincott Williams ; Cognitive And Behavioral Neurology; 24; 4; 12-2011; 194-203
1543-3633
url http://hdl.handle.net/11336/16382
identifier_str_mv Jáuregui, Ignacio Oscar; Costanzo, Elsa Y.; de Achaval, Delfina; Villarreal, Mirta Fabiana; Chu, Elvina; et al.; Autonomic nervous system activation during social cognition tasks in patients with schizophrenia and their unaffected relatives; Lippincott Williams ; Cognitive And Behavioral Neurology; 24; 4; 12-2011; 194-203
1543-3633
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://journals.lww.com/cogbehavneurol/pages/articleviewer.aspx?year=2011&issue=12000&article=00004&type=abstract
info:eu-repo/semantics/altIdentifier/doi/10.1097/WNN.0b013e31824007e9
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Lippincott Williams
publisher.none.fl_str_mv Lippincott Williams
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.10058

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