Activation of brain areas concerned with social cognition during moral decisions is abnormal in schizophrenia patients and unaffected siblings

Autores
de Achaval, Delfina; Villarreal, Mirta Fabiana; Salles, Arleen; Bertomeu, Maria Julia; Costanzo, Elsa Y.; Goldschmidt, Micaela Giuliana; Castro, Mariana Nair; Van Der Poel, Iris; Nemeroff, Charles B.; Guinjoan, Salvador Martín
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Moral decision-making involves complex social cognitive processes which are known to be altered in patients with schizophrenia and first-degree relatives. Traditional philosophical views on human moral behavior have distinguished between utilitarian views (which emphasize outcomes) and deontological approaches (defining what is right to do according to certain norms). Since emotions have been sug- gested to play a determining role in moral behavior, we hypothesized patients with schizophrenia and unaffected siblings would make more utilitarian choices and show faulty activation of brain areas con- cerned with emotion regulation during such tasks. Unexpectedly, all participants (n 1⁄4 13 per group) made the same proportion of utilitarian and deontological decisions. Brain activation common to all groups induced by moral decisions included two circumscribed portions of right ventromedial and dorsolateral prefrontal cortex, adding to previous evidence on a right prosencephalic cognitive network involved in ethical decisions. However, brain activation induced by moral decisions was different in healthy persons, schizophrenia patients, and nonpsychotic siblings in regards to areas directly concerned with emotion processing. These results seem to underscore the role of acquired norms in moral de- cisions, a frequently overlooked concept in the neurobiological characterization of human ethical behavior, and add to previous evidence of abnormal social cognitive processing in schizophrenia.
Fil: de Achaval, Delfina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina;
Fil: Villarreal, Mirta Fabiana. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina;
Fil: Salles, Arleen. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina; Centro de Investigaciones Filosóficas; Argentina;
Fil: Bertomeu, Maria Julia. Centro de Investigaciones Filosóficas; Argentina;
Fil: Costanzo, Elsa Y.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina;
Fil: Goldschmidt, Micaela Giuliana. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina;
Fil: Castro, Mariana Nair. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Neurociencias; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina; Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina;
Fil: Van Der Poel, Iris. Nijmegen Medical Centre. Radboud University; Países Bajos;
Fil: Nemeroff, Charles B.. University of Miami. Leonard M. Miller School of Medicine. Department of Psychiatry and Behavioral Sciences; Estados Unidos de América;
Fil: Guinjoan, Salvador Martín. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Neurociencias; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina; Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina;
Materia
Moral
Emotion
Schizophrenia
Siblings
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/1814
Acceder
id CONICETDig_2c5496719f3b9e8bd5e94f51459eee42
oai_identifier_str oai:ri.conicet.gov.ar:11336/1814
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Activation of brain areas concerned with social cognition during moral decisions is abnormal in schizophrenia patients and unaffected siblingsde Achaval, DelfinaVillarreal, Mirta FabianaSalles, ArleenBertomeu, Maria JuliaCostanzo, Elsa Y.Goldschmidt, Micaela GiulianaCastro, Mariana NairVan Der Poel, IrisNemeroff, Charles B.Guinjoan, Salvador MartínMoralEmotionSchizophreniaSiblingshttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Moral decision-making involves complex social cognitive processes which are known to be altered in patients with schizophrenia and first-degree relatives. Traditional philosophical views on human moral behavior have distinguished between utilitarian views (which emphasize outcomes) and deontological approaches (defining what is right to do according to certain norms). Since emotions have been sug- gested to play a determining role in moral behavior, we hypothesized patients with schizophrenia and unaffected siblings would make more utilitarian choices and show faulty activation of brain areas con- cerned with emotion regulation during such tasks. Unexpectedly, all participants (n 1⁄4 13 per group) made the same proportion of utilitarian and deontological decisions. Brain activation common to all groups induced by moral decisions included two circumscribed portions of right ventromedial and dorsolateral prefrontal cortex, adding to previous evidence on a right prosencephalic cognitive network involved in ethical decisions. However, brain activation induced by moral decisions was different in healthy persons, schizophrenia patients, and nonpsychotic siblings in regards to areas directly concerned with emotion processing. These results seem to underscore the role of acquired norms in moral de- cisions, a frequently overlooked concept in the neurobiological characterization of human ethical behavior, and add to previous evidence of abnormal social cognitive processing in schizophrenia.Fil: de Achaval, Delfina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina;Fil: Villarreal, Mirta Fabiana. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina;Fil: Salles, Arleen. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina; Centro de Investigaciones Filosóficas; Argentina;Fil: Bertomeu, Maria Julia. Centro de Investigaciones Filosóficas; Argentina;Fil: Costanzo, Elsa Y.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina;Fil: Goldschmidt, Micaela Giuliana. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina;Fil: Castro, Mariana Nair. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Neurociencias; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina; Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina;Fil: Van Der Poel, Iris. Nijmegen Medical Centre. Radboud University; Países Bajos;Fil: Nemeroff, Charles B.. University of Miami. Leonard M. Miller School of Medicine. Department of Psychiatry and Behavioral Sciences; Estados Unidos de América;Fil: Guinjoan, Salvador Martín. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Neurociencias; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina; Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina;Elsevier2013-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/1814de Achaval, Delfina; Villarreal, Mirta Fabiana; Salles, Arleen; Bertomeu, Maria Julia; Costanzo, Elsa Y.; et al.; Activation of brain areas concerned with social cognition during moral decisions is abnormal in schizophrenia patients and unaffected siblings; Elsevier; Journal of Psychiatric Research; 47; 6; 6-2013; 774-7820022-3956enginfo:eu-repo/semantics/altIdentifier/doi/doi:10.1016/j.jpsychires.2012.12.018info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0022395613000058info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-17T11:56:31Zoai:ri.conicet.gov.ar:11336/1814instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-17 11:56:31.555CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Activation of brain areas concerned with social cognition during moral decisions is abnormal in schizophrenia patients and unaffected siblings
title Activation of brain areas concerned with social cognition during moral decisions is abnormal in schizophrenia patients and unaffected siblings
spellingShingle Activation of brain areas concerned with social cognition during moral decisions is abnormal in schizophrenia patients and unaffected siblings
de Achaval, Delfina
Moral
Emotion
Schizophrenia
Siblings
title_short Activation of brain areas concerned with social cognition during moral decisions is abnormal in schizophrenia patients and unaffected siblings
title_full Activation of brain areas concerned with social cognition during moral decisions is abnormal in schizophrenia patients and unaffected siblings
title_fullStr Activation of brain areas concerned with social cognition during moral decisions is abnormal in schizophrenia patients and unaffected siblings
title_full_unstemmed Activation of brain areas concerned with social cognition during moral decisions is abnormal in schizophrenia patients and unaffected siblings
title_sort Activation of brain areas concerned with social cognition during moral decisions is abnormal in schizophrenia patients and unaffected siblings
dc.creator.none.fl_str_mv de Achaval, Delfina
Villarreal, Mirta Fabiana
Salles, Arleen
Bertomeu, Maria Julia
Costanzo, Elsa Y.
Goldschmidt, Micaela Giuliana
Castro, Mariana Nair
Van Der Poel, Iris
Nemeroff, Charles B.
Guinjoan, Salvador Martín
author de Achaval, Delfina
author_facet de Achaval, Delfina
Villarreal, Mirta Fabiana
Salles, Arleen
Bertomeu, Maria Julia
Costanzo, Elsa Y.
Goldschmidt, Micaela Giuliana
Castro, Mariana Nair
Van Der Poel, Iris
Nemeroff, Charles B.
Guinjoan, Salvador Martín
author_role author
author2 Villarreal, Mirta Fabiana
Salles, Arleen
Bertomeu, Maria Julia
Costanzo, Elsa Y.
Goldschmidt, Micaela Giuliana
Castro, Mariana Nair
Van Der Poel, Iris
Nemeroff, Charles B.
Guinjoan, Salvador Martín
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Moral
Emotion
Schizophrenia
Siblings
topic Moral
Emotion
Schizophrenia
Siblings
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Moral decision-making involves complex social cognitive processes which are known to be altered in patients with schizophrenia and first-degree relatives. Traditional philosophical views on human moral behavior have distinguished between utilitarian views (which emphasize outcomes) and deontological approaches (defining what is right to do according to certain norms). Since emotions have been sug- gested to play a determining role in moral behavior, we hypothesized patients with schizophrenia and unaffected siblings would make more utilitarian choices and show faulty activation of brain areas con- cerned with emotion regulation during such tasks. Unexpectedly, all participants (n 1⁄4 13 per group) made the same proportion of utilitarian and deontological decisions. Brain activation common to all groups induced by moral decisions included two circumscribed portions of right ventromedial and dorsolateral prefrontal cortex, adding to previous evidence on a right prosencephalic cognitive network involved in ethical decisions. However, brain activation induced by moral decisions was different in healthy persons, schizophrenia patients, and nonpsychotic siblings in regards to areas directly concerned with emotion processing. These results seem to underscore the role of acquired norms in moral de- cisions, a frequently overlooked concept in the neurobiological characterization of human ethical behavior, and add to previous evidence of abnormal social cognitive processing in schizophrenia.
Fil: de Achaval, Delfina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina;
Fil: Villarreal, Mirta Fabiana. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina;
Fil: Salles, Arleen. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina; Centro de Investigaciones Filosóficas; Argentina;
Fil: Bertomeu, Maria Julia. Centro de Investigaciones Filosóficas; Argentina;
Fil: Costanzo, Elsa Y.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina;
Fil: Goldschmidt, Micaela Giuliana. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina;
Fil: Castro, Mariana Nair. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Neurociencias; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina; Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina;
Fil: Van Der Poel, Iris. Nijmegen Medical Centre. Radboud University; Países Bajos;
Fil: Nemeroff, Charles B.. University of Miami. Leonard M. Miller School of Medicine. Department of Psychiatry and Behavioral Sciences; Estados Unidos de América;
Fil: Guinjoan, Salvador Martín. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Neurociencias; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina; Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina;
description Moral decision-making involves complex social cognitive processes which are known to be altered in patients with schizophrenia and first-degree relatives. Traditional philosophical views on human moral behavior have distinguished between utilitarian views (which emphasize outcomes) and deontological approaches (defining what is right to do according to certain norms). Since emotions have been sug- gested to play a determining role in moral behavior, we hypothesized patients with schizophrenia and unaffected siblings would make more utilitarian choices and show faulty activation of brain areas con- cerned with emotion regulation during such tasks. Unexpectedly, all participants (n 1⁄4 13 per group) made the same proportion of utilitarian and deontological decisions. Brain activation common to all groups induced by moral decisions included two circumscribed portions of right ventromedial and dorsolateral prefrontal cortex, adding to previous evidence on a right prosencephalic cognitive network involved in ethical decisions. However, brain activation induced by moral decisions was different in healthy persons, schizophrenia patients, and nonpsychotic siblings in regards to areas directly concerned with emotion processing. These results seem to underscore the role of acquired norms in moral de- cisions, a frequently overlooked concept in the neurobiological characterization of human ethical behavior, and add to previous evidence of abnormal social cognitive processing in schizophrenia.
publishDate 2013
dc.date.none.fl_str_mv 2013-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/1814
de Achaval, Delfina; Villarreal, Mirta Fabiana; Salles, Arleen; Bertomeu, Maria Julia; Costanzo, Elsa Y.; et al.; Activation of brain areas concerned with social cognition during moral decisions is abnormal in schizophrenia patients and unaffected siblings; Elsevier; Journal of Psychiatric Research; 47; 6; 6-2013; 774-782
0022-3956
url http://hdl.handle.net/11336/1814
identifier_str_mv de Achaval, Delfina; Villarreal, Mirta Fabiana; Salles, Arleen; Bertomeu, Maria Julia; Costanzo, Elsa Y.; et al.; Activation of brain areas concerned with social cognition during moral decisions is abnormal in schizophrenia patients and unaffected siblings; Elsevier; Journal of Psychiatric Research; 47; 6; 6-2013; 774-782
0022-3956
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/doi:10.1016/j.jpsychires.2012.12.018
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0022395613000058
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1843606907833548800
score 13.001348

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