Brain activation induced by psychological stress in patients with schizophrenia
- Autores
- Castro, Mariana Nair; Villarreal, Mirta Fabiana; Bolotinsky, N.; Papávero, E.; Goldschmidt, M.G.; Costanzo, E.Y.; Drucaroff, Lucas Javier; Wainsztein, A.; de Achaval, Delfina; Pahissa, J.; Bär, K.-J.; Nemeroff, C.B.; Guinjoan, Salvador Martín
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Environmental influences are critical for the expression of genes putatively related to the behavioral and cognitive phenotypes of schizophrenia. Among such factors, psychosocial stress has been proposed to play a major role in the expression of symptoms. However, it is unsettled how stress interacts with pathophysiological pathways to produce the disease. We studied 21 patients with schizophrenia and 21 healthy controls aged 18 to 50 years with 3T-fMRI, in which a period of 6 min of resting state acquisition was followed by a block design, with three blocks of 1-min control-task, 1-min stress-task and 1-min rest after-task. Self-report of stress and PANSS were measured. Limbic structures were activated in schizophrenia patients by simple tasks and remained active during, and shortly after stress. In controls, stress-related brain activation was more time-focused, and restricted to the stressful task itself. Negative symptom severity was inversely related to activation of anterior cingulum and orbitofrontal cortex. Results might represent the neurobiological aspect of hyper-reactivity to normal stressful situations previously described in schizophrenia, thus providing evidence on the involvement of limbic areas in the response to stress in schizophrenia. Patients present a pattern of persistent limbic activation probably contributing to hypervigilance and subsequent psychotic thought distortions.
Fil: Castro, Mariana Nair. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina
Fil: Villarreal, Mirta Fabiana. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bolotinsky, N.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Papávero, E.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Goldschmidt, M.G.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Costanzo, E.Y.. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Drucaroff, Lucas Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina
Fil: Wainsztein, A.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: de Achaval, Delfina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Pahissa, J.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Bär, K.-J.. Friedrich-Schiller-Universität; Alemania
Fil: Nemeroff, C.B.. University of Miami; Estados Unidos
Fil: Guinjoan, Salvador Martín. Universidad de Buenos Aires. Facultad de Psicología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina - Materia
-
Autonomic nervous system
Endophenotypes
Environment
Limbic system
Psychosis
fMRI
Schizophrenia - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/94485
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Brain activation induced by psychological stress in patients with schizophreniaCastro, Mariana NairVillarreal, Mirta FabianaBolotinsky, N.Papávero, E.Goldschmidt, M.G.Costanzo, E.Y.Drucaroff, Lucas JavierWainsztein, A.de Achaval, DelfinaPahissa, J.Bär, K.-J.Nemeroff, C.B.Guinjoan, Salvador MartínAutonomic nervous systemEndophenotypesEnvironmentLimbic systemPsychosisfMRISchizophreniahttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Environmental influences are critical for the expression of genes putatively related to the behavioral and cognitive phenotypes of schizophrenia. Among such factors, psychosocial stress has been proposed to play a major role in the expression of symptoms. However, it is unsettled how stress interacts with pathophysiological pathways to produce the disease. We studied 21 patients with schizophrenia and 21 healthy controls aged 18 to 50 years with 3T-fMRI, in which a period of 6 min of resting state acquisition was followed by a block design, with three blocks of 1-min control-task, 1-min stress-task and 1-min rest after-task. Self-report of stress and PANSS were measured. Limbic structures were activated in schizophrenia patients by simple tasks and remained active during, and shortly after stress. In controls, stress-related brain activation was more time-focused, and restricted to the stressful task itself. Negative symptom severity was inversely related to activation of anterior cingulum and orbitofrontal cortex. Results might represent the neurobiological aspect of hyper-reactivity to normal stressful situations previously described in schizophrenia, thus providing evidence on the involvement of limbic areas in the response to stress in schizophrenia. Patients present a pattern of persistent limbic activation probably contributing to hypervigilance and subsequent psychotic thought distortions.Fil: Castro, Mariana Nair. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; ArgentinaFil: Villarreal, Mirta Fabiana. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Bolotinsky, N.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Papávero, E.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Goldschmidt, M.G.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Costanzo, E.Y.. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Drucaroff, Lucas Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; ArgentinaFil: Wainsztein, A.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: de Achaval, Delfina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Pahissa, J.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Bär, K.-J.. Friedrich-Schiller-Universität; AlemaniaFil: Nemeroff, C.B.. University of Miami; Estados UnidosFil: Guinjoan, Salvador Martín. Universidad de Buenos Aires. Facultad de Psicología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaElsevier Science2015-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/94485Castro, Mariana Nair; Villarreal, Mirta Fabiana; Bolotinsky, N.; Papávero, E.; Goldschmidt, M.G.; et al.; Brain activation induced by psychological stress in patients with schizophrenia; Elsevier Science; Schizophrenia Research; 168; 1-2; 10-2015; 313-3210920-9964CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0920996415003473info:eu-repo/semantics/altIdentifier/doi/10.1016/j.schres.2015.07.008info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:20:03Zoai:ri.conicet.gov.ar:11336/94485instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:20:03.884CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Brain activation induced by psychological stress in patients with schizophrenia |
title |
Brain activation induced by psychological stress in patients with schizophrenia |
spellingShingle |
Brain activation induced by psychological stress in patients with schizophrenia Castro, Mariana Nair Autonomic nervous system Endophenotypes Environment Limbic system Psychosis fMRI Schizophrenia |
title_short |
Brain activation induced by psychological stress in patients with schizophrenia |
title_full |
Brain activation induced by psychological stress in patients with schizophrenia |
title_fullStr |
Brain activation induced by psychological stress in patients with schizophrenia |
title_full_unstemmed |
Brain activation induced by psychological stress in patients with schizophrenia |
title_sort |
Brain activation induced by psychological stress in patients with schizophrenia |
dc.creator.none.fl_str_mv |
Castro, Mariana Nair Villarreal, Mirta Fabiana Bolotinsky, N. Papávero, E. Goldschmidt, M.G. Costanzo, E.Y. Drucaroff, Lucas Javier Wainsztein, A. de Achaval, Delfina Pahissa, J. Bär, K.-J. Nemeroff, C.B. Guinjoan, Salvador Martín |
author |
Castro, Mariana Nair |
author_facet |
Castro, Mariana Nair Villarreal, Mirta Fabiana Bolotinsky, N. Papávero, E. Goldschmidt, M.G. Costanzo, E.Y. Drucaroff, Lucas Javier Wainsztein, A. de Achaval, Delfina Pahissa, J. Bär, K.-J. Nemeroff, C.B. Guinjoan, Salvador Martín |
author_role |
author |
author2 |
Villarreal, Mirta Fabiana Bolotinsky, N. Papávero, E. Goldschmidt, M.G. Costanzo, E.Y. Drucaroff, Lucas Javier Wainsztein, A. de Achaval, Delfina Pahissa, J. Bär, K.-J. Nemeroff, C.B. Guinjoan, Salvador Martín |
author2_role |
author author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
Autonomic nervous system Endophenotypes Environment Limbic system Psychosis fMRI Schizophrenia |
topic |
Autonomic nervous system Endophenotypes Environment Limbic system Psychosis fMRI Schizophrenia |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Environmental influences are critical for the expression of genes putatively related to the behavioral and cognitive phenotypes of schizophrenia. Among such factors, psychosocial stress has been proposed to play a major role in the expression of symptoms. However, it is unsettled how stress interacts with pathophysiological pathways to produce the disease. We studied 21 patients with schizophrenia and 21 healthy controls aged 18 to 50 years with 3T-fMRI, in which a period of 6 min of resting state acquisition was followed by a block design, with three blocks of 1-min control-task, 1-min stress-task and 1-min rest after-task. Self-report of stress and PANSS were measured. Limbic structures were activated in schizophrenia patients by simple tasks and remained active during, and shortly after stress. In controls, stress-related brain activation was more time-focused, and restricted to the stressful task itself. Negative symptom severity was inversely related to activation of anterior cingulum and orbitofrontal cortex. Results might represent the neurobiological aspect of hyper-reactivity to normal stressful situations previously described in schizophrenia, thus providing evidence on the involvement of limbic areas in the response to stress in schizophrenia. Patients present a pattern of persistent limbic activation probably contributing to hypervigilance and subsequent psychotic thought distortions. Fil: Castro, Mariana Nair. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina Fil: Villarreal, Mirta Fabiana. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Bolotinsky, N.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina Fil: Papávero, E.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina Fil: Goldschmidt, M.G.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina Fil: Costanzo, E.Y.. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina Fil: Drucaroff, Lucas Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina Fil: Wainsztein, A.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina Fil: de Achaval, Delfina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina Fil: Pahissa, J.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina Fil: Bär, K.-J.. Friedrich-Schiller-Universität; Alemania Fil: Nemeroff, C.B.. University of Miami; Estados Unidos Fil: Guinjoan, Salvador Martín. Universidad de Buenos Aires. Facultad de Psicología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina |
description |
Environmental influences are critical for the expression of genes putatively related to the behavioral and cognitive phenotypes of schizophrenia. Among such factors, psychosocial stress has been proposed to play a major role in the expression of symptoms. However, it is unsettled how stress interacts with pathophysiological pathways to produce the disease. We studied 21 patients with schizophrenia and 21 healthy controls aged 18 to 50 years with 3T-fMRI, in which a period of 6 min of resting state acquisition was followed by a block design, with three blocks of 1-min control-task, 1-min stress-task and 1-min rest after-task. Self-report of stress and PANSS were measured. Limbic structures were activated in schizophrenia patients by simple tasks and remained active during, and shortly after stress. In controls, stress-related brain activation was more time-focused, and restricted to the stressful task itself. Negative symptom severity was inversely related to activation of anterior cingulum and orbitofrontal cortex. Results might represent the neurobiological aspect of hyper-reactivity to normal stressful situations previously described in schizophrenia, thus providing evidence on the involvement of limbic areas in the response to stress in schizophrenia. Patients present a pattern of persistent limbic activation probably contributing to hypervigilance and subsequent psychotic thought distortions. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-10 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/94485 Castro, Mariana Nair; Villarreal, Mirta Fabiana; Bolotinsky, N.; Papávero, E.; Goldschmidt, M.G.; et al.; Brain activation induced by psychological stress in patients with schizophrenia; Elsevier Science; Schizophrenia Research; 168; 1-2; 10-2015; 313-321 0920-9964 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/94485 |
identifier_str_mv |
Castro, Mariana Nair; Villarreal, Mirta Fabiana; Bolotinsky, N.; Papávero, E.; Goldschmidt, M.G.; et al.; Brain activation induced by psychological stress in patients with schizophrenia; Elsevier Science; Schizophrenia Research; 168; 1-2; 10-2015; 313-321 0920-9964 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0920996415003473 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.schres.2015.07.008 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier Science |
publisher.none.fl_str_mv |
Elsevier Science |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.070432 |