Brain activation induced by psychological stress in patients with schizophrenia

Autores
Castro, Mariana Nair; Villarreal, Mirta Fabiana; Bolotinsky, N.; Papávero, E.; Goldschmidt, M.G.; Costanzo, E.Y.; Drucaroff, Lucas Javier; Wainsztein, A.; de Achaval, Delfina; Pahissa, J.; Bär, K.-J.; Nemeroff, C.B.; Guinjoan, Salvador Martín
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Environmental influences are critical for the expression of genes putatively related to the behavioral and cognitive phenotypes of schizophrenia. Among such factors, psychosocial stress has been proposed to play a major role in the expression of symptoms. However, it is unsettled how stress interacts with pathophysiological pathways to produce the disease. We studied 21 patients with schizophrenia and 21 healthy controls aged 18 to 50 years with 3T-fMRI, in which a period of 6 min of resting state acquisition was followed by a block design, with three blocks of 1-min control-task, 1-min stress-task and 1-min rest after-task. Self-report of stress and PANSS were measured. Limbic structures were activated in schizophrenia patients by simple tasks and remained active during, and shortly after stress. In controls, stress-related brain activation was more time-focused, and restricted to the stressful task itself. Negative symptom severity was inversely related to activation of anterior cingulum and orbitofrontal cortex. Results might represent the neurobiological aspect of hyper-reactivity to normal stressful situations previously described in schizophrenia, thus providing evidence on the involvement of limbic areas in the response to stress in schizophrenia. Patients present a pattern of persistent limbic activation probably contributing to hypervigilance and subsequent psychotic thought distortions.
Fil: Castro, Mariana Nair. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina
Fil: Villarreal, Mirta Fabiana. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bolotinsky, N.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Papávero, E.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Goldschmidt, M.G.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Costanzo, E.Y.. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Drucaroff, Lucas Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina
Fil: Wainsztein, A.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: de Achaval, Delfina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Pahissa, J.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Bär, K.-J.. Friedrich-Schiller-Universität; Alemania
Fil: Nemeroff, C.B.. University of Miami; Estados Unidos
Fil: Guinjoan, Salvador Martín. Universidad de Buenos Aires. Facultad de Psicología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Materia
Autonomic nervous system
Endophenotypes
Environment
Limbic system
Psychosis
fMRI
Schizophrenia
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/94485

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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Brain activation induced by psychological stress in patients with schizophreniaCastro, Mariana NairVillarreal, Mirta FabianaBolotinsky, N.Papávero, E.Goldschmidt, M.G.Costanzo, E.Y.Drucaroff, Lucas JavierWainsztein, A.de Achaval, DelfinaPahissa, J.Bär, K.-J.Nemeroff, C.B.Guinjoan, Salvador MartínAutonomic nervous systemEndophenotypesEnvironmentLimbic systemPsychosisfMRISchizophreniahttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Environmental influences are critical for the expression of genes putatively related to the behavioral and cognitive phenotypes of schizophrenia. Among such factors, psychosocial stress has been proposed to play a major role in the expression of symptoms. However, it is unsettled how stress interacts with pathophysiological pathways to produce the disease. We studied 21 patients with schizophrenia and 21 healthy controls aged 18 to 50 years with 3T-fMRI, in which a period of 6 min of resting state acquisition was followed by a block design, with three blocks of 1-min control-task, 1-min stress-task and 1-min rest after-task. Self-report of stress and PANSS were measured. Limbic structures were activated in schizophrenia patients by simple tasks and remained active during, and shortly after stress. In controls, stress-related brain activation was more time-focused, and restricted to the stressful task itself. Negative symptom severity was inversely related to activation of anterior cingulum and orbitofrontal cortex. Results might represent the neurobiological aspect of hyper-reactivity to normal stressful situations previously described in schizophrenia, thus providing evidence on the involvement of limbic areas in the response to stress in schizophrenia. Patients present a pattern of persistent limbic activation probably contributing to hypervigilance and subsequent psychotic thought distortions.Fil: Castro, Mariana Nair. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; ArgentinaFil: Villarreal, Mirta Fabiana. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Bolotinsky, N.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Papávero, E.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Goldschmidt, M.G.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Costanzo, E.Y.. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Drucaroff, Lucas Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; ArgentinaFil: Wainsztein, A.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: de Achaval, Delfina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Pahissa, J.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Bär, K.-J.. Friedrich-Schiller-Universität; AlemaniaFil: Nemeroff, C.B.. University of Miami; Estados UnidosFil: Guinjoan, Salvador Martín. Universidad de Buenos Aires. Facultad de Psicología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaElsevier Science2015-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/94485Castro, Mariana Nair; Villarreal, Mirta Fabiana; Bolotinsky, N.; Papávero, E.; Goldschmidt, M.G.; et al.; Brain activation induced by psychological stress in patients with schizophrenia; Elsevier Science; Schizophrenia Research; 168; 1-2; 10-2015; 313-3210920-9964CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0920996415003473info:eu-repo/semantics/altIdentifier/doi/10.1016/j.schres.2015.07.008info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:20:03Zoai:ri.conicet.gov.ar:11336/94485instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:20:03.884CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Brain activation induced by psychological stress in patients with schizophrenia
title Brain activation induced by psychological stress in patients with schizophrenia
spellingShingle Brain activation induced by psychological stress in patients with schizophrenia
Castro, Mariana Nair
Autonomic nervous system
Endophenotypes
Environment
Limbic system
Psychosis
fMRI
Schizophrenia
title_short Brain activation induced by psychological stress in patients with schizophrenia
title_full Brain activation induced by psychological stress in patients with schizophrenia
title_fullStr Brain activation induced by psychological stress in patients with schizophrenia
title_full_unstemmed Brain activation induced by psychological stress in patients with schizophrenia
title_sort Brain activation induced by psychological stress in patients with schizophrenia
dc.creator.none.fl_str_mv Castro, Mariana Nair
Villarreal, Mirta Fabiana
Bolotinsky, N.
Papávero, E.
Goldschmidt, M.G.
Costanzo, E.Y.
Drucaroff, Lucas Javier
Wainsztein, A.
de Achaval, Delfina
Pahissa, J.
Bär, K.-J.
Nemeroff, C.B.
Guinjoan, Salvador Martín
author Castro, Mariana Nair
author_facet Castro, Mariana Nair
Villarreal, Mirta Fabiana
Bolotinsky, N.
Papávero, E.
Goldschmidt, M.G.
Costanzo, E.Y.
Drucaroff, Lucas Javier
Wainsztein, A.
de Achaval, Delfina
Pahissa, J.
Bär, K.-J.
Nemeroff, C.B.
Guinjoan, Salvador Martín
author_role author
author2 Villarreal, Mirta Fabiana
Bolotinsky, N.
Papávero, E.
Goldschmidt, M.G.
Costanzo, E.Y.
Drucaroff, Lucas Javier
Wainsztein, A.
de Achaval, Delfina
Pahissa, J.
Bär, K.-J.
Nemeroff, C.B.
Guinjoan, Salvador Martín
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Autonomic nervous system
Endophenotypes
Environment
Limbic system
Psychosis
fMRI
Schizophrenia
topic Autonomic nervous system
Endophenotypes
Environment
Limbic system
Psychosis
fMRI
Schizophrenia
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Environmental influences are critical for the expression of genes putatively related to the behavioral and cognitive phenotypes of schizophrenia. Among such factors, psychosocial stress has been proposed to play a major role in the expression of symptoms. However, it is unsettled how stress interacts with pathophysiological pathways to produce the disease. We studied 21 patients with schizophrenia and 21 healthy controls aged 18 to 50 years with 3T-fMRI, in which a period of 6 min of resting state acquisition was followed by a block design, with three blocks of 1-min control-task, 1-min stress-task and 1-min rest after-task. Self-report of stress and PANSS were measured. Limbic structures were activated in schizophrenia patients by simple tasks and remained active during, and shortly after stress. In controls, stress-related brain activation was more time-focused, and restricted to the stressful task itself. Negative symptom severity was inversely related to activation of anterior cingulum and orbitofrontal cortex. Results might represent the neurobiological aspect of hyper-reactivity to normal stressful situations previously described in schizophrenia, thus providing evidence on the involvement of limbic areas in the response to stress in schizophrenia. Patients present a pattern of persistent limbic activation probably contributing to hypervigilance and subsequent psychotic thought distortions.
Fil: Castro, Mariana Nair. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina
Fil: Villarreal, Mirta Fabiana. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bolotinsky, N.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Papávero, E.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Goldschmidt, M.G.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Costanzo, E.Y.. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Drucaroff, Lucas Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina
Fil: Wainsztein, A.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: de Achaval, Delfina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Pahissa, J.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Bär, K.-J.. Friedrich-Schiller-Universität; Alemania
Fil: Nemeroff, C.B.. University of Miami; Estados Unidos
Fil: Guinjoan, Salvador Martín. Universidad de Buenos Aires. Facultad de Psicología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
description Environmental influences are critical for the expression of genes putatively related to the behavioral and cognitive phenotypes of schizophrenia. Among such factors, psychosocial stress has been proposed to play a major role in the expression of symptoms. However, it is unsettled how stress interacts with pathophysiological pathways to produce the disease. We studied 21 patients with schizophrenia and 21 healthy controls aged 18 to 50 years with 3T-fMRI, in which a period of 6 min of resting state acquisition was followed by a block design, with three blocks of 1-min control-task, 1-min stress-task and 1-min rest after-task. Self-report of stress and PANSS were measured. Limbic structures were activated in schizophrenia patients by simple tasks and remained active during, and shortly after stress. In controls, stress-related brain activation was more time-focused, and restricted to the stressful task itself. Negative symptom severity was inversely related to activation of anterior cingulum and orbitofrontal cortex. Results might represent the neurobiological aspect of hyper-reactivity to normal stressful situations previously described in schizophrenia, thus providing evidence on the involvement of limbic areas in the response to stress in schizophrenia. Patients present a pattern of persistent limbic activation probably contributing to hypervigilance and subsequent psychotic thought distortions.
publishDate 2015
dc.date.none.fl_str_mv 2015-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/94485
Castro, Mariana Nair; Villarreal, Mirta Fabiana; Bolotinsky, N.; Papávero, E.; Goldschmidt, M.G.; et al.; Brain activation induced by psychological stress in patients with schizophrenia; Elsevier Science; Schizophrenia Research; 168; 1-2; 10-2015; 313-321
0920-9964
CONICET Digital
CONICET
url http://hdl.handle.net/11336/94485
identifier_str_mv Castro, Mariana Nair; Villarreal, Mirta Fabiana; Bolotinsky, N.; Papávero, E.; Goldschmidt, M.G.; et al.; Brain activation induced by psychological stress in patients with schizophrenia; Elsevier Science; Schizophrenia Research; 168; 1-2; 10-2015; 313-321
0920-9964
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/doi/10.1016/j.schres.2015.07.008
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
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dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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