Heart rate variability response to mental arithmetic stress is abnormal in first-degree relatives of individuals with schizophrenia

Autores
Castro, Mariana Nair; Vigo, Daniel Eduardo; Chu, Elvina; Fahrer, Rodolfo D.; de Achával, Delfina; Costanzo, Elsa Y.; Leiguarda, Ramón Carlos; Nogués, Martín; Cardinali, Daniel Pedro; Guinjoan, Salvador Martín
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Schizophrenia patients exhibit an abnormal autonomic response to mental stress. We sought to determine the cardiac autonomic response to mental arithmetic stress in their unaffected first-degree relatives. Methods: Heart rate variability (HRV) analysis was performed on recordings obtained before, during, and after a standard mental arithmetic task to induce mental stress. 22 unaffected first-degree relatives of patients meeting DSM-IV criteria for schizophrenia (R) and 22 healthy individuals (C) were included in this study. Results: Patients' relatives (R) had a normal response to the mental arithmetic stress test, showing an increased heart rate compared with controls. They also displayed the characteristic pattern of relative contributions of HRV components that consists of increased low-frequency (LF) HRV and decreased high-frequency (HF) HRV. Recovery of the resting pattern of HRV immediately after stress termination was observed in healthy subjects (LF 62 ± 16% vs. 74 ± 10%, HF 37 ± 16% vs. 25 ± 10%, F = 9.616, p = 0.004), but not in patients' relatives (LF 60 ± 19% vs. 70 ± 13%, HF 40 ± 19% vs. 29 ± 13%, F = 8.4, p = 0.056). Conclusions: First-degree relatives of schizophrenia patients exhibit an abnormal pattern of protracted response to mental arithmetic stress, though less intense than that observed in patients in a previous study. This suggests that a pattern of autonomic response to stress may therefore be familial and heritable.
Fil: Castro, Mariana Nair. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Vigo, Daniel Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina
Fil: Chu, Elvina. University College London; Estados Unidos
Fil: Fahrer, Rodolfo D.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: de Achával, Delfina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Costanzo, Elsa Y.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Leiguarda, Ramón Carlos. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Nogués, Martín. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Cardinali, Daniel Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina
Fil: Guinjoan, Salvador Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Materia
AUTONOMIC NERVOUS SYSTEM
ENDOPHENOTYPES
HEART RATE VARIABILITY
SCHIZOPHRENIA
STRESS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/117691
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/117691
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Heart rate variability response to mental arithmetic stress is abnormal in first-degree relatives of individuals with schizophreniaCastro, Mariana NairVigo, Daniel EduardoChu, ElvinaFahrer, Rodolfo D.de Achával, DelfinaCostanzo, Elsa Y.Leiguarda, Ramón CarlosNogués, MartínCardinali, Daniel PedroGuinjoan, Salvador MartínAUTONOMIC NERVOUS SYSTEMENDOPHENOTYPESHEART RATE VARIABILITYSCHIZOPHRENIASTRESShttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Background: Schizophrenia patients exhibit an abnormal autonomic response to mental stress. We sought to determine the cardiac autonomic response to mental arithmetic stress in their unaffected first-degree relatives. Methods: Heart rate variability (HRV) analysis was performed on recordings obtained before, during, and after a standard mental arithmetic task to induce mental stress. 22 unaffected first-degree relatives of patients meeting DSM-IV criteria for schizophrenia (R) and 22 healthy individuals (C) were included in this study. Results: Patients' relatives (R) had a normal response to the mental arithmetic stress test, showing an increased heart rate compared with controls. They also displayed the characteristic pattern of relative contributions of HRV components that consists of increased low-frequency (LF) HRV and decreased high-frequency (HF) HRV. Recovery of the resting pattern of HRV immediately after stress termination was observed in healthy subjects (LF 62 ± 16% vs. 74 ± 10%, HF 37 ± 16% vs. 25 ± 10%, F = 9.616, p = 0.004), but not in patients' relatives (LF 60 ± 19% vs. 70 ± 13%, HF 40 ± 19% vs. 29 ± 13%, F = 8.4, p = 0.056). Conclusions: First-degree relatives of schizophrenia patients exhibit an abnormal pattern of protracted response to mental arithmetic stress, though less intense than that observed in patients in a previous study. This suggests that a pattern of autonomic response to stress may therefore be familial and heritable.Fil: Castro, Mariana Nair. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Vigo, Daniel Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; ArgentinaFil: Chu, Elvina. University College London; Estados UnidosFil: Fahrer, Rodolfo D.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: de Achával, Delfina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Costanzo, Elsa Y.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Leiguarda, Ramón Carlos. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Nogués, Martín. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Cardinali, Daniel Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; ArgentinaFil: Guinjoan, Salvador Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaElsevier Science2009-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/117691Castro, Mariana Nair; Vigo, Daniel Eduardo; Chu, Elvina; Fahrer, Rodolfo D.; de Achával, Delfina; et al.; Heart rate variability response to mental arithmetic stress is abnormal in first-degree relatives of individuals with schizophrenia; Elsevier Science; Schizophrenia Research; 109; 1-3; 4-2009; 134-1400920-9964CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0920996409000048info:eu-repo/semantics/altIdentifier/doi/10.1016/j.schres.2008.12.026info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:02:51Zoai:ri.conicet.gov.ar:11336/117691instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:02:51.647CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Heart rate variability response to mental arithmetic stress is abnormal in first-degree relatives of individuals with schizophrenia
title Heart rate variability response to mental arithmetic stress is abnormal in first-degree relatives of individuals with schizophrenia
spellingShingle Heart rate variability response to mental arithmetic stress is abnormal in first-degree relatives of individuals with schizophrenia
Castro, Mariana Nair
AUTONOMIC NERVOUS SYSTEM
ENDOPHENOTYPES
HEART RATE VARIABILITY
SCHIZOPHRENIA
STRESS
title_short Heart rate variability response to mental arithmetic stress is abnormal in first-degree relatives of individuals with schizophrenia
title_full Heart rate variability response to mental arithmetic stress is abnormal in first-degree relatives of individuals with schizophrenia
title_fullStr Heart rate variability response to mental arithmetic stress is abnormal in first-degree relatives of individuals with schizophrenia
title_full_unstemmed Heart rate variability response to mental arithmetic stress is abnormal in first-degree relatives of individuals with schizophrenia
title_sort Heart rate variability response to mental arithmetic stress is abnormal in first-degree relatives of individuals with schizophrenia
dc.creator.none.fl_str_mv Castro, Mariana Nair
Vigo, Daniel Eduardo
Chu, Elvina
Fahrer, Rodolfo D.
de Achával, Delfina
Costanzo, Elsa Y.
Leiguarda, Ramón Carlos
Nogués, Martín
Cardinali, Daniel Pedro
Guinjoan, Salvador Martín
author Castro, Mariana Nair
author_facet Castro, Mariana Nair
Vigo, Daniel Eduardo
Chu, Elvina
Fahrer, Rodolfo D.
de Achával, Delfina
Costanzo, Elsa Y.
Leiguarda, Ramón Carlos
Nogués, Martín
Cardinali, Daniel Pedro
Guinjoan, Salvador Martín
author_role author
author2 Vigo, Daniel Eduardo
Chu, Elvina
Fahrer, Rodolfo D.
de Achával, Delfina
Costanzo, Elsa Y.
Leiguarda, Ramón Carlos
Nogués, Martín
Cardinali, Daniel Pedro
Guinjoan, Salvador Martín
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv AUTONOMIC NERVOUS SYSTEM
ENDOPHENOTYPES
HEART RATE VARIABILITY
SCHIZOPHRENIA
STRESS
topic AUTONOMIC NERVOUS SYSTEM
ENDOPHENOTYPES
HEART RATE VARIABILITY
SCHIZOPHRENIA
STRESS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: Schizophrenia patients exhibit an abnormal autonomic response to mental stress. We sought to determine the cardiac autonomic response to mental arithmetic stress in their unaffected first-degree relatives. Methods: Heart rate variability (HRV) analysis was performed on recordings obtained before, during, and after a standard mental arithmetic task to induce mental stress. 22 unaffected first-degree relatives of patients meeting DSM-IV criteria for schizophrenia (R) and 22 healthy individuals (C) were included in this study. Results: Patients' relatives (R) had a normal response to the mental arithmetic stress test, showing an increased heart rate compared with controls. They also displayed the characteristic pattern of relative contributions of HRV components that consists of increased low-frequency (LF) HRV and decreased high-frequency (HF) HRV. Recovery of the resting pattern of HRV immediately after stress termination was observed in healthy subjects (LF 62 ± 16% vs. 74 ± 10%, HF 37 ± 16% vs. 25 ± 10%, F = 9.616, p = 0.004), but not in patients' relatives (LF 60 ± 19% vs. 70 ± 13%, HF 40 ± 19% vs. 29 ± 13%, F = 8.4, p = 0.056). Conclusions: First-degree relatives of schizophrenia patients exhibit an abnormal pattern of protracted response to mental arithmetic stress, though less intense than that observed in patients in a previous study. This suggests that a pattern of autonomic response to stress may therefore be familial and heritable.
Fil: Castro, Mariana Nair. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Vigo, Daniel Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina
Fil: Chu, Elvina. University College London; Estados Unidos
Fil: Fahrer, Rodolfo D.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: de Achával, Delfina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Costanzo, Elsa Y.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Leiguarda, Ramón Carlos. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Nogués, Martín. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Cardinali, Daniel Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina
Fil: Guinjoan, Salvador Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
description Background: Schizophrenia patients exhibit an abnormal autonomic response to mental stress. We sought to determine the cardiac autonomic response to mental arithmetic stress in their unaffected first-degree relatives. Methods: Heart rate variability (HRV) analysis was performed on recordings obtained before, during, and after a standard mental arithmetic task to induce mental stress. 22 unaffected first-degree relatives of patients meeting DSM-IV criteria for schizophrenia (R) and 22 healthy individuals (C) were included in this study. Results: Patients' relatives (R) had a normal response to the mental arithmetic stress test, showing an increased heart rate compared with controls. They also displayed the characteristic pattern of relative contributions of HRV components that consists of increased low-frequency (LF) HRV and decreased high-frequency (HF) HRV. Recovery of the resting pattern of HRV immediately after stress termination was observed in healthy subjects (LF 62 ± 16% vs. 74 ± 10%, HF 37 ± 16% vs. 25 ± 10%, F = 9.616, p = 0.004), but not in patients' relatives (LF 60 ± 19% vs. 70 ± 13%, HF 40 ± 19% vs. 29 ± 13%, F = 8.4, p = 0.056). Conclusions: First-degree relatives of schizophrenia patients exhibit an abnormal pattern of protracted response to mental arithmetic stress, though less intense than that observed in patients in a previous study. This suggests that a pattern of autonomic response to stress may therefore be familial and heritable.
publishDate 2009
dc.date.none.fl_str_mv 2009-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/117691
Castro, Mariana Nair; Vigo, Daniel Eduardo; Chu, Elvina; Fahrer, Rodolfo D.; de Achával, Delfina; et al.; Heart rate variability response to mental arithmetic stress is abnormal in first-degree relatives of individuals with schizophrenia; Elsevier Science; Schizophrenia Research; 109; 1-3; 4-2009; 134-140
0920-9964
CONICET Digital
CONICET
url http://hdl.handle.net/11336/117691
identifier_str_mv Castro, Mariana Nair; Vigo, Daniel Eduardo; Chu, Elvina; Fahrer, Rodolfo D.; de Achával, Delfina; et al.; Heart rate variability response to mental arithmetic stress is abnormal in first-degree relatives of individuals with schizophrenia; Elsevier Science; Schizophrenia Research; 109; 1-3; 4-2009; 134-140
0920-9964
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0920996409000048
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.schres.2008.12.026
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.221938

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