AP-7 into the nucleus accumbens disrupts acquisition but does not affect consolidation in a passive avoidance task

Autores
Martínez, Gabriel; Ropero, Claudia; Funes, Andrea; Flores, Érica; Landa, Adriana I.; Gargiulo, Pascual Angel
Año de publicación
2002
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The effect of the blockade of N-methyl-D-aspartic acid (NMDA)-type glutamatergic receptors in the nucleus accumbens septi (Acc) during different phases of a passive avoidance task (step-through paradigm, two chambers) of learning was studied in male rats which had been bilaterally cannulated into the Acc. Animals were trained with a punishment procedure (3 s shock of 1 mA) to avoid one of the chambers. The rats received either saline or (±)2-amino-7-phosphonoheptanoic acid (AP-7) solution (1 μg/1 μl) 10 min before training (pretraining schedule) or immediately after the shock (posttraining schedule). In the test phase, the animals were placed back into the white chamber after 1 and 8 days later. In this moment, rats stayed there for 1 min, after which the time elapsed between the removal of the door to the introduction into the dark chamber of the head (Latency 1) and body (Latency 2) and fecal boli expelled were recorded. In the pretraining injection schedule, the drug treatment significantly reduced Latency 2 (P<.05) and fecal boli (P<0.01) on Day 1, and all parameters on Day 8 (P<.05). The posttraining injection schedule did not modify behavior. We conclude that a preshock NMDA-glutamatergic blockade of the Acc leads to cognitive disturbances during acquisition and a decrease in anxiety levels, but that the consolidation of a learned task is not affected by postshock administration.
Fil: Martínez, Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina
Fil: Ropero, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina
Fil: Funes, Andrea. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Flores, Érica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina
Fil: Landa, Adriana I.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina
Fil: Gargiulo, Pascual Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina
Materia
ACCUMBENS
ACQUISITION
COGNITION
GOAL-DIRECTED BEHAVIOR
NMDA-GLUTAMATERGIC TRANSMISSION
PERCEPTION
SCHIZOPHRENIA
WORKING MEMORY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/128654
Acceder
id CONICETDig_931d8d949aa9fcf883a69c554ec4a6d7
oai_identifier_str oai:ri.conicet.gov.ar:11336/128654
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling AP-7 into the nucleus accumbens disrupts acquisition but does not affect consolidation in a passive avoidance taskMartínez, GabrielRopero, ClaudiaFunes, AndreaFlores, ÉricaLanda, Adriana I.Gargiulo, Pascual AngelACCUMBENSACQUISITIONCOGNITIONGOAL-DIRECTED BEHAVIORNMDA-GLUTAMATERGIC TRANSMISSIONPERCEPTIONSCHIZOPHRENIAWORKING MEMORYhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3The effect of the blockade of N-methyl-D-aspartic acid (NMDA)-type glutamatergic receptors in the nucleus accumbens septi (Acc) during different phases of a passive avoidance task (step-through paradigm, two chambers) of learning was studied in male rats which had been bilaterally cannulated into the Acc. Animals were trained with a punishment procedure (3 s shock of 1 mA) to avoid one of the chambers. The rats received either saline or (±)2-amino-7-phosphonoheptanoic acid (AP-7) solution (1 μg/1 μl) 10 min before training (pretraining schedule) or immediately after the shock (posttraining schedule). In the test phase, the animals were placed back into the white chamber after 1 and 8 days later. In this moment, rats stayed there for 1 min, after which the time elapsed between the removal of the door to the introduction into the dark chamber of the head (Latency 1) and body (Latency 2) and fecal boli expelled were recorded. In the pretraining injection schedule, the drug treatment significantly reduced Latency 2 (P<.05) and fecal boli (P<0.01) on Day 1, and all parameters on Day 8 (P<.05). The posttraining injection schedule did not modify behavior. We conclude that a preshock NMDA-glutamatergic blockade of the Acc leads to cognitive disturbances during acquisition and a decrease in anxiety levels, but that the consolidation of a learned task is not affected by postshock administration.Fil: Martínez, Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; ArgentinaFil: Ropero, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; ArgentinaFil: Funes, Andrea. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Flores, Érica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; ArgentinaFil: Landa, Adriana I.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; ArgentinaFil: Gargiulo, Pascual Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; ArgentinaPergamon-Elsevier Science Ltd2002-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/128654Martínez, Gabriel; Ropero, Claudia; Funes, Andrea; Flores, Érica; Landa, Adriana I.; et al.; AP-7 into the nucleus accumbens disrupts acquisition but does not affect consolidation in a passive avoidance task; Pergamon-Elsevier Science Ltd; Physiology And Behavior; 76; 2; 6-2002; 205-2120031-9384CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/s0031-9384(02)00696-0info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0031938402006960info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:37:54Zoai:ri.conicet.gov.ar:11336/128654instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:37:54.794CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv AP-7 into the nucleus accumbens disrupts acquisition but does not affect consolidation in a passive avoidance task
title AP-7 into the nucleus accumbens disrupts acquisition but does not affect consolidation in a passive avoidance task
spellingShingle AP-7 into the nucleus accumbens disrupts acquisition but does not affect consolidation in a passive avoidance task
Martínez, Gabriel
ACCUMBENS
ACQUISITION
COGNITION
GOAL-DIRECTED BEHAVIOR
NMDA-GLUTAMATERGIC TRANSMISSION
PERCEPTION
SCHIZOPHRENIA
WORKING MEMORY
title_short AP-7 into the nucleus accumbens disrupts acquisition but does not affect consolidation in a passive avoidance task
title_full AP-7 into the nucleus accumbens disrupts acquisition but does not affect consolidation in a passive avoidance task
title_fullStr AP-7 into the nucleus accumbens disrupts acquisition but does not affect consolidation in a passive avoidance task
title_full_unstemmed AP-7 into the nucleus accumbens disrupts acquisition but does not affect consolidation in a passive avoidance task
title_sort AP-7 into the nucleus accumbens disrupts acquisition but does not affect consolidation in a passive avoidance task
dc.creator.none.fl_str_mv Martínez, Gabriel
Ropero, Claudia
Funes, Andrea
Flores, Érica
Landa, Adriana I.
Gargiulo, Pascual Angel
author Martínez, Gabriel
author_facet Martínez, Gabriel
Ropero, Claudia
Funes, Andrea
Flores, Érica
Landa, Adriana I.
Gargiulo, Pascual Angel
author_role author
author2 Ropero, Claudia
Funes, Andrea
Flores, Érica
Landa, Adriana I.
Gargiulo, Pascual Angel
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv ACCUMBENS
ACQUISITION
COGNITION
GOAL-DIRECTED BEHAVIOR
NMDA-GLUTAMATERGIC TRANSMISSION
PERCEPTION
SCHIZOPHRENIA
WORKING MEMORY
topic ACCUMBENS
ACQUISITION
COGNITION
GOAL-DIRECTED BEHAVIOR
NMDA-GLUTAMATERGIC TRANSMISSION
PERCEPTION
SCHIZOPHRENIA
WORKING MEMORY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The effect of the blockade of N-methyl-D-aspartic acid (NMDA)-type glutamatergic receptors in the nucleus accumbens septi (Acc) during different phases of a passive avoidance task (step-through paradigm, two chambers) of learning was studied in male rats which had been bilaterally cannulated into the Acc. Animals were trained with a punishment procedure (3 s shock of 1 mA) to avoid one of the chambers. The rats received either saline or (±)2-amino-7-phosphonoheptanoic acid (AP-7) solution (1 μg/1 μl) 10 min before training (pretraining schedule) or immediately after the shock (posttraining schedule). In the test phase, the animals were placed back into the white chamber after 1 and 8 days later. In this moment, rats stayed there for 1 min, after which the time elapsed between the removal of the door to the introduction into the dark chamber of the head (Latency 1) and body (Latency 2) and fecal boli expelled were recorded. In the pretraining injection schedule, the drug treatment significantly reduced Latency 2 (P<.05) and fecal boli (P<0.01) on Day 1, and all parameters on Day 8 (P<.05). The posttraining injection schedule did not modify behavior. We conclude that a preshock NMDA-glutamatergic blockade of the Acc leads to cognitive disturbances during acquisition and a decrease in anxiety levels, but that the consolidation of a learned task is not affected by postshock administration.
Fil: Martínez, Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina
Fil: Ropero, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina
Fil: Funes, Andrea. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Flores, Érica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina
Fil: Landa, Adriana I.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina
Fil: Gargiulo, Pascual Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina
description The effect of the blockade of N-methyl-D-aspartic acid (NMDA)-type glutamatergic receptors in the nucleus accumbens septi (Acc) during different phases of a passive avoidance task (step-through paradigm, two chambers) of learning was studied in male rats which had been bilaterally cannulated into the Acc. Animals were trained with a punishment procedure (3 s shock of 1 mA) to avoid one of the chambers. The rats received either saline or (±)2-amino-7-phosphonoheptanoic acid (AP-7) solution (1 μg/1 μl) 10 min before training (pretraining schedule) or immediately after the shock (posttraining schedule). In the test phase, the animals were placed back into the white chamber after 1 and 8 days later. In this moment, rats stayed there for 1 min, after which the time elapsed between the removal of the door to the introduction into the dark chamber of the head (Latency 1) and body (Latency 2) and fecal boli expelled were recorded. In the pretraining injection schedule, the drug treatment significantly reduced Latency 2 (P<.05) and fecal boli (P<0.01) on Day 1, and all parameters on Day 8 (P<.05). The posttraining injection schedule did not modify behavior. We conclude that a preshock NMDA-glutamatergic blockade of the Acc leads to cognitive disturbances during acquisition and a decrease in anxiety levels, but that the consolidation of a learned task is not affected by postshock administration.
publishDate 2002
dc.date.none.fl_str_mv 2002-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/128654
Martínez, Gabriel; Ropero, Claudia; Funes, Andrea; Flores, Érica; Landa, Adriana I.; et al.; AP-7 into the nucleus accumbens disrupts acquisition but does not affect consolidation in a passive avoidance task; Pergamon-Elsevier Science Ltd; Physiology And Behavior; 76; 2; 6-2002; 205-212
0031-9384
CONICET Digital
CONICET
url http://hdl.handle.net/11336/128654
identifier_str_mv Martínez, Gabriel; Ropero, Claudia; Funes, Andrea; Flores, Érica; Landa, Adriana I.; et al.; AP-7 into the nucleus accumbens disrupts acquisition but does not affect consolidation in a passive avoidance task; Pergamon-Elsevier Science Ltd; Physiology And Behavior; 76; 2; 6-2002; 205-212
0031-9384
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/s0031-9384(02)00696-0
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0031938402006960
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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