Effects of selective NMDA and non-NMDA blockade in the nucleus accumbens on the plus-maze test

Autores
Martínez, Gabriel; Ropero, Claudia; Funes, Andrea; Flores, Erica; Blotta, Carina; Landa, Adriana I.; Gargiulo, Pascual Angel
Año de publicación
2002
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Effect of blocking N-methyl-D-aspartic acid (NMDA) and non-NMDA-glutamatergic receptors on performance in the plus-maze was studied in male rats bilaterally cannulated into the nucleus accumbens (Acc). Rats were divided into seven groups that received either 1 μl injections of saline, (±)2-amino-7-phosphonoheptanoic acid (AP-7, 0.2, 0.5, or 1 μg) or 2,3 dioxo-6-nitro-1,2,3,4,tetrahydrobenzo-(f)quinoxaline-7-sulphonamide disodium (NBQX, 0.2, 0.5, or 1 μg) 15 min before testing. Time spent in open arm, time per entry, end arrivals, open, closed, and total arm entries, relationship between open-, closed-, and total arm entries, rearing, face-, head-, and body grooming, and number of fecal boli were recorded. Time spent in the open arm increased under AP-7 (0.5 and 1 μg; P<.01) and NBQX (1 μg; P<.05) treatment, whereas time per entry was increased only with AP-7 (1 μg; P<.05). Open arm entries were increased by the intermediate doses of AP-7 (0.5 μg; P<.01) and NBQX (0.5 μg; P<.05); end arrivals were increased by the intermediate dose of AP-7 (0.5 μg/1 μl, P<.05). The frequency of rearing, grooming, and closed arm entries was not affected by the treatment. We conclude that NMDA and non-NMDA-glutamatergic blockade in the Acc lead to a behavioral disinhibition of cortical influences with the median doses, but that at higher doses the blockers have an anxiolytic-like effect.
Fil: Martínez, Gabriel. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo; Argentina
Fil: Ropero, Claudia. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina. Universidad Nacional de Cuyo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Funes, Andrea. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina. Universidad Nacional de Cuyo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Flores, Erica. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo; Argentina
Fil: Blotta, Carina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina
Fil: Landa, Adriana I.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina
Fil: Gargiulo, Pascual Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina
Materia
AFFECTIVE FLATNESS
ANXIETY
NMDA-GLUTAMATERGIC TRANSMISSION
NUCLEUS ACCUMBENS
PERCEPTION
PLUS-MAZE
SCHIZOPHRENIA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/128661
Acceder
id CONICETDig_2da0e3b40bada71f163595071f6c1bb9
oai_identifier_str oai:ri.conicet.gov.ar:11336/128661
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Effects of selective NMDA and non-NMDA blockade in the nucleus accumbens on the plus-maze testMartínez, GabrielRopero, ClaudiaFunes, AndreaFlores, EricaBlotta, CarinaLanda, Adriana I.Gargiulo, Pascual AngelAFFECTIVE FLATNESSANXIETYNMDA-GLUTAMATERGIC TRANSMISSIONNUCLEUS ACCUMBENSPERCEPTIONPLUS-MAZESCHIZOPHRENIAhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Effect of blocking N-methyl-D-aspartic acid (NMDA) and non-NMDA-glutamatergic receptors on performance in the plus-maze was studied in male rats bilaterally cannulated into the nucleus accumbens (Acc). Rats were divided into seven groups that received either 1 μl injections of saline, (±)2-amino-7-phosphonoheptanoic acid (AP-7, 0.2, 0.5, or 1 μg) or 2,3 dioxo-6-nitro-1,2,3,4,tetrahydrobenzo-(f)quinoxaline-7-sulphonamide disodium (NBQX, 0.2, 0.5, or 1 μg) 15 min before testing. Time spent in open arm, time per entry, end arrivals, open, closed, and total arm entries, relationship between open-, closed-, and total arm entries, rearing, face-, head-, and body grooming, and number of fecal boli were recorded. Time spent in the open arm increased under AP-7 (0.5 and 1 μg; P<.01) and NBQX (1 μg; P<.05) treatment, whereas time per entry was increased only with AP-7 (1 μg; P<.05). Open arm entries were increased by the intermediate doses of AP-7 (0.5 μg; P<.01) and NBQX (0.5 μg; P<.05); end arrivals were increased by the intermediate dose of AP-7 (0.5 μg/1 μl, P<.05). The frequency of rearing, grooming, and closed arm entries was not affected by the treatment. We conclude that NMDA and non-NMDA-glutamatergic blockade in the Acc lead to a behavioral disinhibition of cortical influences with the median doses, but that at higher doses the blockers have an anxiolytic-like effect.Fil: Martínez, Gabriel. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo; ArgentinaFil: Ropero, Claudia. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina. Universidad Nacional de Cuyo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Funes, Andrea. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina. Universidad Nacional de Cuyo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Flores, Erica. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo; ArgentinaFil: Blotta, Carina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; ArgentinaFil: Landa, Adriana I.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; ArgentinaFil: Gargiulo, Pascual Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; ArgentinaPergamon-Elsevier Science Ltd2002-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/128661Martínez, Gabriel; Ropero, Claudia; Funes, Andrea; Flores, Erica; Blotta, Carina; et al.; Effects of selective NMDA and non-NMDA blockade in the nucleus accumbens on the plus-maze test; Pergamon-Elsevier Science Ltd; Physiology And Behavior; 76; 2; 6-2002; 219-2240031-9384CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0031938402007047info:eu-repo/semantics/altIdentifier/doi/10.1016/S0031-9384(02)00704-7info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:35:10Zoai:ri.conicet.gov.ar:11336/128661instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:35:10.901CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effects of selective NMDA and non-NMDA blockade in the nucleus accumbens on the plus-maze test
title Effects of selective NMDA and non-NMDA blockade in the nucleus accumbens on the plus-maze test
spellingShingle Effects of selective NMDA and non-NMDA blockade in the nucleus accumbens on the plus-maze test
Martínez, Gabriel
AFFECTIVE FLATNESS
ANXIETY
NMDA-GLUTAMATERGIC TRANSMISSION
NUCLEUS ACCUMBENS
PERCEPTION
PLUS-MAZE
SCHIZOPHRENIA
title_short Effects of selective NMDA and non-NMDA blockade in the nucleus accumbens on the plus-maze test
title_full Effects of selective NMDA and non-NMDA blockade in the nucleus accumbens on the plus-maze test
title_fullStr Effects of selective NMDA and non-NMDA blockade in the nucleus accumbens on the plus-maze test
title_full_unstemmed Effects of selective NMDA and non-NMDA blockade in the nucleus accumbens on the plus-maze test
title_sort Effects of selective NMDA and non-NMDA blockade in the nucleus accumbens on the plus-maze test
dc.creator.none.fl_str_mv Martínez, Gabriel
Ropero, Claudia
Funes, Andrea
Flores, Erica
Blotta, Carina
Landa, Adriana I.
Gargiulo, Pascual Angel
author Martínez, Gabriel
author_facet Martínez, Gabriel
Ropero, Claudia
Funes, Andrea
Flores, Erica
Blotta, Carina
Landa, Adriana I.
Gargiulo, Pascual Angel
author_role author
author2 Ropero, Claudia
Funes, Andrea
Flores, Erica
Blotta, Carina
Landa, Adriana I.
Gargiulo, Pascual Angel
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv AFFECTIVE FLATNESS
ANXIETY
NMDA-GLUTAMATERGIC TRANSMISSION
NUCLEUS ACCUMBENS
PERCEPTION
PLUS-MAZE
SCHIZOPHRENIA
topic AFFECTIVE FLATNESS
ANXIETY
NMDA-GLUTAMATERGIC TRANSMISSION
NUCLEUS ACCUMBENS
PERCEPTION
PLUS-MAZE
SCHIZOPHRENIA
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Effect of blocking N-methyl-D-aspartic acid (NMDA) and non-NMDA-glutamatergic receptors on performance in the plus-maze was studied in male rats bilaterally cannulated into the nucleus accumbens (Acc). Rats were divided into seven groups that received either 1 μl injections of saline, (±)2-amino-7-phosphonoheptanoic acid (AP-7, 0.2, 0.5, or 1 μg) or 2,3 dioxo-6-nitro-1,2,3,4,tetrahydrobenzo-(f)quinoxaline-7-sulphonamide disodium (NBQX, 0.2, 0.5, or 1 μg) 15 min before testing. Time spent in open arm, time per entry, end arrivals, open, closed, and total arm entries, relationship between open-, closed-, and total arm entries, rearing, face-, head-, and body grooming, and number of fecal boli were recorded. Time spent in the open arm increased under AP-7 (0.5 and 1 μg; P<.01) and NBQX (1 μg; P<.05) treatment, whereas time per entry was increased only with AP-7 (1 μg; P<.05). Open arm entries were increased by the intermediate doses of AP-7 (0.5 μg; P<.01) and NBQX (0.5 μg; P<.05); end arrivals were increased by the intermediate dose of AP-7 (0.5 μg/1 μl, P<.05). The frequency of rearing, grooming, and closed arm entries was not affected by the treatment. We conclude that NMDA and non-NMDA-glutamatergic blockade in the Acc lead to a behavioral disinhibition of cortical influences with the median doses, but that at higher doses the blockers have an anxiolytic-like effect.
Fil: Martínez, Gabriel. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo; Argentina
Fil: Ropero, Claudia. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina. Universidad Nacional de Cuyo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Funes, Andrea. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina. Universidad Nacional de Cuyo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Flores, Erica. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo; Argentina
Fil: Blotta, Carina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina
Fil: Landa, Adriana I.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina
Fil: Gargiulo, Pascual Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina
description Effect of blocking N-methyl-D-aspartic acid (NMDA) and non-NMDA-glutamatergic receptors on performance in the plus-maze was studied in male rats bilaterally cannulated into the nucleus accumbens (Acc). Rats were divided into seven groups that received either 1 μl injections of saline, (±)2-amino-7-phosphonoheptanoic acid (AP-7, 0.2, 0.5, or 1 μg) or 2,3 dioxo-6-nitro-1,2,3,4,tetrahydrobenzo-(f)quinoxaline-7-sulphonamide disodium (NBQX, 0.2, 0.5, or 1 μg) 15 min before testing. Time spent in open arm, time per entry, end arrivals, open, closed, and total arm entries, relationship between open-, closed-, and total arm entries, rearing, face-, head-, and body grooming, and number of fecal boli were recorded. Time spent in the open arm increased under AP-7 (0.5 and 1 μg; P<.01) and NBQX (1 μg; P<.05) treatment, whereas time per entry was increased only with AP-7 (1 μg; P<.05). Open arm entries were increased by the intermediate doses of AP-7 (0.5 μg; P<.01) and NBQX (0.5 μg; P<.05); end arrivals were increased by the intermediate dose of AP-7 (0.5 μg/1 μl, P<.05). The frequency of rearing, grooming, and closed arm entries was not affected by the treatment. We conclude that NMDA and non-NMDA-glutamatergic blockade in the Acc lead to a behavioral disinhibition of cortical influences with the median doses, but that at higher doses the blockers have an anxiolytic-like effect.
publishDate 2002
dc.date.none.fl_str_mv 2002-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/128661
Martínez, Gabriel; Ropero, Claudia; Funes, Andrea; Flores, Erica; Blotta, Carina; et al.; Effects of selective NMDA and non-NMDA blockade in the nucleus accumbens on the plus-maze test; Pergamon-Elsevier Science Ltd; Physiology And Behavior; 76; 2; 6-2002; 219-224
0031-9384
CONICET Digital
CONICET
url http://hdl.handle.net/11336/128661
identifier_str_mv Martínez, Gabriel; Ropero, Claudia; Funes, Andrea; Flores, Erica; Blotta, Carina; et al.; Effects of selective NMDA and non-NMDA blockade in the nucleus accumbens on the plus-maze test; Pergamon-Elsevier Science Ltd; Physiology And Behavior; 76; 2; 6-2002; 219-224
0031-9384
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0031938402007047
info:eu-repo/semantics/altIdentifier/doi/10.1016/S0031-9384(02)00704-7
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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