Freeze dried bone matrix on rat critical size defect regeneration

Autores
Jammal, María Victoria; Missana, Liliana Raquel; Takabatake, Kiyofumi; Takagi, Shin; Nagatsuka, Hitoshi
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Bone allografts are commonly used for bone regeneration. The aim of this study was evaluate the efficacy of a freeze dried bone matrix (FDBM) in critical size defect (CZD) rat calvaria. Eighteen Wistar female rats (body weight 150 ± 50 g) with CZD (5mm) were divided in two groups: group 1, using freeze dried bone matrix; and group 2, only with coagulum. All samples were evaluated on the 1st, 3rd and 6th weeks post-surgery by soft X-ray, histological and histometric studies. Soft X-ray results showed a radiolucent image with many irregular radiopaque areas. Histologically, bone regeneration was initiated from the 3rd week, when a thin layer of new woven bone could be seen adjacent to the matrix. At the 6th week, lamellar bone covered over half (61.8%) of the defect area. The lack of FDBM resorption allowed its incorporation to the new regenerated bone. This behavior is important in circumstances where it is necessary not only to stimulate bone regeneration but also increase the volume in affected areas, such as during the placement of dental implants. The results obtained in this research are encouraging for the use of freeze dried bone matrix as a bone graft material.
Fil: Jammal, María Victoria. Universidad Nacional de Tucumán. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; Argentina
Fil: Missana, Liliana Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; Argentina. Universidad Nacional de Tucumán. Facultad de Odontología; Argentina
Fil: Takabatake, Kiyofumi. Okayama University; Japón
Fil: Takagi, Shin. Okayama University; Japón
Fil: Nagatsuka, Hitoshi. Okayama University; Japón
Materia
BONE REGENERATION
CRITICAL-SIZED DEFECT
FREEZE DRIED BONE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/1791
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Freeze dried bone matrix on rat critical size defect regenerationJammal, María VictoriaMissana, Liliana RaquelTakabatake, KiyofumiTakagi, ShinNagatsuka, HitoshiBONE REGENERATIONCRITICAL-SIZED DEFECTFREEZE DRIED BONEhttps://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3Bone allografts are commonly used for bone regeneration. The aim of this study was evaluate the efficacy of a freeze dried bone matrix (FDBM) in critical size defect (CZD) rat calvaria. Eighteen Wistar female rats (body weight 150 ± 50 g) with CZD (5mm) were divided in two groups: group 1, using freeze dried bone matrix; and group 2, only with coagulum. All samples were evaluated on the 1st, 3rd and 6th weeks post-surgery by soft X-ray, histological and histometric studies. Soft X-ray results showed a radiolucent image with many irregular radiopaque areas. Histologically, bone regeneration was initiated from the 3rd week, when a thin layer of new woven bone could be seen adjacent to the matrix. At the 6th week, lamellar bone covered over half (61.8%) of the defect area. The lack of FDBM resorption allowed its incorporation to the new regenerated bone. This behavior is important in circumstances where it is necessary not only to stimulate bone regeneration but also increase the volume in affected areas, such as during the placement of dental implants. The results obtained in this research are encouraging for the use of freeze dried bone matrix as a bone graft material.Fil: Jammal, María Victoria. Universidad Nacional de Tucumán. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; ArgentinaFil: Missana, Liliana Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; Argentina. Universidad Nacional de Tucumán. Facultad de Odontología; ArgentinaFil: Takabatake, Kiyofumi. Okayama University; JapónFil: Takagi, Shin. Okayama University; JapónFil: Nagatsuka, Hitoshi. Okayama University; JapónThe Society for Hard Tissue Regenerative Biology2013-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/1791Jammal, María Victoria; Missana, Liliana Raquel; Takabatake, Kiyofumi; Takagi, Shin; Nagatsuka, Hitoshi; Freeze dried bone matrix on rat critical size defect regeneration; The Society for Hard Tissue Regenerative Biology; Journal of Hard Tissue Biology; 23; 2; 12-2013; 233-2371341-7649enginfo:eu-repo/semantics/altIdentifier/doi/10.2485/jhtb.23.233info:eu-repo/semantics/altIdentifier/url/https://www.jstage.jst.go.jp/article/jhtb/23/2/23_233/_articleinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:03:54Zoai:ri.conicet.gov.ar:11336/1791instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:03:54.421CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Freeze dried bone matrix on rat critical size defect regeneration
title Freeze dried bone matrix on rat critical size defect regeneration
spellingShingle Freeze dried bone matrix on rat critical size defect regeneration
Jammal, María Victoria
BONE REGENERATION
CRITICAL-SIZED DEFECT
FREEZE DRIED BONE
title_short Freeze dried bone matrix on rat critical size defect regeneration
title_full Freeze dried bone matrix on rat critical size defect regeneration
title_fullStr Freeze dried bone matrix on rat critical size defect regeneration
title_full_unstemmed Freeze dried bone matrix on rat critical size defect regeneration
title_sort Freeze dried bone matrix on rat critical size defect regeneration
dc.creator.none.fl_str_mv Jammal, María Victoria
Missana, Liliana Raquel
Takabatake, Kiyofumi
Takagi, Shin
Nagatsuka, Hitoshi
author Jammal, María Victoria
author_facet Jammal, María Victoria
Missana, Liliana Raquel
Takabatake, Kiyofumi
Takagi, Shin
Nagatsuka, Hitoshi
author_role author
author2 Missana, Liliana Raquel
Takabatake, Kiyofumi
Takagi, Shin
Nagatsuka, Hitoshi
author2_role author
author
author
author
dc.subject.none.fl_str_mv BONE REGENERATION
CRITICAL-SIZED DEFECT
FREEZE DRIED BONE
topic BONE REGENERATION
CRITICAL-SIZED DEFECT
FREEZE DRIED BONE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.4
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Bone allografts are commonly used for bone regeneration. The aim of this study was evaluate the efficacy of a freeze dried bone matrix (FDBM) in critical size defect (CZD) rat calvaria. Eighteen Wistar female rats (body weight 150 ± 50 g) with CZD (5mm) were divided in two groups: group 1, using freeze dried bone matrix; and group 2, only with coagulum. All samples were evaluated on the 1st, 3rd and 6th weeks post-surgery by soft X-ray, histological and histometric studies. Soft X-ray results showed a radiolucent image with many irregular radiopaque areas. Histologically, bone regeneration was initiated from the 3rd week, when a thin layer of new woven bone could be seen adjacent to the matrix. At the 6th week, lamellar bone covered over half (61.8%) of the defect area. The lack of FDBM resorption allowed its incorporation to the new regenerated bone. This behavior is important in circumstances where it is necessary not only to stimulate bone regeneration but also increase the volume in affected areas, such as during the placement of dental implants. The results obtained in this research are encouraging for the use of freeze dried bone matrix as a bone graft material.
Fil: Jammal, María Victoria. Universidad Nacional de Tucumán. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; Argentina
Fil: Missana, Liliana Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; Argentina. Universidad Nacional de Tucumán. Facultad de Odontología; Argentina
Fil: Takabatake, Kiyofumi. Okayama University; Japón
Fil: Takagi, Shin. Okayama University; Japón
Fil: Nagatsuka, Hitoshi. Okayama University; Japón
description Bone allografts are commonly used for bone regeneration. The aim of this study was evaluate the efficacy of a freeze dried bone matrix (FDBM) in critical size defect (CZD) rat calvaria. Eighteen Wistar female rats (body weight 150 ± 50 g) with CZD (5mm) were divided in two groups: group 1, using freeze dried bone matrix; and group 2, only with coagulum. All samples were evaluated on the 1st, 3rd and 6th weeks post-surgery by soft X-ray, histological and histometric studies. Soft X-ray results showed a radiolucent image with many irregular radiopaque areas. Histologically, bone regeneration was initiated from the 3rd week, when a thin layer of new woven bone could be seen adjacent to the matrix. At the 6th week, lamellar bone covered over half (61.8%) of the defect area. The lack of FDBM resorption allowed its incorporation to the new regenerated bone. This behavior is important in circumstances where it is necessary not only to stimulate bone regeneration but also increase the volume in affected areas, such as during the placement of dental implants. The results obtained in this research are encouraging for the use of freeze dried bone matrix as a bone graft material.
publishDate 2013
dc.date.none.fl_str_mv 2013-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/1791
Jammal, María Victoria; Missana, Liliana Raquel; Takabatake, Kiyofumi; Takagi, Shin; Nagatsuka, Hitoshi; Freeze dried bone matrix on rat critical size defect regeneration; The Society for Hard Tissue Regenerative Biology; Journal of Hard Tissue Biology; 23; 2; 12-2013; 233-237
1341-7649
url http://hdl.handle.net/11336/1791
identifier_str_mv Jammal, María Victoria; Missana, Liliana Raquel; Takabatake, Kiyofumi; Takagi, Shin; Nagatsuka, Hitoshi; Freeze dried bone matrix on rat critical size defect regeneration; The Society for Hard Tissue Regenerative Biology; Journal of Hard Tissue Biology; 23; 2; 12-2013; 233-237
1341-7649
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.2485/jhtb.23.233
info:eu-repo/semantics/altIdentifier/url/https://www.jstage.jst.go.jp/article/jhtb/23/2/23_233/_article
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv The Society for Hard Tissue Regenerative Biology
publisher.none.fl_str_mv The Society for Hard Tissue Regenerative Biology
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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