Biocompatibility and osteoconductive properties of a new bovine bone graft

Autores
Pellegrini, Gretel Gisela; Gonzales Chaves, Macarena Maria Sol; Duran, Francisco Nicolas; Orzuza, Ricardo; Zeni, Susana Noemi
Año de publicación
2017
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Bovine materials are biocompatible and osteoconductive, allowing newly formed bone apposition and partial remodeling process. Synergy Bone Matrix (SBM) (Odontit Implant System) effects on bone healing were compared to those of Bio-Oss (BO) (Geistlich). A critical sized bone defect (CZD) was created on both sides of the mandible in rabbits, and filled either with SBM or BO, or remained unfilled (control). Animals were sacrificed at 4, 8 and 12 weeks. We assessed clinical and biochemically systemic toxicity; lungs, kidney and liver pathology; bone formation and device resorption histomorphometrically; X-rays; and compression and flexural biomechanical tests. None of the rabbits presented signs of systemic toxicity. Control rabbits developed either fibrosis or adipose tissue independently of time-period; new bone formation or remaining bone substitute amount did not show significant differences between SBM and BO (p=ns). CZD in mandibles filled with both bone grafts exhibited radiopacity compatible with proper healing and gradual replacement of bone grafts; no significant differences between SBM and BO were observed for elastic modulus, shear modulus and compressive strength while control group showed significantly lower values (p<0.001). Our findings suggest that both biomaterials are similar regarding bone regeneration, osteoconduction and newly formed bone quality. Therefore SBM, the new bone material, can be used for the repairing of bone defects.
Fil: Pellegrini, Gretel Gisela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Bioquímica General y Bucal; Argentina
Fil: Gonzales Chaves, Macarena Maria Sol. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina
Fil: Duran, Francisco Nicolas. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Bioquímica General y Bucal; Argentina
Fil: Orzuza, Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina
Fil: Zeni, Susana Noemi. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina
44th European Calcified Tissue Society Congress
Salzburg
Austria
European Calcified Tissue Society
Materia
Critical sized bone defect
Histomorphometry
Bone formation
Bone Graft
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/242677
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/242677
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Biocompatibility and osteoconductive properties of a new bovine bone graftPellegrini, Gretel GiselaGonzales Chaves, Macarena Maria SolDuran, Francisco NicolasOrzuza, RicardoZeni, Susana NoemiCritical sized bone defectHistomorphometryBone formationBone Grafthttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Bovine materials are biocompatible and osteoconductive, allowing newly formed bone apposition and partial remodeling process. Synergy Bone Matrix (SBM) (Odontit Implant System) effects on bone healing were compared to those of Bio-Oss (BO) (Geistlich). A critical sized bone defect (CZD) was created on both sides of the mandible in rabbits, and filled either with SBM or BO, or remained unfilled (control). Animals were sacrificed at 4, 8 and 12 weeks. We assessed clinical and biochemically systemic toxicity; lungs, kidney and liver pathology; bone formation and device resorption histomorphometrically; X-rays; and compression and flexural biomechanical tests. None of the rabbits presented signs of systemic toxicity. Control rabbits developed either fibrosis or adipose tissue independently of time-period; new bone formation or remaining bone substitute amount did not show significant differences between SBM and BO (p=ns). CZD in mandibles filled with both bone grafts exhibited radiopacity compatible with proper healing and gradual replacement of bone grafts; no significant differences between SBM and BO were observed for elastic modulus, shear modulus and compressive strength while control group showed significantly lower values (p<0.001). Our findings suggest that both biomaterials are similar regarding bone regeneration, osteoconduction and newly formed bone quality. Therefore SBM, the new bone material, can be used for the repairing of bone defects.Fil: Pellegrini, Gretel Gisela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Bioquímica General y Bucal; ArgentinaFil: Gonzales Chaves, Macarena Maria Sol. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; ArgentinaFil: Duran, Francisco Nicolas. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Bioquímica General y Bucal; ArgentinaFil: Orzuza, Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; ArgentinaFil: Zeni, Susana Noemi. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina44th European Calcified Tissue Society CongressSalzburgAustriaEuropean Calcified Tissue SocietySpringer2017info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectCongresoJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/242677Biocompatibility and osteoconductive properties of a new bovine bone graft; 44th European Calcified Tissue Society Congress; Salzburg; Austria; 2017; 1-30171-967XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://ectsoc.org/wp-content/uploads/2017/07/ECTS-2017-Abstract-Book.pdfinfo:eu-repo/semantics/altIdentifier/doi/10.1007/s00223-017-0267-2Internacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:06:27Zoai:ri.conicet.gov.ar:11336/242677instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:06:28.247CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Biocompatibility and osteoconductive properties of a new bovine bone graft
title Biocompatibility and osteoconductive properties of a new bovine bone graft
spellingShingle Biocompatibility and osteoconductive properties of a new bovine bone graft
Pellegrini, Gretel Gisela
Critical sized bone defect
Histomorphometry
Bone formation
Bone Graft
title_short Biocompatibility and osteoconductive properties of a new bovine bone graft
title_full Biocompatibility and osteoconductive properties of a new bovine bone graft
title_fullStr Biocompatibility and osteoconductive properties of a new bovine bone graft
title_full_unstemmed Biocompatibility and osteoconductive properties of a new bovine bone graft
title_sort Biocompatibility and osteoconductive properties of a new bovine bone graft
dc.creator.none.fl_str_mv Pellegrini, Gretel Gisela
Gonzales Chaves, Macarena Maria Sol
Duran, Francisco Nicolas
Orzuza, Ricardo
Zeni, Susana Noemi
author Pellegrini, Gretel Gisela
author_facet Pellegrini, Gretel Gisela
Gonzales Chaves, Macarena Maria Sol
Duran, Francisco Nicolas
Orzuza, Ricardo
Zeni, Susana Noemi
author_role author
author2 Gonzales Chaves, Macarena Maria Sol
Duran, Francisco Nicolas
Orzuza, Ricardo
Zeni, Susana Noemi
author2_role author
author
author
author
dc.subject.none.fl_str_mv Critical sized bone defect
Histomorphometry
Bone formation
Bone Graft
topic Critical sized bone defect
Histomorphometry
Bone formation
Bone Graft
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Bovine materials are biocompatible and osteoconductive, allowing newly formed bone apposition and partial remodeling process. Synergy Bone Matrix (SBM) (Odontit Implant System) effects on bone healing were compared to those of Bio-Oss (BO) (Geistlich). A critical sized bone defect (CZD) was created on both sides of the mandible in rabbits, and filled either with SBM or BO, or remained unfilled (control). Animals were sacrificed at 4, 8 and 12 weeks. We assessed clinical and biochemically systemic toxicity; lungs, kidney and liver pathology; bone formation and device resorption histomorphometrically; X-rays; and compression and flexural biomechanical tests. None of the rabbits presented signs of systemic toxicity. Control rabbits developed either fibrosis or adipose tissue independently of time-period; new bone formation or remaining bone substitute amount did not show significant differences between SBM and BO (p=ns). CZD in mandibles filled with both bone grafts exhibited radiopacity compatible with proper healing and gradual replacement of bone grafts; no significant differences between SBM and BO were observed for elastic modulus, shear modulus and compressive strength while control group showed significantly lower values (p<0.001). Our findings suggest that both biomaterials are similar regarding bone regeneration, osteoconduction and newly formed bone quality. Therefore SBM, the new bone material, can be used for the repairing of bone defects.
Fil: Pellegrini, Gretel Gisela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Bioquímica General y Bucal; Argentina
Fil: Gonzales Chaves, Macarena Maria Sol. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina
Fil: Duran, Francisco Nicolas. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Bioquímica General y Bucal; Argentina
Fil: Orzuza, Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina
Fil: Zeni, Susana Noemi. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina
44th European Calcified Tissue Society Congress
Salzburg
Austria
European Calcified Tissue Society
description Bovine materials are biocompatible and osteoconductive, allowing newly formed bone apposition and partial remodeling process. Synergy Bone Matrix (SBM) (Odontit Implant System) effects on bone healing were compared to those of Bio-Oss (BO) (Geistlich). A critical sized bone defect (CZD) was created on both sides of the mandible in rabbits, and filled either with SBM or BO, or remained unfilled (control). Animals were sacrificed at 4, 8 and 12 weeks. We assessed clinical and biochemically systemic toxicity; lungs, kidney and liver pathology; bone formation and device resorption histomorphometrically; X-rays; and compression and flexural biomechanical tests. None of the rabbits presented signs of systemic toxicity. Control rabbits developed either fibrosis or adipose tissue independently of time-period; new bone formation or remaining bone substitute amount did not show significant differences between SBM and BO (p=ns). CZD in mandibles filled with both bone grafts exhibited radiopacity compatible with proper healing and gradual replacement of bone grafts; no significant differences between SBM and BO were observed for elastic modulus, shear modulus and compressive strength while control group showed significantly lower values (p<0.001). Our findings suggest that both biomaterials are similar regarding bone regeneration, osteoconduction and newly formed bone quality. Therefore SBM, the new bone material, can be used for the repairing of bone defects.
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Congreso
Journal
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/242677
Biocompatibility and osteoconductive properties of a new bovine bone graft; 44th European Calcified Tissue Society Congress; Salzburg; Austria; 2017; 1-3
0171-967X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/242677
identifier_str_mv Biocompatibility and osteoconductive properties of a new bovine bone graft; 44th European Calcified Tissue Society Congress; Salzburg; Austria; 2017; 1-3
0171-967X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://ectsoc.org/wp-content/uploads/2017/07/ECTS-2017-Abstract-Book.pdf
info:eu-repo/semantics/altIdentifier/doi/10.1007/s00223-017-0267-2
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.coverage.none.fl_str_mv Internacional
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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