Fermented or unfermented milk using Bifidobacterium animalis subsp. lactis HN019: Technological approach determines the probiotic modulation of mucosal cellular immunity

Autores
Bogsan, Cristina Stewart Bittencourt; Ferreira, Luis; Maldonado Galdeano, María Carolina; Perdigon, Gabriela del Valle; Almeida, Sandro Rogério; Oliveira, Maricê Nogueira de
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Functional foods are important sources of probiotic delivery, mainly by fermentedmilk products. The physiological benefits attributed to bifido bacteria are their abilities to interfere with the adhesion of pathogenic species to surfaces of intestinal cells, and to enhance the host's immune function through their metabolic activities. However, the effects of a technological approach ? fermentation or addition of probiotic in milk, and its efficacy in health are rarely taken into consideration. Hence, fermented or unfermented milk using Bifidobacterium animalis subsp. lactis HN019 were administered to BALB/c mice for 14 days. After that, the architecture of the gut was histologically investigated, and the related immune cells were examined by flow cytometry and immunofluorescence. Increase in mucus and cellularity production, changes in immune pattern and preservation of mucosal epithelia in health BALB/c mice were observed only in the fermentedmilk group. This suggested that changes in functionality of bifidobacteria and/or themetabolites produced by the fermentation process are the keys to improving beneficial effects in the host of the gut mucosa.
Fil: Bogsan, Cristina Stewart Bittencourt. Universidade de Sao Paulo; Brasil
Fil: Ferreira, Luis. Universidade de Sao Paulo; Brasil
Fil: Maldonado Galdeano, María Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina
Fil: Perdigon, Gabriela del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina
Fil: Almeida, Sandro Rogério. Universidade de Sao Paulo; Brasil
Fil: Oliveira, Maricê Nogueira de. Universidade de Sao Paulo; Brasil
Materia
Fermented
Milk
Immunomodulation
B1 Cells
Matrix-Probiotic-Mucosa Interaction
Bifidobacterium Animalis Subsp. Lactis Hn019
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/20559
Acceder
id CONICETDig_887e8b4094332cfb6115c39934a36d8b
oai_identifier_str oai:ri.conicet.gov.ar:11336/20559
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Fermented or unfermented milk using Bifidobacterium animalis subsp. lactis HN019: Technological approach determines the probiotic modulation of mucosal cellular immunityBogsan, Cristina Stewart BittencourtFerreira, LuisMaldonado Galdeano, María CarolinaPerdigon, Gabriela del ValleAlmeida, Sandro RogérioOliveira, Maricê Nogueira deFermentedMilkImmunomodulationB1 CellsMatrix-Probiotic-Mucosa InteractionBifidobacterium Animalis Subsp. Lactis Hn019https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Functional foods are important sources of probiotic delivery, mainly by fermentedmilk products. The physiological benefits attributed to bifido bacteria are their abilities to interfere with the adhesion of pathogenic species to surfaces of intestinal cells, and to enhance the host's immune function through their metabolic activities. However, the effects of a technological approach ? fermentation or addition of probiotic in milk, and its efficacy in health are rarely taken into consideration. Hence, fermented or unfermented milk using Bifidobacterium animalis subsp. lactis HN019 were administered to BALB/c mice for 14 days. After that, the architecture of the gut was histologically investigated, and the related immune cells were examined by flow cytometry and immunofluorescence. Increase in mucus and cellularity production, changes in immune pattern and preservation of mucosal epithelia in health BALB/c mice were observed only in the fermentedmilk group. This suggested that changes in functionality of bifidobacteria and/or themetabolites produced by the fermentation process are the keys to improving beneficial effects in the host of the gut mucosa.Fil: Bogsan, Cristina Stewart Bittencourt. Universidade de Sao Paulo; BrasilFil: Ferreira, Luis. Universidade de Sao Paulo; BrasilFil: Maldonado Galdeano, María Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; ArgentinaFil: Perdigon, Gabriela del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; ArgentinaFil: Almeida, Sandro Rogério. Universidade de Sao Paulo; BrasilFil: Oliveira, Maricê Nogueira de. Universidade de Sao Paulo; BrasilElsevier Science2014-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/20559Bogsan, Cristina Stewart Bittencourt; Ferreira, Luis; Maldonado Galdeano, María Carolina; Perdigon, Gabriela del Valle; Almeida, Sandro Rogério; et al.; Fermented or unfermented milk using Bifidobacterium animalis subsp. lactis HN019: Technological approach determines the probiotic modulation of mucosal cellular immunity; Elsevier Science; Food Research International; 64; 6-2014; 283-2880963-99691873-7145CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.foodres.2014.05.036info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0963996914003512info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:57:21Zoai:ri.conicet.gov.ar:11336/20559instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:57:21.862CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Fermented or unfermented milk using Bifidobacterium animalis subsp. lactis HN019: Technological approach determines the probiotic modulation of mucosal cellular immunity
title Fermented or unfermented milk using Bifidobacterium animalis subsp. lactis HN019: Technological approach determines the probiotic modulation of mucosal cellular immunity
spellingShingle Fermented or unfermented milk using Bifidobacterium animalis subsp. lactis HN019: Technological approach determines the probiotic modulation of mucosal cellular immunity
Bogsan, Cristina Stewart Bittencourt
Fermented
Milk
Immunomodulation
B1 Cells
Matrix-Probiotic-Mucosa Interaction
Bifidobacterium Animalis Subsp. Lactis Hn019
title_short Fermented or unfermented milk using Bifidobacterium animalis subsp. lactis HN019: Technological approach determines the probiotic modulation of mucosal cellular immunity
title_full Fermented or unfermented milk using Bifidobacterium animalis subsp. lactis HN019: Technological approach determines the probiotic modulation of mucosal cellular immunity
title_fullStr Fermented or unfermented milk using Bifidobacterium animalis subsp. lactis HN019: Technological approach determines the probiotic modulation of mucosal cellular immunity
title_full_unstemmed Fermented or unfermented milk using Bifidobacterium animalis subsp. lactis HN019: Technological approach determines the probiotic modulation of mucosal cellular immunity
title_sort Fermented or unfermented milk using Bifidobacterium animalis subsp. lactis HN019: Technological approach determines the probiotic modulation of mucosal cellular immunity
dc.creator.none.fl_str_mv Bogsan, Cristina Stewart Bittencourt
Ferreira, Luis
Maldonado Galdeano, María Carolina
Perdigon, Gabriela del Valle
Almeida, Sandro Rogério
Oliveira, Maricê Nogueira de
author Bogsan, Cristina Stewart Bittencourt
author_facet Bogsan, Cristina Stewart Bittencourt
Ferreira, Luis
Maldonado Galdeano, María Carolina
Perdigon, Gabriela del Valle
Almeida, Sandro Rogério
Oliveira, Maricê Nogueira de
author_role author
author2 Ferreira, Luis
Maldonado Galdeano, María Carolina
Perdigon, Gabriela del Valle
Almeida, Sandro Rogério
Oliveira, Maricê Nogueira de
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Fermented
Milk
Immunomodulation
B1 Cells
Matrix-Probiotic-Mucosa Interaction
Bifidobacterium Animalis Subsp. Lactis Hn019
topic Fermented
Milk
Immunomodulation
B1 Cells
Matrix-Probiotic-Mucosa Interaction
Bifidobacterium Animalis Subsp. Lactis Hn019
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Functional foods are important sources of probiotic delivery, mainly by fermentedmilk products. The physiological benefits attributed to bifido bacteria are their abilities to interfere with the adhesion of pathogenic species to surfaces of intestinal cells, and to enhance the host's immune function through their metabolic activities. However, the effects of a technological approach ? fermentation or addition of probiotic in milk, and its efficacy in health are rarely taken into consideration. Hence, fermented or unfermented milk using Bifidobacterium animalis subsp. lactis HN019 were administered to BALB/c mice for 14 days. After that, the architecture of the gut was histologically investigated, and the related immune cells were examined by flow cytometry and immunofluorescence. Increase in mucus and cellularity production, changes in immune pattern and preservation of mucosal epithelia in health BALB/c mice were observed only in the fermentedmilk group. This suggested that changes in functionality of bifidobacteria and/or themetabolites produced by the fermentation process are the keys to improving beneficial effects in the host of the gut mucosa.
Fil: Bogsan, Cristina Stewart Bittencourt. Universidade de Sao Paulo; Brasil
Fil: Ferreira, Luis. Universidade de Sao Paulo; Brasil
Fil: Maldonado Galdeano, María Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina
Fil: Perdigon, Gabriela del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina
Fil: Almeida, Sandro Rogério. Universidade de Sao Paulo; Brasil
Fil: Oliveira, Maricê Nogueira de. Universidade de Sao Paulo; Brasil
description Functional foods are important sources of probiotic delivery, mainly by fermentedmilk products. The physiological benefits attributed to bifido bacteria are their abilities to interfere with the adhesion of pathogenic species to surfaces of intestinal cells, and to enhance the host's immune function through their metabolic activities. However, the effects of a technological approach ? fermentation or addition of probiotic in milk, and its efficacy in health are rarely taken into consideration. Hence, fermented or unfermented milk using Bifidobacterium animalis subsp. lactis HN019 were administered to BALB/c mice for 14 days. After that, the architecture of the gut was histologically investigated, and the related immune cells were examined by flow cytometry and immunofluorescence. Increase in mucus and cellularity production, changes in immune pattern and preservation of mucosal epithelia in health BALB/c mice were observed only in the fermentedmilk group. This suggested that changes in functionality of bifidobacteria and/or themetabolites produced by the fermentation process are the keys to improving beneficial effects in the host of the gut mucosa.
publishDate 2014
dc.date.none.fl_str_mv 2014-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/20559
Bogsan, Cristina Stewart Bittencourt; Ferreira, Luis; Maldonado Galdeano, María Carolina; Perdigon, Gabriela del Valle; Almeida, Sandro Rogério; et al.; Fermented or unfermented milk using Bifidobacterium animalis subsp. lactis HN019: Technological approach determines the probiotic modulation of mucosal cellular immunity; Elsevier Science; Food Research International; 64; 6-2014; 283-288
0963-9969
1873-7145
CONICET Digital
CONICET
url http://hdl.handle.net/11336/20559
identifier_str_mv Bogsan, Cristina Stewart Bittencourt; Ferreira, Luis; Maldonado Galdeano, María Carolina; Perdigon, Gabriela del Valle; Almeida, Sandro Rogério; et al.; Fermented or unfermented milk using Bifidobacterium animalis subsp. lactis HN019: Technological approach determines the probiotic modulation of mucosal cellular immunity; Elsevier Science; Food Research International; 64; 6-2014; 283-288
0963-9969
1873-7145
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.foodres.2014.05.036
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0963996914003512
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269458379309056
score 13.13397

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