Terpenes: Natural Products for Controlling Insects of Importance to Human Health—A Structure-Activity Relationship Study

Autores
Dambolena, Jose Sebastian; Zunino, María Paula; Herrera, Jimena María; Pizzolitto, Romina Paola; Areco, Vanessa Andrea; Zygadlo, Julio Alberto
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Many insects affect food production and human health, and in an attempt to control these insects the use of synthetic insecticideshas become widespread. However, this has resulted in the development of resistance in these organisms, human diseases,contamination of food, and pollution of the environment. Plants natural products and essential oil components such as terpenesand phenylpropenes have been shown to have a significant potential for insect control. However, the molecular properties relatedto their insecticidal activity are not well understood. The purpose of this review is to provide an overview of the toxicity ofterpene compounds against three insects of importance to human health: lice, cockroaches, and Triatominae bugs and to evaluatewhich molecular descriptors are important in the bioactivity of terpenes. For the insects studied, quantitative structure-activityrelationship (QSAR) studies were performed in order to predict the insecticidal activity of terpene compounds. The obtainedQSAR models indicated that the activity of these compounds depends on their ability to reach the targets and to interact withthem.The QSAR analysis can be used to predict the bioactivities of other structurally related molecules. Our findings may providean important contribution in the search for new compounds with insecticidal activity.
Fil: Dambolena, Jose Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Zunino, María Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Herrera, Jimena María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Pizzolitto, Romina Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Areco, Vanessa Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Zygadlo, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Materia
Qsar
Terpenes
Phenylpropenes
Human Health Insects
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/19269
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Terpenes: Natural Products for Controlling Insects of Importance to Human Health—A Structure-Activity Relationship StudyDambolena, Jose SebastianZunino, María PaulaHerrera, Jimena MaríaPizzolitto, Romina PaolaAreco, Vanessa AndreaZygadlo, Julio AlbertoQsarTerpenesPhenylpropenesHuman Health Insectshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Many insects affect food production and human health, and in an attempt to control these insects the use of synthetic insecticideshas become widespread. However, this has resulted in the development of resistance in these organisms, human diseases,contamination of food, and pollution of the environment. Plants natural products and essential oil components such as terpenesand phenylpropenes have been shown to have a significant potential for insect control. However, the molecular properties relatedto their insecticidal activity are not well understood. The purpose of this review is to provide an overview of the toxicity ofterpene compounds against three insects of importance to human health: lice, cockroaches, and Triatominae bugs and to evaluatewhich molecular descriptors are important in the bioactivity of terpenes. For the insects studied, quantitative structure-activityrelationship (QSAR) studies were performed in order to predict the insecticidal activity of terpene compounds. The obtainedQSAR models indicated that the activity of these compounds depends on their ability to reach the targets and to interact withthem.The QSAR analysis can be used to predict the bioactivities of other structurally related molecules. Our findings may providean important contribution in the search for new compounds with insecticidal activity.Fil: Dambolena, Jose Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: Zunino, María Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: Herrera, Jimena María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: Pizzolitto, Romina Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: Areco, Vanessa Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: Zygadlo, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaHindawi Publishing Corporation2016-08-21info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/19269Dambolena, Jose Sebastian; Zunino, María Paula; Herrera, Jimena María; Pizzolitto, Romina Paola; Areco, Vanessa Andrea; et al.; Terpenes: Natural Products for Controlling Insects of Importance to Human Health—A Structure-Activity Relationship Study; Hindawi Publishing Corporation; Psyche; 2016; 21-8-2016; 1-181415-1138CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/psyche/2016/4595823/info:eu-repo/semantics/altIdentifier/doi/10.1155/2016/4595823info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:22:42Zoai:ri.conicet.gov.ar:11336/19269instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:22:42.92CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Terpenes: Natural Products for Controlling Insects of Importance to Human Health—A Structure-Activity Relationship Study
title Terpenes: Natural Products for Controlling Insects of Importance to Human Health—A Structure-Activity Relationship Study
spellingShingle Terpenes: Natural Products for Controlling Insects of Importance to Human Health—A Structure-Activity Relationship Study
Dambolena, Jose Sebastian
Qsar
Terpenes
Phenylpropenes
Human Health Insects
title_short Terpenes: Natural Products for Controlling Insects of Importance to Human Health—A Structure-Activity Relationship Study
title_full Terpenes: Natural Products for Controlling Insects of Importance to Human Health—A Structure-Activity Relationship Study
title_fullStr Terpenes: Natural Products for Controlling Insects of Importance to Human Health—A Structure-Activity Relationship Study
title_full_unstemmed Terpenes: Natural Products for Controlling Insects of Importance to Human Health—A Structure-Activity Relationship Study
title_sort Terpenes: Natural Products for Controlling Insects of Importance to Human Health—A Structure-Activity Relationship Study
dc.creator.none.fl_str_mv Dambolena, Jose Sebastian
Zunino, María Paula
Herrera, Jimena María
Pizzolitto, Romina Paola
Areco, Vanessa Andrea
Zygadlo, Julio Alberto
author Dambolena, Jose Sebastian
author_facet Dambolena, Jose Sebastian
Zunino, María Paula
Herrera, Jimena María
Pizzolitto, Romina Paola
Areco, Vanessa Andrea
Zygadlo, Julio Alberto
author_role author
author2 Zunino, María Paula
Herrera, Jimena María
Pizzolitto, Romina Paola
Areco, Vanessa Andrea
Zygadlo, Julio Alberto
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Qsar
Terpenes
Phenylpropenes
Human Health Insects
topic Qsar
Terpenes
Phenylpropenes
Human Health Insects
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Many insects affect food production and human health, and in an attempt to control these insects the use of synthetic insecticideshas become widespread. However, this has resulted in the development of resistance in these organisms, human diseases,contamination of food, and pollution of the environment. Plants natural products and essential oil components such as terpenesand phenylpropenes have been shown to have a significant potential for insect control. However, the molecular properties relatedto their insecticidal activity are not well understood. The purpose of this review is to provide an overview of the toxicity ofterpene compounds against three insects of importance to human health: lice, cockroaches, and Triatominae bugs and to evaluatewhich molecular descriptors are important in the bioactivity of terpenes. For the insects studied, quantitative structure-activityrelationship (QSAR) studies were performed in order to predict the insecticidal activity of terpene compounds. The obtainedQSAR models indicated that the activity of these compounds depends on their ability to reach the targets and to interact withthem.The QSAR analysis can be used to predict the bioactivities of other structurally related molecules. Our findings may providean important contribution in the search for new compounds with insecticidal activity.
Fil: Dambolena, Jose Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Zunino, María Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Herrera, Jimena María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Pizzolitto, Romina Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Areco, Vanessa Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Zygadlo, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
description Many insects affect food production and human health, and in an attempt to control these insects the use of synthetic insecticideshas become widespread. However, this has resulted in the development of resistance in these organisms, human diseases,contamination of food, and pollution of the environment. Plants natural products and essential oil components such as terpenesand phenylpropenes have been shown to have a significant potential for insect control. However, the molecular properties relatedto their insecticidal activity are not well understood. The purpose of this review is to provide an overview of the toxicity ofterpene compounds against three insects of importance to human health: lice, cockroaches, and Triatominae bugs and to evaluatewhich molecular descriptors are important in the bioactivity of terpenes. For the insects studied, quantitative structure-activityrelationship (QSAR) studies were performed in order to predict the insecticidal activity of terpene compounds. The obtainedQSAR models indicated that the activity of these compounds depends on their ability to reach the targets and to interact withthem.The QSAR analysis can be used to predict the bioactivities of other structurally related molecules. Our findings may providean important contribution in the search for new compounds with insecticidal activity.
publishDate 2016
dc.date.none.fl_str_mv 2016-08-21
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/19269
Dambolena, Jose Sebastian; Zunino, María Paula; Herrera, Jimena María; Pizzolitto, Romina Paola; Areco, Vanessa Andrea; et al.; Terpenes: Natural Products for Controlling Insects of Importance to Human Health—A Structure-Activity Relationship Study; Hindawi Publishing Corporation; Psyche; 2016; 21-8-2016; 1-18
1415-1138
CONICET Digital
CONICET
url http://hdl.handle.net/11336/19269
identifier_str_mv Dambolena, Jose Sebastian; Zunino, María Paula; Herrera, Jimena María; Pizzolitto, Romina Paola; Areco, Vanessa Andrea; et al.; Terpenes: Natural Products for Controlling Insects of Importance to Human Health—A Structure-Activity Relationship Study; Hindawi Publishing Corporation; Psyche; 2016; 21-8-2016; 1-18
1415-1138
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/psyche/2016/4595823/
info:eu-repo/semantics/altIdentifier/doi/10.1155/2016/4595823
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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