Antimicrobial activity of Terpenes against slime producing and non producing Staphylococci

Autores
Gallucci, Mauro Nicolas; Oliva, Maria de Las Mercedes; Carezzano, Maria Evangelina; Zygadlo, Julio Alberto; Demo, Mirta Susana
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Staphylococcus aureus, responsible of several diseases in humans and animals, produce virulence factors like an extracelullar polysacharide or “slime”. Methicillin resistant S. aureus (MRSA) is able to resist -lactamic antibiotics and eventually is a slime producer. Conventional chemotherapics against MRSA are ineffective. Essential oils (EOs) are oily liquids obtained from aromatic plants chemically constituted by terpenes. Their antimicrobial activity against clinical and foodborned pathogenic bacteria has been described. The aim of this work was to study the inhibitory activity of terpenes on slime producing Staphylococcus aureus methicillin sensitive (MSSA) and MRSA. Terpenes were tested against MRSA and MSSA with the resazurin microdilution assay. The terpenes active against all the microorganisms were carvacrol, thymol, geraniol and eugenol. Carvone was only active against S. aureus MSSA, while citronellol, menthol, menthone and myrcene did not show antimicrobial activity. The terpenes active against MRSA when slime was induced were carvacrol, eugenol, geraniol and thymol. This strain showed activity of carvacrol, carvone, eugenol, geraniol and thymol when slime was not induced. The results obtained clearly showed that carvacrol and thymol had the best antimicrobial activity. Carvacrol, eugenol and thymol could be used for therapeutical formulations in replacement of antibiotic to treat diseases caused by resistant microorganisms such as MRS.
Fil: Gallucci, Mauro Nicolas. Universidad Nacional de Santiago del Estero. Instituto de Bionanotecnología del Noa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Bionanotecnología del Noa; Argentina
Fil: Oliva, Maria de Las Mercedes. Universidad Nacional de Rio Cuarto. Facultad de Cs.exactas Fisicoquimicas y Naturales. Instituto de Biotecnologia Ambiental y Salud. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Cordoba. Instituto de Biotecnologia Ambiental y Salud.; Argentina
Fil: Carezzano, Maria Evangelina. Universidad Nacional de Rio Cuarto. Facultad de Cs.exactas Fisicoquimicas y Naturales. Instituto de Biotecnologia Ambiental y Salud. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Cordoba. Instituto de Biotecnologia Ambiental y Salud.; Argentina
Fil: Zygadlo, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Demo, Mirta Susana. Universidad Nacional de Rio Cuarto. Facultad de Cs.exactas Fisicoquimicas y Naturales. Instituto de Biotecnologia Ambiental y Salud. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Cordoba. Instituto de Biotecnologia Ambiental y Salud.; Argentina
Materia
Terpenes
Antimicrobial activity
Slime
Methicillin resistan S. aureus
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/110485
Acceder
id CONICETDig_5a0120befc59cf006bf40fed7900c858
oai_identifier_str oai:ri.conicet.gov.ar:11336/110485
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Antimicrobial activity of Terpenes against slime producing and non producing StaphylococciGallucci, Mauro NicolasOliva, Maria de Las MercedesCarezzano, Maria EvangelinaZygadlo, Julio AlbertoDemo, Mirta SusanaTerpenesAntimicrobial activitySlimeMethicillin resistan S. aureushttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Staphylococcus aureus, responsible of several diseases in humans and animals, produce virulence factors like an extracelullar polysacharide or “slime”. Methicillin resistant S. aureus (MRSA) is able to resist -lactamic antibiotics and eventually is a slime producer. Conventional chemotherapics against MRSA are ineffective. Essential oils (EOs) are oily liquids obtained from aromatic plants chemically constituted by terpenes. Their antimicrobial activity against clinical and foodborned pathogenic bacteria has been described. The aim of this work was to study the inhibitory activity of terpenes on slime producing Staphylococcus aureus methicillin sensitive (MSSA) and MRSA. Terpenes were tested against MRSA and MSSA with the resazurin microdilution assay. The terpenes active against all the microorganisms were carvacrol, thymol, geraniol and eugenol. Carvone was only active against S. aureus MSSA, while citronellol, menthol, menthone and myrcene did not show antimicrobial activity. The terpenes active against MRSA when slime was induced were carvacrol, eugenol, geraniol and thymol. This strain showed activity of carvacrol, carvone, eugenol, geraniol and thymol when slime was not induced. The results obtained clearly showed that carvacrol and thymol had the best antimicrobial activity. Carvacrol, eugenol and thymol could be used for therapeutical formulations in replacement of antibiotic to treat diseases caused by resistant microorganisms such as MRS.Fil: Gallucci, Mauro Nicolas. Universidad Nacional de Santiago del Estero. Instituto de Bionanotecnología del Noa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Bionanotecnología del Noa; ArgentinaFil: Oliva, Maria de Las Mercedes. Universidad Nacional de Rio Cuarto. Facultad de Cs.exactas Fisicoquimicas y Naturales. Instituto de Biotecnologia Ambiental y Salud. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Cordoba. Instituto de Biotecnologia Ambiental y Salud.; ArgentinaFil: Carezzano, Maria Evangelina. Universidad Nacional de Rio Cuarto. Facultad de Cs.exactas Fisicoquimicas y Naturales. Instituto de Biotecnologia Ambiental y Salud. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Cordoba. Instituto de Biotecnologia Ambiental y Salud.; ArgentinaFil: Zygadlo, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: Demo, Mirta Susana. Universidad Nacional de Rio Cuarto. Facultad de Cs.exactas Fisicoquimicas y Naturales. Instituto de Biotecnologia Ambiental y Salud. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Cordoba. Instituto de Biotecnologia Ambiental y Salud.; ArgentinaInstituto de Investigación de las Ciencias Exactas Físicas y Naturales2010-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/110485Gallucci, Mauro Nicolas; Oliva, Maria de Las Mercedes; Carezzano, Maria Evangelina; Zygadlo, Julio Alberto; Demo, Mirta Susana; Antimicrobial activity of Terpenes against slime producing and non producing Staphylococci; Instituto de Investigación de las Ciencias Exactas Físicas y Naturales; Molecular Medicinal Chemistry; 1; 1-2010; 132-1361666-888XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.idecefyn.com.ar/MMC21PDF/vol_21__january.htminfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:48:50Zoai:ri.conicet.gov.ar:11336/110485instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:48:50.477CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Antimicrobial activity of Terpenes against slime producing and non producing Staphylococci
title Antimicrobial activity of Terpenes against slime producing and non producing Staphylococci
spellingShingle Antimicrobial activity of Terpenes against slime producing and non producing Staphylococci
Gallucci, Mauro Nicolas
Terpenes
Antimicrobial activity
Slime
Methicillin resistan S. aureus
title_short Antimicrobial activity of Terpenes against slime producing and non producing Staphylococci
title_full Antimicrobial activity of Terpenes against slime producing and non producing Staphylococci
title_fullStr Antimicrobial activity of Terpenes against slime producing and non producing Staphylococci
title_full_unstemmed Antimicrobial activity of Terpenes against slime producing and non producing Staphylococci
title_sort Antimicrobial activity of Terpenes against slime producing and non producing Staphylococci
dc.creator.none.fl_str_mv Gallucci, Mauro Nicolas
Oliva, Maria de Las Mercedes
Carezzano, Maria Evangelina
Zygadlo, Julio Alberto
Demo, Mirta Susana
author Gallucci, Mauro Nicolas
author_facet Gallucci, Mauro Nicolas
Oliva, Maria de Las Mercedes
Carezzano, Maria Evangelina
Zygadlo, Julio Alberto
Demo, Mirta Susana
author_role author
author2 Oliva, Maria de Las Mercedes
Carezzano, Maria Evangelina
Zygadlo, Julio Alberto
Demo, Mirta Susana
author2_role author
author
author
author
dc.subject.none.fl_str_mv Terpenes
Antimicrobial activity
Slime
Methicillin resistan S. aureus
topic Terpenes
Antimicrobial activity
Slime
Methicillin resistan S. aureus
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Staphylococcus aureus, responsible of several diseases in humans and animals, produce virulence factors like an extracelullar polysacharide or “slime”. Methicillin resistant S. aureus (MRSA) is able to resist -lactamic antibiotics and eventually is a slime producer. Conventional chemotherapics against MRSA are ineffective. Essential oils (EOs) are oily liquids obtained from aromatic plants chemically constituted by terpenes. Their antimicrobial activity against clinical and foodborned pathogenic bacteria has been described. The aim of this work was to study the inhibitory activity of terpenes on slime producing Staphylococcus aureus methicillin sensitive (MSSA) and MRSA. Terpenes were tested against MRSA and MSSA with the resazurin microdilution assay. The terpenes active against all the microorganisms were carvacrol, thymol, geraniol and eugenol. Carvone was only active against S. aureus MSSA, while citronellol, menthol, menthone and myrcene did not show antimicrobial activity. The terpenes active against MRSA when slime was induced were carvacrol, eugenol, geraniol and thymol. This strain showed activity of carvacrol, carvone, eugenol, geraniol and thymol when slime was not induced. The results obtained clearly showed that carvacrol and thymol had the best antimicrobial activity. Carvacrol, eugenol and thymol could be used for therapeutical formulations in replacement of antibiotic to treat diseases caused by resistant microorganisms such as MRS.
Fil: Gallucci, Mauro Nicolas. Universidad Nacional de Santiago del Estero. Instituto de Bionanotecnología del Noa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Bionanotecnología del Noa; Argentina
Fil: Oliva, Maria de Las Mercedes. Universidad Nacional de Rio Cuarto. Facultad de Cs.exactas Fisicoquimicas y Naturales. Instituto de Biotecnologia Ambiental y Salud. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Cordoba. Instituto de Biotecnologia Ambiental y Salud.; Argentina
Fil: Carezzano, Maria Evangelina. Universidad Nacional de Rio Cuarto. Facultad de Cs.exactas Fisicoquimicas y Naturales. Instituto de Biotecnologia Ambiental y Salud. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Cordoba. Instituto de Biotecnologia Ambiental y Salud.; Argentina
Fil: Zygadlo, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Demo, Mirta Susana. Universidad Nacional de Rio Cuarto. Facultad de Cs.exactas Fisicoquimicas y Naturales. Instituto de Biotecnologia Ambiental y Salud. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Cordoba. Instituto de Biotecnologia Ambiental y Salud.; Argentina
description Staphylococcus aureus, responsible of several diseases in humans and animals, produce virulence factors like an extracelullar polysacharide or “slime”. Methicillin resistant S. aureus (MRSA) is able to resist -lactamic antibiotics and eventually is a slime producer. Conventional chemotherapics against MRSA are ineffective. Essential oils (EOs) are oily liquids obtained from aromatic plants chemically constituted by terpenes. Their antimicrobial activity against clinical and foodborned pathogenic bacteria has been described. The aim of this work was to study the inhibitory activity of terpenes on slime producing Staphylococcus aureus methicillin sensitive (MSSA) and MRSA. Terpenes were tested against MRSA and MSSA with the resazurin microdilution assay. The terpenes active against all the microorganisms were carvacrol, thymol, geraniol and eugenol. Carvone was only active against S. aureus MSSA, while citronellol, menthol, menthone and myrcene did not show antimicrobial activity. The terpenes active against MRSA when slime was induced were carvacrol, eugenol, geraniol and thymol. This strain showed activity of carvacrol, carvone, eugenol, geraniol and thymol when slime was not induced. The results obtained clearly showed that carvacrol and thymol had the best antimicrobial activity. Carvacrol, eugenol and thymol could be used for therapeutical formulations in replacement of antibiotic to treat diseases caused by resistant microorganisms such as MRS.
publishDate 2010
dc.date.none.fl_str_mv 2010-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/110485
Gallucci, Mauro Nicolas; Oliva, Maria de Las Mercedes; Carezzano, Maria Evangelina; Zygadlo, Julio Alberto; Demo, Mirta Susana; Antimicrobial activity of Terpenes against slime producing and non producing Staphylococci; Instituto de Investigación de las Ciencias Exactas Físicas y Naturales; Molecular Medicinal Chemistry; 1; 1-2010; 132-136
1666-888X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/110485
identifier_str_mv Gallucci, Mauro Nicolas; Oliva, Maria de Las Mercedes; Carezzano, Maria Evangelina; Zygadlo, Julio Alberto; Demo, Mirta Susana; Antimicrobial activity of Terpenes against slime producing and non producing Staphylococci; Instituto de Investigación de las Ciencias Exactas Físicas y Naturales; Molecular Medicinal Chemistry; 1; 1-2010; 132-136
1666-888X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.idecefyn.com.ar/MMC21PDF/vol_21__january.htm
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Instituto de Investigación de las Ciencias Exactas Físicas y Naturales
publisher.none.fl_str_mv Instituto de Investigación de las Ciencias Exactas Físicas y Naturales
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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