Glial and light-dependent glutamate metabolism in the suprachiasmatic nuclei

Autores
Leone, Maria Juliana; Beaule, C.; Marpegan, Luciano; Simon, T.; Herzog, E.D.; Golombek, Diego Andrés
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The suprachiasmatic nuclei, the main circadian clock in mammals, are entrained by light through glutamate released from retinal cells. Astrocytes are key players in glutamate metabolism but their role in the entrainment process is unknown. We studied the time dependence of glutamate uptake and glutamine synthetase (GS) activity finding diurnal oscillations in glutamate uptake (high levels during the light phase) and daily and circadian fluctuations in GS activity (higher during the light phase and the subjective day). These results show that glutamate-related astroglial processes exhibit diurnal and circadian variations, which could affect photic entrainment of the circadian system.
Fil: Leone, Maria Juliana. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Beaule, C.. Washington University in St. Louis; Estados Unidos
Fil: Marpegan, Luciano. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Simon, T.. Washington University in St. Louis; Estados Unidos
Fil: Herzog, E.D.. Washington University in St. Louis; Estados Unidos
Fil: Golombek, Diego Andrés. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Astrocytes
Circadian
Glutamate Uptake
Glutamine Synthetase
Scn
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/38460
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Glial and light-dependent glutamate metabolism in the suprachiasmatic nucleiLeone, Maria JulianaBeaule, C.Marpegan, LucianoSimon, T.Herzog, E.D.Golombek, Diego AndrésAstrocytesCircadianGlutamate UptakeGlutamine SynthetaseScnhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The suprachiasmatic nuclei, the main circadian clock in mammals, are entrained by light through glutamate released from retinal cells. Astrocytes are key players in glutamate metabolism but their role in the entrainment process is unknown. We studied the time dependence of glutamate uptake and glutamine synthetase (GS) activity finding diurnal oscillations in glutamate uptake (high levels during the light phase) and daily and circadian fluctuations in GS activity (higher during the light phase and the subjective day). These results show that glutamate-related astroglial processes exhibit diurnal and circadian variations, which could affect photic entrainment of the circadian system.Fil: Leone, Maria Juliana. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Beaule, C.. Washington University in St. Louis; Estados UnidosFil: Marpegan, Luciano. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Simon, T.. Washington University in St. Louis; Estados UnidosFil: Herzog, E.D.. Washington University in St. Louis; Estados UnidosFil: Golombek, Diego Andrés. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaTaylor2015-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/38460Leone, Maria Juliana; Beaule, C.; Marpegan, Luciano; Simon, T.; Herzog, E.D.; et al.; Glial and light-dependent glutamate metabolism in the suprachiasmatic nuclei; Taylor ; Chronobiology International; 32; 4; 5-2015; 573-5780742-0528CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3109/07420528.2015.1006328info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.3109/07420528.2015.1006328?journalCode=icbi20info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-17T11:09:16Zoai:ri.conicet.gov.ar:11336/38460instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-17 11:09:16.415CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Glial and light-dependent glutamate metabolism in the suprachiasmatic nuclei
title Glial and light-dependent glutamate metabolism in the suprachiasmatic nuclei
spellingShingle Glial and light-dependent glutamate metabolism in the suprachiasmatic nuclei
Leone, Maria Juliana
Astrocytes
Circadian
Glutamate Uptake
Glutamine Synthetase
Scn
title_short Glial and light-dependent glutamate metabolism in the suprachiasmatic nuclei
title_full Glial and light-dependent glutamate metabolism in the suprachiasmatic nuclei
title_fullStr Glial and light-dependent glutamate metabolism in the suprachiasmatic nuclei
title_full_unstemmed Glial and light-dependent glutamate metabolism in the suprachiasmatic nuclei
title_sort Glial and light-dependent glutamate metabolism in the suprachiasmatic nuclei
dc.creator.none.fl_str_mv Leone, Maria Juliana
Beaule, C.
Marpegan, Luciano
Simon, T.
Herzog, E.D.
Golombek, Diego Andrés
author Leone, Maria Juliana
author_facet Leone, Maria Juliana
Beaule, C.
Marpegan, Luciano
Simon, T.
Herzog, E.D.
Golombek, Diego Andrés
author_role author
author2 Beaule, C.
Marpegan, Luciano
Simon, T.
Herzog, E.D.
Golombek, Diego Andrés
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Astrocytes
Circadian
Glutamate Uptake
Glutamine Synthetase
Scn
topic Astrocytes
Circadian
Glutamate Uptake
Glutamine Synthetase
Scn
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The suprachiasmatic nuclei, the main circadian clock in mammals, are entrained by light through glutamate released from retinal cells. Astrocytes are key players in glutamate metabolism but their role in the entrainment process is unknown. We studied the time dependence of glutamate uptake and glutamine synthetase (GS) activity finding diurnal oscillations in glutamate uptake (high levels during the light phase) and daily and circadian fluctuations in GS activity (higher during the light phase and the subjective day). These results show that glutamate-related astroglial processes exhibit diurnal and circadian variations, which could affect photic entrainment of the circadian system.
Fil: Leone, Maria Juliana. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Beaule, C.. Washington University in St. Louis; Estados Unidos
Fil: Marpegan, Luciano. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Simon, T.. Washington University in St. Louis; Estados Unidos
Fil: Herzog, E.D.. Washington University in St. Louis; Estados Unidos
Fil: Golombek, Diego Andrés. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description The suprachiasmatic nuclei, the main circadian clock in mammals, are entrained by light through glutamate released from retinal cells. Astrocytes are key players in glutamate metabolism but their role in the entrainment process is unknown. We studied the time dependence of glutamate uptake and glutamine synthetase (GS) activity finding diurnal oscillations in glutamate uptake (high levels during the light phase) and daily and circadian fluctuations in GS activity (higher during the light phase and the subjective day). These results show that glutamate-related astroglial processes exhibit diurnal and circadian variations, which could affect photic entrainment of the circadian system.
publishDate 2015
dc.date.none.fl_str_mv 2015-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/38460
Leone, Maria Juliana; Beaule, C.; Marpegan, Luciano; Simon, T.; Herzog, E.D.; et al.; Glial and light-dependent glutamate metabolism in the suprachiasmatic nuclei; Taylor ; Chronobiology International; 32; 4; 5-2015; 573-578
0742-0528
CONICET Digital
CONICET
url http://hdl.handle.net/11336/38460
identifier_str_mv Leone, Maria Juliana; Beaule, C.; Marpegan, Luciano; Simon, T.; Herzog, E.D.; et al.; Glial and light-dependent glutamate metabolism in the suprachiasmatic nuclei; Taylor ; Chronobiology International; 32; 4; 5-2015; 573-578
0742-0528
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3109/07420528.2015.1006328
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.3109/07420528.2015.1006328?journalCode=icbi20
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor
publisher.none.fl_str_mv Taylor
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1843606420438646784
score 13.000565

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