Insights into Acinetobacter baumannii AMA205’s Unprecedented Antibiotic Resistance

Autores
Traglia, German Matias; Pasteran, Fernando; Moheb, Samyar; Akhtar, Usman; González, Sebastián; Maldonado, Carolina; Furtado, Nicholas; Mohamed, Ahmed; Escalante, Jenny; Tuttobene, Marisel Romina; Quillen, Araceli; Fontan, Claudia; Albornoz, Ezequiel Pablo; Corso, Alejandra; Bonomo, Robert A.; Rao, Gauri G.; Tolmasky, Marcelo E.; Ramirez, Maria Soledad
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The rise of antibiotic-resistant bacteria in clinical settings has become a significant global concern. Among these bacteria, Acinetobacter baumannii stands out due to its remarkable ability to acquire resistance genes and persist in hospital environments, leading to some of the most challenging infections. Horizontal gene transfer (HGT) plays a crucial role in the evolution of this pathogen. TheA. baumannii AMA205 strain, belonging to sequence type ST79, was isolated from a COVID-19 patient in Argentina in 2021. This strain’s antimicrobial resistance profile is notable as it harbors multiple resistance genes, some of which had not been previously described in this species. The AmpC family β-lactamase blaCMY-6, commonly found in Enterobacterales, had never been detected in A. baumannii before. Furthermore, this is the first ST79 strain known to carry the carbapenemase blaNDM-1 gene. Other acquired resistance genes include the carbapenemase blaOXA-23, further complicating treatment. Susceptibility testing revealed high resistance to most antibiotic families, including cefiderocol, with significant contributions from blaCMY-6 and blaNDM-1 genes to the cephalosporin and carbapenem resistance profiles. The A. baumannii AMA205 genome also contains genetic traits coding for 111 potential virulence factors, such as the iron-uptake system and biofilm-associated proteins. This study underscores A. baumannii’s ability to acquire multiple resistance genes and highlights the need for alternative therapies and effective antimicrobial stewardship to control the spread of these highly resistant strains.
Fil: Traglia, German Matias. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina. Universidad de la República; Uruguay
Fil: Pasteran, Fernando. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina
Fil: Moheb, Samyar. California State University; Estados Unidos
Fil: Akhtar, Usman. California State University; Estados Unidos
Fil: González, Sebastián. California State University; Estados Unidos
Fil: Maldonado, Carolina. California State University; Estados Unidos
Fil: Furtado, Nicholas. California State University; Estados Unidos
Fil: Mohamed, Ahmed. California State University; Estados Unidos
Fil: Escalante, Jenny. California State University; Estados Unidos
Fil: Tuttobene, Marisel Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina
Fil: Quillen, Araceli. Gobierno de la Provincia de Santiago del Estero. Hospital Regional Dr. Ramón Carrillo; Argentina
Fil: Fontan, Claudia. Gobierno de la Provincia de Santiago del Estero. Hospital Regional Dr. Ramón Carrillo; Argentina
Fil: Albornoz, Ezequiel Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas. Área de Antimicrobianos; Argentina
Fil: Corso, Alejandra. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas. Área de Antimicrobianos; Argentina
Fil: Bonomo, Robert A.. Louis Stokes Cleveland Department of Veterans Affairs Medical Center; Estados Unidos. Case Western Reserve University; Estados Unidos. Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology; Estados Unidos
Fil: Rao, Gauri G.. Universidad Autonoma de Baja California Sur; Estados Unidos
Fil: Tolmasky, Marcelo E.. California State University; Estados Unidos
Fil: Ramirez, Maria Soledad. California State University; Estados Unidos
Materia
ACINETOBACTER BAUMANNII
CARBAPENEMASES
DNA ACQUISITION
ANTIBIOTIC RESISTANCE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/266760
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Insights into Acinetobacter baumannii AMA205’s Unprecedented Antibiotic ResistanceTraglia, German MatiasPasteran, FernandoMoheb, SamyarAkhtar, UsmanGonzález, SebastiánMaldonado, CarolinaFurtado, NicholasMohamed, AhmedEscalante, JennyTuttobene, Marisel RominaQuillen, AraceliFontan, ClaudiaAlbornoz, Ezequiel PabloCorso, AlejandraBonomo, Robert A.Rao, Gauri G.Tolmasky, Marcelo E.Ramirez, Maria SoledadACINETOBACTER BAUMANNIICARBAPENEMASESDNA ACQUISITIONANTIBIOTIC RESISTANCEhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The rise of antibiotic-resistant bacteria in clinical settings has become a significant global concern. Among these bacteria, Acinetobacter baumannii stands out due to its remarkable ability to acquire resistance genes and persist in hospital environments, leading to some of the most challenging infections. Horizontal gene transfer (HGT) plays a crucial role in the evolution of this pathogen. TheA. baumannii AMA205 strain, belonging to sequence type ST79, was isolated from a COVID-19 patient in Argentina in 2021. This strain’s antimicrobial resistance profile is notable as it harbors multiple resistance genes, some of which had not been previously described in this species. The AmpC family β-lactamase blaCMY-6, commonly found in Enterobacterales, had never been detected in A. baumannii before. Furthermore, this is the first ST79 strain known to carry the carbapenemase blaNDM-1 gene. Other acquired resistance genes include the carbapenemase blaOXA-23, further complicating treatment. Susceptibility testing revealed high resistance to most antibiotic families, including cefiderocol, with significant contributions from blaCMY-6 and blaNDM-1 genes to the cephalosporin and carbapenem resistance profiles. The A. baumannii AMA205 genome also contains genetic traits coding for 111 potential virulence factors, such as the iron-uptake system and biofilm-associated proteins. This study underscores A. baumannii’s ability to acquire multiple resistance genes and highlights the need for alternative therapies and effective antimicrobial stewardship to control the spread of these highly resistant strains.Fil: Traglia, German Matias. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina. Universidad de la República; UruguayFil: Pasteran, Fernando. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; ArgentinaFil: Moheb, Samyar. California State University; Estados UnidosFil: Akhtar, Usman. California State University; Estados UnidosFil: González, Sebastián. California State University; Estados UnidosFil: Maldonado, Carolina. California State University; Estados UnidosFil: Furtado, Nicholas. California State University; Estados UnidosFil: Mohamed, Ahmed. California State University; Estados UnidosFil: Escalante, Jenny. California State University; Estados UnidosFil: Tuttobene, Marisel Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; ArgentinaFil: Quillen, Araceli. Gobierno de la Provincia de Santiago del Estero. Hospital Regional Dr. Ramón Carrillo; ArgentinaFil: Fontan, Claudia. Gobierno de la Provincia de Santiago del Estero. Hospital Regional Dr. Ramón Carrillo; ArgentinaFil: Albornoz, Ezequiel Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas. Área de Antimicrobianos; ArgentinaFil: Corso, Alejandra. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas. Área de Antimicrobianos; ArgentinaFil: Bonomo, Robert A.. Louis Stokes Cleveland Department of Veterans Affairs Medical Center; Estados Unidos. Case Western Reserve University; Estados Unidos. Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology; Estados UnidosFil: Rao, Gauri G.. Universidad Autonoma de Baja California Sur; Estados UnidosFil: Tolmasky, Marcelo E.. California State University; Estados UnidosFil: Ramirez, Maria Soledad. California State University; Estados UnidosMolecular Diversity Preservation International2024-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/266760Traglia, German Matias; Pasteran, Fernando; Moheb, Samyar; Akhtar, Usman; González, Sebastián; et al.; Insights into Acinetobacter baumannii AMA205’s Unprecedented Antibiotic Resistance; Molecular Diversity Preservation International; International Journal of Molecular Sciences; 25; 21; 10-2024; 1-131422-0067CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1422-0067/25/21/11424info:eu-repo/semantics/altIdentifier/doi/10.3390/ijms252111424info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:06:44Zoai:ri.conicet.gov.ar:11336/266760instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:06:44.513CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Insights into Acinetobacter baumannii AMA205’s Unprecedented Antibiotic Resistance
title Insights into Acinetobacter baumannii AMA205’s Unprecedented Antibiotic Resistance
spellingShingle Insights into Acinetobacter baumannii AMA205’s Unprecedented Antibiotic Resistance
Traglia, German Matias
ACINETOBACTER BAUMANNII
CARBAPENEMASES
DNA ACQUISITION
ANTIBIOTIC RESISTANCE
title_short Insights into Acinetobacter baumannii AMA205’s Unprecedented Antibiotic Resistance
title_full Insights into Acinetobacter baumannii AMA205’s Unprecedented Antibiotic Resistance
title_fullStr Insights into Acinetobacter baumannii AMA205’s Unprecedented Antibiotic Resistance
title_full_unstemmed Insights into Acinetobacter baumannii AMA205’s Unprecedented Antibiotic Resistance
title_sort Insights into Acinetobacter baumannii AMA205’s Unprecedented Antibiotic Resistance
dc.creator.none.fl_str_mv Traglia, German Matias
Pasteran, Fernando
Moheb, Samyar
Akhtar, Usman
González, Sebastián
Maldonado, Carolina
Furtado, Nicholas
Mohamed, Ahmed
Escalante, Jenny
Tuttobene, Marisel Romina
Quillen, Araceli
Fontan, Claudia
Albornoz, Ezequiel Pablo
Corso, Alejandra
Bonomo, Robert A.
Rao, Gauri G.
Tolmasky, Marcelo E.
Ramirez, Maria Soledad
author Traglia, German Matias
author_facet Traglia, German Matias
Pasteran, Fernando
Moheb, Samyar
Akhtar, Usman
González, Sebastián
Maldonado, Carolina
Furtado, Nicholas
Mohamed, Ahmed
Escalante, Jenny
Tuttobene, Marisel Romina
Quillen, Araceli
Fontan, Claudia
Albornoz, Ezequiel Pablo
Corso, Alejandra
Bonomo, Robert A.
Rao, Gauri G.
Tolmasky, Marcelo E.
Ramirez, Maria Soledad
author_role author
author2 Pasteran, Fernando
Moheb, Samyar
Akhtar, Usman
González, Sebastián
Maldonado, Carolina
Furtado, Nicholas
Mohamed, Ahmed
Escalante, Jenny
Tuttobene, Marisel Romina
Quillen, Araceli
Fontan, Claudia
Albornoz, Ezequiel Pablo
Corso, Alejandra
Bonomo, Robert A.
Rao, Gauri G.
Tolmasky, Marcelo E.
Ramirez, Maria Soledad
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ACINETOBACTER BAUMANNII
CARBAPENEMASES
DNA ACQUISITION
ANTIBIOTIC RESISTANCE
topic ACINETOBACTER BAUMANNII
CARBAPENEMASES
DNA ACQUISITION
ANTIBIOTIC RESISTANCE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The rise of antibiotic-resistant bacteria in clinical settings has become a significant global concern. Among these bacteria, Acinetobacter baumannii stands out due to its remarkable ability to acquire resistance genes and persist in hospital environments, leading to some of the most challenging infections. Horizontal gene transfer (HGT) plays a crucial role in the evolution of this pathogen. TheA. baumannii AMA205 strain, belonging to sequence type ST79, was isolated from a COVID-19 patient in Argentina in 2021. This strain’s antimicrobial resistance profile is notable as it harbors multiple resistance genes, some of which had not been previously described in this species. The AmpC family β-lactamase blaCMY-6, commonly found in Enterobacterales, had never been detected in A. baumannii before. Furthermore, this is the first ST79 strain known to carry the carbapenemase blaNDM-1 gene. Other acquired resistance genes include the carbapenemase blaOXA-23, further complicating treatment. Susceptibility testing revealed high resistance to most antibiotic families, including cefiderocol, with significant contributions from blaCMY-6 and blaNDM-1 genes to the cephalosporin and carbapenem resistance profiles. The A. baumannii AMA205 genome also contains genetic traits coding for 111 potential virulence factors, such as the iron-uptake system and biofilm-associated proteins. This study underscores A. baumannii’s ability to acquire multiple resistance genes and highlights the need for alternative therapies and effective antimicrobial stewardship to control the spread of these highly resistant strains.
Fil: Traglia, German Matias. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina. Universidad de la República; Uruguay
Fil: Pasteran, Fernando. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina
Fil: Moheb, Samyar. California State University; Estados Unidos
Fil: Akhtar, Usman. California State University; Estados Unidos
Fil: González, Sebastián. California State University; Estados Unidos
Fil: Maldonado, Carolina. California State University; Estados Unidos
Fil: Furtado, Nicholas. California State University; Estados Unidos
Fil: Mohamed, Ahmed. California State University; Estados Unidos
Fil: Escalante, Jenny. California State University; Estados Unidos
Fil: Tuttobene, Marisel Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina
Fil: Quillen, Araceli. Gobierno de la Provincia de Santiago del Estero. Hospital Regional Dr. Ramón Carrillo; Argentina
Fil: Fontan, Claudia. Gobierno de la Provincia de Santiago del Estero. Hospital Regional Dr. Ramón Carrillo; Argentina
Fil: Albornoz, Ezequiel Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas. Área de Antimicrobianos; Argentina
Fil: Corso, Alejandra. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas. Área de Antimicrobianos; Argentina
Fil: Bonomo, Robert A.. Louis Stokes Cleveland Department of Veterans Affairs Medical Center; Estados Unidos. Case Western Reserve University; Estados Unidos. Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology; Estados Unidos
Fil: Rao, Gauri G.. Universidad Autonoma de Baja California Sur; Estados Unidos
Fil: Tolmasky, Marcelo E.. California State University; Estados Unidos
Fil: Ramirez, Maria Soledad. California State University; Estados Unidos
description The rise of antibiotic-resistant bacteria in clinical settings has become a significant global concern. Among these bacteria, Acinetobacter baumannii stands out due to its remarkable ability to acquire resistance genes and persist in hospital environments, leading to some of the most challenging infections. Horizontal gene transfer (HGT) plays a crucial role in the evolution of this pathogen. TheA. baumannii AMA205 strain, belonging to sequence type ST79, was isolated from a COVID-19 patient in Argentina in 2021. This strain’s antimicrobial resistance profile is notable as it harbors multiple resistance genes, some of which had not been previously described in this species. The AmpC family β-lactamase blaCMY-6, commonly found in Enterobacterales, had never been detected in A. baumannii before. Furthermore, this is the first ST79 strain known to carry the carbapenemase blaNDM-1 gene. Other acquired resistance genes include the carbapenemase blaOXA-23, further complicating treatment. Susceptibility testing revealed high resistance to most antibiotic families, including cefiderocol, with significant contributions from blaCMY-6 and blaNDM-1 genes to the cephalosporin and carbapenem resistance profiles. The A. baumannii AMA205 genome also contains genetic traits coding for 111 potential virulence factors, such as the iron-uptake system and biofilm-associated proteins. This study underscores A. baumannii’s ability to acquire multiple resistance genes and highlights the need for alternative therapies and effective antimicrobial stewardship to control the spread of these highly resistant strains.
publishDate 2024
dc.date.none.fl_str_mv 2024-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/266760
Traglia, German Matias; Pasteran, Fernando; Moheb, Samyar; Akhtar, Usman; González, Sebastián; et al.; Insights into Acinetobacter baumannii AMA205’s Unprecedented Antibiotic Resistance; Molecular Diversity Preservation International; International Journal of Molecular Sciences; 25; 21; 10-2024; 1-13
1422-0067
CONICET Digital
CONICET
url http://hdl.handle.net/11336/266760
identifier_str_mv Traglia, German Matias; Pasteran, Fernando; Moheb, Samyar; Akhtar, Usman; González, Sebastián; et al.; Insights into Acinetobacter baumannii AMA205’s Unprecedented Antibiotic Resistance; Molecular Diversity Preservation International; International Journal of Molecular Sciences; 25; 21; 10-2024; 1-13
1422-0067
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/doi/10.3390/ijms252111424
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Molecular Diversity Preservation International
publisher.none.fl_str_mv Molecular Diversity Preservation International
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
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reponame_str CONICET Digital (CONICET)
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repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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