Bioadhesive properties of poly(anhydride) nanoparticles coated with different molecular weights chitosan

Autores
Llabot, Juan Manuel; Hesham, Salman; Millotti, Gioconda; Bernkop Schnürch, Andreas; Allemandi, Daniel Alberto; Manuel Irache, Juan
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim of this study was to develop and characterize the bioadhesive properties of poly(anhydride) nanoparticles coated with two types of low-molecular weight chitosan (CH20 of 20?kDa or CH50 of 50?kDa) or their thiolated conjugates. Nanoparticles were prepared by a solvent displacement method and characterized by measuring the size, zeta potential, morphology and composition. For bioadhesion studies, nanoparticles were fluorescently labelled with rhodamine B isothiocyanate. In all cases, coated nanoparticles showed a slightly higher size and lower negative zeta potential than uncoated nanoparticles. Nanoparticles coated with CH20 showed a higher adhesive capacity than uncoated nanoparticles. On the contrary, when nanoparticles were coated with CH50, the resulting carriers displayed a decreased ability to develop adhesive interactions within the gut. Finally, the coating of nanoparticles with thiolated chitosan improved their adhesive abilities. Poly(anhydride) nanoparticles coated with thiolated chitosan can be considered as promising bioadhesive particulate carriers for oral delivery strategies.
Fil: Llabot, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina
Fil: Hesham, Salman. Universidad de Navarra; España
Fil: Millotti, Gioconda. Universidad de Innsbruck; Austria
Fil: Bernkop Schnürch, Andreas. Universidad de Innsbruck; Austria
Fil: Allemandi, Daniel Alberto. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Manuel Irache, Juan. Universidad de Navarra; España
Materia
BIOADHESION
CHITOSAN
NANOPARTICLES
POLY(ANHYDRIDE)
THIOLATED CHITOSAN
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/193593
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/193593
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Bioadhesive properties of poly(anhydride) nanoparticles coated with different molecular weights chitosanLlabot, Juan ManuelHesham, SalmanMillotti, GiocondaBernkop Schnürch, AndreasAllemandi, Daniel AlbertoManuel Irache, JuanBIOADHESIONCHITOSANNANOPARTICLESPOLY(ANHYDRIDE)THIOLATED CHITOSANhttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2The aim of this study was to develop and characterize the bioadhesive properties of poly(anhydride) nanoparticles coated with two types of low-molecular weight chitosan (CH20 of 20?kDa or CH50 of 50?kDa) or their thiolated conjugates. Nanoparticles were prepared by a solvent displacement method and characterized by measuring the size, zeta potential, morphology and composition. For bioadhesion studies, nanoparticles were fluorescently labelled with rhodamine B isothiocyanate. In all cases, coated nanoparticles showed a slightly higher size and lower negative zeta potential than uncoated nanoparticles. Nanoparticles coated with CH20 showed a higher adhesive capacity than uncoated nanoparticles. On the contrary, when nanoparticles were coated with CH50, the resulting carriers displayed a decreased ability to develop adhesive interactions within the gut. Finally, the coating of nanoparticles with thiolated chitosan improved their adhesive abilities. Poly(anhydride) nanoparticles coated with thiolated chitosan can be considered as promising bioadhesive particulate carriers for oral delivery strategies.Fil: Llabot, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; ArgentinaFil: Hesham, Salman. Universidad de Navarra; EspañaFil: Millotti, Gioconda. Universidad de Innsbruck; AustriaFil: Bernkop Schnürch, Andreas. Universidad de Innsbruck; AustriaFil: Allemandi, Daniel Alberto. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Manuel Irache, Juan. Universidad de Navarra; EspañaTaylor & Francis Ltd2011-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/193593Llabot, Juan Manuel; Hesham, Salman; Millotti, Gioconda; Bernkop Schnürch, Andreas; Allemandi, Daniel Alberto; et al.; Bioadhesive properties of poly(anhydride) nanoparticles coated with different molecular weights chitosan; Taylor & Francis Ltd; Journal Of Microencapsulation; 28; 5; 8-2011; 455-4630265-2048CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.3109/02652048.2011.576787?journalCode=imnc20info:eu-repo/semantics/altIdentifier/doi/10.3109/02652048.2011.576787info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:58:41Zoai:ri.conicet.gov.ar:11336/193593instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:58:41.837CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Bioadhesive properties of poly(anhydride) nanoparticles coated with different molecular weights chitosan
title Bioadhesive properties of poly(anhydride) nanoparticles coated with different molecular weights chitosan
spellingShingle Bioadhesive properties of poly(anhydride) nanoparticles coated with different molecular weights chitosan
Llabot, Juan Manuel
BIOADHESION
CHITOSAN
NANOPARTICLES
POLY(ANHYDRIDE)
THIOLATED CHITOSAN
title_short Bioadhesive properties of poly(anhydride) nanoparticles coated with different molecular weights chitosan
title_full Bioadhesive properties of poly(anhydride) nanoparticles coated with different molecular weights chitosan
title_fullStr Bioadhesive properties of poly(anhydride) nanoparticles coated with different molecular weights chitosan
title_full_unstemmed Bioadhesive properties of poly(anhydride) nanoparticles coated with different molecular weights chitosan
title_sort Bioadhesive properties of poly(anhydride) nanoparticles coated with different molecular weights chitosan
dc.creator.none.fl_str_mv Llabot, Juan Manuel
Hesham, Salman
Millotti, Gioconda
Bernkop Schnürch, Andreas
Allemandi, Daniel Alberto
Manuel Irache, Juan
author Llabot, Juan Manuel
author_facet Llabot, Juan Manuel
Hesham, Salman
Millotti, Gioconda
Bernkop Schnürch, Andreas
Allemandi, Daniel Alberto
Manuel Irache, Juan
author_role author
author2 Hesham, Salman
Millotti, Gioconda
Bernkop Schnürch, Andreas
Allemandi, Daniel Alberto
Manuel Irache, Juan
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv BIOADHESION
CHITOSAN
NANOPARTICLES
POLY(ANHYDRIDE)
THIOLATED CHITOSAN
topic BIOADHESION
CHITOSAN
NANOPARTICLES
POLY(ANHYDRIDE)
THIOLATED CHITOSAN
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv The aim of this study was to develop and characterize the bioadhesive properties of poly(anhydride) nanoparticles coated with two types of low-molecular weight chitosan (CH20 of 20?kDa or CH50 of 50?kDa) or their thiolated conjugates. Nanoparticles were prepared by a solvent displacement method and characterized by measuring the size, zeta potential, morphology and composition. For bioadhesion studies, nanoparticles were fluorescently labelled with rhodamine B isothiocyanate. In all cases, coated nanoparticles showed a slightly higher size and lower negative zeta potential than uncoated nanoparticles. Nanoparticles coated with CH20 showed a higher adhesive capacity than uncoated nanoparticles. On the contrary, when nanoparticles were coated with CH50, the resulting carriers displayed a decreased ability to develop adhesive interactions within the gut. Finally, the coating of nanoparticles with thiolated chitosan improved their adhesive abilities. Poly(anhydride) nanoparticles coated with thiolated chitosan can be considered as promising bioadhesive particulate carriers for oral delivery strategies.
Fil: Llabot, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina
Fil: Hesham, Salman. Universidad de Navarra; España
Fil: Millotti, Gioconda. Universidad de Innsbruck; Austria
Fil: Bernkop Schnürch, Andreas. Universidad de Innsbruck; Austria
Fil: Allemandi, Daniel Alberto. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Manuel Irache, Juan. Universidad de Navarra; España
description The aim of this study was to develop and characterize the bioadhesive properties of poly(anhydride) nanoparticles coated with two types of low-molecular weight chitosan (CH20 of 20?kDa or CH50 of 50?kDa) or their thiolated conjugates. Nanoparticles were prepared by a solvent displacement method and characterized by measuring the size, zeta potential, morphology and composition. For bioadhesion studies, nanoparticles were fluorescently labelled with rhodamine B isothiocyanate. In all cases, coated nanoparticles showed a slightly higher size and lower negative zeta potential than uncoated nanoparticles. Nanoparticles coated with CH20 showed a higher adhesive capacity than uncoated nanoparticles. On the contrary, when nanoparticles were coated with CH50, the resulting carriers displayed a decreased ability to develop adhesive interactions within the gut. Finally, the coating of nanoparticles with thiolated chitosan improved their adhesive abilities. Poly(anhydride) nanoparticles coated with thiolated chitosan can be considered as promising bioadhesive particulate carriers for oral delivery strategies.
publishDate 2011
dc.date.none.fl_str_mv 2011-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/193593
Llabot, Juan Manuel; Hesham, Salman; Millotti, Gioconda; Bernkop Schnürch, Andreas; Allemandi, Daniel Alberto; et al.; Bioadhesive properties of poly(anhydride) nanoparticles coated with different molecular weights chitosan; Taylor & Francis Ltd; Journal Of Microencapsulation; 28; 5; 8-2011; 455-463
0265-2048
CONICET Digital
CONICET
url http://hdl.handle.net/11336/193593
identifier_str_mv Llabot, Juan Manuel; Hesham, Salman; Millotti, Gioconda; Bernkop Schnürch, Andreas; Allemandi, Daniel Alberto; et al.; Bioadhesive properties of poly(anhydride) nanoparticles coated with different molecular weights chitosan; Taylor & Francis Ltd; Journal Of Microencapsulation; 28; 5; 8-2011; 455-463
0265-2048
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.3109/02652048.2011.576787?journalCode=imnc20
info:eu-repo/semantics/altIdentifier/doi/10.3109/02652048.2011.576787
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis Ltd
publisher.none.fl_str_mv Taylor & Francis Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269535688720384
score 13.13397

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