AOT reverse micelles as versatile reaction media for chitosan nanoparticles synthesis

Autores
Orellano, María Soledad; Porporatto, Carina; Silber, Juana J.; Falcone, Ruben Dario; Correa, Nestor Mariano
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
It is known that Chitosan (Ch) can be used in several applications, such as antimicrobial agent or as drug delivery agent. However, being its water dispersibility very low at physiological pH it is necessary to find a way to improve it. One attractive strategy is to synthesize Chitosan Nanoparticles (Ch-NPs). In this work, a versatile method to obtain Ch-NPs with different and controlled sizes, that were successfully prepared by cross-linking reaction of glutaraldehyde and native chitosan inside of n-heptane/sodium 1,4-bis-2-ethylhexylsulfosuccinate (AOT)/water reverse micelles (RMs) is presented. Highly monodisperse NPs were synthesized as confirmed by Dynamic Light Scattering (DLS) and Scanning Electron Microscopy (SEM) techniques. The particle size was dependent on the reactants concentration, cross-linking degree and mainly the amount of water inside of the AOT RMs used as nanoreactors. While the cross-linking is quite difficult to control in bulk water, the reaction inside the RMs is more manageable and efficient.
Fil: Orellano, María Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones y Transferencia de Villa María. Universidad Nacional de Villa María. Centro de Investigaciones y Transferencia de Villa María; Argentina
Fil: Porporatto, Carina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones y Transferencia de Villa María. Universidad Nacional de Villa María. Centro de Investigaciones y Transferencia de Villa María; Argentina
Fil: Silber, Juana J.. Universidad Nacional de Villa María; Argentina
Fil: Falcone, Ruben Dario. Universidad Nacional de Río Cuarto; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Correa, Nestor Mariano. Universidad Nacional de Río Cuarto; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Aot
Chitosan
Glutaraldehyde
Nanoparticles
Reverse Micelles
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/74759
Acceder
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network_name_str CONICET Digital (CONICET)
spelling AOT reverse micelles as versatile reaction media for chitosan nanoparticles synthesisOrellano, María SoledadPorporatto, CarinaSilber, Juana J.Falcone, Ruben DarioCorrea, Nestor MarianoAotChitosanGlutaraldehydeNanoparticlesReverse Micelleshttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1It is known that Chitosan (Ch) can be used in several applications, such as antimicrobial agent or as drug delivery agent. However, being its water dispersibility very low at physiological pH it is necessary to find a way to improve it. One attractive strategy is to synthesize Chitosan Nanoparticles (Ch-NPs). In this work, a versatile method to obtain Ch-NPs with different and controlled sizes, that were successfully prepared by cross-linking reaction of glutaraldehyde and native chitosan inside of n-heptane/sodium 1,4-bis-2-ethylhexylsulfosuccinate (AOT)/water reverse micelles (RMs) is presented. Highly monodisperse NPs were synthesized as confirmed by Dynamic Light Scattering (DLS) and Scanning Electron Microscopy (SEM) techniques. The particle size was dependent on the reactants concentration, cross-linking degree and mainly the amount of water inside of the AOT RMs used as nanoreactors. While the cross-linking is quite difficult to control in bulk water, the reaction inside the RMs is more manageable and efficient.Fil: Orellano, María Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones y Transferencia de Villa María. Universidad Nacional de Villa María. Centro de Investigaciones y Transferencia de Villa María; ArgentinaFil: Porporatto, Carina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones y Transferencia de Villa María. Universidad Nacional de Villa María. Centro de Investigaciones y Transferencia de Villa María; ArgentinaFil: Silber, Juana J.. Universidad Nacional de Villa María; ArgentinaFil: Falcone, Ruben Dario. Universidad Nacional de Río Cuarto; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Correa, Nestor Mariano. Universidad Nacional de Río Cuarto; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier2017-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/74759Orellano, María Soledad; Porporatto, Carina; Silber, Juana J.; Falcone, Ruben Dario; Correa, Nestor Mariano; AOT reverse micelles as versatile reaction media for chitosan nanoparticles synthesis; Elsevier; Carbohydrate Polymers; 171; 9-2017; 85-930144-8617CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.carbpol.2017.04.074info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0144861717304733info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:47:28Zoai:ri.conicet.gov.ar:11336/74759instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:47:29.155CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv AOT reverse micelles as versatile reaction media for chitosan nanoparticles synthesis
title AOT reverse micelles as versatile reaction media for chitosan nanoparticles synthesis
spellingShingle AOT reverse micelles as versatile reaction media for chitosan nanoparticles synthesis
Orellano, María Soledad
Aot
Chitosan
Glutaraldehyde
Nanoparticles
Reverse Micelles
title_short AOT reverse micelles as versatile reaction media for chitosan nanoparticles synthesis
title_full AOT reverse micelles as versatile reaction media for chitosan nanoparticles synthesis
title_fullStr AOT reverse micelles as versatile reaction media for chitosan nanoparticles synthesis
title_full_unstemmed AOT reverse micelles as versatile reaction media for chitosan nanoparticles synthesis
title_sort AOT reverse micelles as versatile reaction media for chitosan nanoparticles synthesis
dc.creator.none.fl_str_mv Orellano, María Soledad
Porporatto, Carina
Silber, Juana J.
Falcone, Ruben Dario
Correa, Nestor Mariano
author Orellano, María Soledad
author_facet Orellano, María Soledad
Porporatto, Carina
Silber, Juana J.
Falcone, Ruben Dario
Correa, Nestor Mariano
author_role author
author2 Porporatto, Carina
Silber, Juana J.
Falcone, Ruben Dario
Correa, Nestor Mariano
author2_role author
author
author
author
dc.subject.none.fl_str_mv Aot
Chitosan
Glutaraldehyde
Nanoparticles
Reverse Micelles
topic Aot
Chitosan
Glutaraldehyde
Nanoparticles
Reverse Micelles
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv It is known that Chitosan (Ch) can be used in several applications, such as antimicrobial agent or as drug delivery agent. However, being its water dispersibility very low at physiological pH it is necessary to find a way to improve it. One attractive strategy is to synthesize Chitosan Nanoparticles (Ch-NPs). In this work, a versatile method to obtain Ch-NPs with different and controlled sizes, that were successfully prepared by cross-linking reaction of glutaraldehyde and native chitosan inside of n-heptane/sodium 1,4-bis-2-ethylhexylsulfosuccinate (AOT)/water reverse micelles (RMs) is presented. Highly monodisperse NPs were synthesized as confirmed by Dynamic Light Scattering (DLS) and Scanning Electron Microscopy (SEM) techniques. The particle size was dependent on the reactants concentration, cross-linking degree and mainly the amount of water inside of the AOT RMs used as nanoreactors. While the cross-linking is quite difficult to control in bulk water, the reaction inside the RMs is more manageable and efficient.
Fil: Orellano, María Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones y Transferencia de Villa María. Universidad Nacional de Villa María. Centro de Investigaciones y Transferencia de Villa María; Argentina
Fil: Porporatto, Carina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones y Transferencia de Villa María. Universidad Nacional de Villa María. Centro de Investigaciones y Transferencia de Villa María; Argentina
Fil: Silber, Juana J.. Universidad Nacional de Villa María; Argentina
Fil: Falcone, Ruben Dario. Universidad Nacional de Río Cuarto; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Correa, Nestor Mariano. Universidad Nacional de Río Cuarto; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description It is known that Chitosan (Ch) can be used in several applications, such as antimicrobial agent or as drug delivery agent. However, being its water dispersibility very low at physiological pH it is necessary to find a way to improve it. One attractive strategy is to synthesize Chitosan Nanoparticles (Ch-NPs). In this work, a versatile method to obtain Ch-NPs with different and controlled sizes, that were successfully prepared by cross-linking reaction of glutaraldehyde and native chitosan inside of n-heptane/sodium 1,4-bis-2-ethylhexylsulfosuccinate (AOT)/water reverse micelles (RMs) is presented. Highly monodisperse NPs were synthesized as confirmed by Dynamic Light Scattering (DLS) and Scanning Electron Microscopy (SEM) techniques. The particle size was dependent on the reactants concentration, cross-linking degree and mainly the amount of water inside of the AOT RMs used as nanoreactors. While the cross-linking is quite difficult to control in bulk water, the reaction inside the RMs is more manageable and efficient.
publishDate 2017
dc.date.none.fl_str_mv 2017-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/74759
Orellano, María Soledad; Porporatto, Carina; Silber, Juana J.; Falcone, Ruben Dario; Correa, Nestor Mariano; AOT reverse micelles as versatile reaction media for chitosan nanoparticles synthesis; Elsevier; Carbohydrate Polymers; 171; 9-2017; 85-93
0144-8617
CONICET Digital
CONICET
url http://hdl.handle.net/11336/74759
identifier_str_mv Orellano, María Soledad; Porporatto, Carina; Silber, Juana J.; Falcone, Ruben Dario; Correa, Nestor Mariano; AOT reverse micelles as versatile reaction media for chitosan nanoparticles synthesis; Elsevier; Carbohydrate Polymers; 171; 9-2017; 85-93
0144-8617
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.carbpol.2017.04.074
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0144861717304733
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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