Plasma and tissue clindamycin antimicrobial activity after parenteral administration to cats under surgical conditions
- Autores
- Passini, Sabrina Mariela; Montoya, L.; Lupi, Martin Pablo; Lorenzini, Paula Mercedes; Landoni, María Fabiana; Albarellos, G. A.
- Año de publicación
- 2017
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Clindamycin plasma and tissue disposition in cats under surgical conditions after a single intravenous (IV), intramuscular (IM) and subcutaneous (SC) administration at a dose rate of 10 mg/kg were studied. After intravenous, intramuscular and subcutaneous administration, peak plasma concentrations were 10.93±3.78 μg/mL (Cp(0)), 5.93±1.18 μg/mL (Cmax)) and 6.30±0.88 μg/mL (Cmax)), respectively. Eight hours after clindamycin IV, IM and SC administration plasma concentrations declined to 2.01±0.61 μg/mL, 2.96±0.43 μg/mL and 3.36±0.97 μg/mL, respectively. Sixty to 90 minutes after clindamycin administration, tissue concentrations ranged from a minimum in subcutaneous tissue of 4.90 μg/g (IV), 3.06 μg/g (IM) and, 3.13 μg/g (SC) to a maximum in uterus of 13.41 μg/g (IV), 14.07 μg/g (IM) and, 14.44 μg/g (SC). The lowest tissue/plasma concentration ratio for the three administration routes was observed in subcutaneous tissue, while the highest was observed at genital level (ovary for IV and IM and uterus for SC). Estimated efficacy predictor (AUC/MIC), considering MIC breakpoint for bacteria isolated from animals, indicates that clindamycin administered IV, IM or SC at the studied dose is appropriated for perioperative prophylactic protocols and that given with a dose interval of 12 hours would be effective for susceptible infection treatment in cats.
Facultad de Ciencias Veterinarias - Materia
-
Ciencias Veterinarias
Antimicrobials
Clindamycin
Plasma concentrations
Tissue concentrations
Cats - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by-nc/4.0/
- Repositorio
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/128043
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Plasma and tissue clindamycin antimicrobial activity after parenteral administration to cats under surgical conditionsPassini, Sabrina MarielaMontoya, L.Lupi, Martin PabloLorenzini, Paula MercedesLandoni, María FabianaAlbarellos, G. A.Ciencias VeterinariasAntimicrobialsClindamycinPlasma concentrationsTissue concentrationsCatsClindamycin plasma and tissue disposition in cats under surgical conditions after a single intravenous (IV), intramuscular (IM) and subcutaneous (SC) administration at a dose rate of 10 mg/kg were studied. After intravenous, intramuscular and subcutaneous administration, peak plasma concentrations were 10.93±3.78 μg/mL (Cp(0)), 5.93±1.18 μg/mL (Cmax)) and 6.30±0.88 μg/mL (Cmax)), respectively. Eight hours after clindamycin IV, IM and SC administration plasma concentrations declined to 2.01±0.61 μg/mL, 2.96±0.43 μg/mL and 3.36±0.97 μg/mL, respectively. Sixty to 90 minutes after clindamycin administration, tissue concentrations ranged from a minimum in subcutaneous tissue of 4.90 μg/g (IV), 3.06 μg/g (IM) and, 3.13 μg/g (SC) to a maximum in uterus of 13.41 μg/g (IV), 14.07 μg/g (IM) and, 14.44 μg/g (SC). The lowest tissue/plasma concentration ratio for the three administration routes was observed in subcutaneous tissue, while the highest was observed at genital level (ovary for IV and IM and uterus for SC). Estimated efficacy predictor (AUC/MIC), considering MIC breakpoint for bacteria isolated from animals, indicates that clindamycin administered IV, IM or SC at the studied dose is appropriated for perioperative prophylactic protocols and that given with a dose interval of 12 hours would be effective for susceptible infection treatment in cats.Facultad de Ciencias Veterinarias2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf40-43http://sedici.unlp.edu.ar/handle/10915/128043enginfo:eu-repo/semantics/altIdentifier/issn/2038-9698info:eu-repo/semantics/altIdentifier/issn/2038-9701info:eu-repo/semantics/altIdentifier/doi/10.4081/vsd.2017.6341info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc/4.0/Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-03T11:03:13Zoai:sedici.unlp.edu.ar:10915/128043Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-03 11:03:13.499SEDICI (UNLP) - Universidad Nacional de La Platafalse |
dc.title.none.fl_str_mv |
Plasma and tissue clindamycin antimicrobial activity after parenteral administration to cats under surgical conditions |
title |
Plasma and tissue clindamycin antimicrobial activity after parenteral administration to cats under surgical conditions |
spellingShingle |
Plasma and tissue clindamycin antimicrobial activity after parenteral administration to cats under surgical conditions Passini, Sabrina Mariela Ciencias Veterinarias Antimicrobials Clindamycin Plasma concentrations Tissue concentrations Cats |
title_short |
Plasma and tissue clindamycin antimicrobial activity after parenteral administration to cats under surgical conditions |
title_full |
Plasma and tissue clindamycin antimicrobial activity after parenteral administration to cats under surgical conditions |
title_fullStr |
Plasma and tissue clindamycin antimicrobial activity after parenteral administration to cats under surgical conditions |
title_full_unstemmed |
Plasma and tissue clindamycin antimicrobial activity after parenteral administration to cats under surgical conditions |
title_sort |
Plasma and tissue clindamycin antimicrobial activity after parenteral administration to cats under surgical conditions |
dc.creator.none.fl_str_mv |
Passini, Sabrina Mariela Montoya, L. Lupi, Martin Pablo Lorenzini, Paula Mercedes Landoni, María Fabiana Albarellos, G. A. |
author |
Passini, Sabrina Mariela |
author_facet |
Passini, Sabrina Mariela Montoya, L. Lupi, Martin Pablo Lorenzini, Paula Mercedes Landoni, María Fabiana Albarellos, G. A. |
author_role |
author |
author2 |
Montoya, L. Lupi, Martin Pablo Lorenzini, Paula Mercedes Landoni, María Fabiana Albarellos, G. A. |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
Ciencias Veterinarias Antimicrobials Clindamycin Plasma concentrations Tissue concentrations Cats |
topic |
Ciencias Veterinarias Antimicrobials Clindamycin Plasma concentrations Tissue concentrations Cats |
dc.description.none.fl_txt_mv |
Clindamycin plasma and tissue disposition in cats under surgical conditions after a single intravenous (IV), intramuscular (IM) and subcutaneous (SC) administration at a dose rate of 10 mg/kg were studied. After intravenous, intramuscular and subcutaneous administration, peak plasma concentrations were 10.93±3.78 μg/mL (Cp(0)), 5.93±1.18 μg/mL (Cmax)) and 6.30±0.88 μg/mL (Cmax)), respectively. Eight hours after clindamycin IV, IM and SC administration plasma concentrations declined to 2.01±0.61 μg/mL, 2.96±0.43 μg/mL and 3.36±0.97 μg/mL, respectively. Sixty to 90 minutes after clindamycin administration, tissue concentrations ranged from a minimum in subcutaneous tissue of 4.90 μg/g (IV), 3.06 μg/g (IM) and, 3.13 μg/g (SC) to a maximum in uterus of 13.41 μg/g (IV), 14.07 μg/g (IM) and, 14.44 μg/g (SC). The lowest tissue/plasma concentration ratio for the three administration routes was observed in subcutaneous tissue, while the highest was observed at genital level (ovary for IV and IM and uterus for SC). Estimated efficacy predictor (AUC/MIC), considering MIC breakpoint for bacteria isolated from animals, indicates that clindamycin administered IV, IM or SC at the studied dose is appropriated for perioperative prophylactic protocols and that given with a dose interval of 12 hours would be effective for susceptible infection treatment in cats. Facultad de Ciencias Veterinarias |
description |
Clindamycin plasma and tissue disposition in cats under surgical conditions after a single intravenous (IV), intramuscular (IM) and subcutaneous (SC) administration at a dose rate of 10 mg/kg were studied. After intravenous, intramuscular and subcutaneous administration, peak plasma concentrations were 10.93±3.78 μg/mL (Cp(0)), 5.93±1.18 μg/mL (Cmax)) and 6.30±0.88 μg/mL (Cmax)), respectively. Eight hours after clindamycin IV, IM and SC administration plasma concentrations declined to 2.01±0.61 μg/mL, 2.96±0.43 μg/mL and 3.36±0.97 μg/mL, respectively. Sixty to 90 minutes after clindamycin administration, tissue concentrations ranged from a minimum in subcutaneous tissue of 4.90 μg/g (IV), 3.06 μg/g (IM) and, 3.13 μg/g (SC) to a maximum in uterus of 13.41 μg/g (IV), 14.07 μg/g (IM) and, 14.44 μg/g (SC). The lowest tissue/plasma concentration ratio for the three administration routes was observed in subcutaneous tissue, while the highest was observed at genital level (ovary for IV and IM and uterus for SC). Estimated efficacy predictor (AUC/MIC), considering MIC breakpoint for bacteria isolated from animals, indicates that clindamycin administered IV, IM or SC at the studied dose is appropriated for perioperative prophylactic protocols and that given with a dose interval of 12 hours would be effective for susceptible infection treatment in cats. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Articulo http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://sedici.unlp.edu.ar/handle/10915/128043 |
url |
http://sedici.unlp.edu.ar/handle/10915/128043 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/issn/2038-9698 info:eu-repo/semantics/altIdentifier/issn/2038-9701 info:eu-repo/semantics/altIdentifier/doi/10.4081/vsd.2017.6341 |
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info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) |
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openAccess |
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http://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) |
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