Plasma and tissue clindamycin antimicrobial activity after parenteral administration to cats under surgical conditions

Autores
Passini, Sabrina Mariela; Montoya, L.; Lupi, Martin Pablo; Lorenzini, Paula Mercedes; Landoni, María Fabiana; Albarellos, G. A.
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Clindamycin plasma and tissue disposition in cats under surgical conditions after a single intravenous (IV), intramuscular (IM) and subcutaneous (SC) administration at a dose rate of 10 mg/kg were studied. After intravenous, intramuscular and subcutaneous administration, peak plasma concentrations were 10.93±3.78 μg/mL (Cp(0)), 5.93±1.18 μg/mL (Cmax)) and 6.30±0.88 μg/mL (Cmax)), respectively. Eight hours after clindamycin IV, IM and SC administration plasma concentrations declined to 2.01±0.61 μg/mL, 2.96±0.43 μg/mL and 3.36±0.97 μg/mL, respectively. Sixty to 90 minutes after clindamycin administration, tissue concentrations ranged from a minimum in subcutaneous tissue of 4.90 μg/g (IV), 3.06 μg/g (IM) and, 3.13 μg/g (SC) to a maximum in uterus of 13.41 μg/g (IV), 14.07 μg/g (IM) and, 14.44 μg/g (SC). The lowest tissue/plasma concentration ratio for the three administration routes was observed in subcutaneous tissue, while the highest was observed at genital level (ovary for IV and IM and uterus for SC). Estimated efficacy predictor (AUC/MIC), considering MIC breakpoint for bacteria isolated from animals, indicates that clindamycin administered IV, IM or SC at the studied dose is appropriated for perioperative prophylactic protocols and that given with a dose interval of 12 hours would be effective for susceptible infection treatment in cats.
Facultad de Ciencias Veterinarias
Materia
Ciencias Veterinarias
Antimicrobials
Clindamycin
Plasma concentrations
Tissue concentrations
Cats
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/128043

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spelling Plasma and tissue clindamycin antimicrobial activity after parenteral administration to cats under surgical conditionsPassini, Sabrina MarielaMontoya, L.Lupi, Martin PabloLorenzini, Paula MercedesLandoni, María FabianaAlbarellos, G. A.Ciencias VeterinariasAntimicrobialsClindamycinPlasma concentrationsTissue concentrationsCatsClindamycin plasma and tissue disposition in cats under surgical conditions after a single intravenous (IV), intramuscular (IM) and subcutaneous (SC) administration at a dose rate of 10 mg/kg were studied. After intravenous, intramuscular and subcutaneous administration, peak plasma concentrations were 10.93±3.78 μg/mL (Cp(0)), 5.93±1.18 μg/mL (Cmax)) and 6.30±0.88 μg/mL (Cmax)), respectively. Eight hours after clindamycin IV, IM and SC administration plasma concentrations declined to 2.01±0.61 μg/mL, 2.96±0.43 μg/mL and 3.36±0.97 μg/mL, respectively. Sixty to 90 minutes after clindamycin administration, tissue concentrations ranged from a minimum in subcutaneous tissue of 4.90 μg/g (IV), 3.06 μg/g (IM) and, 3.13 μg/g (SC) to a maximum in uterus of 13.41 μg/g (IV), 14.07 μg/g (IM) and, 14.44 μg/g (SC). The lowest tissue/plasma concentration ratio for the three administration routes was observed in subcutaneous tissue, while the highest was observed at genital level (ovary for IV and IM and uterus for SC). Estimated efficacy predictor (AUC/MIC), considering MIC breakpoint for bacteria isolated from animals, indicates that clindamycin administered IV, IM or SC at the studied dose is appropriated for perioperative prophylactic protocols and that given with a dose interval of 12 hours would be effective for susceptible infection treatment in cats.Facultad de Ciencias Veterinarias2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf40-43http://sedici.unlp.edu.ar/handle/10915/128043enginfo:eu-repo/semantics/altIdentifier/issn/2038-9698info:eu-repo/semantics/altIdentifier/issn/2038-9701info:eu-repo/semantics/altIdentifier/doi/10.4081/vsd.2017.6341info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc/4.0/Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-03T11:03:13Zoai:sedici.unlp.edu.ar:10915/128043Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-03 11:03:13.499SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Plasma and tissue clindamycin antimicrobial activity after parenteral administration to cats under surgical conditions
title Plasma and tissue clindamycin antimicrobial activity after parenteral administration to cats under surgical conditions
spellingShingle Plasma and tissue clindamycin antimicrobial activity after parenteral administration to cats under surgical conditions
Passini, Sabrina Mariela
Ciencias Veterinarias
Antimicrobials
Clindamycin
Plasma concentrations
Tissue concentrations
Cats
title_short Plasma and tissue clindamycin antimicrobial activity after parenteral administration to cats under surgical conditions
title_full Plasma and tissue clindamycin antimicrobial activity after parenteral administration to cats under surgical conditions
title_fullStr Plasma and tissue clindamycin antimicrobial activity after parenteral administration to cats under surgical conditions
title_full_unstemmed Plasma and tissue clindamycin antimicrobial activity after parenteral administration to cats under surgical conditions
title_sort Plasma and tissue clindamycin antimicrobial activity after parenteral administration to cats under surgical conditions
dc.creator.none.fl_str_mv Passini, Sabrina Mariela
Montoya, L.
Lupi, Martin Pablo
Lorenzini, Paula Mercedes
Landoni, María Fabiana
Albarellos, G. A.
author Passini, Sabrina Mariela
author_facet Passini, Sabrina Mariela
Montoya, L.
Lupi, Martin Pablo
Lorenzini, Paula Mercedes
Landoni, María Fabiana
Albarellos, G. A.
author_role author
author2 Montoya, L.
Lupi, Martin Pablo
Lorenzini, Paula Mercedes
Landoni, María Fabiana
Albarellos, G. A.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Ciencias Veterinarias
Antimicrobials
Clindamycin
Plasma concentrations
Tissue concentrations
Cats
topic Ciencias Veterinarias
Antimicrobials
Clindamycin
Plasma concentrations
Tissue concentrations
Cats
dc.description.none.fl_txt_mv Clindamycin plasma and tissue disposition in cats under surgical conditions after a single intravenous (IV), intramuscular (IM) and subcutaneous (SC) administration at a dose rate of 10 mg/kg were studied. After intravenous, intramuscular and subcutaneous administration, peak plasma concentrations were 10.93±3.78 μg/mL (Cp(0)), 5.93±1.18 μg/mL (Cmax)) and 6.30±0.88 μg/mL (Cmax)), respectively. Eight hours after clindamycin IV, IM and SC administration plasma concentrations declined to 2.01±0.61 μg/mL, 2.96±0.43 μg/mL and 3.36±0.97 μg/mL, respectively. Sixty to 90 minutes after clindamycin administration, tissue concentrations ranged from a minimum in subcutaneous tissue of 4.90 μg/g (IV), 3.06 μg/g (IM) and, 3.13 μg/g (SC) to a maximum in uterus of 13.41 μg/g (IV), 14.07 μg/g (IM) and, 14.44 μg/g (SC). The lowest tissue/plasma concentration ratio for the three administration routes was observed in subcutaneous tissue, while the highest was observed at genital level (ovary for IV and IM and uterus for SC). Estimated efficacy predictor (AUC/MIC), considering MIC breakpoint for bacteria isolated from animals, indicates that clindamycin administered IV, IM or SC at the studied dose is appropriated for perioperative prophylactic protocols and that given with a dose interval of 12 hours would be effective for susceptible infection treatment in cats.
Facultad de Ciencias Veterinarias
description Clindamycin plasma and tissue disposition in cats under surgical conditions after a single intravenous (IV), intramuscular (IM) and subcutaneous (SC) administration at a dose rate of 10 mg/kg were studied. After intravenous, intramuscular and subcutaneous administration, peak plasma concentrations were 10.93±3.78 μg/mL (Cp(0)), 5.93±1.18 μg/mL (Cmax)) and 6.30±0.88 μg/mL (Cmax)), respectively. Eight hours after clindamycin IV, IM and SC administration plasma concentrations declined to 2.01±0.61 μg/mL, 2.96±0.43 μg/mL and 3.36±0.97 μg/mL, respectively. Sixty to 90 minutes after clindamycin administration, tissue concentrations ranged from a minimum in subcutaneous tissue of 4.90 μg/g (IV), 3.06 μg/g (IM) and, 3.13 μg/g (SC) to a maximum in uterus of 13.41 μg/g (IV), 14.07 μg/g (IM) and, 14.44 μg/g (SC). The lowest tissue/plasma concentration ratio for the three administration routes was observed in subcutaneous tissue, while the highest was observed at genital level (ovary for IV and IM and uterus for SC). Estimated efficacy predictor (AUC/MIC), considering MIC breakpoint for bacteria isolated from animals, indicates that clindamycin administered IV, IM or SC at the studied dose is appropriated for perioperative prophylactic protocols and that given with a dose interval of 12 hours would be effective for susceptible infection treatment in cats.
publishDate 2017
dc.date.none.fl_str_mv 2017
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info:eu-repo/semantics/publishedVersion
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dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/issn/2038-9701
info:eu-repo/semantics/altIdentifier/doi/10.4081/vsd.2017.6341
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc/4.0/
Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc/4.0/
Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
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