Plasma and tissue clindamycin antimicrobial activity after parenteral administration to cats under surgical conditions
- Autores
- Passini, Sabrina Mariela; Montoya, Laura; Lupi, Martin Pablo; Lorenzini, Paula Mercedes; Landoni, Maria Fabiana; Albarellos, Gabriela Alejandra
- Año de publicación
- 2017
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Clindamycin plasma and tissue disposition in cats under surgical conditions after a single intravenous (IV), intramuscular (IM) and subcutaneous (SC) administration at a dose rate of 10 mg/kg were studied. After intravenous, intramuscular and subcutaneous administration, peak plasma concentrations were 10.93±3.78 μg/mL (Cp(0)), 5.93±1.18 μg/mL (Cmax)) and 6.30±0.88 μg/mL (Cmax)), respectively. Eight hours after clindamycin IV, IM and SC administration plasma concentrations declined to 2.01±0.61 μg/mL, 2.96±0.43 μg/mL and 3.36±0.97 μg/mL, respectively. Sixty to 90 minutes after clindamycin administration, tissue concentrations ranged from a minimum in subcutaneous tissue of 4.90 μg/g (IV), 3.06 μg/g (IM) and, 3.13 μg/g (SC) to a maximum in uterus of 13.41 μg/g (IV), 14.07 μg/g (IM) and, 14.44 μg/g (SC). The lowest tissue/plasma concentration ratio for the three administration routes was observed in subcutaneous tissue, while the highest was observed at genital level (ovary for IV and IM and uterus for SC). Estimated efficacy predictor (AUC/MIC), considering MIC breakpoint for bacteria isolated from animals, indicates that clindamycin administered IV, IM or SC at the studied dose is appropriated for perioperative prophylactic protocols and that given with a dose interval of 12 hours would be effective for susceptible infection treatment in cats.
Fil: Passini, Sabrina Mariela. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Área de Farmacología; Argentina
Fil: Montoya, Laura. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Área de Farmacología; Argentina
Fil: Lupi, Martin Pablo. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Área de Farmacología; Argentina
Fil: Lorenzini, Paula Mercedes. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Área de Farmacología; Argentina
Fil: Landoni, Maria Fabiana. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Área de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Albarellos, Gabriela Alejandra. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Área de Farmacología; Argentina - Materia
-
CLINDAMYCIN
PHARMACOKINETICS
CAT
ANTIMICROBIALS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/56360
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Plasma and tissue clindamycin antimicrobial activity after parenteral administration to cats under surgical conditionsPassini, Sabrina MarielaMontoya, LauraLupi, Martin PabloLorenzini, Paula MercedesLandoni, Maria FabianaAlbarellos, Gabriela AlejandraCLINDAMYCINPHARMACOKINETICSCATANTIMICROBIALShttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Clindamycin plasma and tissue disposition in cats under surgical conditions after a single intravenous (IV), intramuscular (IM) and subcutaneous (SC) administration at a dose rate of 10 mg/kg were studied. After intravenous, intramuscular and subcutaneous administration, peak plasma concentrations were 10.93±3.78 μg/mL (Cp(0)), 5.93±1.18 μg/mL (Cmax)) and 6.30±0.88 μg/mL (Cmax)), respectively. Eight hours after clindamycin IV, IM and SC administration plasma concentrations declined to 2.01±0.61 μg/mL, 2.96±0.43 μg/mL and 3.36±0.97 μg/mL, respectively. Sixty to 90 minutes after clindamycin administration, tissue concentrations ranged from a minimum in subcutaneous tissue of 4.90 μg/g (IV), 3.06 μg/g (IM) and, 3.13 μg/g (SC) to a maximum in uterus of 13.41 μg/g (IV), 14.07 μg/g (IM) and, 14.44 μg/g (SC). The lowest tissue/plasma concentration ratio for the three administration routes was observed in subcutaneous tissue, while the highest was observed at genital level (ovary for IV and IM and uterus for SC). Estimated efficacy predictor (AUC/MIC), considering MIC breakpoint for bacteria isolated from animals, indicates that clindamycin administered IV, IM or SC at the studied dose is appropriated for perioperative prophylactic protocols and that given with a dose interval of 12 hours would be effective for susceptible infection treatment in cats.Fil: Passini, Sabrina Mariela. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Área de Farmacología; ArgentinaFil: Montoya, Laura. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Área de Farmacología; ArgentinaFil: Lupi, Martin Pablo. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Área de Farmacología; ArgentinaFil: Lorenzini, Paula Mercedes. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Área de Farmacología; ArgentinaFil: Landoni, Maria Fabiana. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Área de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Albarellos, Gabriela Alejandra. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Área de Farmacología; ArgentinaPagePress2017-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/56360Passini, Sabrina Mariela; Montoya, Laura; Lupi, Martin Pablo; Lorenzini, Paula Mercedes; Landoni, Maria Fabiana; et al.; Plasma and tissue clindamycin antimicrobial activity after parenteral administration to cats under surgical conditions; PagePress; Veterinary Science Development; 7; 1; 1-2017; 6341-63452038-9701CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.4081/vsd.2017.6341info:eu-repo/semantics/altIdentifier/url/https://www.pagepress.org/journals/index.php/vsd/article/view/6341info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:04:39Zoai:ri.conicet.gov.ar:11336/56360instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:04:40.099CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Plasma and tissue clindamycin antimicrobial activity after parenteral administration to cats under surgical conditions |
title |
Plasma and tissue clindamycin antimicrobial activity after parenteral administration to cats under surgical conditions |
spellingShingle |
Plasma and tissue clindamycin antimicrobial activity after parenteral administration to cats under surgical conditions Passini, Sabrina Mariela CLINDAMYCIN PHARMACOKINETICS CAT ANTIMICROBIALS |
title_short |
Plasma and tissue clindamycin antimicrobial activity after parenteral administration to cats under surgical conditions |
title_full |
Plasma and tissue clindamycin antimicrobial activity after parenteral administration to cats under surgical conditions |
title_fullStr |
Plasma and tissue clindamycin antimicrobial activity after parenteral administration to cats under surgical conditions |
title_full_unstemmed |
Plasma and tissue clindamycin antimicrobial activity after parenteral administration to cats under surgical conditions |
title_sort |
Plasma and tissue clindamycin antimicrobial activity after parenteral administration to cats under surgical conditions |
dc.creator.none.fl_str_mv |
Passini, Sabrina Mariela Montoya, Laura Lupi, Martin Pablo Lorenzini, Paula Mercedes Landoni, Maria Fabiana Albarellos, Gabriela Alejandra |
author |
Passini, Sabrina Mariela |
author_facet |
Passini, Sabrina Mariela Montoya, Laura Lupi, Martin Pablo Lorenzini, Paula Mercedes Landoni, Maria Fabiana Albarellos, Gabriela Alejandra |
author_role |
author |
author2 |
Montoya, Laura Lupi, Martin Pablo Lorenzini, Paula Mercedes Landoni, Maria Fabiana Albarellos, Gabriela Alejandra |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
CLINDAMYCIN PHARMACOKINETICS CAT ANTIMICROBIALS |
topic |
CLINDAMYCIN PHARMACOKINETICS CAT ANTIMICROBIALS |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/4.3 https://purl.org/becyt/ford/4 |
dc.description.none.fl_txt_mv |
Clindamycin plasma and tissue disposition in cats under surgical conditions after a single intravenous (IV), intramuscular (IM) and subcutaneous (SC) administration at a dose rate of 10 mg/kg were studied. After intravenous, intramuscular and subcutaneous administration, peak plasma concentrations were 10.93±3.78 μg/mL (Cp(0)), 5.93±1.18 μg/mL (Cmax)) and 6.30±0.88 μg/mL (Cmax)), respectively. Eight hours after clindamycin IV, IM and SC administration plasma concentrations declined to 2.01±0.61 μg/mL, 2.96±0.43 μg/mL and 3.36±0.97 μg/mL, respectively. Sixty to 90 minutes after clindamycin administration, tissue concentrations ranged from a minimum in subcutaneous tissue of 4.90 μg/g (IV), 3.06 μg/g (IM) and, 3.13 μg/g (SC) to a maximum in uterus of 13.41 μg/g (IV), 14.07 μg/g (IM) and, 14.44 μg/g (SC). The lowest tissue/plasma concentration ratio for the three administration routes was observed in subcutaneous tissue, while the highest was observed at genital level (ovary for IV and IM and uterus for SC). Estimated efficacy predictor (AUC/MIC), considering MIC breakpoint for bacteria isolated from animals, indicates that clindamycin administered IV, IM or SC at the studied dose is appropriated for perioperative prophylactic protocols and that given with a dose interval of 12 hours would be effective for susceptible infection treatment in cats. Fil: Passini, Sabrina Mariela. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Área de Farmacología; Argentina Fil: Montoya, Laura. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Área de Farmacología; Argentina Fil: Lupi, Martin Pablo. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Área de Farmacología; Argentina Fil: Lorenzini, Paula Mercedes. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Área de Farmacología; Argentina Fil: Landoni, Maria Fabiana. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Área de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Albarellos, Gabriela Alejandra. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Área de Farmacología; Argentina |
description |
Clindamycin plasma and tissue disposition in cats under surgical conditions after a single intravenous (IV), intramuscular (IM) and subcutaneous (SC) administration at a dose rate of 10 mg/kg were studied. After intravenous, intramuscular and subcutaneous administration, peak plasma concentrations were 10.93±3.78 μg/mL (Cp(0)), 5.93±1.18 μg/mL (Cmax)) and 6.30±0.88 μg/mL (Cmax)), respectively. Eight hours after clindamycin IV, IM and SC administration plasma concentrations declined to 2.01±0.61 μg/mL, 2.96±0.43 μg/mL and 3.36±0.97 μg/mL, respectively. Sixty to 90 minutes after clindamycin administration, tissue concentrations ranged from a minimum in subcutaneous tissue of 4.90 μg/g (IV), 3.06 μg/g (IM) and, 3.13 μg/g (SC) to a maximum in uterus of 13.41 μg/g (IV), 14.07 μg/g (IM) and, 14.44 μg/g (SC). The lowest tissue/plasma concentration ratio for the three administration routes was observed in subcutaneous tissue, while the highest was observed at genital level (ovary for IV and IM and uterus for SC). Estimated efficacy predictor (AUC/MIC), considering MIC breakpoint for bacteria isolated from animals, indicates that clindamycin administered IV, IM or SC at the studied dose is appropriated for perioperative prophylactic protocols and that given with a dose interval of 12 hours would be effective for susceptible infection treatment in cats. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-01 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/56360 Passini, Sabrina Mariela; Montoya, Laura; Lupi, Martin Pablo; Lorenzini, Paula Mercedes; Landoni, Maria Fabiana; et al.; Plasma and tissue clindamycin antimicrobial activity after parenteral administration to cats under surgical conditions; PagePress; Veterinary Science Development; 7; 1; 1-2017; 6341-6345 2038-9701 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/56360 |
identifier_str_mv |
Passini, Sabrina Mariela; Montoya, Laura; Lupi, Martin Pablo; Lorenzini, Paula Mercedes; Landoni, Maria Fabiana; et al.; Plasma and tissue clindamycin antimicrobial activity after parenteral administration to cats under surgical conditions; PagePress; Veterinary Science Development; 7; 1; 1-2017; 6341-6345 2038-9701 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.4081/vsd.2017.6341 info:eu-repo/semantics/altIdentifier/url/https://www.pagepress.org/journals/index.php/vsd/article/view/6341 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
PagePress |
publisher.none.fl_str_mv |
PagePress |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.13397 |