Plasma pharmacokinetics, tissue concentrations and urine elimination after cephalothin intravenous administration to cats under surgical conditions

Autores
Albarellos, Gabriela A.; Montoya, Laura; Lupi, Martín P.; Passini, Sabrina M.; Lorenzini, Paula; Landoni, María Fabiana
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Pharmacokinetic profile, tissue concentrations and urine elimination of cephalothin in cats under surgical conditions after a single intravenous dose (30 mg/kg) were studied. Initial plasma concentrations were high [Cp(0), 353.79±118.92 μg/mL], with fast and moderately wide distribution [T1⁄2(d) 0.14±0.10 h] [V(d(ss)) 0.19±0.03 L/kg] and rapid elimination (ClB, 0.16±0.03 L/h.kg; T1⁄2, 1.07±0.23 h; MRT, 1.16±0.21 h). Thirty to 60 minutes after intravenous administration, cephalothin tissue concentrations were in the range of 3.73 μg/g (testicle tissue) to 25.63 μg/g (uterus). Tissue/plasma concentrations rate was in a range of 0.04 (testicle) to 0.21 (uterus). Cephalothin urine elimination was 66.49% in the first 6 hours after administration. Cephalothin plasma concentrations remained above a MIC≥1 μg/mL up to 5.5 hours in all the studied cats. However, for MIC≥8 –μg/mL (MIC breakpoint) this time is reduced to 2.5 hours. This suggests that proper perioperative prophylactic use of cephalothin in cats requires a dose interval not longer than 2 hours.
Facultad de Ciencias Veterinarias
Materia
Ciencias Veterinarias
Antimicrobials
Cephalosporins
Pharmacokinetics
Tissue concentrations
Cats
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/120562
Acceder
id SEDICI_4dd0ee8e9a7e7d81a56dc4c5f9bbb427
oai_identifier_str oai:sedici.unlp.edu.ar:10915/120562
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Plasma pharmacokinetics, tissue concentrations and urine elimination after cephalothin intravenous administration to cats under surgical conditionsAlbarellos, Gabriela A.Montoya, LauraLupi, Martín P.Passini, Sabrina M.Lorenzini, PaulaLandoni, María FabianaCiencias VeterinariasAntimicrobialsCephalosporinsPharmacokineticsTissue concentrationsCatsPharmacokinetic profile, tissue concentrations and urine elimination of cephalothin in cats under surgical conditions after a single intravenous dose (30 mg/kg) were studied. Initial plasma concentrations were high [Cp(0), 353.79±118.92 μg/mL], with fast and moderately wide distribution [T1⁄2(d) 0.14±0.10 h] [V(d(ss)) 0.19±0.03 L/kg] and rapid elimination (ClB, 0.16±0.03 L/h.kg; T1⁄2, 1.07±0.23 h; MRT, 1.16±0.21 h). Thirty to 60 minutes after intravenous administration, cephalothin tissue concentrations were in the range of 3.73 μg/g (testicle tissue) to 25.63 μg/g (uterus). Tissue/plasma concentrations rate was in a range of 0.04 (testicle) to 0.21 (uterus). Cephalothin urine elimination was 66.49% in the first 6 hours after administration. Cephalothin plasma concentrations remained above a MIC≥1 μg/mL up to 5.5 hours in all the studied cats. However, for MIC≥8 –μg/mL (MIC breakpoint) this time is reduced to 2.5 hours. This suggests that proper perioperative prophylactic use of cephalothin in cats requires a dose interval not longer than 2 hours.Facultad de Ciencias Veterinarias2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf37-40http://sedici.unlp.edu.ar/handle/10915/120562enginfo:eu-repo/semantics/altIdentifier/issn/2038-9701info:eu-repo/semantics/altIdentifier/doi/10.4081/vsd.2015.5742info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc/4.0/Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-03T11:00:38Zoai:sedici.unlp.edu.ar:10915/120562Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-03 11:00:38.52SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Plasma pharmacokinetics, tissue concentrations and urine elimination after cephalothin intravenous administration to cats under surgical conditions
title Plasma pharmacokinetics, tissue concentrations and urine elimination after cephalothin intravenous administration to cats under surgical conditions
spellingShingle Plasma pharmacokinetics, tissue concentrations and urine elimination after cephalothin intravenous administration to cats under surgical conditions
Albarellos, Gabriela A.
Ciencias Veterinarias
Antimicrobials
Cephalosporins
Pharmacokinetics
Tissue concentrations
Cats
title_short Plasma pharmacokinetics, tissue concentrations and urine elimination after cephalothin intravenous administration to cats under surgical conditions
title_full Plasma pharmacokinetics, tissue concentrations and urine elimination after cephalothin intravenous administration to cats under surgical conditions
title_fullStr Plasma pharmacokinetics, tissue concentrations and urine elimination after cephalothin intravenous administration to cats under surgical conditions
title_full_unstemmed Plasma pharmacokinetics, tissue concentrations and urine elimination after cephalothin intravenous administration to cats under surgical conditions
title_sort Plasma pharmacokinetics, tissue concentrations and urine elimination after cephalothin intravenous administration to cats under surgical conditions
dc.creator.none.fl_str_mv Albarellos, Gabriela A.
Montoya, Laura
Lupi, Martín P.
Passini, Sabrina M.
Lorenzini, Paula
Landoni, María Fabiana
author Albarellos, Gabriela A.
author_facet Albarellos, Gabriela A.
Montoya, Laura
Lupi, Martín P.
Passini, Sabrina M.
Lorenzini, Paula
Landoni, María Fabiana
author_role author
author2 Montoya, Laura
Lupi, Martín P.
Passini, Sabrina M.
Lorenzini, Paula
Landoni, María Fabiana
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Ciencias Veterinarias
Antimicrobials
Cephalosporins
Pharmacokinetics
Tissue concentrations
Cats
topic Ciencias Veterinarias
Antimicrobials
Cephalosporins
Pharmacokinetics
Tissue concentrations
Cats
dc.description.none.fl_txt_mv Pharmacokinetic profile, tissue concentrations and urine elimination of cephalothin in cats under surgical conditions after a single intravenous dose (30 mg/kg) were studied. Initial plasma concentrations were high [Cp(0), 353.79±118.92 μg/mL], with fast and moderately wide distribution [T1⁄2(d) 0.14±0.10 h] [V(d(ss)) 0.19±0.03 L/kg] and rapid elimination (ClB, 0.16±0.03 L/h.kg; T1⁄2, 1.07±0.23 h; MRT, 1.16±0.21 h). Thirty to 60 minutes after intravenous administration, cephalothin tissue concentrations were in the range of 3.73 μg/g (testicle tissue) to 25.63 μg/g (uterus). Tissue/plasma concentrations rate was in a range of 0.04 (testicle) to 0.21 (uterus). Cephalothin urine elimination was 66.49% in the first 6 hours after administration. Cephalothin plasma concentrations remained above a MIC≥1 μg/mL up to 5.5 hours in all the studied cats. However, for MIC≥8 –μg/mL (MIC breakpoint) this time is reduced to 2.5 hours. This suggests that proper perioperative prophylactic use of cephalothin in cats requires a dose interval not longer than 2 hours.
Facultad de Ciencias Veterinarias
description Pharmacokinetic profile, tissue concentrations and urine elimination of cephalothin in cats under surgical conditions after a single intravenous dose (30 mg/kg) were studied. Initial plasma concentrations were high [Cp(0), 353.79±118.92 μg/mL], with fast and moderately wide distribution [T1⁄2(d) 0.14±0.10 h] [V(d(ss)) 0.19±0.03 L/kg] and rapid elimination (ClB, 0.16±0.03 L/h.kg; T1⁄2, 1.07±0.23 h; MRT, 1.16±0.21 h). Thirty to 60 minutes after intravenous administration, cephalothin tissue concentrations were in the range of 3.73 μg/g (testicle tissue) to 25.63 μg/g (uterus). Tissue/plasma concentrations rate was in a range of 0.04 (testicle) to 0.21 (uterus). Cephalothin urine elimination was 66.49% in the first 6 hours after administration. Cephalothin plasma concentrations remained above a MIC≥1 μg/mL up to 5.5 hours in all the studied cats. However, for MIC≥8 –μg/mL (MIC breakpoint) this time is reduced to 2.5 hours. This suggests that proper perioperative prophylactic use of cephalothin in cats requires a dose interval not longer than 2 hours.
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/120562
url http://sedici.unlp.edu.ar/handle/10915/120562
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/2038-9701
info:eu-repo/semantics/altIdentifier/doi/10.4081/vsd.2015.5742
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc/4.0/
Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc/4.0/
Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
dc.format.none.fl_str_mv application/pdf
37-40
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
_version_ 1842260501871984640
score 13.13397

Publicaciones similares