Plasma pharmacokinetics tissue concentration and urine elimination after cephalotin intravenous administration to cats under surgical conditions

Autores
Albarellos, Gabriela Alejandra; Montoya, Laura; Lupi, Martin Pablo; Passini, Sabrina Mariela; Lorenzini, Paula Mercedes; Landoni, Maria Fabiana
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Pharmacokinetic profile, tissue concentrations and urine elimination of cephalothin in cats under surgical conditions after a single intravenous dose (30 mg/kg) were studied. Initial plasma concentrations were high (Cp(0), 353.79±118.92 μg/mL), with fast and moderately wide distribution (T1⁄2(d) 0.14±0.10 h) (V(d(ss)) 0.19±0.03 L/kg) and rapid elimination (ClB, 0.16±0.03 L/h.kg; T1⁄2, 1.07±0.23 h; MRT, 1.16±0.21 h). Thirty to 60 minutes after intravenous administration, cephalothin tissue concentrations were in the range of 3.73 μg/g (testicle tissue) to 25.63 μg/g (uterus). Tissue/plasma concentrations rate was in a range of 0.04 (testicle) to 0.21 (uterus). Cephalothin urine elimination was 66.49% in the first 6 hours after administration. Cephalothin plasma concentrations remained above a MIC≥1μg/mL up to 5.5 hours in all the studied cats. However, for MIC≥8μg/mL (MIC breakpoint) this time is reduced to 2.5 hours. This suggests that proper perioperative prophylactic use of cephalothin in cats requires a dose interval not longer than 2 hours.
Fil: Albarellos, Gabriela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Área de Farmacología; Argentina
Fil: Montoya, Laura. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Área de Farmacología; Argentina
Fil: Lupi, Martin Pablo. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Área de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Passini, Sabrina Mariela. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Área de Farmacología; Argentina
Fil: Lorenzini, Paula Mercedes. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Área de Farmacología; Argentina
Fil: Landoni, Maria Fabiana. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Materia
CEPHALOTIN
PHARMACOKINETICS
TISSUE
URINE
CATS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/130083
Acceder
id CONICETDig_4d6ed0418b7815db348bc35ae3678f5c
oai_identifier_str oai:ri.conicet.gov.ar:11336/130083
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Plasma pharmacokinetics tissue concentration and urine elimination after cephalotin intravenous administration to cats under surgical conditionsAlbarellos, Gabriela AlejandraMontoya, LauraLupi, Martin PabloPassini, Sabrina MarielaLorenzini, Paula MercedesLandoni, Maria FabianaCEPHALOTINPHARMACOKINETICSTISSUEURINECATShttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Pharmacokinetic profile, tissue concentrations and urine elimination of cephalothin in cats under surgical conditions after a single intravenous dose (30 mg/kg) were studied. Initial plasma concentrations were high (Cp(0), 353.79±118.92 μg/mL), with fast and moderately wide distribution (T1⁄2(d) 0.14±0.10 h) (V(d(ss)) 0.19±0.03 L/kg) and rapid elimination (ClB, 0.16±0.03 L/h.kg; T1⁄2, 1.07±0.23 h; MRT, 1.16±0.21 h). Thirty to 60 minutes after intravenous administration, cephalothin tissue concentrations were in the range of 3.73 μg/g (testicle tissue) to 25.63 μg/g (uterus). Tissue/plasma concentrations rate was in a range of 0.04 (testicle) to 0.21 (uterus). Cephalothin urine elimination was 66.49% in the first 6 hours after administration. Cephalothin plasma concentrations remained above a MIC≥1μg/mL up to 5.5 hours in all the studied cats. However, for MIC≥8μg/mL (MIC breakpoint) this time is reduced to 2.5 hours. This suggests that proper perioperative prophylactic use of cephalothin in cats requires a dose interval not longer than 2 hours.Fil: Albarellos, Gabriela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Área de Farmacología; ArgentinaFil: Montoya, Laura. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Área de Farmacología; ArgentinaFil: Lupi, Martin Pablo. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Área de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Passini, Sabrina Mariela. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Área de Farmacología; ArgentinaFil: Lorenzini, Paula Mercedes. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Área de Farmacología; ArgentinaFil: Landoni, Maria Fabiana. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaPagePress2015-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/130083Albarellos, Gabriela Alejandra; Montoya, Laura; Lupi, Martin Pablo; Passini, Sabrina Mariela; Lorenzini, Paula Mercedes; et al.; Plasma pharmacokinetics tissue concentration and urine elimination after cephalotin intravenous administration to cats under surgical conditions; PagePress; Veterinary Science Development; 5; 5-2015; 37-402038-9701CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.4081/vsd.2015.5742info:eu-repo/semantics/altIdentifier/url/https://www.pagepress.org/journals/index.php/vsd/article/view/5742info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:03:49Zoai:ri.conicet.gov.ar:11336/130083instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:03:49.487CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Plasma pharmacokinetics tissue concentration and urine elimination after cephalotin intravenous administration to cats under surgical conditions
title Plasma pharmacokinetics tissue concentration and urine elimination after cephalotin intravenous administration to cats under surgical conditions
spellingShingle Plasma pharmacokinetics tissue concentration and urine elimination after cephalotin intravenous administration to cats under surgical conditions
Albarellos, Gabriela Alejandra
CEPHALOTIN
PHARMACOKINETICS
TISSUE
URINE
CATS
title_short Plasma pharmacokinetics tissue concentration and urine elimination after cephalotin intravenous administration to cats under surgical conditions
title_full Plasma pharmacokinetics tissue concentration and urine elimination after cephalotin intravenous administration to cats under surgical conditions
title_fullStr Plasma pharmacokinetics tissue concentration and urine elimination after cephalotin intravenous administration to cats under surgical conditions
title_full_unstemmed Plasma pharmacokinetics tissue concentration and urine elimination after cephalotin intravenous administration to cats under surgical conditions
title_sort Plasma pharmacokinetics tissue concentration and urine elimination after cephalotin intravenous administration to cats under surgical conditions
dc.creator.none.fl_str_mv Albarellos, Gabriela Alejandra
Montoya, Laura
Lupi, Martin Pablo
Passini, Sabrina Mariela
Lorenzini, Paula Mercedes
Landoni, Maria Fabiana
author Albarellos, Gabriela Alejandra
author_facet Albarellos, Gabriela Alejandra
Montoya, Laura
Lupi, Martin Pablo
Passini, Sabrina Mariela
Lorenzini, Paula Mercedes
Landoni, Maria Fabiana
author_role author
author2 Montoya, Laura
Lupi, Martin Pablo
Passini, Sabrina Mariela
Lorenzini, Paula Mercedes
Landoni, Maria Fabiana
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv CEPHALOTIN
PHARMACOKINETICS
TISSUE
URINE
CATS
topic CEPHALOTIN
PHARMACOKINETICS
TISSUE
URINE
CATS
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv Pharmacokinetic profile, tissue concentrations and urine elimination of cephalothin in cats under surgical conditions after a single intravenous dose (30 mg/kg) were studied. Initial plasma concentrations were high (Cp(0), 353.79±118.92 μg/mL), with fast and moderately wide distribution (T1⁄2(d) 0.14±0.10 h) (V(d(ss)) 0.19±0.03 L/kg) and rapid elimination (ClB, 0.16±0.03 L/h.kg; T1⁄2, 1.07±0.23 h; MRT, 1.16±0.21 h). Thirty to 60 minutes after intravenous administration, cephalothin tissue concentrations were in the range of 3.73 μg/g (testicle tissue) to 25.63 μg/g (uterus). Tissue/plasma concentrations rate was in a range of 0.04 (testicle) to 0.21 (uterus). Cephalothin urine elimination was 66.49% in the first 6 hours after administration. Cephalothin plasma concentrations remained above a MIC≥1μg/mL up to 5.5 hours in all the studied cats. However, for MIC≥8μg/mL (MIC breakpoint) this time is reduced to 2.5 hours. This suggests that proper perioperative prophylactic use of cephalothin in cats requires a dose interval not longer than 2 hours.
Fil: Albarellos, Gabriela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Área de Farmacología; Argentina
Fil: Montoya, Laura. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Área de Farmacología; Argentina
Fil: Lupi, Martin Pablo. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Área de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Passini, Sabrina Mariela. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Área de Farmacología; Argentina
Fil: Lorenzini, Paula Mercedes. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Área de Farmacología; Argentina
Fil: Landoni, Maria Fabiana. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
description Pharmacokinetic profile, tissue concentrations and urine elimination of cephalothin in cats under surgical conditions after a single intravenous dose (30 mg/kg) were studied. Initial plasma concentrations were high (Cp(0), 353.79±118.92 μg/mL), with fast and moderately wide distribution (T1⁄2(d) 0.14±0.10 h) (V(d(ss)) 0.19±0.03 L/kg) and rapid elimination (ClB, 0.16±0.03 L/h.kg; T1⁄2, 1.07±0.23 h; MRT, 1.16±0.21 h). Thirty to 60 minutes after intravenous administration, cephalothin tissue concentrations were in the range of 3.73 μg/g (testicle tissue) to 25.63 μg/g (uterus). Tissue/plasma concentrations rate was in a range of 0.04 (testicle) to 0.21 (uterus). Cephalothin urine elimination was 66.49% in the first 6 hours after administration. Cephalothin plasma concentrations remained above a MIC≥1μg/mL up to 5.5 hours in all the studied cats. However, for MIC≥8μg/mL (MIC breakpoint) this time is reduced to 2.5 hours. This suggests that proper perioperative prophylactic use of cephalothin in cats requires a dose interval not longer than 2 hours.
publishDate 2015
dc.date.none.fl_str_mv 2015-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/130083
Albarellos, Gabriela Alejandra; Montoya, Laura; Lupi, Martin Pablo; Passini, Sabrina Mariela; Lorenzini, Paula Mercedes; et al.; Plasma pharmacokinetics tissue concentration and urine elimination after cephalotin intravenous administration to cats under surgical conditions; PagePress; Veterinary Science Development; 5; 5-2015; 37-40
2038-9701
CONICET Digital
CONICET
url http://hdl.handle.net/11336/130083
identifier_str_mv Albarellos, Gabriela Alejandra; Montoya, Laura; Lupi, Martin Pablo; Passini, Sabrina Mariela; Lorenzini, Paula Mercedes; et al.; Plasma pharmacokinetics tissue concentration and urine elimination after cephalotin intravenous administration to cats under surgical conditions; PagePress; Veterinary Science Development; 5; 5-2015; 37-40
2038-9701
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.4081/vsd.2015.5742
info:eu-repo/semantics/altIdentifier/url/https://www.pagepress.org/journals/index.php/vsd/article/view/5742
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv PagePress
publisher.none.fl_str_mv PagePress
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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