Comparative ivermectin plasma concentration profiles after subcutaneous administration of different long-acting formulations to cattle

Autores
Leite, Paula; Fonseca, Evelise; Fernandez, Sandra; Imato, Reinaldo; Oliveira, Bergson; Alvarez, Luis Ignacio; Ballent, Mariana; Virkel, Guillermo Leon; Dominguez, Maria Paula; Cantón, Candela; Lanusse, Carlos Edmundo; Lifschitz, Adrian Luis
Año de publicación
2019
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
The current study evaluated the ivermectin comparative pharmacokinetic behaviour and systemic availability following administration of six different available long-acting formulations to cattle. Forty-two healthy calves were randomly allocated into six experimental groups (n=7). Animals in each group were subcutaneously treated at label recommended doses with a different ivermectin formulation (Formulation A= 700 µg/kg; B= 700 µg/kg; C= 630 µg/kg, D= 800 µg/kg; E= 700 µg/kg; F= 630 µg/kg). Blood samples were collected over 120 days post-treatment (14 sampling times). Ivermectin concentrations in plasma were measured by HPLC. A complete pharmacokinetic analysis was performed for all the ivermectin preparations. The mean peak plasma concentration (Cmax) and area under the concentration vs time curves (AUC, drug exposure) obtained for each formulation were compared following dose rate normalization. The statistically significant differences observed among the kinetic parameters reflecting the rate and extent of IVM absorption from the different formulations assayed here, indicate the existence of some differences among preparations in terms of pharmaceutical behaviour. The relationship between the plasma kinetic profiles for the different formulations and the ?theoretical threshold? to obtain an optimal efficacy against ticks was calculated using the period of time in which ivermectin concentrations were above 10 ng/mL. Formulations A, B and D remained above 10 ng/mL for a longer period of time compared to Formulations C, E and F (a highest dose rate of 800 µg/kg was used for formulation D). The available long-acting ivermectin formulations under evaluation showed slight differences in their absorption patterns, which was reflected in the observed plasma pharmacokinetic behavior. Formulations A and B showed the best performance from the pharmacokinetic point of view, showing initial higher ivermectin concentrations followed by a sustained plasma concentration above 10 ng/mL for more than 40 days that may be relevant to obtain an optimal efficacy against ticks.
Fil: Leite, Paula. Ceva Saúde Animal Ltda.; Brasil
Fil: Fonseca, Evelise. Ceva Saúde Animal Ltda.; Brasil
Fil: Fernandez, Sandra. Ceva Saúde Animal Ltda.; Brasil
Fil: Imato, Reinaldo. Ceva Saúde Animal Ltda.; Brasil
Fil: Oliveira, Bergson. Ceva Saúde Animal Ltda.; Brasil
Fil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Ballent, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Virkel, Guillermo Leon. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Dominguez, Maria Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Cantón, Candela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Lifschitz, Adrian Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
27th Conference of the World Association for the Advancement of Veterinary Parasitology
Madison
Estados Unidos
World Association for the Advancement of Veterinary Parasitology
Materia
Ivermectin
Long-acting formulations
Cattle
Plasma concentrations
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/160696
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/160696
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Comparative ivermectin plasma concentration profiles after subcutaneous administration of different long-acting formulations to cattleLeite, PaulaFonseca, EveliseFernandez, SandraImato, ReinaldoOliveira, BergsonAlvarez, Luis IgnacioBallent, MarianaVirkel, Guillermo LeonDominguez, Maria PaulaCantón, CandelaLanusse, Carlos EdmundoLifschitz, Adrian LuisIvermectinLong-acting formulationsCattlePlasma concentrationshttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4The current study evaluated the ivermectin comparative pharmacokinetic behaviour and systemic availability following administration of six different available long-acting formulations to cattle. Forty-two healthy calves were randomly allocated into six experimental groups (n=7). Animals in each group were subcutaneously treated at label recommended doses with a different ivermectin formulation (Formulation A= 700 µg/kg; B= 700 µg/kg; C= 630 µg/kg, D= 800 µg/kg; E= 700 µg/kg; F= 630 µg/kg). Blood samples were collected over 120 days post-treatment (14 sampling times). Ivermectin concentrations in plasma were measured by HPLC. A complete pharmacokinetic analysis was performed for all the ivermectin preparations. The mean peak plasma concentration (Cmax) and area under the concentration vs time curves (AUC, drug exposure) obtained for each formulation were compared following dose rate normalization. The statistically significant differences observed among the kinetic parameters reflecting the rate and extent of IVM absorption from the different formulations assayed here, indicate the existence of some differences among preparations in terms of pharmaceutical behaviour. The relationship between the plasma kinetic profiles for the different formulations and the ?theoretical threshold? to obtain an optimal efficacy against ticks was calculated using the period of time in which ivermectin concentrations were above 10 ng/mL. Formulations A, B and D remained above 10 ng/mL for a longer period of time compared to Formulations C, E and F (a highest dose rate of 800 µg/kg was used for formulation D). The available long-acting ivermectin formulations under evaluation showed slight differences in their absorption patterns, which was reflected in the observed plasma pharmacokinetic behavior. Formulations A and B showed the best performance from the pharmacokinetic point of view, showing initial higher ivermectin concentrations followed by a sustained plasma concentration above 10 ng/mL for more than 40 days that may be relevant to obtain an optimal efficacy against ticks.Fil: Leite, Paula. Ceva Saúde Animal Ltda.; BrasilFil: Fonseca, Evelise. Ceva Saúde Animal Ltda.; BrasilFil: Fernandez, Sandra. Ceva Saúde Animal Ltda.; BrasilFil: Imato, Reinaldo. Ceva Saúde Animal Ltda.; BrasilFil: Oliveira, Bergson. Ceva Saúde Animal Ltda.; BrasilFil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Ballent, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Virkel, Guillermo Leon. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Dominguez, Maria Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Cantón, Candela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Lifschitz, Adrian Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina27th Conference of the World Association for the Advancement of Veterinary ParasitologyMadisonEstados UnidosWorld Association for the Advancement of Veterinary ParasitologyWorld Association for the Advancement of Veterinary Parasitology2019info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectConferenciaBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/160696Comparative ivermectin plasma concentration profiles after subcutaneous administration of different long-acting formulations to cattle; 27th Conference of the World Association for the Advancement of Veterinary Parasitology; Madison; Estados Unidos; 2019; 277-277CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.waavp2019.com/wp-content/uploads/2019/07/WAAVP2019-Abstract-Book.pdfinfo:eu-repo/semantics/altIdentifier/url/http://www.waavp2019.comInternacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:47:33Zoai:ri.conicet.gov.ar:11336/160696instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:47:33.584CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Comparative ivermectin plasma concentration profiles after subcutaneous administration of different long-acting formulations to cattle
title Comparative ivermectin plasma concentration profiles after subcutaneous administration of different long-acting formulations to cattle
spellingShingle Comparative ivermectin plasma concentration profiles after subcutaneous administration of different long-acting formulations to cattle
Leite, Paula
Ivermectin
Long-acting formulations
Cattle
Plasma concentrations
title_short Comparative ivermectin plasma concentration profiles after subcutaneous administration of different long-acting formulations to cattle
title_full Comparative ivermectin plasma concentration profiles after subcutaneous administration of different long-acting formulations to cattle
title_fullStr Comparative ivermectin plasma concentration profiles after subcutaneous administration of different long-acting formulations to cattle
title_full_unstemmed Comparative ivermectin plasma concentration profiles after subcutaneous administration of different long-acting formulations to cattle
title_sort Comparative ivermectin plasma concentration profiles after subcutaneous administration of different long-acting formulations to cattle
dc.creator.none.fl_str_mv Leite, Paula
Fonseca, Evelise
Fernandez, Sandra
Imato, Reinaldo
Oliveira, Bergson
Alvarez, Luis Ignacio
Ballent, Mariana
Virkel, Guillermo Leon
Dominguez, Maria Paula
Cantón, Candela
Lanusse, Carlos Edmundo
Lifschitz, Adrian Luis
author Leite, Paula
author_facet Leite, Paula
Fonseca, Evelise
Fernandez, Sandra
Imato, Reinaldo
Oliveira, Bergson
Alvarez, Luis Ignacio
Ballent, Mariana
Virkel, Guillermo Leon
Dominguez, Maria Paula
Cantón, Candela
Lanusse, Carlos Edmundo
Lifschitz, Adrian Luis
author_role author
author2 Fonseca, Evelise
Fernandez, Sandra
Imato, Reinaldo
Oliveira, Bergson
Alvarez, Luis Ignacio
Ballent, Mariana
Virkel, Guillermo Leon
Dominguez, Maria Paula
Cantón, Candela
Lanusse, Carlos Edmundo
Lifschitz, Adrian Luis
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Ivermectin
Long-acting formulations
Cattle
Plasma concentrations
topic Ivermectin
Long-acting formulations
Cattle
Plasma concentrations
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv The current study evaluated the ivermectin comparative pharmacokinetic behaviour and systemic availability following administration of six different available long-acting formulations to cattle. Forty-two healthy calves were randomly allocated into six experimental groups (n=7). Animals in each group were subcutaneously treated at label recommended doses with a different ivermectin formulation (Formulation A= 700 µg/kg; B= 700 µg/kg; C= 630 µg/kg, D= 800 µg/kg; E= 700 µg/kg; F= 630 µg/kg). Blood samples were collected over 120 days post-treatment (14 sampling times). Ivermectin concentrations in plasma were measured by HPLC. A complete pharmacokinetic analysis was performed for all the ivermectin preparations. The mean peak plasma concentration (Cmax) and area under the concentration vs time curves (AUC, drug exposure) obtained for each formulation were compared following dose rate normalization. The statistically significant differences observed among the kinetic parameters reflecting the rate and extent of IVM absorption from the different formulations assayed here, indicate the existence of some differences among preparations in terms of pharmaceutical behaviour. The relationship between the plasma kinetic profiles for the different formulations and the ?theoretical threshold? to obtain an optimal efficacy against ticks was calculated using the period of time in which ivermectin concentrations were above 10 ng/mL. Formulations A, B and D remained above 10 ng/mL for a longer period of time compared to Formulations C, E and F (a highest dose rate of 800 µg/kg was used for formulation D). The available long-acting ivermectin formulations under evaluation showed slight differences in their absorption patterns, which was reflected in the observed plasma pharmacokinetic behavior. Formulations A and B showed the best performance from the pharmacokinetic point of view, showing initial higher ivermectin concentrations followed by a sustained plasma concentration above 10 ng/mL for more than 40 days that may be relevant to obtain an optimal efficacy against ticks.
Fil: Leite, Paula. Ceva Saúde Animal Ltda.; Brasil
Fil: Fonseca, Evelise. Ceva Saúde Animal Ltda.; Brasil
Fil: Fernandez, Sandra. Ceva Saúde Animal Ltda.; Brasil
Fil: Imato, Reinaldo. Ceva Saúde Animal Ltda.; Brasil
Fil: Oliveira, Bergson. Ceva Saúde Animal Ltda.; Brasil
Fil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Ballent, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Virkel, Guillermo Leon. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Dominguez, Maria Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Cantón, Candela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Lifschitz, Adrian Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
27th Conference of the World Association for the Advancement of Veterinary Parasitology
Madison
Estados Unidos
World Association for the Advancement of Veterinary Parasitology
description The current study evaluated the ivermectin comparative pharmacokinetic behaviour and systemic availability following administration of six different available long-acting formulations to cattle. Forty-two healthy calves were randomly allocated into six experimental groups (n=7). Animals in each group were subcutaneously treated at label recommended doses with a different ivermectin formulation (Formulation A= 700 µg/kg; B= 700 µg/kg; C= 630 µg/kg, D= 800 µg/kg; E= 700 µg/kg; F= 630 µg/kg). Blood samples were collected over 120 days post-treatment (14 sampling times). Ivermectin concentrations in plasma were measured by HPLC. A complete pharmacokinetic analysis was performed for all the ivermectin preparations. The mean peak plasma concentration (Cmax) and area under the concentration vs time curves (AUC, drug exposure) obtained for each formulation were compared following dose rate normalization. The statistically significant differences observed among the kinetic parameters reflecting the rate and extent of IVM absorption from the different formulations assayed here, indicate the existence of some differences among preparations in terms of pharmaceutical behaviour. The relationship between the plasma kinetic profiles for the different formulations and the ?theoretical threshold? to obtain an optimal efficacy against ticks was calculated using the period of time in which ivermectin concentrations were above 10 ng/mL. Formulations A, B and D remained above 10 ng/mL for a longer period of time compared to Formulations C, E and F (a highest dose rate of 800 µg/kg was used for formulation D). The available long-acting ivermectin formulations under evaluation showed slight differences in their absorption patterns, which was reflected in the observed plasma pharmacokinetic behavior. Formulations A and B showed the best performance from the pharmacokinetic point of view, showing initial higher ivermectin concentrations followed by a sustained plasma concentration above 10 ng/mL for more than 40 days that may be relevant to obtain an optimal efficacy against ticks.
publishDate 2019
dc.date.none.fl_str_mv 2019
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info:eu-repo/semantics/conferenceObject
Conferencia
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http://purl.org/coar/resource_type/c_5794
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status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/160696
Comparative ivermectin plasma concentration profiles after subcutaneous administration of different long-acting formulations to cattle; 27th Conference of the World Association for the Advancement of Veterinary Parasitology; Madison; Estados Unidos; 2019; 277-277
CONICET Digital
CONICET
url http://hdl.handle.net/11336/160696
identifier_str_mv Comparative ivermectin plasma concentration profiles after subcutaneous administration of different long-acting formulations to cattle; 27th Conference of the World Association for the Advancement of Veterinary Parasitology; Madison; Estados Unidos; 2019; 277-277
CONICET Digital
CONICET
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dc.coverage.none.fl_str_mv Internacional
dc.publisher.none.fl_str_mv World Association for the Advancement of Veterinary Parasitology
publisher.none.fl_str_mv World Association for the Advancement of Veterinary Parasitology
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
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