OKB, a novel family of brain-gut neuropeptides from insects
- Autores
- Sterkel, Marcos; Oliveira, Pedro L.; Urlaub, Henning; Hernández Martínez, Salvador; Rivera Pomar, Rolando Víctor; Ons, Sheila
- Año de publicación
- 2012
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- In insects, neuropeptides play a central role in the control of most physiological processes. The knowledge and characterization of new neuropeptide families, is of interest on the fields of Genetics, Genomics, Neurobiology, Endocrinology and Evolution. This knowledge also provides the tools for the design of peptidomimetics, pseudopeptides or small molecules, capable of disrupting the physiological processes regulated by the signaling molecules and their receptors. This is a promising target for a novel generation of insecticides. Using database searches, mass spectrometry and RACE-PCR, we identified a neuropeptide precursor transcript encoding a new family of insect neuropeptides in the hemipteran Rhodnius prolixus. We named this precursor Orcokinin B, because is originated by the alternative splicing of the Orcokinin gen. EST and genomic data suggests that Orcokinin B is expressed in the nervous system and gut from several insect species, with the exception of Drosophila sp. (Diptera) and Acyirthosiphon pisum (Hemiptera). Mass spectrometry and RT-PCR confirmed the expression of Orcokinin B in brain and anterior midgut of R. prolixus. Furthermore, we identified orthologues of this new family of peptides in genomic and EST databases from Arachnids and Crustaceans.
Centro Regional de Estudios Genómicos - Materia
-
Biología
Neuropeptides
Orcokinins
Insects
Rhodnius prolixus
Chagas’ disease - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/127976
Ver los metadatos del registro completo
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OKB, a novel family of brain-gut neuropeptides from insectsSterkel, MarcosOliveira, Pedro L.Urlaub, HenningHernández Martínez, SalvadorRivera Pomar, Rolando VíctorOns, SheilaBiologíaNeuropeptidesOrcokininsInsectsRhodnius prolixusChagas’ diseaseIn insects, neuropeptides play a central role in the control of most physiological processes. The knowledge and characterization of new neuropeptide families, is of interest on the fields of Genetics, Genomics, Neurobiology, Endocrinology and Evolution. This knowledge also provides the tools for the design of peptidomimetics, pseudopeptides or small molecules, capable of disrupting the physiological processes regulated by the signaling molecules and their receptors. This is a promising target for a novel generation of insecticides. Using database searches, mass spectrometry and RACE-PCR, we identified a neuropeptide precursor transcript encoding a new family of insect neuropeptides in the hemipteran Rhodnius prolixus. We named this precursor Orcokinin B, because is originated by the alternative splicing of the Orcokinin gen. EST and genomic data suggests that Orcokinin B is expressed in the nervous system and gut from several insect species, with the exception of Drosophila sp. (Diptera) and Acyirthosiphon pisum (Hemiptera). Mass spectrometry and RT-PCR confirmed the expression of Orcokinin B in brain and anterior midgut of R. prolixus. Furthermore, we identified orthologues of this new family of peptides in genomic and EST databases from Arachnids and Crustaceans.Centro Regional de Estudios Genómicos2012info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf466-473http://sedici.unlp.edu.ar/handle/10915/127976enginfo:eu-repo/semantics/altIdentifier/issn/1879-0240info:eu-repo/semantics/altIdentifier/issn/0965-1748info:eu-repo/semantics/altIdentifier/pmid/22480496info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ibmb.2012.03.003info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:31:02Zoai:sedici.unlp.edu.ar:10915/127976Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:31:02.844SEDICI (UNLP) - Universidad Nacional de La Platafalse |
dc.title.none.fl_str_mv |
OKB, a novel family of brain-gut neuropeptides from insects |
title |
OKB, a novel family of brain-gut neuropeptides from insects |
spellingShingle |
OKB, a novel family of brain-gut neuropeptides from insects Sterkel, Marcos Biología Neuropeptides Orcokinins Insects Rhodnius prolixus Chagas’ disease |
title_short |
OKB, a novel family of brain-gut neuropeptides from insects |
title_full |
OKB, a novel family of brain-gut neuropeptides from insects |
title_fullStr |
OKB, a novel family of brain-gut neuropeptides from insects |
title_full_unstemmed |
OKB, a novel family of brain-gut neuropeptides from insects |
title_sort |
OKB, a novel family of brain-gut neuropeptides from insects |
dc.creator.none.fl_str_mv |
Sterkel, Marcos Oliveira, Pedro L. Urlaub, Henning Hernández Martínez, Salvador Rivera Pomar, Rolando Víctor Ons, Sheila |
author |
Sterkel, Marcos |
author_facet |
Sterkel, Marcos Oliveira, Pedro L. Urlaub, Henning Hernández Martínez, Salvador Rivera Pomar, Rolando Víctor Ons, Sheila |
author_role |
author |
author2 |
Oliveira, Pedro L. Urlaub, Henning Hernández Martínez, Salvador Rivera Pomar, Rolando Víctor Ons, Sheila |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
Biología Neuropeptides Orcokinins Insects Rhodnius prolixus Chagas’ disease |
topic |
Biología Neuropeptides Orcokinins Insects Rhodnius prolixus Chagas’ disease |
dc.description.none.fl_txt_mv |
In insects, neuropeptides play a central role in the control of most physiological processes. The knowledge and characterization of new neuropeptide families, is of interest on the fields of Genetics, Genomics, Neurobiology, Endocrinology and Evolution. This knowledge also provides the tools for the design of peptidomimetics, pseudopeptides or small molecules, capable of disrupting the physiological processes regulated by the signaling molecules and their receptors. This is a promising target for a novel generation of insecticides. Using database searches, mass spectrometry and RACE-PCR, we identified a neuropeptide precursor transcript encoding a new family of insect neuropeptides in the hemipteran Rhodnius prolixus. We named this precursor Orcokinin B, because is originated by the alternative splicing of the Orcokinin gen. EST and genomic data suggests that Orcokinin B is expressed in the nervous system and gut from several insect species, with the exception of Drosophila sp. (Diptera) and Acyirthosiphon pisum (Hemiptera). Mass spectrometry and RT-PCR confirmed the expression of Orcokinin B in brain and anterior midgut of R. prolixus. Furthermore, we identified orthologues of this new family of peptides in genomic and EST databases from Arachnids and Crustaceans. Centro Regional de Estudios Genómicos |
description |
In insects, neuropeptides play a central role in the control of most physiological processes. The knowledge and characterization of new neuropeptide families, is of interest on the fields of Genetics, Genomics, Neurobiology, Endocrinology and Evolution. This knowledge also provides the tools for the design of peptidomimetics, pseudopeptides or small molecules, capable of disrupting the physiological processes regulated by the signaling molecules and their receptors. This is a promising target for a novel generation of insecticides. Using database searches, mass spectrometry and RACE-PCR, we identified a neuropeptide precursor transcript encoding a new family of insect neuropeptides in the hemipteran Rhodnius prolixus. We named this precursor Orcokinin B, because is originated by the alternative splicing of the Orcokinin gen. EST and genomic data suggests that Orcokinin B is expressed in the nervous system and gut from several insect species, with the exception of Drosophila sp. (Diptera) and Acyirthosiphon pisum (Hemiptera). Mass spectrometry and RT-PCR confirmed the expression of Orcokinin B in brain and anterior midgut of R. prolixus. Furthermore, we identified orthologues of this new family of peptides in genomic and EST databases from Arachnids and Crustaceans. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Articulo http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
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article |
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publishedVersion |
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http://sedici.unlp.edu.ar/handle/10915/127976 |
url |
http://sedici.unlp.edu.ar/handle/10915/127976 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/issn/1879-0240 info:eu-repo/semantics/altIdentifier/issn/0965-1748 info:eu-repo/semantics/altIdentifier/pmid/22480496 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ibmb.2012.03.003 |
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info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
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openAccess |
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http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
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