Functional proteomics of neuropeptidome dynamics during the feeding process of Rhodnius prolixus

Autores
Sterkel, Marcos; Urlaub, Henning; Rivera Pomar, Rolando; Ons, Sheila
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In hematophagous insects, blood intake triggers a prompt response mediated by neuropeptides, which regulates a variety of physiological processes. Here we report a quantitative proteomic analysis of the postfeeding response in the central nervous system of Rhodnius prolixus, a vector of Chagas disease. The concentration of neuropeptides NVP-like, ITG-like, kinin-precursor peptide, and neuropeptide-like precursor 1 (NPLP1) significantly changes in response to blood intake. We also performed a neuropeptidomic analysis of other feeding-related organs, namely salivary glands and gut. We identified NPLP1 in salivary glands and myosuppressin in midgut. This is the first report suggesting a role for NPLP1, involving the peptides processed from this precursor in the hormonal control of the production and/or release of saliva. Our results contribute to the understanding of the postprandial neuroendocrine response in hematophagous and provide important information for physiological and pharmacological studies aimed to the design of next-generation insecticides such as peptidomimetics.
Fil: Sterkel, Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Centro Regional de Estudios Genómicos; Argentina
Fil: Urlaub, Henning. Institut Max Planck fuer Bioanorganische Chemie; Alemania
Fil: Rivera Pomar, Rolando. Universidad Nacional de La Plata. Centro Regional de Estudios Genómicos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Noroeste de la Provincia de Buenos Aires; Argentina
Fil: Ons, Sheila. Universidad Nacional de La Plata. Centro Regional de Estudios Genómicos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
QUANTITATIVE PROTEOMICS
PEPTIDOMICS
RHODNIUS PROLIXUS
CHAGAS DISEASE
NEUROPEPTIDES
FEEDING
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/95271
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/95271
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Functional proteomics of neuropeptidome dynamics during the feeding process of Rhodnius prolixusSterkel, MarcosUrlaub, HenningRivera Pomar, RolandoOns, SheilaQUANTITATIVE PROTEOMICSPEPTIDOMICSRHODNIUS PROLIXUSCHAGAS DISEASENEUROPEPTIDESFEEDINGhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1In hematophagous insects, blood intake triggers a prompt response mediated by neuropeptides, which regulates a variety of physiological processes. Here we report a quantitative proteomic analysis of the postfeeding response in the central nervous system of Rhodnius prolixus, a vector of Chagas disease. The concentration of neuropeptides NVP-like, ITG-like, kinin-precursor peptide, and neuropeptide-like precursor 1 (NPLP1) significantly changes in response to blood intake. We also performed a neuropeptidomic analysis of other feeding-related organs, namely salivary glands and gut. We identified NPLP1 in salivary glands and myosuppressin in midgut. This is the first report suggesting a role for NPLP1, involving the peptides processed from this precursor in the hormonal control of the production and/or release of saliva. Our results contribute to the understanding of the postprandial neuroendocrine response in hematophagous and provide important information for physiological and pharmacological studies aimed to the design of next-generation insecticides such as peptidomimetics.Fil: Sterkel, Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Centro Regional de Estudios Genómicos; ArgentinaFil: Urlaub, Henning. Institut Max Planck fuer Bioanorganische Chemie; AlemaniaFil: Rivera Pomar, Rolando. Universidad Nacional de La Plata. Centro Regional de Estudios Genómicos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Noroeste de la Provincia de Buenos Aires; ArgentinaFil: Ons, Sheila. Universidad Nacional de La Plata. Centro Regional de Estudios Genómicos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaAmerican Chemical Society2011-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/95271Sterkel, Marcos; Urlaub, Henning; Rivera Pomar, Rolando; Ons, Sheila; Functional proteomics of neuropeptidome dynamics during the feeding process of Rhodnius prolixus; American Chemical Society; Journal of Proteome Research; 10; 8; 8-2011; 3363-33711535-3893CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/full/10.1021/pr2001012info:eu-repo/semantics/altIdentifier/doi/10.1021/pr2001012info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:35:36Zoai:ri.conicet.gov.ar:11336/95271instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:35:36.386CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Functional proteomics of neuropeptidome dynamics during the feeding process of Rhodnius prolixus
title Functional proteomics of neuropeptidome dynamics during the feeding process of Rhodnius prolixus
spellingShingle Functional proteomics of neuropeptidome dynamics during the feeding process of Rhodnius prolixus
Sterkel, Marcos
QUANTITATIVE PROTEOMICS
PEPTIDOMICS
RHODNIUS PROLIXUS
CHAGAS DISEASE
NEUROPEPTIDES
FEEDING
title_short Functional proteomics of neuropeptidome dynamics during the feeding process of Rhodnius prolixus
title_full Functional proteomics of neuropeptidome dynamics during the feeding process of Rhodnius prolixus
title_fullStr Functional proteomics of neuropeptidome dynamics during the feeding process of Rhodnius prolixus
title_full_unstemmed Functional proteomics of neuropeptidome dynamics during the feeding process of Rhodnius prolixus
title_sort Functional proteomics of neuropeptidome dynamics during the feeding process of Rhodnius prolixus
dc.creator.none.fl_str_mv Sterkel, Marcos
Urlaub, Henning
Rivera Pomar, Rolando
Ons, Sheila
author Sterkel, Marcos
author_facet Sterkel, Marcos
Urlaub, Henning
Rivera Pomar, Rolando
Ons, Sheila
author_role author
author2 Urlaub, Henning
Rivera Pomar, Rolando
Ons, Sheila
author2_role author
author
author
dc.subject.none.fl_str_mv QUANTITATIVE PROTEOMICS
PEPTIDOMICS
RHODNIUS PROLIXUS
CHAGAS DISEASE
NEUROPEPTIDES
FEEDING
topic QUANTITATIVE PROTEOMICS
PEPTIDOMICS
RHODNIUS PROLIXUS
CHAGAS DISEASE
NEUROPEPTIDES
FEEDING
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv In hematophagous insects, blood intake triggers a prompt response mediated by neuropeptides, which regulates a variety of physiological processes. Here we report a quantitative proteomic analysis of the postfeeding response in the central nervous system of Rhodnius prolixus, a vector of Chagas disease. The concentration of neuropeptides NVP-like, ITG-like, kinin-precursor peptide, and neuropeptide-like precursor 1 (NPLP1) significantly changes in response to blood intake. We also performed a neuropeptidomic analysis of other feeding-related organs, namely salivary glands and gut. We identified NPLP1 in salivary glands and myosuppressin in midgut. This is the first report suggesting a role for NPLP1, involving the peptides processed from this precursor in the hormonal control of the production and/or release of saliva. Our results contribute to the understanding of the postprandial neuroendocrine response in hematophagous and provide important information for physiological and pharmacological studies aimed to the design of next-generation insecticides such as peptidomimetics.
Fil: Sterkel, Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Centro Regional de Estudios Genómicos; Argentina
Fil: Urlaub, Henning. Institut Max Planck fuer Bioanorganische Chemie; Alemania
Fil: Rivera Pomar, Rolando. Universidad Nacional de La Plata. Centro Regional de Estudios Genómicos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Noroeste de la Provincia de Buenos Aires; Argentina
Fil: Ons, Sheila. Universidad Nacional de La Plata. Centro Regional de Estudios Genómicos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description In hematophagous insects, blood intake triggers a prompt response mediated by neuropeptides, which regulates a variety of physiological processes. Here we report a quantitative proteomic analysis of the postfeeding response in the central nervous system of Rhodnius prolixus, a vector of Chagas disease. The concentration of neuropeptides NVP-like, ITG-like, kinin-precursor peptide, and neuropeptide-like precursor 1 (NPLP1) significantly changes in response to blood intake. We also performed a neuropeptidomic analysis of other feeding-related organs, namely salivary glands and gut. We identified NPLP1 in salivary glands and myosuppressin in midgut. This is the first report suggesting a role for NPLP1, involving the peptides processed from this precursor in the hormonal control of the production and/or release of saliva. Our results contribute to the understanding of the postprandial neuroendocrine response in hematophagous and provide important information for physiological and pharmacological studies aimed to the design of next-generation insecticides such as peptidomimetics.
publishDate 2011
dc.date.none.fl_str_mv 2011-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/95271
Sterkel, Marcos; Urlaub, Henning; Rivera Pomar, Rolando; Ons, Sheila; Functional proteomics of neuropeptidome dynamics during the feeding process of Rhodnius prolixus; American Chemical Society; Journal of Proteome Research; 10; 8; 8-2011; 3363-3371
1535-3893
CONICET Digital
CONICET
url http://hdl.handle.net/11336/95271
identifier_str_mv Sterkel, Marcos; Urlaub, Henning; Rivera Pomar, Rolando; Ons, Sheila; Functional proteomics of neuropeptidome dynamics during the feeding process of Rhodnius prolixus; American Chemical Society; Journal of Proteome Research; 10; 8; 8-2011; 3363-3371
1535-3893
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/full/10.1021/pr2001012
info:eu-repo/semantics/altIdentifier/doi/10.1021/pr2001012
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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