Accelerated cell divisions drive the outgrowth of the regenerating spinal cord in axolotls

Autores
Rost, Fabian; Albors, Aida Rodrigo; Mazurov, Vladimir; Brusch, Lutz; Deutsch, Andreas; Tanaka, Elly M.; Chara, Osvaldo
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Axolotls are unique in their ability to regenerate the spinal cord. However, the mechanisms that underlie this phenomenon remain poorly understood. Previously, we showed that regenerating stem cells in the axolotl spinal cord revert to a molecular state resembling embryonic neuroepithelial cells and functionally acquire rapid proliferative divisions (Rodrigo Albors et al., 2015). Here, we refine the analysis of cell proliferation in space and time and identify a high- proliferation zone in the regenerating spinal cord that shifts posteriorly over time. By tracking sparsely-labeled cells, we also quantify cell influx into the regenerate. Taking a mathematical modeling approach, we integrate these quantitative datasets of cell proliferation, neural stem cell activation and cell influx, to predict regenerative tissue outgrowth. Our model shows that while cell influx and neural stem cell activation play a minor role, the acceleration of the cell cycle is the major driver of regenerative spinal cord outgrowth in axolotls.
Facultad de Ciencias Exactas
Instituto de Física de Líquidos y Sistemas Biológicos
Materia
Ciencias Exactas
Axolotl
Regeneration
Extremities
Blastema formation
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/85906
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/85906
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Accelerated cell divisions drive the outgrowth of the regenerating spinal cord in axolotlsRost, FabianAlbors, Aida RodrigoMazurov, VladimirBrusch, LutzDeutsch, AndreasTanaka, Elly M.Chara, OsvaldoCiencias ExactasAxolotlRegenerationExtremitiesBlastema formationAxolotls are unique in their ability to regenerate the spinal cord. However, the mechanisms that underlie this phenomenon remain poorly understood. Previously, we showed that regenerating stem cells in the axolotl spinal cord revert to a molecular state resembling embryonic neuroepithelial cells and functionally acquire rapid proliferative divisions (Rodrigo Albors et al., 2015). Here, we refine the analysis of cell proliferation in space and time and identify a high- proliferation zone in the regenerating spinal cord that shifts posteriorly over time. By tracking sparsely-labeled cells, we also quantify cell influx into the regenerate. Taking a mathematical modeling approach, we integrate these quantitative datasets of cell proliferation, neural stem cell activation and cell influx, to predict regenerative tissue outgrowth. Our model shows that while cell influx and neural stem cell activation play a minor role, the acceleration of the cell cycle is the major driver of regenerative spinal cord outgrowth in axolotls.Facultad de Ciencias ExactasInstituto de Física de Líquidos y Sistemas Biológicos2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/85906enginfo:eu-repo/semantics/altIdentifier/issn/2050-084Xinfo:eu-repo/semantics/altIdentifier/doi/10.7554/eLife.20357.001info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-10-15T11:08:36Zoai:sedici.unlp.edu.ar:10915/85906Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-10-15 11:08:36.993SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Accelerated cell divisions drive the outgrowth of the regenerating spinal cord in axolotls
title Accelerated cell divisions drive the outgrowth of the regenerating spinal cord in axolotls
spellingShingle Accelerated cell divisions drive the outgrowth of the regenerating spinal cord in axolotls
Rost, Fabian
Ciencias Exactas
Axolotl
Regeneration
Extremities
Blastema formation
title_short Accelerated cell divisions drive the outgrowth of the regenerating spinal cord in axolotls
title_full Accelerated cell divisions drive the outgrowth of the regenerating spinal cord in axolotls
title_fullStr Accelerated cell divisions drive the outgrowth of the regenerating spinal cord in axolotls
title_full_unstemmed Accelerated cell divisions drive the outgrowth of the regenerating spinal cord in axolotls
title_sort Accelerated cell divisions drive the outgrowth of the regenerating spinal cord in axolotls
dc.creator.none.fl_str_mv Rost, Fabian
Albors, Aida Rodrigo
Mazurov, Vladimir
Brusch, Lutz
Deutsch, Andreas
Tanaka, Elly M.
Chara, Osvaldo
author Rost, Fabian
author_facet Rost, Fabian
Albors, Aida Rodrigo
Mazurov, Vladimir
Brusch, Lutz
Deutsch, Andreas
Tanaka, Elly M.
Chara, Osvaldo
author_role author
author2 Albors, Aida Rodrigo
Mazurov, Vladimir
Brusch, Lutz
Deutsch, Andreas
Tanaka, Elly M.
Chara, Osvaldo
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Ciencias Exactas
Axolotl
Regeneration
Extremities
Blastema formation
topic Ciencias Exactas
Axolotl
Regeneration
Extremities
Blastema formation
dc.description.none.fl_txt_mv Axolotls are unique in their ability to regenerate the spinal cord. However, the mechanisms that underlie this phenomenon remain poorly understood. Previously, we showed that regenerating stem cells in the axolotl spinal cord revert to a molecular state resembling embryonic neuroepithelial cells and functionally acquire rapid proliferative divisions (Rodrigo Albors et al., 2015). Here, we refine the analysis of cell proliferation in space and time and identify a high- proliferation zone in the regenerating spinal cord that shifts posteriorly over time. By tracking sparsely-labeled cells, we also quantify cell influx into the regenerate. Taking a mathematical modeling approach, we integrate these quantitative datasets of cell proliferation, neural stem cell activation and cell influx, to predict regenerative tissue outgrowth. Our model shows that while cell influx and neural stem cell activation play a minor role, the acceleration of the cell cycle is the major driver of regenerative spinal cord outgrowth in axolotls.
Facultad de Ciencias Exactas
Instituto de Física de Líquidos y Sistemas Biológicos
description Axolotls are unique in their ability to regenerate the spinal cord. However, the mechanisms that underlie this phenomenon remain poorly understood. Previously, we showed that regenerating stem cells in the axolotl spinal cord revert to a molecular state resembling embryonic neuroepithelial cells and functionally acquire rapid proliferative divisions (Rodrigo Albors et al., 2015). Here, we refine the analysis of cell proliferation in space and time and identify a high- proliferation zone in the regenerating spinal cord that shifts posteriorly over time. By tracking sparsely-labeled cells, we also quantify cell influx into the regenerate. Taking a mathematical modeling approach, we integrate these quantitative datasets of cell proliferation, neural stem cell activation and cell influx, to predict regenerative tissue outgrowth. Our model shows that while cell influx and neural stem cell activation play a minor role, the acceleration of the cell cycle is the major driver of regenerative spinal cord outgrowth in axolotls.
publishDate 2016
dc.date.none.fl_str_mv 2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/85906
url http://sedici.unlp.edu.ar/handle/10915/85906
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/2050-084X
info:eu-repo/semantics/altIdentifier/doi/10.7554/eLife.20357.001
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.22299

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