Bioavailability study of paracetamol tablets in saliva and urine

Autores
Retaco, Patricia Alejandra; González, M.; Pizzorno, María T.; Volonté, María Guillermina
Año de publicación
1996
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A bioavailability study of two lots of paracetamol tablets was carried out in 5 healthy volunteers, using a crossover aleatory design, and drug monitoring in urine and saliva by high performance liquid chromatography (HPLC). Results were correlated with those obtained in an in vitro dissolution study. Statistical evaluation of bioavailability parameters indicates that the two formulations may be considered bioequivalent, in spite of differences found during early stages of the absorption process, which were preventable according to an in vitro dissolution study.
Facultad de Ciencias Exactas
Materia
Farmacia
Paracetamol
bioavailability
in vitro-in vivo correlation
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/142040
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/142040
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Bioavailability study of paracetamol tablets in saliva and urineRetaco, Patricia AlejandraGonzález, M.Pizzorno, María T.Volonté, María GuillerminaFarmaciaParacetamolbioavailabilityin vitro-in vivo correlationA bioavailability study of two lots of paracetamol tablets was carried out in 5 healthy volunteers, using a crossover aleatory design, and drug monitoring in urine and saliva by high performance liquid chromatography (HPLC). Results were correlated with those obtained in an in vitro dissolution study. Statistical evaluation of bioavailability parameters indicates that the two formulations may be considered bioequivalent, in spite of differences found during early stages of the absorption process, which were preventable according to an in vitro dissolution study.Facultad de Ciencias Exactas1996info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf295-300http://sedici.unlp.edu.ar/handle/10915/142040enginfo:eu-repo/semantics/altIdentifier/issn/0378-7966info:eu-repo/semantics/altIdentifier/issn/2107-0180info:eu-repo/semantics/altIdentifier/doi/10.1007/bf03189730info:eu-repo/semantics/altIdentifier/pmid/9074893info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc/4.0/Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-10-15T11:24:03Zoai:sedici.unlp.edu.ar:10915/142040Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-10-15 11:24:03.383SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Bioavailability study of paracetamol tablets in saliva and urine
title Bioavailability study of paracetamol tablets in saliva and urine
spellingShingle Bioavailability study of paracetamol tablets in saliva and urine
Retaco, Patricia Alejandra
Farmacia
Paracetamol
bioavailability
in vitro-in vivo correlation
title_short Bioavailability study of paracetamol tablets in saliva and urine
title_full Bioavailability study of paracetamol tablets in saliva and urine
title_fullStr Bioavailability study of paracetamol tablets in saliva and urine
title_full_unstemmed Bioavailability study of paracetamol tablets in saliva and urine
title_sort Bioavailability study of paracetamol tablets in saliva and urine
dc.creator.none.fl_str_mv Retaco, Patricia Alejandra
González, M.
Pizzorno, María T.
Volonté, María Guillermina
author Retaco, Patricia Alejandra
author_facet Retaco, Patricia Alejandra
González, M.
Pizzorno, María T.
Volonté, María Guillermina
author_role author
author2 González, M.
Pizzorno, María T.
Volonté, María Guillermina
author2_role author
author
author
dc.subject.none.fl_str_mv Farmacia
Paracetamol
bioavailability
in vitro-in vivo correlation
topic Farmacia
Paracetamol
bioavailability
in vitro-in vivo correlation
dc.description.none.fl_txt_mv A bioavailability study of two lots of paracetamol tablets was carried out in 5 healthy volunteers, using a crossover aleatory design, and drug monitoring in urine and saliva by high performance liquid chromatography (HPLC). Results were correlated with those obtained in an in vitro dissolution study. Statistical evaluation of bioavailability parameters indicates that the two formulations may be considered bioequivalent, in spite of differences found during early stages of the absorption process, which were preventable according to an in vitro dissolution study.
Facultad de Ciencias Exactas
description A bioavailability study of two lots of paracetamol tablets was carried out in 5 healthy volunteers, using a crossover aleatory design, and drug monitoring in urine and saliva by high performance liquid chromatography (HPLC). Results were correlated with those obtained in an in vitro dissolution study. Statistical evaluation of bioavailability parameters indicates that the two formulations may be considered bioequivalent, in spite of differences found during early stages of the absorption process, which were preventable according to an in vitro dissolution study.
publishDate 1996
dc.date.none.fl_str_mv 1996
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/142040
url http://sedici.unlp.edu.ar/handle/10915/142040
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/0378-7966
info:eu-repo/semantics/altIdentifier/issn/2107-0180
info:eu-repo/semantics/altIdentifier/doi/10.1007/bf03189730
info:eu-repo/semantics/altIdentifier/pmid/9074893
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc/4.0/
Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc/4.0/
Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
dc.format.none.fl_str_mv application/pdf
295-300
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.22299

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