The use of saliva as a biological fluid in relative bioavailability studies: Comparison and correlation with plasma results

Autores
Ruiz, María Esperanza; Conforti, Paula Andrea; Fagolino, Pietro; Volonté, Maria Guillermina
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim of the present study was to present new evidence supporting the use of saliva as a biological fluid in relative bioavailability studies. Carbamazepine was chosen as a model drug because of its suitability for salivary therapeutic drug monitoring and its well-documented plasma bioavailability. A relative bioavailability study of four different immediate release carbamazepine products was performed. Stimulated saliva samples were collected by chewing on parafilm wax and by the spitting method. In vitro dissolution testing of formulations, using 900 ml of 1% sodium lauryl sulphate in water, was also carried out. The in vitro–in vivo correlations obtained in this salivary study were consistent with previous correlations assessed using plasma. These results support the suitability of saliva as the biological fluid in relative bioavailability studies.
Fil: Ruiz, María Esperanza. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Conforti, Paula Andrea. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos; Argentina
Fil: Fagolino, Pietro. Universidad de la República; Uruguay
Fil: Volonté, Maria Guillermina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; Argentina
Materia
CARBAMAZEPINE
DISSOLUTION PROFILES
IN VITRO-IN VIVO CORRELATIONS
RELATIVE BIOAVAILABILITY
SALIVA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/132571
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/132571
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The use of saliva as a biological fluid in relative bioavailability studies: Comparison and correlation with plasma resultsRuiz, María EsperanzaConforti, Paula AndreaFagolino, PietroVolonté, Maria GuillerminaCARBAMAZEPINEDISSOLUTION PROFILESIN VITRO-IN VIVO CORRELATIONSRELATIVE BIOAVAILABILITYSALIVAhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The aim of the present study was to present new evidence supporting the use of saliva as a biological fluid in relative bioavailability studies. Carbamazepine was chosen as a model drug because of its suitability for salivary therapeutic drug monitoring and its well-documented plasma bioavailability. A relative bioavailability study of four different immediate release carbamazepine products was performed. Stimulated saliva samples were collected by chewing on parafilm wax and by the spitting method. In vitro dissolution testing of formulations, using 900 ml of 1% sodium lauryl sulphate in water, was also carried out. The in vitro–in vivo correlations obtained in this salivary study were consistent with previous correlations assessed using plasma. These results support the suitability of saliva as the biological fluid in relative bioavailability studies.Fil: Ruiz, María Esperanza. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Conforti, Paula Andrea. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos; ArgentinaFil: Fagolino, Pietro. Universidad de la República; UruguayFil: Volonté, Maria Guillermina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; ArgentinaJohn Wiley & Sons Ltd2010-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/132571Ruiz, María Esperanza; Conforti, Paula Andrea; Fagolino, Pietro; Volonté, Maria Guillermina; The use of saliva as a biological fluid in relative bioavailability studies: Comparison and correlation with plasma results; John Wiley & Sons Ltd; Biopharmaceutics & Drug Disposition; 31; 8-9; 11-2010; 476-4851099-081X0142-2782CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1002/bdd.728info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/bdd.728info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:33:47Zoai:ri.conicet.gov.ar:11336/132571instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:33:48.052CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The use of saliva as a biological fluid in relative bioavailability studies: Comparison and correlation with plasma results
title The use of saliva as a biological fluid in relative bioavailability studies: Comparison and correlation with plasma results
spellingShingle The use of saliva as a biological fluid in relative bioavailability studies: Comparison and correlation with plasma results
Ruiz, María Esperanza
CARBAMAZEPINE
DISSOLUTION PROFILES
IN VITRO-IN VIVO CORRELATIONS
RELATIVE BIOAVAILABILITY
SALIVA
title_short The use of saliva as a biological fluid in relative bioavailability studies: Comparison and correlation with plasma results
title_full The use of saliva as a biological fluid in relative bioavailability studies: Comparison and correlation with plasma results
title_fullStr The use of saliva as a biological fluid in relative bioavailability studies: Comparison and correlation with plasma results
title_full_unstemmed The use of saliva as a biological fluid in relative bioavailability studies: Comparison and correlation with plasma results
title_sort The use of saliva as a biological fluid in relative bioavailability studies: Comparison and correlation with plasma results
dc.creator.none.fl_str_mv Ruiz, María Esperanza
Conforti, Paula Andrea
Fagolino, Pietro
Volonté, Maria Guillermina
author Ruiz, María Esperanza
author_facet Ruiz, María Esperanza
Conforti, Paula Andrea
Fagolino, Pietro
Volonté, Maria Guillermina
author_role author
author2 Conforti, Paula Andrea
Fagolino, Pietro
Volonté, Maria Guillermina
author2_role author
author
author
dc.subject.none.fl_str_mv CARBAMAZEPINE
DISSOLUTION PROFILES
IN VITRO-IN VIVO CORRELATIONS
RELATIVE BIOAVAILABILITY
SALIVA
topic CARBAMAZEPINE
DISSOLUTION PROFILES
IN VITRO-IN VIVO CORRELATIONS
RELATIVE BIOAVAILABILITY
SALIVA
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The aim of the present study was to present new evidence supporting the use of saliva as a biological fluid in relative bioavailability studies. Carbamazepine was chosen as a model drug because of its suitability for salivary therapeutic drug monitoring and its well-documented plasma bioavailability. A relative bioavailability study of four different immediate release carbamazepine products was performed. Stimulated saliva samples were collected by chewing on parafilm wax and by the spitting method. In vitro dissolution testing of formulations, using 900 ml of 1% sodium lauryl sulphate in water, was also carried out. The in vitro–in vivo correlations obtained in this salivary study were consistent with previous correlations assessed using plasma. These results support the suitability of saliva as the biological fluid in relative bioavailability studies.
Fil: Ruiz, María Esperanza. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Conforti, Paula Andrea. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos; Argentina
Fil: Fagolino, Pietro. Universidad de la República; Uruguay
Fil: Volonté, Maria Guillermina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; Argentina
description The aim of the present study was to present new evidence supporting the use of saliva as a biological fluid in relative bioavailability studies. Carbamazepine was chosen as a model drug because of its suitability for salivary therapeutic drug monitoring and its well-documented plasma bioavailability. A relative bioavailability study of four different immediate release carbamazepine products was performed. Stimulated saliva samples were collected by chewing on parafilm wax and by the spitting method. In vitro dissolution testing of formulations, using 900 ml of 1% sodium lauryl sulphate in water, was also carried out. The in vitro–in vivo correlations obtained in this salivary study were consistent with previous correlations assessed using plasma. These results support the suitability of saliva as the biological fluid in relative bioavailability studies.
publishDate 2010
dc.date.none.fl_str_mv 2010-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/132571
Ruiz, María Esperanza; Conforti, Paula Andrea; Fagolino, Pietro; Volonté, Maria Guillermina; The use of saliva as a biological fluid in relative bioavailability studies: Comparison and correlation with plasma results; John Wiley & Sons Ltd; Biopharmaceutics & Drug Disposition; 31; 8-9; 11-2010; 476-485
1099-081X
0142-2782
CONICET Digital
CONICET
url http://hdl.handle.net/11336/132571
identifier_str_mv Ruiz, María Esperanza; Conforti, Paula Andrea; Fagolino, Pietro; Volonté, Maria Guillermina; The use of saliva as a biological fluid in relative bioavailability studies: Comparison and correlation with plasma results; John Wiley & Sons Ltd; Biopharmaceutics & Drug Disposition; 31; 8-9; 11-2010; 476-485
1099-081X
0142-2782
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1002/bdd.728
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/bdd.728
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons Ltd
publisher.none.fl_str_mv John Wiley & Sons Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083467375280128
score 13.22299

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