Effect of Thyroxine on Δ6 and Δ9 Desaturation Activity
- Autores
- Tacconi de Gómez Dumm, Irma Nelva; Tacconi de Alaniz, María Josefa; Brenner, Rodolfo Roberto; Bazán, Nicolás G.; Brenner, Rodolfo Roberto; Giusto, Norma M.
- Año de publicación
- 1977
- Idioma
- inglés
- Tipo de recurso
- parte de libro
- Estado
- versión publicada
- Descripción
- Many studies have revealed that thyroid hormones markedly affect lipid metabolism in man and in several species of animals. Concerning fatty acid biosynthesis it was demonstrated that the administration of thyroxine stimulates the incorporation of l–14c acetate into fatty acids in rats and mice (Dayton et al, 1960) (Gompertz and Greenbaum, 1966) (Marchi and Mayer, 1959). According to Gompertz and Greenbaum (1966) these observations appear to be associated with an increase of stearyl-CoA desaturase activity. Moreover Myant and Iliffe (1963) found that rats treated with thyroxine showed an inhibition of acetate incorporation, but not of malonate incorporation, into fatty acids by mitochondria free, subcellular liver preparations. Other authors have shown that the thyrotoxic state was accompanied by an increased incorporation of acetyl-CoA to fatty acid and a rise in the activity of fatty acid synthetase in rat livers (Diamant et al, 1972) (Roncari and Murthy, 1975). However, in vitro studies of fatty acid synthesis in which liver supernatant of 105,000 xg and microsomal preparations were incubated with the hormone showed that thyroxine inhibits de novo synthesis of palmitate and stimulates the desaturation reactions (Faas et al, 1972).
Facultad de Ciencias Médicas - Materia
- Ciencias Médicas
- Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/143657
Ver los metadatos del registro completo
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Effect of Thyroxine on Δ6 and Δ9 Desaturation ActivityTacconi de Gómez Dumm, Irma NelvaTacconi de Alaniz, María JosefaBrenner, Rodolfo RobertoBazán, Nicolás G.Brenner, Rodolfo RobertoGiusto, Norma M.Ciencias MédicasMany studies have revealed that thyroid hormones markedly affect lipid metabolism in man and in several species of animals. Concerning fatty acid biosynthesis it was demonstrated that the administration of thyroxine stimulates the incorporation of l–14c acetate into fatty acids in rats and mice (Dayton et al, 1960) (Gompertz and Greenbaum, 1966) (Marchi and Mayer, 1959). According to Gompertz and Greenbaum (1966) these observations appear to be associated with an increase of stearyl-CoA desaturase activity. Moreover Myant and Iliffe (1963) found that rats treated with thyroxine showed an inhibition of acetate incorporation, but not of malonate incorporation, into fatty acids by mitochondria free, subcellular liver preparations. Other authors have shown that the thyrotoxic state was accompanied by an increased incorporation of acetyl-CoA to fatty acid and a rise in the activity of fatty acid synthetase in rat livers (Diamant et al, 1972) (Roncari and Murthy, 1975). However, in vitro studies of fatty acid synthesis in which liver supernatant of 105,000 xg and microsomal preparations were incubated with the hormone showed that thyroxine inhibits de novo synthesis of palmitate and stimulates the desaturation reactions (Faas et al, 1972).Facultad de Ciencias MédicasSpringer1977info:eu-repo/semantics/bookPartinfo:eu-repo/semantics/publishedVersionCapitulo de librohttp://purl.org/coar/resource_type/c_3248info:ar-repo/semantics/parteDeLibroapplication/pdf609-616http://sedici.unlp.edu.ar/handle/10915/143657enginfo:eu-repo/semantics/altIdentifier/isbn/978-1-4684-3276-3info:eu-repo/semantics/altIdentifier/issn/0065-2598info:eu-repo/semantics/altIdentifier/doi/10.1007/978-1-4684-3276-3_54info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:32:02Zoai:sedici.unlp.edu.ar:10915/143657Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:32:02.395SEDICI (UNLP) - Universidad Nacional de La Platafalse |
dc.title.none.fl_str_mv |
Effect of Thyroxine on Δ6 and Δ9 Desaturation Activity |
title |
Effect of Thyroxine on Δ6 and Δ9 Desaturation Activity |
spellingShingle |
Effect of Thyroxine on Δ6 and Δ9 Desaturation Activity Tacconi de Gómez Dumm, Irma Nelva Ciencias Médicas |
title_short |
Effect of Thyroxine on Δ6 and Δ9 Desaturation Activity |
title_full |
Effect of Thyroxine on Δ6 and Δ9 Desaturation Activity |
title_fullStr |
Effect of Thyroxine on Δ6 and Δ9 Desaturation Activity |
title_full_unstemmed |
Effect of Thyroxine on Δ6 and Δ9 Desaturation Activity |
title_sort |
Effect of Thyroxine on Δ6 and Δ9 Desaturation Activity |
dc.creator.none.fl_str_mv |
Tacconi de Gómez Dumm, Irma Nelva Tacconi de Alaniz, María Josefa Brenner, Rodolfo Roberto Bazán, Nicolás G. Brenner, Rodolfo Roberto Giusto, Norma M. |
author |
Tacconi de Gómez Dumm, Irma Nelva |
author_facet |
Tacconi de Gómez Dumm, Irma Nelva Tacconi de Alaniz, María Josefa Brenner, Rodolfo Roberto Bazán, Nicolás G. Giusto, Norma M. |
author_role |
author |
author2 |
Tacconi de Alaniz, María Josefa Brenner, Rodolfo Roberto Bazán, Nicolás G. Giusto, Norma M. |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
Ciencias Médicas |
topic |
Ciencias Médicas |
dc.description.none.fl_txt_mv |
Many studies have revealed that thyroid hormones markedly affect lipid metabolism in man and in several species of animals. Concerning fatty acid biosynthesis it was demonstrated that the administration of thyroxine stimulates the incorporation of l–14c acetate into fatty acids in rats and mice (Dayton et al, 1960) (Gompertz and Greenbaum, 1966) (Marchi and Mayer, 1959). According to Gompertz and Greenbaum (1966) these observations appear to be associated with an increase of stearyl-CoA desaturase activity. Moreover Myant and Iliffe (1963) found that rats treated with thyroxine showed an inhibition of acetate incorporation, but not of malonate incorporation, into fatty acids by mitochondria free, subcellular liver preparations. Other authors have shown that the thyrotoxic state was accompanied by an increased incorporation of acetyl-CoA to fatty acid and a rise in the activity of fatty acid synthetase in rat livers (Diamant et al, 1972) (Roncari and Murthy, 1975). However, in vitro studies of fatty acid synthesis in which liver supernatant of 105,000 xg and microsomal preparations were incubated with the hormone showed that thyroxine inhibits de novo synthesis of palmitate and stimulates the desaturation reactions (Faas et al, 1972). Facultad de Ciencias Médicas |
description |
Many studies have revealed that thyroid hormones markedly affect lipid metabolism in man and in several species of animals. Concerning fatty acid biosynthesis it was demonstrated that the administration of thyroxine stimulates the incorporation of l–14c acetate into fatty acids in rats and mice (Dayton et al, 1960) (Gompertz and Greenbaum, 1966) (Marchi and Mayer, 1959). According to Gompertz and Greenbaum (1966) these observations appear to be associated with an increase of stearyl-CoA desaturase activity. Moreover Myant and Iliffe (1963) found that rats treated with thyroxine showed an inhibition of acetate incorporation, but not of malonate incorporation, into fatty acids by mitochondria free, subcellular liver preparations. Other authors have shown that the thyrotoxic state was accompanied by an increased incorporation of acetyl-CoA to fatty acid and a rise in the activity of fatty acid synthetase in rat livers (Diamant et al, 1972) (Roncari and Murthy, 1975). However, in vitro studies of fatty acid synthesis in which liver supernatant of 105,000 xg and microsomal preparations were incubated with the hormone showed that thyroxine inhibits de novo synthesis of palmitate and stimulates the desaturation reactions (Faas et al, 1972). |
publishDate |
1977 |
dc.date.none.fl_str_mv |
1977 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/bookPart info:eu-repo/semantics/publishedVersion Capitulo de libro http://purl.org/coar/resource_type/c_3248 info:ar-repo/semantics/parteDeLibro |
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http://sedici.unlp.edu.ar/handle/10915/143657 |
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http://sedici.unlp.edu.ar/handle/10915/143657 |
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eng |
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eng |
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info:eu-repo/semantics/altIdentifier/isbn/978-1-4684-3276-3 info:eu-repo/semantics/altIdentifier/issn/0065-2598 info:eu-repo/semantics/altIdentifier/doi/10.1007/978-1-4684-3276-3_54 |
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openAccess |
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http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
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application/pdf 609-616 |
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Springer |
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Springer |
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