Effect of Thyroxine on Δ6 and Δ9 Desaturation Activity

Autores
Tacconi de Gómez Dumm, Irma Nelva; Tacconi de Alaniz, María Josefa; Brenner, Rodolfo Roberto; Bazán, Nicolás G.; Brenner, Rodolfo Roberto; Giusto, Norma M.
Año de publicación
1977
Idioma
inglés
Tipo de recurso
parte de libro
Estado
versión publicada
Descripción
Many studies have revealed that thyroid hormones markedly affect lipid metabolism in man and in several species of animals. Concerning fatty acid biosynthesis it was demonstrated that the administration of thyroxine stimulates the incorporation of l–14c acetate into fatty acids in rats and mice (Dayton et al, 1960) (Gompertz and Greenbaum, 1966) (Marchi and Mayer, 1959). According to Gompertz and Greenbaum (1966) these observations appear to be associated with an increase of stearyl-CoA desaturase activity. Moreover Myant and Iliffe (1963) found that rats treated with thyroxine showed an inhibition of acetate incorporation, but not of malonate incorporation, into fatty acids by mitochondria free, subcellular liver preparations. Other authors have shown that the thyrotoxic state was accompanied by an increased incorporation of acetyl-CoA to fatty acid and a rise in the activity of fatty acid synthetase in rat livers (Diamant et al, 1972) (Roncari and Murthy, 1975). However, in vitro studies of fatty acid synthesis in which liver supernatant of 105,000 xg and microsomal preparations were incubated with the hormone showed that thyroxine inhibits de novo synthesis of palmitate and stimulates the desaturation reactions (Faas et al, 1972).
Facultad de Ciencias Médicas
Materia
Ciencias Médicas
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/143657

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network_name_str SEDICI (UNLP)
spelling Effect of Thyroxine on Δ6 and Δ9 Desaturation ActivityTacconi de Gómez Dumm, Irma NelvaTacconi de Alaniz, María JosefaBrenner, Rodolfo RobertoBazán, Nicolás G.Brenner, Rodolfo RobertoGiusto, Norma M.Ciencias MédicasMany studies have revealed that thyroid hormones markedly affect lipid metabolism in man and in several species of animals. Concerning fatty acid biosynthesis it was demonstrated that the administration of thyroxine stimulates the incorporation of l–14c acetate into fatty acids in rats and mice (Dayton et al, 1960) (Gompertz and Greenbaum, 1966) (Marchi and Mayer, 1959). According to Gompertz and Greenbaum (1966) these observations appear to be associated with an increase of stearyl-CoA desaturase activity. Moreover Myant and Iliffe (1963) found that rats treated with thyroxine showed an inhibition of acetate incorporation, but not of malonate incorporation, into fatty acids by mitochondria free, subcellular liver preparations. Other authors have shown that the thyrotoxic state was accompanied by an increased incorporation of acetyl-CoA to fatty acid and a rise in the activity of fatty acid synthetase in rat livers (Diamant et al, 1972) (Roncari and Murthy, 1975). However, in vitro studies of fatty acid synthesis in which liver supernatant of 105,000 xg and microsomal preparations were incubated with the hormone showed that thyroxine inhibits de novo synthesis of palmitate and stimulates the desaturation reactions (Faas et al, 1972).Facultad de Ciencias MédicasSpringer1977info:eu-repo/semantics/bookPartinfo:eu-repo/semantics/publishedVersionCapitulo de librohttp://purl.org/coar/resource_type/c_3248info:ar-repo/semantics/parteDeLibroapplication/pdf609-616http://sedici.unlp.edu.ar/handle/10915/143657enginfo:eu-repo/semantics/altIdentifier/isbn/978-1-4684-3276-3info:eu-repo/semantics/altIdentifier/issn/0065-2598info:eu-repo/semantics/altIdentifier/doi/10.1007/978-1-4684-3276-3_54info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:32:02Zoai:sedici.unlp.edu.ar:10915/143657Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:32:02.395SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Effect of Thyroxine on Δ6 and Δ9 Desaturation Activity
title Effect of Thyroxine on Δ6 and Δ9 Desaturation Activity
spellingShingle Effect of Thyroxine on Δ6 and Δ9 Desaturation Activity
Tacconi de Gómez Dumm, Irma Nelva
Ciencias Médicas
title_short Effect of Thyroxine on Δ6 and Δ9 Desaturation Activity
title_full Effect of Thyroxine on Δ6 and Δ9 Desaturation Activity
title_fullStr Effect of Thyroxine on Δ6 and Δ9 Desaturation Activity
title_full_unstemmed Effect of Thyroxine on Δ6 and Δ9 Desaturation Activity
title_sort Effect of Thyroxine on Δ6 and Δ9 Desaturation Activity
dc.creator.none.fl_str_mv Tacconi de Gómez Dumm, Irma Nelva
Tacconi de Alaniz, María Josefa
Brenner, Rodolfo Roberto
Bazán, Nicolás G.
Brenner, Rodolfo Roberto
Giusto, Norma M.
author Tacconi de Gómez Dumm, Irma Nelva
author_facet Tacconi de Gómez Dumm, Irma Nelva
Tacconi de Alaniz, María Josefa
Brenner, Rodolfo Roberto
Bazán, Nicolás G.
Giusto, Norma M.
author_role author
author2 Tacconi de Alaniz, María Josefa
Brenner, Rodolfo Roberto
Bazán, Nicolás G.
Giusto, Norma M.
author2_role author
author
author
author
dc.subject.none.fl_str_mv Ciencias Médicas
topic Ciencias Médicas
dc.description.none.fl_txt_mv Many studies have revealed that thyroid hormones markedly affect lipid metabolism in man and in several species of animals. Concerning fatty acid biosynthesis it was demonstrated that the administration of thyroxine stimulates the incorporation of l–14c acetate into fatty acids in rats and mice (Dayton et al, 1960) (Gompertz and Greenbaum, 1966) (Marchi and Mayer, 1959). According to Gompertz and Greenbaum (1966) these observations appear to be associated with an increase of stearyl-CoA desaturase activity. Moreover Myant and Iliffe (1963) found that rats treated with thyroxine showed an inhibition of acetate incorporation, but not of malonate incorporation, into fatty acids by mitochondria free, subcellular liver preparations. Other authors have shown that the thyrotoxic state was accompanied by an increased incorporation of acetyl-CoA to fatty acid and a rise in the activity of fatty acid synthetase in rat livers (Diamant et al, 1972) (Roncari and Murthy, 1975). However, in vitro studies of fatty acid synthesis in which liver supernatant of 105,000 xg and microsomal preparations were incubated with the hormone showed that thyroxine inhibits de novo synthesis of palmitate and stimulates the desaturation reactions (Faas et al, 1972).
Facultad de Ciencias Médicas
description Many studies have revealed that thyroid hormones markedly affect lipid metabolism in man and in several species of animals. Concerning fatty acid biosynthesis it was demonstrated that the administration of thyroxine stimulates the incorporation of l–14c acetate into fatty acids in rats and mice (Dayton et al, 1960) (Gompertz and Greenbaum, 1966) (Marchi and Mayer, 1959). According to Gompertz and Greenbaum (1966) these observations appear to be associated with an increase of stearyl-CoA desaturase activity. Moreover Myant and Iliffe (1963) found that rats treated with thyroxine showed an inhibition of acetate incorporation, but not of malonate incorporation, into fatty acids by mitochondria free, subcellular liver preparations. Other authors have shown that the thyrotoxic state was accompanied by an increased incorporation of acetyl-CoA to fatty acid and a rise in the activity of fatty acid synthetase in rat livers (Diamant et al, 1972) (Roncari and Murthy, 1975). However, in vitro studies of fatty acid synthesis in which liver supernatant of 105,000 xg and microsomal preparations were incubated with the hormone showed that thyroxine inhibits de novo synthesis of palmitate and stimulates the desaturation reactions (Faas et al, 1972).
publishDate 1977
dc.date.none.fl_str_mv 1977
dc.type.none.fl_str_mv info:eu-repo/semantics/bookPart
info:eu-repo/semantics/publishedVersion
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http://purl.org/coar/resource_type/c_3248
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format bookPart
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/143657
url http://sedici.unlp.edu.ar/handle/10915/143657
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/isbn/978-1-4684-3276-3
info:eu-repo/semantics/altIdentifier/issn/0065-2598
info:eu-repo/semantics/altIdentifier/doi/10.1007/978-1-4684-3276-3_54
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
609-616
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
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instname:Universidad Nacional de La Plata
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instname_str Universidad Nacional de La Plata
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repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
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