Region-specific changes in <i>Mus musculus</i> brain size and cell composition under chronic nutrient restriction

Autores
Barbeito Andrés, Jimena; Castro Fonseca, Emily; Qiu, Lily R.; Bernal, Valeria; Lent, Roberto; Henkelman, Mark; Lukowiak, Ken; Gleiser, Pablo M.; Hallgrimsson, Benedikt; González, Paula Natalia
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Nutrition is one of the most influential environmental factors affecting the development of different tissues and organs. It is suggested that under nutrient restriction the growth of the brain is spared as a result of the differential allocation of resources from other organs. However, it is not clear whether this sparing occurs brain-wide. Here, we analyzed morphological changes and cell composition in different regions of the offspring mouse brain after maternal exposure to nutrient restriction during pregnancy and lactation. Using high-resolution magnetic resonance imaging, we found that brain regions were differentially sensitive to maternal protein restriction and exhibited particular patterns of volume reduction. The cerebellum was reduced in absolute and relative volume, while cortex volume was relatively preserved. Alterations in cell composition (examined by the isotropic fractionator method) and organization of white matter (measured by diffusor tensor images) were also region specific. These changes were not related to the metabolic rate of the regions and were only partially explained by their specific growth trajectories. This study is a first step towards understanding the mechanisms of regional brain sparing at microstructural and macrostructural levels resulting from undernutrition.
Facultad de Ciencias Naturales y Museo
Materia
Ciencias Naturales
Brain sparing
Brain cortex
Cerebellum
Magnetic resonance imaging
Isotropic fractionator
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/125046

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network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Region-specific changes in <i>Mus musculus</i> brain size and cell composition under chronic nutrient restrictionBarbeito Andrés, JimenaCastro Fonseca, EmilyQiu, Lily R.Bernal, ValeriaLent, RobertoHenkelman, MarkLukowiak, KenGleiser, Pablo M.Hallgrimsson, BenediktGonzález, Paula NataliaCiencias NaturalesBrain sparingBrain cortexCerebellumMagnetic resonance imagingIsotropic fractionatorNutrition is one of the most influential environmental factors affecting the development of different tissues and organs. It is suggested that under nutrient restriction the growth of the brain is spared as a result of the differential allocation of resources from other organs. However, it is not clear whether this sparing occurs brain-wide. Here, we analyzed morphological changes and cell composition in different regions of the offspring mouse brain after maternal exposure to nutrient restriction during pregnancy and lactation. Using high-resolution magnetic resonance imaging, we found that brain regions were differentially sensitive to maternal protein restriction and exhibited particular patterns of volume reduction. The cerebellum was reduced in absolute and relative volume, while cortex volume was relatively preserved. Alterations in cell composition (examined by the isotropic fractionator method) and organization of white matter (measured by diffusor tensor images) were also region specific. These changes were not related to the metabolic rate of the regions and were only partially explained by their specific growth trajectories. This study is a first step towards understanding the mechanisms of regional brain sparing at microstructural and macrostructural levels resulting from undernutrition.Facultad de Ciencias Naturales y Museo2019-09-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/125046enginfo:eu-repo/semantics/altIdentifier/issn/1477-9145info:eu-repo/semantics/altIdentifier/issn/0022-0949info:eu-repo/semantics/altIdentifier/pmid/31395680info:eu-repo/semantics/altIdentifier/doi/10.1242/jeb.204651info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:29:54Zoai:sedici.unlp.edu.ar:10915/125046Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:29:54.677SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Region-specific changes in <i>Mus musculus</i> brain size and cell composition under chronic nutrient restriction
title Region-specific changes in <i>Mus musculus</i> brain size and cell composition under chronic nutrient restriction
spellingShingle Region-specific changes in <i>Mus musculus</i> brain size and cell composition under chronic nutrient restriction
Barbeito Andrés, Jimena
Ciencias Naturales
Brain sparing
Brain cortex
Cerebellum
Magnetic resonance imaging
Isotropic fractionator
title_short Region-specific changes in <i>Mus musculus</i> brain size and cell composition under chronic nutrient restriction
title_full Region-specific changes in <i>Mus musculus</i> brain size and cell composition under chronic nutrient restriction
title_fullStr Region-specific changes in <i>Mus musculus</i> brain size and cell composition under chronic nutrient restriction
title_full_unstemmed Region-specific changes in <i>Mus musculus</i> brain size and cell composition under chronic nutrient restriction
title_sort Region-specific changes in <i>Mus musculus</i> brain size and cell composition under chronic nutrient restriction
dc.creator.none.fl_str_mv Barbeito Andrés, Jimena
Castro Fonseca, Emily
Qiu, Lily R.
Bernal, Valeria
Lent, Roberto
Henkelman, Mark
Lukowiak, Ken
Gleiser, Pablo M.
Hallgrimsson, Benedikt
González, Paula Natalia
author Barbeito Andrés, Jimena
author_facet Barbeito Andrés, Jimena
Castro Fonseca, Emily
Qiu, Lily R.
Bernal, Valeria
Lent, Roberto
Henkelman, Mark
Lukowiak, Ken
Gleiser, Pablo M.
Hallgrimsson, Benedikt
González, Paula Natalia
author_role author
author2 Castro Fonseca, Emily
Qiu, Lily R.
Bernal, Valeria
Lent, Roberto
Henkelman, Mark
Lukowiak, Ken
Gleiser, Pablo M.
Hallgrimsson, Benedikt
González, Paula Natalia
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Ciencias Naturales
Brain sparing
Brain cortex
Cerebellum
Magnetic resonance imaging
Isotropic fractionator
topic Ciencias Naturales
Brain sparing
Brain cortex
Cerebellum
Magnetic resonance imaging
Isotropic fractionator
dc.description.none.fl_txt_mv Nutrition is one of the most influential environmental factors affecting the development of different tissues and organs. It is suggested that under nutrient restriction the growth of the brain is spared as a result of the differential allocation of resources from other organs. However, it is not clear whether this sparing occurs brain-wide. Here, we analyzed morphological changes and cell composition in different regions of the offspring mouse brain after maternal exposure to nutrient restriction during pregnancy and lactation. Using high-resolution magnetic resonance imaging, we found that brain regions were differentially sensitive to maternal protein restriction and exhibited particular patterns of volume reduction. The cerebellum was reduced in absolute and relative volume, while cortex volume was relatively preserved. Alterations in cell composition (examined by the isotropic fractionator method) and organization of white matter (measured by diffusor tensor images) were also region specific. These changes were not related to the metabolic rate of the regions and were only partially explained by their specific growth trajectories. This study is a first step towards understanding the mechanisms of regional brain sparing at microstructural and macrostructural levels resulting from undernutrition.
Facultad de Ciencias Naturales y Museo
description Nutrition is one of the most influential environmental factors affecting the development of different tissues and organs. It is suggested that under nutrient restriction the growth of the brain is spared as a result of the differential allocation of resources from other organs. However, it is not clear whether this sparing occurs brain-wide. Here, we analyzed morphological changes and cell composition in different regions of the offspring mouse brain after maternal exposure to nutrient restriction during pregnancy and lactation. Using high-resolution magnetic resonance imaging, we found that brain regions were differentially sensitive to maternal protein restriction and exhibited particular patterns of volume reduction. The cerebellum was reduced in absolute and relative volume, while cortex volume was relatively preserved. Alterations in cell composition (examined by the isotropic fractionator method) and organization of white matter (measured by diffusor tensor images) were also region specific. These changes were not related to the metabolic rate of the regions and were only partially explained by their specific growth trajectories. This study is a first step towards understanding the mechanisms of regional brain sparing at microstructural and macrostructural levels resulting from undernutrition.
publishDate 2019
dc.date.none.fl_str_mv 2019-09-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/125046
url http://sedici.unlp.edu.ar/handle/10915/125046
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/1477-9145
info:eu-repo/semantics/altIdentifier/issn/0022-0949
info:eu-repo/semantics/altIdentifier/pmid/31395680
info:eu-repo/semantics/altIdentifier/doi/10.1242/jeb.204651
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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