Region-specific changes in <i>Mus musculus</i> brain size and cell composition under chronic nutrient restriction
- Autores
- Barbeito Andrés, Jimena; Castro Fonseca, Emily; Qiu, Lily R.; Bernal, Valeria; Lent, Roberto; Henkelman, Mark; Lukowiak, Ken; Gleiser, Pablo M.; Hallgrimsson, Benedikt; González, Paula Natalia
- Año de publicación
- 2019
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Nutrition is one of the most influential environmental factors affecting the development of different tissues and organs. It is suggested that under nutrient restriction the growth of the brain is spared as a result of the differential allocation of resources from other organs. However, it is not clear whether this sparing occurs brain-wide. Here, we analyzed morphological changes and cell composition in different regions of the offspring mouse brain after maternal exposure to nutrient restriction during pregnancy and lactation. Using high-resolution magnetic resonance imaging, we found that brain regions were differentially sensitive to maternal protein restriction and exhibited particular patterns of volume reduction. The cerebellum was reduced in absolute and relative volume, while cortex volume was relatively preserved. Alterations in cell composition (examined by the isotropic fractionator method) and organization of white matter (measured by diffusor tensor images) were also region specific. These changes were not related to the metabolic rate of the regions and were only partially explained by their specific growth trajectories. This study is a first step towards understanding the mechanisms of regional brain sparing at microstructural and macrostructural levels resulting from undernutrition.
Facultad de Ciencias Naturales y Museo - Materia
-
Ciencias Naturales
Brain sparing
Brain cortex
Cerebellum
Magnetic resonance imaging
Isotropic fractionator - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/125046
Ver los metadatos del registro completo
id |
SEDICI_46e76f02c5f98e4551f6e776d2aa4196 |
---|---|
oai_identifier_str |
oai:sedici.unlp.edu.ar:10915/125046 |
network_acronym_str |
SEDICI |
repository_id_str |
1329 |
network_name_str |
SEDICI (UNLP) |
spelling |
Region-specific changes in <i>Mus musculus</i> brain size and cell composition under chronic nutrient restrictionBarbeito Andrés, JimenaCastro Fonseca, EmilyQiu, Lily R.Bernal, ValeriaLent, RobertoHenkelman, MarkLukowiak, KenGleiser, Pablo M.Hallgrimsson, BenediktGonzález, Paula NataliaCiencias NaturalesBrain sparingBrain cortexCerebellumMagnetic resonance imagingIsotropic fractionatorNutrition is one of the most influential environmental factors affecting the development of different tissues and organs. It is suggested that under nutrient restriction the growth of the brain is spared as a result of the differential allocation of resources from other organs. However, it is not clear whether this sparing occurs brain-wide. Here, we analyzed morphological changes and cell composition in different regions of the offspring mouse brain after maternal exposure to nutrient restriction during pregnancy and lactation. Using high-resolution magnetic resonance imaging, we found that brain regions were differentially sensitive to maternal protein restriction and exhibited particular patterns of volume reduction. The cerebellum was reduced in absolute and relative volume, while cortex volume was relatively preserved. Alterations in cell composition (examined by the isotropic fractionator method) and organization of white matter (measured by diffusor tensor images) were also region specific. These changes were not related to the metabolic rate of the regions and were only partially explained by their specific growth trajectories. This study is a first step towards understanding the mechanisms of regional brain sparing at microstructural and macrostructural levels resulting from undernutrition.Facultad de Ciencias Naturales y Museo2019-09-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/125046enginfo:eu-repo/semantics/altIdentifier/issn/1477-9145info:eu-repo/semantics/altIdentifier/issn/0022-0949info:eu-repo/semantics/altIdentifier/pmid/31395680info:eu-repo/semantics/altIdentifier/doi/10.1242/jeb.204651info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:29:54Zoai:sedici.unlp.edu.ar:10915/125046Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:29:54.677SEDICI (UNLP) - Universidad Nacional de La Platafalse |
dc.title.none.fl_str_mv |
Region-specific changes in <i>Mus musculus</i> brain size and cell composition under chronic nutrient restriction |
title |
Region-specific changes in <i>Mus musculus</i> brain size and cell composition under chronic nutrient restriction |
spellingShingle |
Region-specific changes in <i>Mus musculus</i> brain size and cell composition under chronic nutrient restriction Barbeito Andrés, Jimena Ciencias Naturales Brain sparing Brain cortex Cerebellum Magnetic resonance imaging Isotropic fractionator |
title_short |
Region-specific changes in <i>Mus musculus</i> brain size and cell composition under chronic nutrient restriction |
title_full |
Region-specific changes in <i>Mus musculus</i> brain size and cell composition under chronic nutrient restriction |
title_fullStr |
Region-specific changes in <i>Mus musculus</i> brain size and cell composition under chronic nutrient restriction |
title_full_unstemmed |
Region-specific changes in <i>Mus musculus</i> brain size and cell composition under chronic nutrient restriction |
title_sort |
Region-specific changes in <i>Mus musculus</i> brain size and cell composition under chronic nutrient restriction |
dc.creator.none.fl_str_mv |
Barbeito Andrés, Jimena Castro Fonseca, Emily Qiu, Lily R. Bernal, Valeria Lent, Roberto Henkelman, Mark Lukowiak, Ken Gleiser, Pablo M. Hallgrimsson, Benedikt González, Paula Natalia |
author |
Barbeito Andrés, Jimena |
author_facet |
Barbeito Andrés, Jimena Castro Fonseca, Emily Qiu, Lily R. Bernal, Valeria Lent, Roberto Henkelman, Mark Lukowiak, Ken Gleiser, Pablo M. Hallgrimsson, Benedikt González, Paula Natalia |
author_role |
author |
author2 |
Castro Fonseca, Emily Qiu, Lily R. Bernal, Valeria Lent, Roberto Henkelman, Mark Lukowiak, Ken Gleiser, Pablo M. Hallgrimsson, Benedikt González, Paula Natalia |
author2_role |
author author author author author author author author author |
dc.subject.none.fl_str_mv |
Ciencias Naturales Brain sparing Brain cortex Cerebellum Magnetic resonance imaging Isotropic fractionator |
topic |
Ciencias Naturales Brain sparing Brain cortex Cerebellum Magnetic resonance imaging Isotropic fractionator |
dc.description.none.fl_txt_mv |
Nutrition is one of the most influential environmental factors affecting the development of different tissues and organs. It is suggested that under nutrient restriction the growth of the brain is spared as a result of the differential allocation of resources from other organs. However, it is not clear whether this sparing occurs brain-wide. Here, we analyzed morphological changes and cell composition in different regions of the offspring mouse brain after maternal exposure to nutrient restriction during pregnancy and lactation. Using high-resolution magnetic resonance imaging, we found that brain regions were differentially sensitive to maternal protein restriction and exhibited particular patterns of volume reduction. The cerebellum was reduced in absolute and relative volume, while cortex volume was relatively preserved. Alterations in cell composition (examined by the isotropic fractionator method) and organization of white matter (measured by diffusor tensor images) were also region specific. These changes were not related to the metabolic rate of the regions and were only partially explained by their specific growth trajectories. This study is a first step towards understanding the mechanisms of regional brain sparing at microstructural and macrostructural levels resulting from undernutrition. Facultad de Ciencias Naturales y Museo |
description |
Nutrition is one of the most influential environmental factors affecting the development of different tissues and organs. It is suggested that under nutrient restriction the growth of the brain is spared as a result of the differential allocation of resources from other organs. However, it is not clear whether this sparing occurs brain-wide. Here, we analyzed morphological changes and cell composition in different regions of the offspring mouse brain after maternal exposure to nutrient restriction during pregnancy and lactation. Using high-resolution magnetic resonance imaging, we found that brain regions were differentially sensitive to maternal protein restriction and exhibited particular patterns of volume reduction. The cerebellum was reduced in absolute and relative volume, while cortex volume was relatively preserved. Alterations in cell composition (examined by the isotropic fractionator method) and organization of white matter (measured by diffusor tensor images) were also region specific. These changes were not related to the metabolic rate of the regions and were only partially explained by their specific growth trajectories. This study is a first step towards understanding the mechanisms of regional brain sparing at microstructural and macrostructural levels resulting from undernutrition. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-09-05 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Articulo http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://sedici.unlp.edu.ar/handle/10915/125046 |
url |
http://sedici.unlp.edu.ar/handle/10915/125046 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/issn/1477-9145 info:eu-repo/semantics/altIdentifier/issn/0022-0949 info:eu-repo/semantics/altIdentifier/pmid/31395680 info:eu-repo/semantics/altIdentifier/doi/10.1242/jeb.204651 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:SEDICI (UNLP) instname:Universidad Nacional de La Plata instacron:UNLP |
reponame_str |
SEDICI (UNLP) |
collection |
SEDICI (UNLP) |
instname_str |
Universidad Nacional de La Plata |
instacron_str |
UNLP |
institution |
UNLP |
repository.name.fl_str_mv |
SEDICI (UNLP) - Universidad Nacional de La Plata |
repository.mail.fl_str_mv |
alira@sedici.unlp.edu.ar |
_version_ |
1844616178514788352 |
score |
13.070432 |