Remote brain network changes after unilateral cortical impact injury and their modulation by Acetylcholinesterase inhibition
- Autores
- Holschneider, Daniel P.; Guo, Yumei; Wang, Zhuo; Roch, Margareth; Scremin, Oscar Umberto
- Año de publicación
- 2013
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- We explored whether cerebral cortical impact injury (CCI) effects extend beyond direct lesion sites to affect remote brain networks, and whether acetylcholinesterase (AChE) inhibition elicits discrete changes in functional activation of motor circuits following CCI. Adult male rats underwent unilateral motor-sensory CCI or sham injury. Physostigmine (AChE inhibitor) or saline were administered subcutaneously continuously via implanted minipumps (1.6 micromoles/kg/day) for 3 weeks, followed by cerebral perfusion mapping during treadmill walking using [14C]-iodoantipyrine. Quantitative autoradiographs were analyzed by statistical parametric mapping and functional connectivity (FC) analysis. CCI resulted in functional deficits in the ipsilesional basal ganglia, with increased activation contralesionally. Recruitment was also observed, especially contralesionally, of the red nucleus, superior colliculus, pedunculopontine tegmental nucleus, thalamus (ventrolateral n., central medial n.), cerebellum, and sensory cortex. FC decreased significantly within ipsi- and contralesional motor circuits and between hemispheres, but increased between midline cerebellum and select regions of the basal ganglia within each hemisphere. Physostigmine significantly increased functional brain activation in the cerebellar thalamocortical pathway (midline cerebellum/ventrolateral thalamus/motor cortex), subthalamic nucleus/zona incerta, and red nucleus and bilateral sensory cortex. In conclusion, CCI resulted in increased functional recruitment of contralesional motor cortex and bilateral subcortical motor regions, as well as recruitment of the cerebellar– thalamocortical circuit and contralesional sensory cortex. This phenomenon, augmented by physostigmine, may partially compensate motor deficits. FC decreased inter-hemispherically and in negative, but not positive, intra-hemispherical FC, and it was not affected by physostigmine. Circuit-based approaches into functional brain reorganization may inform future behavioral or molecular strategies to augment targeted neurorehabilitation.
Fil: Holschneider, Daniel P.. University of California at Los Angeles; Estados Unidos
Fil: Guo, Yumei. University of California at Los Angeles; Estados Unidos
Fil: Wang, Zhuo. University of California at Los Angeles; Estados Unidos
Fil: Roch, Margareth. University of California at Los Angeles; Estados Unidos
Fil: Scremin, Oscar Umberto. University of California at Los Angeles; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina - Materia
-
Brain Imaging
Brain Trauma
Rats
Autoradiography - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/21589
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Remote brain network changes after unilateral cortical impact injury and their modulation by Acetylcholinesterase inhibitionHolschneider, Daniel P.Guo, YumeiWang, ZhuoRoch, MargarethScremin, Oscar UmbertoBrain ImagingBrain TraumaRatsAutoradiographyhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1We explored whether cerebral cortical impact injury (CCI) effects extend beyond direct lesion sites to affect remote brain networks, and whether acetylcholinesterase (AChE) inhibition elicits discrete changes in functional activation of motor circuits following CCI. Adult male rats underwent unilateral motor-sensory CCI or sham injury. Physostigmine (AChE inhibitor) or saline were administered subcutaneously continuously via implanted minipumps (1.6 micromoles/kg/day) for 3 weeks, followed by cerebral perfusion mapping during treadmill walking using [14C]-iodoantipyrine. Quantitative autoradiographs were analyzed by statistical parametric mapping and functional connectivity (FC) analysis. CCI resulted in functional deficits in the ipsilesional basal ganglia, with increased activation contralesionally. Recruitment was also observed, especially contralesionally, of the red nucleus, superior colliculus, pedunculopontine tegmental nucleus, thalamus (ventrolateral n., central medial n.), cerebellum, and sensory cortex. FC decreased significantly within ipsi- and contralesional motor circuits and between hemispheres, but increased between midline cerebellum and select regions of the basal ganglia within each hemisphere. Physostigmine significantly increased functional brain activation in the cerebellar thalamocortical pathway (midline cerebellum/ventrolateral thalamus/motor cortex), subthalamic nucleus/zona incerta, and red nucleus and bilateral sensory cortex. In conclusion, CCI resulted in increased functional recruitment of contralesional motor cortex and bilateral subcortical motor regions, as well as recruitment of the cerebellar– thalamocortical circuit and contralesional sensory cortex. This phenomenon, augmented by physostigmine, may partially compensate motor deficits. FC decreased inter-hemispherically and in negative, but not positive, intra-hemispherical FC, and it was not affected by physostigmine. Circuit-based approaches into functional brain reorganization may inform future behavioral or molecular strategies to augment targeted neurorehabilitation.Fil: Holschneider, Daniel P.. University of California at Los Angeles; Estados UnidosFil: Guo, Yumei. University of California at Los Angeles; Estados UnidosFil: Wang, Zhuo. University of California at Los Angeles; Estados UnidosFil: Roch, Margareth. University of California at Los Angeles; Estados UnidosFil: Scremin, Oscar Umberto. University of California at Los Angeles; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaMary Ann Liebert Inc2013-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/21589Holschneider, Daniel P.; Guo, Yumei; Wang, Zhuo; Roch, Margareth; Scremin, Oscar Umberto; Remote brain network changes after unilateral cortical impact injury and their modulation by Acetylcholinesterase inhibition; Mary Ann Liebert Inc; Journal of Neurotrauma; 30; 11; 1-2013; 907-9190897-7151CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1089/neu.2012.2657info:eu-repo/semantics/altIdentifier/url/http://online.liebertpub.com/doi/abs/10.1089/neu.2012.2657info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:37:27Zoai:ri.conicet.gov.ar:11336/21589instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:37:27.27CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Remote brain network changes after unilateral cortical impact injury and their modulation by Acetylcholinesterase inhibition |
title |
Remote brain network changes after unilateral cortical impact injury and their modulation by Acetylcholinesterase inhibition |
spellingShingle |
Remote brain network changes after unilateral cortical impact injury and their modulation by Acetylcholinesterase inhibition Holschneider, Daniel P. Brain Imaging Brain Trauma Rats Autoradiography |
title_short |
Remote brain network changes after unilateral cortical impact injury and their modulation by Acetylcholinesterase inhibition |
title_full |
Remote brain network changes after unilateral cortical impact injury and their modulation by Acetylcholinesterase inhibition |
title_fullStr |
Remote brain network changes after unilateral cortical impact injury and their modulation by Acetylcholinesterase inhibition |
title_full_unstemmed |
Remote brain network changes after unilateral cortical impact injury and their modulation by Acetylcholinesterase inhibition |
title_sort |
Remote brain network changes after unilateral cortical impact injury and their modulation by Acetylcholinesterase inhibition |
dc.creator.none.fl_str_mv |
Holschneider, Daniel P. Guo, Yumei Wang, Zhuo Roch, Margareth Scremin, Oscar Umberto |
author |
Holschneider, Daniel P. |
author_facet |
Holschneider, Daniel P. Guo, Yumei Wang, Zhuo Roch, Margareth Scremin, Oscar Umberto |
author_role |
author |
author2 |
Guo, Yumei Wang, Zhuo Roch, Margareth Scremin, Oscar Umberto |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
Brain Imaging Brain Trauma Rats Autoradiography |
topic |
Brain Imaging Brain Trauma Rats Autoradiography |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
We explored whether cerebral cortical impact injury (CCI) effects extend beyond direct lesion sites to affect remote brain networks, and whether acetylcholinesterase (AChE) inhibition elicits discrete changes in functional activation of motor circuits following CCI. Adult male rats underwent unilateral motor-sensory CCI or sham injury. Physostigmine (AChE inhibitor) or saline were administered subcutaneously continuously via implanted minipumps (1.6 micromoles/kg/day) for 3 weeks, followed by cerebral perfusion mapping during treadmill walking using [14C]-iodoantipyrine. Quantitative autoradiographs were analyzed by statistical parametric mapping and functional connectivity (FC) analysis. CCI resulted in functional deficits in the ipsilesional basal ganglia, with increased activation contralesionally. Recruitment was also observed, especially contralesionally, of the red nucleus, superior colliculus, pedunculopontine tegmental nucleus, thalamus (ventrolateral n., central medial n.), cerebellum, and sensory cortex. FC decreased significantly within ipsi- and contralesional motor circuits and between hemispheres, but increased between midline cerebellum and select regions of the basal ganglia within each hemisphere. Physostigmine significantly increased functional brain activation in the cerebellar thalamocortical pathway (midline cerebellum/ventrolateral thalamus/motor cortex), subthalamic nucleus/zona incerta, and red nucleus and bilateral sensory cortex. In conclusion, CCI resulted in increased functional recruitment of contralesional motor cortex and bilateral subcortical motor regions, as well as recruitment of the cerebellar– thalamocortical circuit and contralesional sensory cortex. This phenomenon, augmented by physostigmine, may partially compensate motor deficits. FC decreased inter-hemispherically and in negative, but not positive, intra-hemispherical FC, and it was not affected by physostigmine. Circuit-based approaches into functional brain reorganization may inform future behavioral or molecular strategies to augment targeted neurorehabilitation. Fil: Holschneider, Daniel P.. University of California at Los Angeles; Estados Unidos Fil: Guo, Yumei. University of California at Los Angeles; Estados Unidos Fil: Wang, Zhuo. University of California at Los Angeles; Estados Unidos Fil: Roch, Margareth. University of California at Los Angeles; Estados Unidos Fil: Scremin, Oscar Umberto. University of California at Los Angeles; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina |
description |
We explored whether cerebral cortical impact injury (CCI) effects extend beyond direct lesion sites to affect remote brain networks, and whether acetylcholinesterase (AChE) inhibition elicits discrete changes in functional activation of motor circuits following CCI. Adult male rats underwent unilateral motor-sensory CCI or sham injury. Physostigmine (AChE inhibitor) or saline were administered subcutaneously continuously via implanted minipumps (1.6 micromoles/kg/day) for 3 weeks, followed by cerebral perfusion mapping during treadmill walking using [14C]-iodoantipyrine. Quantitative autoradiographs were analyzed by statistical parametric mapping and functional connectivity (FC) analysis. CCI resulted in functional deficits in the ipsilesional basal ganglia, with increased activation contralesionally. Recruitment was also observed, especially contralesionally, of the red nucleus, superior colliculus, pedunculopontine tegmental nucleus, thalamus (ventrolateral n., central medial n.), cerebellum, and sensory cortex. FC decreased significantly within ipsi- and contralesional motor circuits and between hemispheres, but increased between midline cerebellum and select regions of the basal ganglia within each hemisphere. Physostigmine significantly increased functional brain activation in the cerebellar thalamocortical pathway (midline cerebellum/ventrolateral thalamus/motor cortex), subthalamic nucleus/zona incerta, and red nucleus and bilateral sensory cortex. In conclusion, CCI resulted in increased functional recruitment of contralesional motor cortex and bilateral subcortical motor regions, as well as recruitment of the cerebellar– thalamocortical circuit and contralesional sensory cortex. This phenomenon, augmented by physostigmine, may partially compensate motor deficits. FC decreased inter-hemispherically and in negative, but not positive, intra-hemispherical FC, and it was not affected by physostigmine. Circuit-based approaches into functional brain reorganization may inform future behavioral or molecular strategies to augment targeted neurorehabilitation. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-01 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/21589 Holschneider, Daniel P.; Guo, Yumei; Wang, Zhuo; Roch, Margareth; Scremin, Oscar Umberto; Remote brain network changes after unilateral cortical impact injury and their modulation by Acetylcholinesterase inhibition; Mary Ann Liebert Inc; Journal of Neurotrauma; 30; 11; 1-2013; 907-919 0897-7151 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/21589 |
identifier_str_mv |
Holschneider, Daniel P.; Guo, Yumei; Wang, Zhuo; Roch, Margareth; Scremin, Oscar Umberto; Remote brain network changes after unilateral cortical impact injury and their modulation by Acetylcholinesterase inhibition; Mary Ann Liebert Inc; Journal of Neurotrauma; 30; 11; 1-2013; 907-919 0897-7151 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1089/neu.2012.2657 info:eu-repo/semantics/altIdentifier/url/http://online.liebertpub.com/doi/abs/10.1089/neu.2012.2657 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Mary Ann Liebert Inc |
publisher.none.fl_str_mv |
Mary Ann Liebert Inc |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.070432 |