Region-specific changes in Mus musculus brain size and cell composition under chronic nutrient restriction

Autores
Barbeito Andrés, Jimena; Castro Fonseca, Emily; Qiu, Lily R.; Bernal, Valeria; Lent, Roberto; Henkelman, Mark; Lukowiak, Kenneth; Gleiser, Pablo Martin; Hallgrimsson, Benedikt; Gonzalez, Paula Natalia
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Nutrition is one of the most influential environmental factors affecting the development of different tissues and organs. It is suggested that under nutrient restriction the growth of the brain is spared as a result of the differential allocation of resources from other organs. However, it is not clear whether this sparing occurs brain-wide. Here, we analyzed morphological changes and cell composition in different regions of the offspring mouse brain after maternal exposure to nutrient restriction during pregnancy and lactation. Using highresolution magnetic resonance imaging, we found that brain regions were differentially sensitive to maternal protein restriction and exhibited particular patterns of volume reduction. The cerebellum was reduced in absolute and relative volume, while cortex volume was relatively preserved. Alterations in cell composition (examined by the isotropic fractionator method) and organization of white matter (measured by diffusor tensor images) were also region specific. These changes were not related to the metabolic rate of the regions and were only partially explained by their specific growth trajectories. This study is a first step towards understanding the mechanisms of regional brain sparing at microstructural and macrostructural levels resulting from undernutrition.
Fil: Barbeito Andrés, Jimena. Universidad Nacional Arturo Jauretche. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos; Argentina
Fil: Castro Fonseca, Emily. Universidade Federal do Rio de Janeiro; Brasil
Fil: Qiu, Lily R.. University of Toronto; Canadá
Fil: Bernal, Valeria. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. División Antropología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Lent, Roberto. Universidade Federal do Rio de Janeiro; Brasil
Fil: Henkelman, Mark. University of Toronto; Canadá
Fil: Lukowiak, Kenneth. University of Calgary; Canadá
Fil: Gleiser, Pablo Martin. Consejo Nacional de Investigaciones Cientcasy Tecnicas (conicet); Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina
Fil: Hallgrimsson, Benedikt. University of Calgary; Canadá
Fil: Gonzalez, Paula Natalia. Universidad Nacional Arturo Jauretche. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos; Argentina
Materia
Brain sparing
Brain cortex
Cerebellum
Magnetic resonance imaging
Isotropic fractionator
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/121433
Acceder
id CONICETDig_a97a1770f1bd2347925e20b55fb90442
oai_identifier_str oai:ri.conicet.gov.ar:11336/121433
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Region-specific changes in Mus musculus brain size and cell composition under chronic nutrient restrictionBarbeito Andrés, JimenaCastro Fonseca, EmilyQiu, Lily R.Bernal, ValeriaLent, RobertoHenkelman, MarkLukowiak, KennethGleiser, Pablo MartinHallgrimsson, BenediktGonzalez, Paula NataliaBrain sparingBrain cortexCerebellumMagnetic resonance imagingIsotropic fractionatorhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Nutrition is one of the most influential environmental factors affecting the development of different tissues and organs. It is suggested that under nutrient restriction the growth of the brain is spared as a result of the differential allocation of resources from other organs. However, it is not clear whether this sparing occurs brain-wide. Here, we analyzed morphological changes and cell composition in different regions of the offspring mouse brain after maternal exposure to nutrient restriction during pregnancy and lactation. Using highresolution magnetic resonance imaging, we found that brain regions were differentially sensitive to maternal protein restriction and exhibited particular patterns of volume reduction. The cerebellum was reduced in absolute and relative volume, while cortex volume was relatively preserved. Alterations in cell composition (examined by the isotropic fractionator method) and organization of white matter (measured by diffusor tensor images) were also region specific. These changes were not related to the metabolic rate of the regions and were only partially explained by their specific growth trajectories. This study is a first step towards understanding the mechanisms of regional brain sparing at microstructural and macrostructural levels resulting from undernutrition.Fil: Barbeito Andrés, Jimena. Universidad Nacional Arturo Jauretche. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos; ArgentinaFil: Castro Fonseca, Emily. Universidade Federal do Rio de Janeiro; BrasilFil: Qiu, Lily R.. University of Toronto; CanadáFil: Bernal, Valeria. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. División Antropología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Lent, Roberto. Universidade Federal do Rio de Janeiro; BrasilFil: Henkelman, Mark. University of Toronto; CanadáFil: Lukowiak, Kenneth. University of Calgary; CanadáFil: Gleiser, Pablo Martin. Consejo Nacional de Investigaciones Cientcasy Tecnicas (conicet); Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; ArgentinaFil: Hallgrimsson, Benedikt. University of Calgary; CanadáFil: Gonzalez, Paula Natalia. Universidad Nacional Arturo Jauretche. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos; ArgentinaCompany of Biologists2019-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/121433Barbeito Andrés, Jimena; Castro Fonseca, Emily; Qiu, Lily R.; Bernal, Valeria; Lent, Roberto; et al.; Region-specific changes in Mus musculus brain size and cell composition under chronic nutrient restriction; Company of Biologists; Journal of Experimental Biology; 222; 17; 9-2019; 1-100022-0949CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://jeb.biologists.org/lookup/doi/10.1242/jeb.204651info:eu-repo/semantics/altIdentifier/doi/10.1242/jeb.204651info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:11:44Zoai:ri.conicet.gov.ar:11336/121433instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:11:44.504CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Region-specific changes in Mus musculus brain size and cell composition under chronic nutrient restriction
title Region-specific changes in Mus musculus brain size and cell composition under chronic nutrient restriction
spellingShingle Region-specific changes in Mus musculus brain size and cell composition under chronic nutrient restriction
Barbeito Andrés, Jimena
Brain sparing
Brain cortex
Cerebellum
Magnetic resonance imaging
Isotropic fractionator
title_short Region-specific changes in Mus musculus brain size and cell composition under chronic nutrient restriction
title_full Region-specific changes in Mus musculus brain size and cell composition under chronic nutrient restriction
title_fullStr Region-specific changes in Mus musculus brain size and cell composition under chronic nutrient restriction
title_full_unstemmed Region-specific changes in Mus musculus brain size and cell composition under chronic nutrient restriction
title_sort Region-specific changes in Mus musculus brain size and cell composition under chronic nutrient restriction
dc.creator.none.fl_str_mv Barbeito Andrés, Jimena
Castro Fonseca, Emily
Qiu, Lily R.
Bernal, Valeria
Lent, Roberto
Henkelman, Mark
Lukowiak, Kenneth
Gleiser, Pablo Martin
Hallgrimsson, Benedikt
Gonzalez, Paula Natalia
author Barbeito Andrés, Jimena
author_facet Barbeito Andrés, Jimena
Castro Fonseca, Emily
Qiu, Lily R.
Bernal, Valeria
Lent, Roberto
Henkelman, Mark
Lukowiak, Kenneth
Gleiser, Pablo Martin
Hallgrimsson, Benedikt
Gonzalez, Paula Natalia
author_role author
author2 Castro Fonseca, Emily
Qiu, Lily R.
Bernal, Valeria
Lent, Roberto
Henkelman, Mark
Lukowiak, Kenneth
Gleiser, Pablo Martin
Hallgrimsson, Benedikt
Gonzalez, Paula Natalia
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Brain sparing
Brain cortex
Cerebellum
Magnetic resonance imaging
Isotropic fractionator
topic Brain sparing
Brain cortex
Cerebellum
Magnetic resonance imaging
Isotropic fractionator
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Nutrition is one of the most influential environmental factors affecting the development of different tissues and organs. It is suggested that under nutrient restriction the growth of the brain is spared as a result of the differential allocation of resources from other organs. However, it is not clear whether this sparing occurs brain-wide. Here, we analyzed morphological changes and cell composition in different regions of the offspring mouse brain after maternal exposure to nutrient restriction during pregnancy and lactation. Using highresolution magnetic resonance imaging, we found that brain regions were differentially sensitive to maternal protein restriction and exhibited particular patterns of volume reduction. The cerebellum was reduced in absolute and relative volume, while cortex volume was relatively preserved. Alterations in cell composition (examined by the isotropic fractionator method) and organization of white matter (measured by diffusor tensor images) were also region specific. These changes were not related to the metabolic rate of the regions and were only partially explained by their specific growth trajectories. This study is a first step towards understanding the mechanisms of regional brain sparing at microstructural and macrostructural levels resulting from undernutrition.
Fil: Barbeito Andrés, Jimena. Universidad Nacional Arturo Jauretche. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos; Argentina
Fil: Castro Fonseca, Emily. Universidade Federal do Rio de Janeiro; Brasil
Fil: Qiu, Lily R.. University of Toronto; Canadá
Fil: Bernal, Valeria. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. División Antropología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Lent, Roberto. Universidade Federal do Rio de Janeiro; Brasil
Fil: Henkelman, Mark. University of Toronto; Canadá
Fil: Lukowiak, Kenneth. University of Calgary; Canadá
Fil: Gleiser, Pablo Martin. Consejo Nacional de Investigaciones Cientcasy Tecnicas (conicet); Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina
Fil: Hallgrimsson, Benedikt. University of Calgary; Canadá
Fil: Gonzalez, Paula Natalia. Universidad Nacional Arturo Jauretche. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos; Argentina
description Nutrition is one of the most influential environmental factors affecting the development of different tissues and organs. It is suggested that under nutrient restriction the growth of the brain is spared as a result of the differential allocation of resources from other organs. However, it is not clear whether this sparing occurs brain-wide. Here, we analyzed morphological changes and cell composition in different regions of the offspring mouse brain after maternal exposure to nutrient restriction during pregnancy and lactation. Using highresolution magnetic resonance imaging, we found that brain regions were differentially sensitive to maternal protein restriction and exhibited particular patterns of volume reduction. The cerebellum was reduced in absolute and relative volume, while cortex volume was relatively preserved. Alterations in cell composition (examined by the isotropic fractionator method) and organization of white matter (measured by diffusor tensor images) were also region specific. These changes were not related to the metabolic rate of the regions and were only partially explained by their specific growth trajectories. This study is a first step towards understanding the mechanisms of regional brain sparing at microstructural and macrostructural levels resulting from undernutrition.
publishDate 2019
dc.date.none.fl_str_mv 2019-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/121433
Barbeito Andrés, Jimena; Castro Fonseca, Emily; Qiu, Lily R.; Bernal, Valeria; Lent, Roberto; et al.; Region-specific changes in Mus musculus brain size and cell composition under chronic nutrient restriction; Company of Biologists; Journal of Experimental Biology; 222; 17; 9-2019; 1-10
0022-0949
CONICET Digital
CONICET
url http://hdl.handle.net/11336/121433
identifier_str_mv Barbeito Andrés, Jimena; Castro Fonseca, Emily; Qiu, Lily R.; Bernal, Valeria; Lent, Roberto; et al.; Region-specific changes in Mus musculus brain size and cell composition under chronic nutrient restriction; Company of Biologists; Journal of Experimental Biology; 222; 17; 9-2019; 1-10
0022-0949
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://jeb.biologists.org/lookup/doi/10.1242/jeb.204651
info:eu-repo/semantics/altIdentifier/doi/10.1242/jeb.204651
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Company of Biologists
publisher.none.fl_str_mv Company of Biologists
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083265500282880
score 13.22299

Publicaciones similares