Protein kinase C and cancer: what we know and what we do not

Autores
Garg, R.; Benedetti, L.G.; Abera, M. B.; Wang, H.; Abba, Martín Carlos; Kazanietz, M.G.
Año de publicación
2014
Idioma
inglés
Tipo de recurso
reseña artículo
Estado
versión publicada
Descripción
Since their discovery in the late 1970s, protein kinase C (PKC) isozymes represent one of the most extensively studied signaling kinases. PKCs signal through multiple pathways and control the expression of genes relevant for cell cycle progression, tumorigenesis and metastatic dissemination. Despite the vast amount of information concerning the mechanisms that control PKC activation and function in cellular models, the relevance of individual PKC isozymes in the progression of human cancer is still a matter of controversy. Although the expression of PKC isozymes is altered in multiple cancer types, the causal relationship between such changes and the initiation and progression of the disease remains poorly defined. Animal models developed in the last years helped to better understand the involvement of individual PKCs in various cancer types and in the context of specific oncogenic alterations. Unraveling the enormous complexity in the mechanisms by which PKC isozymes have an impact on tumorigenesis and metastasis is key for reassessing their potential as pharmacological targets for cancer treatment.
Centro de Investigaciones Inmunológicas Básicas y Aplicadas
Materia
Ciencias Médicas
Animal models
Apoptosis
Metastasis
Protein kinase C (PKC)
Survival
Tumorigenesis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/85265

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network_name_str SEDICI (UNLP)
spelling Protein kinase C and cancer: what we know and what we do notGarg, R.Benedetti, L.G.Abera, M. B.Wang, H.Abba, Martín CarlosKazanietz, M.G.Ciencias MédicasAnimal modelsApoptosisMetastasisProtein kinase C (PKC)SurvivalTumorigenesisSince their discovery in the late 1970s, protein kinase C (PKC) isozymes represent one of the most extensively studied signaling kinases. PKCs signal through multiple pathways and control the expression of genes relevant for cell cycle progression, tumorigenesis and metastatic dissemination. Despite the vast amount of information concerning the mechanisms that control PKC activation and function in cellular models, the relevance of individual PKC isozymes in the progression of human cancer is still a matter of controversy. Although the expression of PKC isozymes is altered in multiple cancer types, the causal relationship between such changes and the initiation and progression of the disease remains poorly defined. Animal models developed in the last years helped to better understand the involvement of individual PKCs in various cancer types and in the context of specific oncogenic alterations. Unraveling the enormous complexity in the mechanisms by which PKC isozymes have an impact on tumorigenesis and metastasis is key for reassessing their potential as pharmacological targets for cancer treatment.Centro de Investigaciones Inmunológicas Básicas y Aplicadas2014info:eu-repo/semantics/reviewinfo:eu-repo/semantics/publishedVersionRevisionhttp://purl.org/coar/resource_type/c_dcae04bcinfo:ar-repo/semantics/resenaArticuloapplication/pdf5225-5237http://sedici.unlp.edu.ar/handle/10915/85265enginfo:eu-repo/semantics/altIdentifier/issn/0950-9232info:eu-repo/semantics/altIdentifier/doi/10.1038/onc.2013.524info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:16:24Zoai:sedici.unlp.edu.ar:10915/85265Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:16:25.217SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Protein kinase C and cancer: what we know and what we do not
title Protein kinase C and cancer: what we know and what we do not
spellingShingle Protein kinase C and cancer: what we know and what we do not
Garg, R.
Ciencias Médicas
Animal models
Apoptosis
Metastasis
Protein kinase C (PKC)
Survival
Tumorigenesis
title_short Protein kinase C and cancer: what we know and what we do not
title_full Protein kinase C and cancer: what we know and what we do not
title_fullStr Protein kinase C and cancer: what we know and what we do not
title_full_unstemmed Protein kinase C and cancer: what we know and what we do not
title_sort Protein kinase C and cancer: what we know and what we do not
dc.creator.none.fl_str_mv Garg, R.
Benedetti, L.G.
Abera, M. B.
Wang, H.
Abba, Martín Carlos
Kazanietz, M.G.
author Garg, R.
author_facet Garg, R.
Benedetti, L.G.
Abera, M. B.
Wang, H.
Abba, Martín Carlos
Kazanietz, M.G.
author_role author
author2 Benedetti, L.G.
Abera, M. B.
Wang, H.
Abba, Martín Carlos
Kazanietz, M.G.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Ciencias Médicas
Animal models
Apoptosis
Metastasis
Protein kinase C (PKC)
Survival
Tumorigenesis
topic Ciencias Médicas
Animal models
Apoptosis
Metastasis
Protein kinase C (PKC)
Survival
Tumorigenesis
dc.description.none.fl_txt_mv Since their discovery in the late 1970s, protein kinase C (PKC) isozymes represent one of the most extensively studied signaling kinases. PKCs signal through multiple pathways and control the expression of genes relevant for cell cycle progression, tumorigenesis and metastatic dissemination. Despite the vast amount of information concerning the mechanisms that control PKC activation and function in cellular models, the relevance of individual PKC isozymes in the progression of human cancer is still a matter of controversy. Although the expression of PKC isozymes is altered in multiple cancer types, the causal relationship between such changes and the initiation and progression of the disease remains poorly defined. Animal models developed in the last years helped to better understand the involvement of individual PKCs in various cancer types and in the context of specific oncogenic alterations. Unraveling the enormous complexity in the mechanisms by which PKC isozymes have an impact on tumorigenesis and metastasis is key for reassessing their potential as pharmacological targets for cancer treatment.
Centro de Investigaciones Inmunológicas Básicas y Aplicadas
description Since their discovery in the late 1970s, protein kinase C (PKC) isozymes represent one of the most extensively studied signaling kinases. PKCs signal through multiple pathways and control the expression of genes relevant for cell cycle progression, tumorigenesis and metastatic dissemination. Despite the vast amount of information concerning the mechanisms that control PKC activation and function in cellular models, the relevance of individual PKC isozymes in the progression of human cancer is still a matter of controversy. Although the expression of PKC isozymes is altered in multiple cancer types, the causal relationship between such changes and the initiation and progression of the disease remains poorly defined. Animal models developed in the last years helped to better understand the involvement of individual PKCs in various cancer types and in the context of specific oncogenic alterations. Unraveling the enormous complexity in the mechanisms by which PKC isozymes have an impact on tumorigenesis and metastasis is key for reassessing their potential as pharmacological targets for cancer treatment.
publishDate 2014
dc.date.none.fl_str_mv 2014
dc.type.none.fl_str_mv info:eu-repo/semantics/review
info:eu-repo/semantics/publishedVersion
Revision
http://purl.org/coar/resource_type/c_dcae04bc
info:ar-repo/semantics/resenaArticulo
format review
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/85265
url http://sedici.unlp.edu.ar/handle/10915/85265
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/0950-9232
info:eu-repo/semantics/altIdentifier/doi/10.1038/onc.2013.524
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
5225-5237
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instname:Universidad Nacional de La Plata
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repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
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