Protein kinase C and cancer: what we know and what we do not
- Autores
- Garg, R.; Benedetti, L.G.; Abera, M. B.; Wang, H.; Abba, Martín Carlos; Kazanietz, M.G.
- Año de publicación
- 2014
- Idioma
- inglés
- Tipo de recurso
- reseña artículo
- Estado
- versión publicada
- Descripción
- Since their discovery in the late 1970s, protein kinase C (PKC) isozymes represent one of the most extensively studied signaling kinases. PKCs signal through multiple pathways and control the expression of genes relevant for cell cycle progression, tumorigenesis and metastatic dissemination. Despite the vast amount of information concerning the mechanisms that control PKC activation and function in cellular models, the relevance of individual PKC isozymes in the progression of human cancer is still a matter of controversy. Although the expression of PKC isozymes is altered in multiple cancer types, the causal relationship between such changes and the initiation and progression of the disease remains poorly defined. Animal models developed in the last years helped to better understand the involvement of individual PKCs in various cancer types and in the context of specific oncogenic alterations. Unraveling the enormous complexity in the mechanisms by which PKC isozymes have an impact on tumorigenesis and metastasis is key for reassessing their potential as pharmacological targets for cancer treatment.
Centro de Investigaciones Inmunológicas Básicas y Aplicadas - Materia
-
Ciencias Médicas
Animal models
Apoptosis
Metastasis
Protein kinase C (PKC)
Survival
Tumorigenesis - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/85265
Ver los metadatos del registro completo
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Protein kinase C and cancer: what we know and what we do notGarg, R.Benedetti, L.G.Abera, M. B.Wang, H.Abba, Martín CarlosKazanietz, M.G.Ciencias MédicasAnimal modelsApoptosisMetastasisProtein kinase C (PKC)SurvivalTumorigenesisSince their discovery in the late 1970s, protein kinase C (PKC) isozymes represent one of the most extensively studied signaling kinases. PKCs signal through multiple pathways and control the expression of genes relevant for cell cycle progression, tumorigenesis and metastatic dissemination. Despite the vast amount of information concerning the mechanisms that control PKC activation and function in cellular models, the relevance of individual PKC isozymes in the progression of human cancer is still a matter of controversy. Although the expression of PKC isozymes is altered in multiple cancer types, the causal relationship between such changes and the initiation and progression of the disease remains poorly defined. Animal models developed in the last years helped to better understand the involvement of individual PKCs in various cancer types and in the context of specific oncogenic alterations. Unraveling the enormous complexity in the mechanisms by which PKC isozymes have an impact on tumorigenesis and metastasis is key for reassessing their potential as pharmacological targets for cancer treatment.Centro de Investigaciones Inmunológicas Básicas y Aplicadas2014info:eu-repo/semantics/reviewinfo:eu-repo/semantics/publishedVersionRevisionhttp://purl.org/coar/resource_type/c_dcae04bcinfo:ar-repo/semantics/resenaArticuloapplication/pdf5225-5237http://sedici.unlp.edu.ar/handle/10915/85265enginfo:eu-repo/semantics/altIdentifier/issn/0950-9232info:eu-repo/semantics/altIdentifier/doi/10.1038/onc.2013.524info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:16:24Zoai:sedici.unlp.edu.ar:10915/85265Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:16:25.217SEDICI (UNLP) - Universidad Nacional de La Platafalse |
dc.title.none.fl_str_mv |
Protein kinase C and cancer: what we know and what we do not |
title |
Protein kinase C and cancer: what we know and what we do not |
spellingShingle |
Protein kinase C and cancer: what we know and what we do not Garg, R. Ciencias Médicas Animal models Apoptosis Metastasis Protein kinase C (PKC) Survival Tumorigenesis |
title_short |
Protein kinase C and cancer: what we know and what we do not |
title_full |
Protein kinase C and cancer: what we know and what we do not |
title_fullStr |
Protein kinase C and cancer: what we know and what we do not |
title_full_unstemmed |
Protein kinase C and cancer: what we know and what we do not |
title_sort |
Protein kinase C and cancer: what we know and what we do not |
dc.creator.none.fl_str_mv |
Garg, R. Benedetti, L.G. Abera, M. B. Wang, H. Abba, Martín Carlos Kazanietz, M.G. |
author |
Garg, R. |
author_facet |
Garg, R. Benedetti, L.G. Abera, M. B. Wang, H. Abba, Martín Carlos Kazanietz, M.G. |
author_role |
author |
author2 |
Benedetti, L.G. Abera, M. B. Wang, H. Abba, Martín Carlos Kazanietz, M.G. |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
Ciencias Médicas Animal models Apoptosis Metastasis Protein kinase C (PKC) Survival Tumorigenesis |
topic |
Ciencias Médicas Animal models Apoptosis Metastasis Protein kinase C (PKC) Survival Tumorigenesis |
dc.description.none.fl_txt_mv |
Since their discovery in the late 1970s, protein kinase C (PKC) isozymes represent one of the most extensively studied signaling kinases. PKCs signal through multiple pathways and control the expression of genes relevant for cell cycle progression, tumorigenesis and metastatic dissemination. Despite the vast amount of information concerning the mechanisms that control PKC activation and function in cellular models, the relevance of individual PKC isozymes in the progression of human cancer is still a matter of controversy. Although the expression of PKC isozymes is altered in multiple cancer types, the causal relationship between such changes and the initiation and progression of the disease remains poorly defined. Animal models developed in the last years helped to better understand the involvement of individual PKCs in various cancer types and in the context of specific oncogenic alterations. Unraveling the enormous complexity in the mechanisms by which PKC isozymes have an impact on tumorigenesis and metastasis is key for reassessing their potential as pharmacological targets for cancer treatment. Centro de Investigaciones Inmunológicas Básicas y Aplicadas |
description |
Since their discovery in the late 1970s, protein kinase C (PKC) isozymes represent one of the most extensively studied signaling kinases. PKCs signal through multiple pathways and control the expression of genes relevant for cell cycle progression, tumorigenesis and metastatic dissemination. Despite the vast amount of information concerning the mechanisms that control PKC activation and function in cellular models, the relevance of individual PKC isozymes in the progression of human cancer is still a matter of controversy. Although the expression of PKC isozymes is altered in multiple cancer types, the causal relationship between such changes and the initiation and progression of the disease remains poorly defined. Animal models developed in the last years helped to better understand the involvement of individual PKCs in various cancer types and in the context of specific oncogenic alterations. Unraveling the enormous complexity in the mechanisms by which PKC isozymes have an impact on tumorigenesis and metastasis is key for reassessing their potential as pharmacological targets for cancer treatment. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/review info:eu-repo/semantics/publishedVersion Revision http://purl.org/coar/resource_type/c_dcae04bc info:ar-repo/semantics/resenaArticulo |
format |
review |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://sedici.unlp.edu.ar/handle/10915/85265 |
url |
http://sedici.unlp.edu.ar/handle/10915/85265 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
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info:eu-repo/semantics/altIdentifier/issn/0950-9232 info:eu-repo/semantics/altIdentifier/doi/10.1038/onc.2013.524 |
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info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
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openAccess |
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http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
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application/pdf 5225-5237 |
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